Dr Samuel Forster | NHMRC CJ Martin Biomedical Fellow

Forster, Samuel

Sam's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.

Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into health and disease. Sam's research seeks to understand the relationship between host state, microbiota community and the susceptibility to diseases including inflammatory bowel disease and infections by opportunistic pathogens such as Clostridium difficile. His research is focused on:

  • Metagenomic sequencing from large patient cohorts to understand microbiota community structure in health and disease and the factors that cause it to change
  • Computational modelling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease
  • Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities

This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health

Publications

  • Illuminating microbial diversity.

    Forster SC

    Nature reviews. Microbiology 2017;15;10;578

  • Transmission of the gut microbiota: spreading of health.

    Browne HP, Neville BA, Forster SC and Lawley TD

    Nature reviews. Microbiology 2017;15;9;531-543

  • Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.

    Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA et al.

    Nature 2016;533;7604;543-546

  • HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes.

    Forster SC, Browne HP, Kumar N, Hunt M, Denise H et al.

    Nucleic acids research 2016;44;D1;D604-9

  • Systematic discovery of probiotics.

    Forster SC and Lawley TD

    Nature biotechnology 2015;33;1;47-9

  • Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1.

    de Weerd NA, Vivian JP, Nguyen TK, Mangan NE, Gould JA et al.

    Nature immunology 2013;14;9;901-7

  • RNA-eXpress annotates novel transcript features in RNA-seq data.

    Forster SC, Finkel AM, Gould JA and Hertzog PJ

    Bioinformatics (Oxford, England) 2013;29;6;810-2

  • Interferome v2.0: an updated database of annotated interferon-regulated genes.

    Rusinova I, Forster S, Yu S, Kannan A, Masse M et al.

    Nucleic acids research 2013;41;Database issue;D1040-6

  • Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.

    Bidwell BN, Slaney CY, Withana NP, Forster S, Cao Y et al.

    Nature medicine 2012;18;8;1224-31

  • Illuminating microbial diversity.

    Forster SC

    Nature reviews. Microbiology 2017;15;10;578

  • Transmission of the gut microbiota: spreading of health.

    Browne HP, Neville BA, Forster SC and Lawley TD

    Nature reviews. Microbiology 2017;15;9;531-543

  • Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.

    Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA et al.

    Nature 2016;533;7604;543-546

  • HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes.

    Forster SC, Browne HP, Kumar N, Hunt M, Denise H et al.

    Nucleic acids research 2016;44;D1;D604-9

  • MicroRNA as Type I Interferon-Regulated Transcripts and Modulators of the Innate Immune Response.

    Forster SC, Tate MD and Hertzog PJ

    Frontiers in immunology 2015;6;334

  • Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.

    Sarvestani ST, Stunden HJ, Behlke MA, Forster SC, McCoy CE et al.

    Nucleic acids research 2015;43;2;1177-88

  • Systematic discovery of probiotics.

    Forster SC and Lawley TD

    Nature biotechnology 2015;33;1;47-9

  • IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.

    Cheon H, Holvey-Bates EG, Schoggins JW, Forster S, Hertzog P et al.

    The EMBO journal 2013;32;20;2751-63

  • Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1.

    de Weerd NA, Vivian JP, Nguyen TK, Mangan NE, Gould JA et al.

    Nature immunology 2013;14;9;901-7

  • Helicobacter pylori VacA suppresses Lactobacillus acidophilus-induced interferon beta signaling in macrophages via alterations in the endocytic pathway.

    Weiss G, Forster S, Irving A, Tate M, Ferrero RL et al.

    mBio 2013;4;3;e00609-12

  • RNA-eXpress annotates novel transcript features in RNA-seq data.

    Forster SC, Finkel AM, Gould JA and Hertzog PJ

    Bioinformatics (Oxford, England) 2013;29;6;810-2

  • Interferome v2.0: an updated database of annotated interferon-regulated genes.

    Rusinova I, Forster S, Yu S, Kannan A, Masse M et al.

    Nucleic acids research 2013;41;Database issue;D1040-6

  • Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.

    Bidwell BN, Slaney CY, Withana NP, Forster S, Cao Y et al.

    Nature medicine 2012;18;8;1224-31

  • Interferon signatures in immune disorders and disease.

    Forster S

    Immunology and cell biology 2012;90;5;520-7

  • Systems biology of interferon responses.

    Hertzog P, Forster S and Samarajiwa S

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31;1;5-11

  • Toll-like receptors as interferon-regulated genes and their role in disease.

    Khoo JJ, Forster S and Mansell A

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31;1;13-25

  • INTERFEROME: the database of interferon regulated genes.

    Samarajiwa SA, Forster S, Auchettl K and Hertzog PJ

    Nucleic acids research 2009;37;Database issue;D852-7

Forster, Samuel
Samuel's Timeline
2015

Adjunct Research Fellow, Faculty of Medicine Nursing and Health Science, Monash University

Research Fellow, Hudson Institute of Medical Research, Australia

Awarded Australian NHMRC CJ-Martin Biomedical Fellowship

2014

Joined Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute