I am a bioinformatician working on parasitic worm genomes. I am interested in understanding how the genomes of parasitic worms (nematodes and platyhelminths) evolve; in identifying worm drug targets and predicting potential novel anthelmintic drugs; and in helping lab biologists to develop new tools to study the biology of parasitic worms.
I am also interested in statistics and bioinformatics methodology, and I've written The Little Books of R (http://little-books-of-r.readthedocs.io/en/latest/) and write a blog on things I learn about bioinformatics, called avrilomics (http://avrilomics.blogspot.co.uk/).
The genomic basis of parasitism in the Strongyloides clade of nematodes.
Nature genetics 2016;48;3;299-307
The genome of the sparganosis tapeworm Spirometra erinaceieuropaei isolated from the biopsy of a migrating brain lesion.
Genome biology 2014;15;11;510
Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses.
PLoS genetics 2013;9;5;e1003330
The genome of the blood fluke Schistosoma mansoni.
TreeFam: a curated database of phylogenetic trees of animal gene families.
Nucleic acids research 2006;34;Database issue;D572-80
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.
PLoS biology 2003;1;2;E45
Origins of recently gained introns in Caenorhabditis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101;31;11362-7
Fourfold faster rate of genome rearrangement in nematodes than in Drosophila.
Genome research 2002;12;6;857-67
Relationship of codon bias to mRNA concentration and protein length in Saccharomyces cerevisiae.
Yeast (Chichester, England) 2000;16;12;1131-45
Genomix: a method for combining gene-finders' predictions, which uses evolutionary conservation of sequence and intron-exon structure.
Bioinformatics (Oxford, England) 2007;23;12;1468-75