News Archive

News Archive

Public Consortium Launches Final Phase of Human Genome Sequencing: 85 percent of Human Genome Sequence Assembled and Available to the Public

Public Consortium Launches Final Phase of Human Genome Sequencing: 85 percent of Human Genome Sequence Assembled and Available to the Public

The milestone marks the transition from the initial phase of generating a 'working draft' of the human DNA to the final phase of producing the complete 'finished' sequence.

Sixteen genome centres around the world from the United States and Europe to Japan and China will officially begin Phase Two of the Human Genome Project tomorrow, May 9 2000.

A collaboration between the Sanger Centre and the EBI adds critical annotation to sequence data from the Human Genome Project

A collaboration between the Sanger Centre and the EBI adds critical annotation to sequence data from the Human Genome Project

Today researchers at the Sanger Centre, a world-leading DNA sequencing centre, and the European Bioinformatics Institute (EBI) announced that their joint bioinformatics project called Ensembl has now confirmed the location of the sequence of more than 35,000 genes on the human genome and has identified a further 150,000 potential gene fragments.

Ensembl is an automatic tool that adds critical information to sequence information as it is submitted to genome databases, enhancing the usefulness of this data to academia and industry. One effect will be to speed up the process of identifying new targets for drug development. The new tool can be found at http://www.ensembl.org/.

Largest grant to study horse disease

Largest grant to study horse disease

A leading horse charity has teamed up with genome researchers in an effort to beat the equine disease strangles.

The Home of Rest for Horses, based in Buckinghamshire, has financed a £250,000 project to decode all the genes in the bacterium that causes strangles, Streptococcus equi. Hundreds of outbreaks of strangles occur each year in the UK and they are often difficult to control and individual cases can be difficult to treat.

Beowulf announces £3 million of new funding for pathogen sequencing

Beowulf announces £3 million of new funding for pathogen sequencing

The Wellcome Trust, via its Beowulf Genomics initiative, has committed more than £3 million to help scientists learn more about some of the causes of sleeping sickness, gastrointestinal infection and toxoplasmosis.

Researchers at the Sanger Centre, near Cambridge, will carry out sequencing work on the genomes of Trypanosoma brucei, Bacteroides fragilis, Yersinia enterocolitica, and Toxoplasma gondii.

The complete genome of the leprosy bacillus has been sequenced

The complete genome of the leprosy bacillus has been sequenced

The sequence of the entire genome of the bacillus causing leprosy has been determined in a collaborative effort between Stewart Cole's team at Institut Pasteur and the Sanger Centre in the Great Britain

Leprosy is a chronic infectious disease mostly affecting the skin, peripheral nerves, mucosa membranes of the upper respiratory tract and the eyes. The mutilations it causes result in lepers being rejected in many societies. Sequencing the genome of the leprosy bacillus (Mycobacterium leprae) was a priority both for research into the disease and for its control.

Two-thirds of Human Genome Given to Researchers Worldwide

Two-thirds of Human Genome Given to Researchers Worldwide

Cambridge scientists are celebrating a monumental milestone in the international Human Genome Project to decode the genetic instructions of humankind.

The Sanger Centre team and their research colleagues from around the world have today announced that they have sequenced two billion 'letters' of human DNA. The sequence is deposited in public databases and is being used daily by researchers worldwide in the quest to understand human disease.

Meningitis Bacterium Code Cracked

Meningitis Bacterium Code Cracked

Researchers in the UK and Germany have decoded all the genes of a bacterium that causes the most common form of meningitis.

Neisseria meningitidis infects half a million people each year, and is associated with major epidemics of meningitis in developing countries. The research paves the way for new methods of detecting, preventing and treating infections.

Wellcome applauds USA and UK governments' commitment to free sequence data

Wellcome applauds USA and UK governments' commitment to free sequence data

Today the United States government and UK Government announced that all DNA sequence data from the Human Genome Project would remain free for use worldwide.

Ensuring that the data from the Human Genome Project remains in the public domain will allow the fruits of this work to be fully exploited by research groups worldwide to develop real healthcare advances.

Genome talks collapse over commercial ownership

Genome talks collapse over commercial ownership

The publicly funded Human Genome Project (HGP) today announced that negotiations with the commercial DNA sequencing company Celera Genomics had broken down. The HGP had hoped that the combined effort of the public and private sector would bring more rapid benefits from the programme.

The talks stumbled when Celera refused to accept a statement of 'Shared Principles' prepared by the HGP participants. The HGP team made repeated attempts to discuss differences with the President of Celera, Dr J. Craig Venter, but received no response from him throughout January and February.

Scientists reveal clues to food poisoning bug

Scientists reveal clues to food poisoning bug

Scientists have identified the genetic make-up of the bug responsible for the majority of food poisoning outbreaks. The work paves the way for treatments that may eventually prevent or cure gastro-enteritis attacks that are, at best, extremely unpleasant, and, at worst, can kill.

The first food-borne pathogen to be sequenced, C. jejuni is harboured by half of the poultry destined for human consumption. It is responsible for around 60,000 reported cases of food poisoning in the UK each year - over three times more than the infamous Salmonella. The bacterium thrives in the human gut where it can cause severe diarrhoea and, in rare cases, Guillain-Barre syndrome, a neuromuscular condition that can lead to death.

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