News Archive

News Archive

Scientists Identify Gene Involved In 70 Percent Of Melanomas

Scientists Identify Gene Involved In 70 Percent Of Melanomas

Researchers have identified a major genetic change that leads to malignant melanoma, a potentially lethal form of skin cancer that kills more than 1600 people per year in the UK.

Researchers say that the mutation, which makes skin cells grow out of control, is so clear-cut that drugs are already being designed to block the action of the defective gene.

Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society

Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society

Professor Allan Bradley, Director of the Wellcome Trust Sanger Institute, has been elected to Fellowship of the Royal Society, an honour regarded as the UK's premier scientific accolade.

Professor Bradley took over as Director of the Wellcome Trust Sanger Institute in 2000 to develop programmes to capitalize on decoding the human genome and other genomes. He is a world leader in the field of stem cell research - methods he and his colleagues developed in the early 1980s that today provide one of the most promising routes for understanding and treating genetic disease

Scientists sequence Nature's antibiotic factory

Scientists sequence Nature's antibiotic factory

The genome sequence of Streptomyces coelicolor, one of the family of common soil bacteria that produce more than two thirds of the world's antibiotic medicines, is published in the journal Nature.

Streptomyces are almost ubiquitous in the soils and are responsible for its familiar 'earthy' smell. The genome data, collected by British scientists from the John Innes Centre and The Wellcome Trust Sanger Institute, is already being used in research that will help develop new types of antibiotics, anticancer agents and other beneficial chemicals.

International Team of Researchers Assembles Draft Sequence of Mouse Genome

International Team of Researchers Assembles Draft Sequence of Mouse Genome

Ninety-six percent of mouse genome sequenced; Results freely available in public databases on Internet

This achievement represents a major milestone for the Human Genome Project because it provides a key tool needed to interpret the human sequence, a draft version of which was published last year. Researchers will be better able to understand the function of many human genes because the mouse carries virtually the same set of genes as the human but can be used in laboratory research.

Wellcome Trust Proposal To Extend Genome Campus

Wellcome Trust Proposal To Extend Genome Campus

The proposal will extend the leading genome centre to include a post-genomic research facility for academic and industry scientists.

The proposed extension will provide cutting-edge academic research facilities for the Sanger Institute as it progresses from sequencing the human genome to discovering what genes do. It will also include an Innovation Centre for genomics start-up companies and space for grow-on companies seeking to expand.

MHC Haplotype Consortium Web Resource

MHC Haplotype Consortium Web Resource

A Cambridge-based Consortium today announced a new web resource designed to help medical researchers in the fight against diseases like diabetes, rheumatoid arthritis and multiple sclerosis.

The MHC Haplotype Consortium - formed by researchers at the Wellcome Trust Sanger Institute and the University of Cambridge - will define the most common differences in DNA code that can lead to these diseases. An accurate molecular understanding should lead to improved diagnosis and treatment.

The complete genome of Mycobacterium bovis has been sequenced

The complete genome of Mycobacterium bovis has been sequenced

A step forward in the fight against bovine tuberculosis: The complete genome of Mycobacterium bovis has been sequenced

The sequencing project has revealed that the genome of M. bovis is greater than 99.9% identical to Mycobacterium tuberculosis, the causative agent of human tuberculosis, which kills over two million people a year. Analysis of the two genomes has revealed an unexpected evolutionary scenario for the development of these two pathogens. Since the M. bovis genome is smaller than that of M. tuberculosis, it is more likely that man gave tuberculosis to cattle or that the two organisms evolved separately from a common ancestor.

Humble yeast to help tackle cancer

Humble yeast to help tackle cancer

A British-led international team of scientists has broken the genetic code of fission yeast, a development which is likely to have major implications for the future of cancer and bio-medical research.

In today's Nature (Thursday 21 February 2002), Dr Paul Nurse, who is Joint Director General of Cancer Research UK, and Dr Bart Barrell and Val Wood from the Wellcome Trust Sanger Institute, report their analysis of the genome of fission yeast (Schizosaccharomyces pombe). Fifty of the yeast genes were found to have significant similarity with genes involved in human diseases, including cystic fibrosis, hereditary deafness and non insulin dependent diabetes, and half were found to be cancer related.

Dermatitis, Diabetes, Dementia:

Dermatitis, Diabetes, Dementia:

Chromosome 20 Gives up its Secrets

A treasure trove for biomedical science, chromosome 20 contains nearly 60 million DNA "letters", and more than 720 genes - less than half of which have been fully characterized. An intriguing discovery is that the sequence also shows that two in five of us have an extra 'chunk' of DNA. This region appears to be an 'insertion' and contains at least one gene.

Typhoid fever bug sequence raises hope of complete eradication

Typhoid fever bug sequence raises hope of complete eradication

Scientists from Britain, Denmark and Vietnam have deciphered the genetic code of the bacterium responsible for typhoid fever, Salmonella typhi.

Their achievement, reported in the magazine Nature today, raises hope for the prospects of completely eradicating typhoid, which currently claims 600,000 lives a year globally.

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