Phenotyping Data for Mysm1 (MAHN) Associated with 'limbs/digits/tail' (MP:0005371)

Dysmorphology: Dysmorphology - significant parameters
Dysmorphology (week 9) [Mice were fed on High Fat Diet (21.4% crude fat content, Western RD, 829100, Special Diets Services) from 4 weeks of age]: Whole body morphology is examined using a standardised checklist.
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Het
Female
Hom
Male
Het
Male
Hom
population
parameter
Graph MP Annotation
Forelimb Size
Forepaw Size
Forepaw Foot Pads
Hindlimb Size view graph MP:0000556 - abnormal hindlimb morphology
Hind Paw Size view graph MP:0000556 - abnormal hindlimb morphology
Tail Morphology view graph MP:0003051 - curly tail
Tail Length view graph MP:0000592 - short tail
X-ray Imaging: Standard Protocol - significant parameters
X-Ray Morphology (week 14) [Mice were fed on High Fat Diet (21.4% crude fat content, Western RD, 829100, Special Diets Services) from 4 weeks of age]: Digital X-Ray images are acquired using a Faxitron system MX20 (Faxitron X-ray Corporation). Mice are anaesthetised and up to five standard images are taken for each mouse. The images are annotated using a standardised protocol
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Het
Female
Hom
Male
Het
Male
Hom
population
parameter
Graph MP Annotation
Humerus
Radius
Ulna
Femur
Tibia
Number of Caudal Vertebrae view graph MP:0001539 - decreased caudal vertebrae number
Transitional Vertebrae
Fusion of Vertebrae view graph
Fibula
Joints
Number of Digits
Polysyndactylism
Brachydactylism
Syndactylism
Digit Integrity
Recessive Lethal Study: Standard Protocol - significant parameters
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter population
parameter
Graph MP Annotation
Recessive Lethal Study MP:0003051 - oedema
Tail Epidermis Wholemount: Standard Protocol - significant parameters
Tail Epidermis Whole mount Collaboration (week 16) [Mice were fed on Mouse Breeder Diet (5021, Labdiet) from weaning]: Whole mount preparations of tail epidermis are prepared essentially as described by Braun et al (Development 130:5241-5255, 2003). Whole mounts are labeled with antibodies to keratin 14 (red) and keratin 15 (green), and counter-stained with DAPI to reveal cell nuclei (blue). Keratin 14 is expressed by undifferentiated cells in the hair follicles, sebaceous glands and interfollicular epidermis. Keratin 15 is expressed by the reservoir of stem cells in the hair follicle bulge. This phenotyping collaboration is performed with Fiona Watt and colleagues at the Cambridge Research Institute.
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter population
parameter
Graph MP Annotation
Tail Epidermis Wholemount MP:0002111 - distorted hair follicle pattern
MicroCT & Quantitative Faxitron: Standard Protocol
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter population
parameter
Graph MP Annotation
MicroCT & Quantitative Faxitron