Available Products
- Mice (1931)
- EUCOMM Mice (898)
- KOMP-CSD Mice (469)
- KOMP-Regeneron Mice (448)
- NorCOMM Mice (4)
- mirKO Mice (0)
- TIGM Mice (149)
- ES Cells (17305)
- EUCOMM ES Cells (7773)
- KOMP-CSD ES Cells (5518)
- KOMP-Regeneron ES Cells (4009)
- NorCOMM ES Cells (569)
- mirKO ES Cells (223)
- TIGM ES Cells (9356)
- Vectors (16322)
- EUCOMM Vectors (9885)
- KOMP-CSD Vectors (6591)
- KOMP-Regeneron Vectors (4731)
- NorCOMM Vectors (839)
- mirKO Vectors (0)
- TIGM Vectors (0)
Mammalian Phenotype
- adipose tissue (33)
- behavior/neurological (85)
- cardiovascular system (57)
- cellular (22)
- craniofacial (32)
- digestive/alimentary (0)
- embryogenesis (6)
- endocrine/exocrine gland (6)
- growth/size (70)
- hearing/vestibular/ear (26)
- hematopoietic system (89)
- homeostasis/metabolism (136)
- immune system (119)
- lethality-postnatal (0)
- lethality-prenatal/perinatal (0)
- life span-post-weaning/aging (0)
- limbs/digits/tail (24)
- liver/biliary system (0)
- muscle (0)
- nervous system (27)
- no phenotypic analysis (0)
- normal (0)
- other (0)
- pigmentation (62)
- renal/urinary system (2)
- reproductive system (28)
- respiratory system (1)
- skeleton (92)
- skin/coat/nails (0)
- taste/olfaction (0)
- touch/vibrissae (0)
- tumorigenesis (0)
- vision/eye (205)
Chromosome
Browsing Data by Mammalian Phenotype: 'nervous system'
Ap4e1 |
Gene Details
| Marker Name(s): |
adaptor-related protein complex AP-4, epsilon 1 view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | 2310033A20Rik, 9930028M04Rik, AV087807 |
| Location: | Chr2:127008717-127067909(+) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1336993 | Ensembl Gene ID: | ENSMUSG00000001998 | Vega Gene ID: | OTTMUSG00000016016 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 108011 | CCDS ID: |
Interpro Families
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ap4e1tm1a(KOMP)Wtsi | MYFZ | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ap4e1tm1a(KOMP)Wtsi | MYFZ | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
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Link to a test report page |
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Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| contact distributor | Ap4e1tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | MYFZ | EPD0025_5_A08 | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
view data
( about ) |
WTSI/UCD | |||||||||||||||||||||||||||||||
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Data provided by The International Knockout Mouse Consortium (IKMC)
IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
|---|---|---|---|
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KOMP-CSD (Project: 26007) |
order | order | view details |
ES Cell Clones
| Cassette Type | 15 Knockout-First Alleles | 1 Targeted Non-Conditional Alleles | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Promotorless |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_A07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_A08 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_A09 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_B09 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_C07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_C08 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_C09 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_E07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_E09 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_F07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_F09 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_G07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_G09 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_H07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_H08 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0025_5_B07 | PGS00023_A_B07 | C57BL/6N | JM8.N4 | tm1e(KOMP)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
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| 35132 | PGS00023_A_B07 | PCS00023_E_B07 | L1L2_gt0 | L3L4_pZero_DTA_kan | view |
| 35132 | PGS00023_A_B07 | PCS00023_E_B07 | L1L2_gt0 | L3L4_pZero_DTA_kan | view |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
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| 31 | 10 | 2 | 2 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Arl4d |
Gene Details
| Marker Name(s): |
ADP-ribosylation factor-like 4D view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | 1110036H21Rik, AW456149, Arf4l, Arfl4, Arl5 |
| Location: | Chr11:101665541-101667832(+) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1933155 | Ensembl Gene ID: | ENSMUSG00000034936 | Vega Gene ID: | OTTMUSG00000014383 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 80981 | CCDS ID: |
Interpro Families
- Elongation Factor, Gtp Binding Domain (IPR000795)
- Small Gt Pase Superfamily (IPR001806)
- Small Gt Pase Superfamily, Rab Type (IPR003579)
- Small Gtp Binding Protein Domain (IPR005225)
- Small Gt Pase Superfamily, Sar1 Type (IPR006687)
- Small Gt Pase Superfamily, Arf/Sar Type (IPR006689)
- Gtr1/Rag A G Protein (IPR006762)
- Mitochondrial Rho Like (IPR013684)
- Signal Recognition Particle Receptor, Beta Subunit (IPR019009)
- Small Gt Pase Superfamily, Arf Type (IPR024156)
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arl4dtm1a(EUCOMM)Wtsi | MBTW | C57BL/6Dnk;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arl4dtm1a(EUCOMM)Wtsi | MBTW | C57BL/6Dnk;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
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Link to a test report page |
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Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| contact distributor | Arl4dtm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | EM:05856 | MBTW | EPD0117_1_G06 | C57BL/6Dnk;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
view data
( about ) |
WTSI/Harwell | ||||||||||||||||||||||||||||||
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IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
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EUCOMM (Project: 29643) |
order | order | view details |
ES Cell Clones
| Cassette Type | 5 Knockout-First Alleles | 0 Targeted Non-Conditional Alleles | ||||||
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| Promotorless |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0117_1_B05 | PGS00064_A_B05 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0117_1_B06 | PGS00064_A_B05 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0117_1_C06 | PGS00064_A_B05 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0117_1_F05 | PGS00064_A_B05 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0117_1_G06 | PGS00064_A_B05 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
No clones available.
Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 47396 | PGS00064_A_B05 | PCS00064_A_B05 | L1L2_gt0 | L3L4_pZero_DTA_kan | view |
| Vectors | ES Cells | ||
|---|---|---|---|
|
KOMP-Regeneron |
ES cell colonies picked | Projects: VG18495 |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
|---|---|---|---|---|
| 36 | 2 | 0 | 1 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Brd7 |
Gene Details
| Marker Name(s): |
bromodomain containing 7 view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | BP75, CELTIX1, bromodomain protein 75 kDa |
| Location: | Chr8:88331039-88362194(-) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1349766 | Ensembl Gene ID: | ENSMUSG00000031660 | Vega Gene ID: | OTTMUSG00000017292 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 26992 | CCDS ID: |
Interpro Families
Orthologs / Homologs
| Species | Marker Symbol | Entrez Gene ID | Ensembl Gene ID |
|---|---|---|---|
| Human | BRD7 | 29117 |
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brd7tm2a(EUCOMM)Wtsi | MAAB | 129S5/SvEvBrd/Wtsi;129S5/SvEvBrd/Wtsi;129S7 |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brd7tm2a(EUCOMM)Wtsi | MAAB | 129S5/SvEvBrd/Wtsi;129S5/SvEvBrd/Wtsi;129S7 |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
|
Link to a test report page |
|
Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| contact distributor | Brd7tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | EM:04469 | MAAB | EPD0001_3_E04 | 129S5/SvEvBrd/Wtsi;129S5/SvEvBrd/Wtsi;129S7 |
view data
( about ) |
WTSI/Harwell | ||||||||||||||||||||||||||||||
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IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
|---|---|---|---|
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EUCOMM (Project: 72416) |
order | order | view details |
ES Cell Clones
| Cassette Type | 1 Knockout-First Alleles | 0 Targeted Non-Conditional Alleles | ||||||
|---|---|---|---|---|---|---|---|---|
| Promotorless |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EPD0001_3_E04 | PGS00001_A_C12 | SI2.3 | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
No clones available.
Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 39614 | PGS00001_A_C12 | PCS00001_A_C12 | L1L2_gt2 | L3L4_pZero_DTA_kan | view |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
|---|---|---|---|---|
| 22 | 2 | 1 | 2 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Ccdc57 |
Gene Details
| Marker Name(s): |
coiled-coil domain containing 57 view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | 4933434G05Rik |
| Location: | Chr11:120826529-120932872(-) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1918526 | Ensembl Gene ID: | ENSMUSG00000048445 | Vega Gene ID: | OTTMUSG00000004162 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 71276 | CCDS ID: |
Orthologs / Homologs
| Species | Marker Symbol | Entrez Gene ID | Ensembl Gene ID |
|---|---|---|---|
| Human | CCDC57 | 284001 |
Data provided by Mouse Genome Informatics (MGI)
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ccdc57tm1a(EUCOMM)Wtsi | MALA | C57BL/6Dnk;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ccdc57tm1a(EUCOMM)Wtsi | MALA | C57BL/6Dnk;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
|
Link to a test report page |
|
Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| contact distributor | Ccdc57tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | EM:05377 | MALA | EPD0037_3_D11 | C57BL/6Dnk;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
view data
( about ) |
WTSI/CNB | ||||||||||||||||||||||||||||||
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IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
|---|---|---|---|
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EUCOMM (Project: 28283) |
order | order | view details |
ES Cell Clones
| Cassette Type | 40 Knockout-First Alleles | 14 Targeted Non-Conditional Alleles | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Promotorless |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_A07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_A09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_B07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_B09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_C08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_D07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_D08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_D09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_E08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_E09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_F07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_F08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_F09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_G07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_G08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_H07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_H08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_H09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_B01 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_B03 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_C01 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_C02 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_D01 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_D02 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_E02 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_F01 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_F02 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_G01 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_G02 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_G03 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_A10 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_A11 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_B12 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_C12 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_D11 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_D12 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_F12 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_G11 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_H10 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_H12 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EPD0014_3_A08 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_C07 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_C09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0014_3_G09 | PGS00006_A_C05 | 129S7 | AB2.2 | tm3e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_C03 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_E03 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_H01 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0021_5_H02 | PGS00006_A_C05 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_B10 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_C11 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_E12 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_F10 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_F11 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0037_3_G10 | PGS00016_A_C11 | C57BL/6N | JM8.N4 | tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 162 | PGS00016_A_C11 | PCS00016_A_C11 | L1L2_gt2 | L3L4_pZero_DTA_kan | view |
| 162 | PGS00016_A_C11 | PCS00016_A_C11 | L1L2_gt2 | L3L4_pZero_DTA_kan | view |
| 162 | PGS00006_A_C05 | PCS00006_A_C11 | L1L2_gt2 | L3L4_pZero_DTA_kan | view |
| 162 | PGS00006_A_C05 | PCS00006_A_C11 | L1L2_gt2 | L3L4_pZero_DTA_kan | view |
| Vectors | ES Cells | ||
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KOMP-Regeneron (Project: VG17827) |
order | order | view details |
ES Cell Clones
| Cassette Type | 6 Deletion Alleles | ||||
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| Promotor Driven |
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ES Cell Clones With Conditional Potential
No clones available.
ES Cell Clones Without Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 17827A-A6 | VG17827 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 17827A-F12 | VG17827 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 17827A-F5 | VG17827 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 17827A-F9 | VG17827 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 17827A-G12 | VG17827 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 17827A-G2 | VG17827 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
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| VG17827 | ZEN-Ub1 | view |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
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| 30 | 11 | 3 | 4 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Ccl22 |
Gene Details
| Marker Name(s): |
chemokine (C-C motif) ligand 22 view this gene in MGI |
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| Marker Type: | protein coding gene |
| Synonyms: | ABCD-1, MDC, Scya22 |
| Location: | Chr8:94745590-94751699(+) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1306779 | Ensembl Gene ID: | ENSMUSG00000031779 | Vega Gene ID: | OTTMUSG00000016635 |
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| Entrez Gene ID: | 20299 | CCDS ID: |
Interpro Families
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ccl22tm1a(EUCOMM)Wtsi | MDML | C57BL/6NTac;C57BL/6NTac;C57BL/6N-Atm1Brd/a |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ccl22tm1a(EUCOMM)Wtsi | MDML | C57BL/6NTac;C57BL/6NTac;C57BL/6N-Atm1Brd/a |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
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Link to a test report page |
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Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| currently unavailable | Ccl22tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | EM:05530 | MDML | EPD0497_2_E09 | C57BL/6NTac;C57BL/6NTac;C57BL/6N-Atm1Brd/a |
view data
( about ) |
WTSI | ||||||||||||||||||||||||||||||
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| currently unavailable | Ccl22tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | BL1979 | 14851B-D3 | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
view data
( about ) |
UCD/ | |||||||||||||||||||||||||||||||
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IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
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EUCOMM (Project: 72403) |
order | order | view details |
ES Cell Clones
| Cassette Type | 3 Knockout-First Alleles | 0 Targeted Non-Conditional Alleles | ||||||
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| Promotor Driven |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0497_2_E09 | PG00056_Y_1_D07 | C57BL/6N-Atm1Brd/a | JM8A3.N1 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0497_2_F10 | PG00056_Y_1_D07 | C57BL/6N-Atm1Brd/a | JM8A3.N1 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0497_2_F12 | PG00056_Y_1_D07 | C57BL/6N-Atm1Brd/a | JM8A3.N1 | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
No clones available.
Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 44448 | PG00056_Y_1_D07 | PCS00056_A_A11 | L1L2_Bact_P | L3L4_pZero_DTA_kan | view |
| Vectors | ES Cells | ||
|---|---|---|---|
|
KOMP-Regeneron (Project: VG14851) |
order | order | view details |
ES Cell Clones
| Cassette Type | 2 Deletion Alleles | ||||
|---|---|---|---|---|---|
| Promotor Driven |
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ES Cell Clones With Conditional Potential
No clones available.
ES Cell Clones Without Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 14851B-D3 | VG14851 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 14851B-G2 | VG14851 | C57BL/6NTac | VGB6 | tm1(KOMP)Vlcg | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| VG14851 | ZEN-Ub1 | view |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
|---|---|---|---|---|
| 18 | 3 | 3 | 1 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Chd7 |
Gene Details
| Marker Name(s): |
chromodomain helicase DNA binding protein 7 view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | A730019I05Rik, Cycn, Cyn, Dz, Edy, Flo, GENA 47, GENA 60, Gena 52, Lda, Mt, Obt, Todo, WBE1, Whi |
| Location: | Chr4:8690406-8867659(+) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:2444748 | Ensembl Gene ID: | ENSMUSG00000041235 | Vega Gene ID: | OTTMUSG00000004417 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 320790 | CCDS ID: |
Interpro Families
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chd7 |
FL |
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| Chd7 |
MAMF |
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| Chd7tm2a(EUCOMM)Wtsi | MAWN | 129S5/SvEvBrd/Wtsi;C57BL/6N |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chd7 |
FL |
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| Chd7 |
MAMF |
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| Chd7tm2a(EUCOMM)Wtsi | MAWN | 129S5/SvEvBrd/Wtsi;C57BL/6N |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
|
Link to a test report page |
|
Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| contact distributor | Chd7tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | EM:04817 | MAWN | EPD0019_1_D07 | 129S5/SvEvBrd/Wtsi;C57BL/6N |
view data
( about ) |
WTSI/CNB | ||||||||||||||||||||||||||||||
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| order | Chd7Mt | EM:00082 | Metis; BDV | C3;C-Chd7 |
no data reported
( about ) |
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| order | Chd7Cycn | EM:00108 | Cyclone, BDS. Sp.79+ | C3;C-Chd7 |
no data reported
( about ) |
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| order | Chd7Todo | EM:01900 | Chd7 |
C3;C-Chd7 |
no data reported
( about ) |
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| order | Chd7Edy | EM:01902 | Chd7 |
C3;C-Chd7 |
no data reported
( about ) |
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| order | Chd7Dz | EM:01904 | Chd7 |
C3;C-Chd7 |
no data reported
( about ) |
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| order | Chd7Whi | EM:04923 | Whirligig, Chd7 |
C3HeB/FeJ-Chd7 |
no data reported
( about ) |
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| order | Chd7Flo | EM:05017 | Flouncer | C3HeB/FeJ-Chd7 |
no data reported
( about ) |
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IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
|---|---|---|---|
|
EUCOMM (Project: 35714) |
order | order | view details |
ES Cell Clones
| Cassette Type | 9 Knockout-First Alleles | 8 Targeted Non-Conditional Alleles | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Promotorless |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EPD0019_1_A09 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_B09 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_C09 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_D07 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_E07 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_F08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_G09 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_H07 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_H08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EPD0019_1_A07 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_B08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_C07 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_C08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_D08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_D09 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_E08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0019_1_G08 | PGS00021_B_F02 | C57BL/6N | JM8 parental | tm2e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 35837 | PGS00021_B_F02 | PCS00021_A_F02 | L1L2_st0 | L3L4_pZero_DTA_kan | view |
| 35837 | PGS00021_B_F02 | PCS00021_A_F02 | L1L2_st0 | L3L4_pZero_DTA_kan | view |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
|---|---|---|---|---|
| 45 | 8 | 5 | 4 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Dnase1l2 |
Gene Details
| Marker Name(s): |
deoxyribonuclease 1-like 2 view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | 4733401H14Rik |
| Location: | Chr17:24440081-24443105(-) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1913955 | Ensembl Gene ID: | ENSMUSG00000024136 | Vega Gene ID: | OTTMUSG00000029900 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 66705 | CCDS ID: |
Interpro Families
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dnase1l2tm1(KOMP)Wtsi | MAYG | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dnase1l2tm1(KOMP)Wtsi | MAYG | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
|
Link to a test report page |
|
Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| contact distributor | Dnase1l2tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | MAYG | EPD0296_2_A10 | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
view data
( about ) |
WTSI/UCD | |||||||||||||||||||||||||||||||
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Data provided by The International Knockout Mouse Consortium (IKMC)
IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
|---|---|---|---|
|
KOMP-CSD (Project: 33505) |
order | order | view details |
ES Cell Clones
| Cassette Type | 10 Deletion Alleles | ||||
|---|---|---|---|---|---|
| Promotor Driven |
|
ES Cell Clones With Conditional Potential
No clones available.
ES Cell Clones Without Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_A10 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_B11 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_B12 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_C09 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_D10 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_F10 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_F11 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_G09 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_G11 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0296_2_G12 | DPGS00107_A_D08 | C57BL/6N | JM8.N4 | tm1(KOMP)Wtsi | Deletion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 96758 | DPGS00107_A_D08 | PCS00107_A_D08 | L1L2_Bact_P | L4L3_pD223_DTA_spec | view |
| Vectors | ES Cells | ||
|---|---|---|---|
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EUCOMM |
Design Completed | Projects: 117202 |
| Vectors | ES Cells | ||
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KOMP-Regeneron |
Targeting Vector QC Completed | Projects: VG14857 |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
|---|---|---|---|---|
| 15 | 6 | 0 | 1 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Dusp3 |
Gene Details
| Marker Name(s): |
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | 2210015O03Rik, 5031436O03Rik, T-DSP11, VHR |
| Location: | Chr11:101971143-101987013(-) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1919599 | Ensembl Gene ID: | ENSMUSG00000003518 | Vega Gene ID: | OTTMUSG00000002139 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 72349 | CCDS ID: |
Interpro Families
- Protein Tyrosine Phosphatase, Receptor/Non Receptor Type (IPR000242)
- Dual Specificity Phosphatase, Catalytic Domain (IPR000340)
- Protein Tyrosine/Dual Specificity Phosphatase (IPR000387)
- Atypical Dual Specificity Phosphatase, Subfamily A (IPR020405)
- Atypical Dual Specificity Phosphatase (IPR020417)
- Dual Specificity Phosphatase, Subgroup, Catalytic Domain (IPR020422)
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dusp3tm1a(KOMP)Wtsi | MBVF | C57BL/6N;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
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| Dusp3 |
MDUS |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dusp3tm1a(KOMP)Wtsi | MBVF | C57BL/6N;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
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| Dusp3 |
MDUS |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
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Link to a test report page |
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Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| currently unavailable | Dusp3tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | BL856 | EPD0090_4_C10 | C57BL/6N |
view data
( about ) |
UCD | |||||||||||||||||||||||||||||||
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| currently unavailable | Dusp3tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | MFTP | EPD0090_4_C10 | C57BL/6NTac;C57BL/6NTac;C57BL/6N |
view data
( about ) |
WTSI | |||||||||||||||||||||||||||||||
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| currently unavailable | Dusp3tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | MBVF | EPD0090_4_H11 | C57BL/6N;C57BL/6Brd-Tyrc-Brd;C57BL/6N |
view data
( about ) |
WTSI/UCD | |||||||||||||||||||||||||||||||
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Data provided by The International Knockout Mouse Consortium (IKMC)
IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
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KOMP-CSD (Project: 32778) |
order | order | view details |
ES Cell Clones
| Cassette Type | 4 Knockout-First Alleles | 0 Targeted Non-Conditional Alleles | ||||||
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| Promotor Driven |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0090_4_A10 | PRPGS00048_A_B06 | C57BL/6N | JM8.N19 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0090_4_C10 | PRPGS00048_A_B06 | C57BL/6N | JM8.N19 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0090_4_C10 | PRPGS00048_A_B06 | C57BL/6N | JM8.N19 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0090_4_H11 | PRPGS00048_A_B06 | C57BL/6N | JM8.N19 | tm1a(KOMP)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ES Cell Clones Without Conditional Potential
No clones available.
Targeting Vectors
| Design | Targeting Vector | Intermediate Vector | Cassette | Backbone | Targeting Vector Genbank File |
|---|---|---|---|---|---|
| 43878 | PRPGS00048_A_B06 | PCS00048_A_B06 | L1L2_Bact_P | R3R4_pBR_amp | view |
Data provided by The International Knockout Mouse Consortium (IKMC)
DNA Clone Resources
| C57Bl/6J Bacs | 129 Bacs | MICER clones | KO Targeting Vectors | |
|---|---|---|---|---|
| 22 | 8 | 3 | 3 | view in Ensembl |
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Epc2 |
Gene Details
| Marker Name(s): |
enhancer of polycomb homolog 2 (Drosophila) view this gene in MGI |
|---|---|
| Marker Type: | protein coding gene |
| Synonyms: | D2Ertd694e |
| Location: | Chr2:49451486-49551948(+) |
Related Human Conditions (from OMIM) - no related Human Condition
More Information
| MGI Gene Accession: | MGI:1278321 | Ensembl Gene ID: | ENSMUSG00000069495 | Vega Gene ID: | OTTMUSG00000012480 |
|---|---|---|---|---|---|
| Entrez Gene ID: | 227867 | CCDS ID: |
Interpro Families
WTSI Phenotyping
MP Ontology Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | adipose tissue | behavior/neurological | cardiovascular system | cellular | craniofacial | digestive/alimentary | embryogenesis | endocrine/exocrine gland | growth/size | hearing/vestibular/ear | hematopoietic system | homeostasis/metabolism | immune system | integument | limbs/digits/tail | liver/biliary system | mortality/aging | muscle | nervous system | other | pigmentation | renal/urinary system | reproductive system | respiratory system | skeleton | taste/olfaction | tumorigenesis | vision/eye |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Epc2tm1e(EUCOMM)Wtsi | MACG | C57BL/6Dnk;C57BL/6Dnk;C57BL/6N |
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| Legend: | No Raw Data | No Significant Annotations | Significant Annotation Present | |
Link to a test report page |
About This Heatmap
This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.
Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.
Phenotyping Test Based Heatmap
| Allele Name | Colony Prefix | Colony Strain | Viability at weaning | Recessive Lethal Study | Fertility | Embryo LacZ Expression | Adult LacZ Expression | General Observations | Weight Curves | Open Field | Modified SHIRPA | Grip Strength | Hot Plate | Dysmorphology | Rotarod | Non-Invasive Blood Pressure | Prepulse Inhibition | Indirect Calorimetry | Glucose Tolerance (ip) | Auditory Brainstem Response | Body Composition (DEXA) | X-ray Imaging | Stress Induced Hyperthermia | Eye Morphology | Plasma Chemistry | Plasma Immunoglobulins | Haematology (CBC) | Peripheral Blood Lymphocytes | Micronuclei | Tissue Biobank | Heart Weight | Heart Histology | Tail Epidermis Wholemount | Skin Histopathology | Brain Histopathology | Eye Histopathology | MicroCT & Quantitative Faxitron | Salmonella Challenge | Citrobacter Challenge |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Epc2tm1e(EUCOMM)Wtsi | MACG | C57BL/6Dnk;C57BL/6Dnk;C57BL/6N |
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| Legend - hover over each heading to get a more complete description | ||||||||
| Test complete and data/resources are available | Test is complete and the data are considered interesting | Preliminary indication of an interesting phenotype | ||||||
| Test is complete but the data are not considered interesting | Test not performed or applicable | Test pending | ||||||
| Test abandoned |
|
Link to a test report page |
|
Link to a pdf report | ||||
Data provided by The Wellcome Trust Sanger Institute (WTSI)
Mice
| Allele Name | Allele Type | EMMA ID | Colony Prefix | ES Cell/Common Name | Genetic Background | QC/Screening Data | MI/Distribution Centre | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| currently unavailable | Epc2tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | EM:05198 | GSF-EPD0018_2_G10-1 | EPD0018_2_G10 | C57BL/6NTac;C57BL/6N |
view data
( about ) |
HMGU | ||||||||||||||||||||||||||||||
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| currently unavailable | Epc2tm1e(EUCOMM)Wtsi | Targeted Non-Conditional (Promotorless Cassette) | EM:05434 | MACG | EPD0013_1_B09 | C57BL/6Dnk;C57BL/6Dnk;C57BL/6N |
view data
( about ) |
WTSI/Oulu | ||||||||||||||||||||||||||||||
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IKMC Vectors and ES Cells
| Vectors | ES Cells | ||
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EUCOMM (Project: 37325) |
order | order | view details |
ES Cell Clones
| Cassette Type | 26 Knockout-First Alleles | 4 Targeted Non-Conditional Alleles | ||||||||
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| Promotorless |
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ES Cell Clones With Conditional Potential
| ES Cell Clone | Targeting Vector | ES Cell Strain | ES Cell Line | Allele | Allele Type | QC/Screening Data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0011_3_D02 | PGS00013_A_A01 | C57BL/6N | SI6.C21 | tm2a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_A09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_B09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_C09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_D09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_E09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_F09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0013_1_G09 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0018_2_A11 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0018_2_A12 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0018_2_B10 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0018_2_B11 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0018_2_B12 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| EPD0018_2_C10 | PGS00013_A_A01 | C57BL/6N | JM8 parental | tm1a(EUCOMM)Wtsi | Knockout-First - Reporter Tagged Insertion (Promotorless Cassette) | view data ( about ) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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