The Wellcome Trust Sanger Institute produces, characterizes, and utilizes a variety of biological reagents to advance mammalian genetics research using the mouse as a model. To maximize the generation of new knowledge, the Institute also aims to facilitate the distribution of these resources to the external scientific community, click here for the mouse resource portal. Click here to view a beta version of the new portal,

Mouse Genetics Programme:

A high throughput programme to generate and characterize genetically altered mice to further the understanding of the mechanisms underlying human diseases.

HTGT:

As part of the international knockout mouse consortium, a high-throughput pipeline has been established to generate conditional targeted mutations in C57BL/6 embryonic stem cells.

Genetrap:

Sanger Institute Gene Trap Resource has more than 10,000 characterized lacZ-tagged insertional mutations in 129 embryonic stem cells.

MICER:

Mutagenic Insertion and Chromosome Engineering Resource

Mouse Genomics:

Investigations of the function of genes using the mouse as model genetic system

Genetics Of Deafness:

Developmental studies, detailed electrophysiological measurements of cochlear function, genetic manipulation and high-quality ultrastructural studies, to get an insight into the basic biological mechanisms underlying hearing impairment

Genes to Cognition:

Our research focus is on the molecular basis of learning and memory. Using mouse genetic and proteomic approaches we have characterised a multiprotein complex of proteins found at the synapse

Mouse Cancer Genetics:

Cloning of a large number of putative oncogenes and tumour suppressor genes will enable us to develop a rational database to delineate the genetic pathways, or signal transduction pathways, required for the tumour development

Mouse Developmental Genetics:

Define new genetic pathways that are critical for normal mammalian development