The "Matched Pair Cancer Cell Lines" are a set of 40 cancer cell lines
each of which has a matched normal. The set consists of 9 breast ductal
carcinomas, 11 lung carcinomas, 5 renal cell carcinomas, 6 malignant
melanomas, 3 head/neck squamous cell carcinomas, 2 bladder carcinomas,
and 1 of each of the following, glioma, colorectal adenocarcinoma,
pancreatic ductal carcinoma and pleura mesothelioma.
This series of cell lines is being screened across the CGP Candidate
Cancer Gene set of 4,000 genes. These genes have been selected on the
basis of:-
- 1. Involved in the same pathways as known cancer genes.
- 2. Are members of gene families which include known cancer genes.
- 3. Reside in pathways which may be involved in tumourgenesis.
All mutations have been verified as somatic by analysis of the matched cell line normal.
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