25 April 2014

Seeking causes of osteoarthritis

New Cambridgeshire study aims to unravel the genetic causes of osteoarthritis

Dr Kalliope Panoutsopoulou

Dr Kalliope Panoutsopoulou [K Panoutsopoulou]

Researchers at the Wellcome Trust Sanger Institute near Cambridge have been awarded funding by medical research charity Arthritis Research UK to uncover rare genetic factors that could affect people's risk of developing osteoarthritis.

Osteoarthritis is caused by a complex interplay between genetic and environmental factors and is the most common musculoskeletal condition in older people. Around a third of people aged 45 years and over in the UK, almost nine million people, have sought treatment from their GP for osteoarthritis.

The researchers, Dr Kalliope Panoutsopoulou and Professor Eleftheria Zeggini from the Wellcome Trust Sanger Institute in Hinxton, Cambridgeshire, will now aim to identify genetic factors that lead to the development of osteoarthritis and look at how they interact with environmental factors to increase a person's risk of developing the disease.

This particular study will focus on rare genetic variants which may have escaped detection using previous research and technologies. The team will also investigate the genetic differences in the clinical characteristics and disease severity seen between patients.

The £365,056 five-year study will build upon previous information made available from the arcOGEN project, the largest genetic study of osteoarthritis to date. Funded by Arthritis Research UK and involving researchers across the UK, including the Sanger Institute, the project identified nine genetic regions which are associated with disease. However there are also thought to be additional genetic variants yet to be identified. These may be less common in the population but may have a bigger contribution to people's risk of osteoarthritis, making them attractive targets for future treatments.

" Investigating the genetic determinants that underlie differences in disease will enable better therapies and more personalised treatment options. "

Dr Kalliope Panoutsopoulou

"Establishing the genetic factors that predispose people to developing this debilitating and painful disease is a crucial first step in the research path towards developing new treatments," says Lead Investigator, Dr Panoutsopoulou. "Investigating the genetic determinants that underlie differences in disease, for example severity, coupled with looking at environmental factors such as weight, will enable better therapies and more personalised treatment options."

"Osteoarthritis can have a very negative impact on a person's life causing loss of freedom of movement and pain," says Medical director at Arthritis Research UK, Professor Alan Silman. "This important study could have far-reaching effects in terms of better understanding of the disease and identifying new treatment targets."

Osteoarthritis can develop in any joint in the body, although the knee and hip are often the most commonly affected joints. In severe cases, osteoarthritis can be a substantial barrier to mobility and independence, affecting wellbeing and quality of life, by causing people's joints to become painful and stopping them moving freely.

Arthritis Research UK is the leading authority on arthritis in the UK, conducting scientific and medical research into all types of arthritis and related musculoskeletal conditions. Receiving no government funding, it is the UK's fourth largest medical research charity and the only charity solely committed to funding high quality research into the cause, treatment and cure of arthritis.

Notes to Editors

Arthritis Research UK

Arthritis Research UK is the leading authority on arthritis in the UK, conducting scientific and medical research into all types of arthritis and related musculoskeletal conditions. It is the UK's fourth largest medical research charity and the only charity solely committed to funding high quality research into the cause, treatment and cure of arthritis.

For further information, please email Wesley Hutchins in the Arthritis Research UK press office or phone on 020 7307 2228.

Websites

The Wellcome Trust Sanger Institute

The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease.

Website

The Wellcome Trust

The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. We support the brightest minds in biomedical research and the medical humanities. Our breadth of support includes public engagement, education and the application of research to improve health. We are independent of both political and commercial interests.

Website

Contact the Press Office

Don Powell Media and Public Relations Manager
Wellcome Trust Sanger Institute, Hinxton, Cambs, CB10 1SA, UK

Tel +44 (0)1223 496 928
Mobile +44 (0)7753 775 397
Fax +44 (0)1223 494 919
Email press.office@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/ahf5fw5e