Professor Nicholas Thomson

Professor Nicholas Thomson's research uses genomic techniques to understand infectious disease in the context of global health. His studies include investigating how variation in bacterial genomes impacts on host-bacteria interaction. In addition, his team uses phylogenomics of pathogens competing within their natural host to identify novel and known factors associated with 'fitness' and onward transmission.

Nicholas graduated from Warwick University in 1991 in Microbiology and Microbial Technology and then went on to earn a PhD in global regulation of virulence and secondary metabolism in enteric bacteria.

Before joining the Sanger Institute, Nicholas worked as a Postdoctoral Fellow at the University of Cambridge Biochemistry Department and L'Institut National des Sciences Appliquées (INSA) de Lyon, France.

In 1999, Nicholas moved to the Institute as a Senior Computer Biologist. He has subsequently become a Principal Scientist and runs a group focussed on bacterial genomics. In 2012 he received an honorary chair at the University of St Andrews, School of Medicine. At the end of 2013 Nicholas took up a joint appointment between the Sanger Institute and the London School of Hygiene and Tropical Medicine where he is Chair of Bacterial Genomics and Evolution.

Selected Publications

  • Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts.

    Mather AE, Reid SW, Maskell DJ, Parkhill J, Fookes MC, Harris SR, Brown DJ, Coia JE, Mulvey MR, Gilmour MW, Petrovska L, de Pinna E, Kuroda M, Akiba M, Izumiya H, Connor TR, Suchard MA, Lemey P, Mellor DJ, Haydon DT and Thomson NR

    Science (New York, N.Y.) 2013;341;6153;1514-7

  • Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe.

    Holt KE, Baker S, Weill FX, Holmes EC, Kitchen A, Yu J, Sangal V, Brown DJ, Coia JE, Kim DW, Choi SY, Kim SH, da Silveira WD, Pickard DJ, Farrar JJ, Parkhill J, Dougan G and Thomson NR

    Nature genetics 2012;44;9;1056-9

  • Evidence for several waves of global transmission in the seventh cholera pandemic.

    Mutreja A, Kim DW, Thomson NR, Connor TR, Lee JH, Kariuki S, Croucher NJ, Choi SY, Harris SR, Lebens M, Niyogi SK, Kim EJ, Ramamurthy T, Chun J, Wood JL, Clemens JD, Czerkinsky C, Nair GB, Holmgren J, Parkhill J and Dougan G

    Nature 2011;477;7365;462-5

[Wellcome Library, London]

Role
Principal Scientist, Bacterial genomics
Email
nicholas.thomson@sanger.ac.uk
* quick link - http://q.sanger.ac.uk/vzbfjdqz