ID MTBH37RV standard; circular genomic DNA; PRO; 4411532 BP. XX AC AL123456; XX SV AL123456.1 XX DT 18-JUL-2002 (Rel. 72, Created) DT 18-JUL-2002 (Rel. 72, Last updated, Version 1) XX DE Mycobacterium tuberculosis H37Rv complete genome. XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex; Mycobacterium tuberculosis. XX RN [1] RX MEDLINE; 98295987. RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393:537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology 148:2967-2973(2002). XX RN [3] RP 1-4411529 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX XX FH Key Location/Qualifiers FH FT source 1..4411532 FT /db_xref="taxon:83332" FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT CDS 1..1524 FT /evidence=experimental FT /function="PLAYS AN IMPORTANT ROLE IN THE INITIATION AND FT REGULATION OF CHROMOSOMAL REPLICATION. BINDS TO THE ORIGIN FT OF REPLICATION; IT BINDS SPECIFICALLY DOUBLE-STRANDED DNA FT AT A 9 BP CONSENSUS (DNAA BOX): 5'-TTATC(C/A)A(C/A)A-3'. FT DNAA BINDS TO ATP AND TO ACIDIC PHOSPHOLIPIDS. DNAA FT PROTEIN BINDS THE ORIGIN OF REPLICATION (oriC), ATP AND FT ADP, AND EXHIBITED WEAK ATPase ACTIVITY." FT /gene="dnaA" FT /locus_tag="Rv0001" FT /note="Rv0001, (MT0001, MTV029.01, P49993), len: 507 aa. FT dnaA, chromosomal replication initiator protein (see FT citations below), equivalent to other Mycobacterial FT CHROMOSOMAL REPLICATION INITIATOR PROTEINS e.g. FT P46388|DNAA_MYCLE from Mycobacterium leprae (502 aa); FT Q9L7L7|DNAA_MYCPA from Mycobacterium paratuberculosis (509 FT aa); P49990|DNAA_MYCAV from Mycobacterium avium (508 aa); FT P49992|DNAA_MYCSM from Mycobacterium smegmatis (504 aa); FT etc. Also highly similar to others except in N-terminus FT e.g. Q9ZH75|DNAA_STRCH CHROMOSOMAL REPLICATION INITIATOR FT PROTEIN from Streptomyces chrysomallus (624 aa); FT Q9ZH76|DNAA_STRRE from Streptomyces reticuli (643 aa); FT DNAA_ECOLI|P03004|B3702 chromosomal replication initiator FT protein from Escherichia coli strain K12 (467 aa), FASTA FT scores: opt: 986, E(): 0, (43.2% identity in 389 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop) and PS01008 DnaA protein signature. BELONGS TO FT THE DNAA FAMILY. Note that the first base of this gene has FT been taken as base 1 of the Mycobacterium tuberculosis FT H37Rv genomic sequence." FT /product="CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA" FT misc_feature 622..645 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 1384..1440 FT /note="PS01008 DnaA protein signature" FT CDS 2052..3260 FT /EC_number="2.7.7.7" FT /evidence=experimental FT /function="DNA POLYMERASE III IS A COMPLEX, MULTICHAIN FT ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS FT IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' FT EXONUCLEASE ACTIVITY. THE BETA CHAIN IS REQUIRED FOR FT INITIATION OF REPLICATION ONCE IT IS CLAMPED ONTO DNA, IT FT SLIDES FREELY (BIDIRECTIONAL AND ATP-INDEPENDENT) ALONG FT DUPLEX DNA [CATALYTIC ACTIVITY: N deoxynucleoside FT triphosphate = N diphosphate + {DNA}N]." FT /gene="dnaN" FT /locus_tag="Rv0002" FT /note="Rv0002, (MTV029.02, MTCY10H4.0), len: 402 aa. dnaN, FT DNA polymerase III (beta chain) (EC 2.7.7.7) (see FT citations below), equivalent to other Mycobacterial DNA FT POLYMERASES III BETA CHAIN e.g. NP_301130.1|NC_002677 from FT Mycobacterium leprae (399 aa); Q9L7L6|DP3B_MYCPA from FT Mycobacterium avium subsp. paratuberculosis (399 aa); FT P52851|DP3B_MYCSM from Mycobacterium smegmatis (397 aa); FT etc. Also highly similar to others e.g. P27903|DP3B_STRCO FT DNA POLYMERASE III BETA CHAIN from Streptomyces coelicolor FT (376 aa), FASTA scores: opt: 1189, E(): 0, (52.8% identity FT in 337 aa overlap); P21174|DP3B_MICLU from Micrococcus FT luteus (310 aa); P52023|DP3B_SYNP7 from Synechococcus sp. FT strain PCC 7942 (375 aa); etc. Overlaps and extends CDS in FT neighbouring cosmid MTCY10H4.01." FT /product="DNA POLYMERASE III (BETA CHAIN) DNAN (DNA FT NUCLEOTIDYLTRANSFERASE)" FT CDS 3280..4437 FT /evidence=experimental FT /function="THE RECF PROTEIN IS INVOLVED IN DNA METABOLISM FT AND RECOMBINATION; IT IS REQUIRED FOR DNA REPLICATION AND FT NORMAL SOS INDUCIBILITY. RECF BINDS PREFERENTIALLY TO FT SINGLE-STRANDED, LINEAR DNA. IT ALSO SEEMS TO BIND ATP." FT /gene="recF" FT /locus_tag="Rv0003" FT /note="Rv0003, (MTCY10H4.01), len: 385 aa. recF, DNA FT replication and repair protein (see citations below), FT equivalent to others Mycobacterial DNA replication and FT repair proteins e.g. NP_301131.1|NC_002677 from FT Mycobacterium leprae (385 aa); Q9L7L5|RECF_MYCPA from FT Mycobacterium avium subsp. paratuberculosis (385 aa); FT P50916|RECF_MYCSM from Mycobacterium smegmatis (384 aa); FT etc. Also highly similar to others e.g. P36176|RECF_STRCO FT DNA REPLICATION AND REPAIR PROTEIN from Streptomyces FT coelicolor (373 aa); NP_440892.1|NC_000911 from FT Synechocystis sp. strain PCC 6803 (384 aa); FT NP_469352.1|NC_003212 from Listeria innocua (370 aa); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00617 RecF protein signature 1, and PS00618 RecF protein FT signature 2. BELONGS TO THE RECF FAMILY." FT /product="DNA REPLICATION AND REPAIR PROTEIN RECF FT (SINGLE-STRAND DNA BINDING PROTEIN)" FT misc_feature 3367..3390 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 3634..3690 FT /note="PS00617 RecF protein signature 1" FT misc_feature 4243..4296 FT /note="PS00618 RecF protein signature 2" FT CDS 4434..4997 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0004" FT /note="Rv0004, (MTCY10H4.02), len: 187 aa. Conserved FT hypothetical protein (see Salazar et al., 1996), highly FT similar, but longer 21 aa in N-terminus, to FT AAF33696.1|AF222789 unknown protein from Mycobacterium FT avium subsp. paratuberculosis (166 aa); and highly similar FT to NP_301132.1|NC_002677 conserved hypothetical protein FT from Mycobacterium leprae (189 aa); S70990 hypothetical FT protein from Mycobacterium smegmatis (194 aa). Also highly FT similar, except in N-terminal part, to FT NP_599256.1|NC_003450 conserved hypothetical protein from FT Corynebacterium glutamicum (178 aa), 47.0% identity. Also FT very weakly similar in C-terminus to C-terminal part of FT P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN FT RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor FT (190 aa), FASTA scores: opt: 404, E(): 3.9e-18, (40.7% FT identity in 189 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 5123..7267 FT /EC_number="5.99.1.3" FT /evidence=experimental FT /function="DNA GYRASE NEGATIVELY SUPERCOILS CLOSED FT CIRCULAR DOUBLE-STRANDED DNA IN AN ATP-DEPENDENT MANNER FT AND ALSO CATALYZES THE INTERCONVERSION OF OTHER FT TOPOLOGICAL ISOMERS OF DOUBLE-STRANDED DNA RINGS, FT INCLUDING CATENANES AND KNOTTED RINGS [CATALYTIC ACTIVITY: FT ATP-dependent breakage, passage and rejoining of FT double-stranded DNA]." FT /gene="gyrB" FT /locus_tag="Rv0005" FT /note="Rv0005, (MTCY10H4.03), len: 714 aa. gyrB, DNA FT gyrase subunit B (EC 5.99.1.3) (see citations below), FT equivalent, except in N-terminus, to other Mycobacterial FT DNA GYRASES SUBUNIT B e.g. T10005 from Mycobacterium FT leprae (697 aa); Q9L7L3|GYRB_MYCPA from Mycobacterium FT avium subsp. paratuberculosis (677 aa) (has its N-terminus FT shorter); P48355|GYRB_MYCSM from Mycobacterium smegmatis FT (675 aa); etc. Also highly similar to others e.g. T10969 FT from Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH FT from Streptomyces spheroides (684 aa); etc. Contains FT PS00177 DNA topoisomerase II signature. BELONGS TO THE FT TYPE II TOPOISOMERASE FAMILY." FT /product="DNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE FT (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA FT TOPOISOMERASE)" FT misc_feature 6608..6634 FT /note="PS00177 DNA topoisomerase II signature" FT CDS 7302..9818 FT /EC_number="5.99.1.3" FT /evidence=experimental FT /function="DNA GYRASE NEGATIVELY SUPERCOILS CLOSED FT CIRCULAR DOUBLE-STRANDED DNA IN AN ATP-DEPENDENT MANNER FT AND ALSO CATALYZES THE INTERCONVERSION OF OTHER FT TOPOLOGICAL ISOMERS OF DOUBLE-STRANDED DNA RINGS, FT INCLUDING CATENANES AND KNOTTED RINGS [CATALYTIC ACTIVITY: FT ATP-dependent breakage, passage and rejoining of FT double-stranded DNA]." FT /gene="gyrA" FT /locus_tag="Rv0006" FT /note="Rv0006, (MTCY10H4.04), len: 838 aa. gyrA, DNA FT gyrase subunit A (EC 5.99.1.3) (see citations below), FT equivalent, except in N-terminus, to other Mycobacterial FT DNA GYRASES SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from FT Mycobacterium leprae (1273 aa); P48354|GYRA_MYCSM from FT Mycobacterium smegmatis (842 aa); etc. Also highly similar FT to others e.g. P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from FT Streptomyces coelicolor (864 aa); NP_346654.1|NC_003030 FT from Clostridium acetobutylicum (830 aa); FT NP_387888.1|NC_000964 from Bacillus subtilis (821 aa); FT etc. Contains PS00018 EF-hand calcium-binding domain." FT /product="DNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE FT (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA FT TOPOISOMERASE)" FT misc_feature 8811..8849 FT /note="PS00018 EF-hand calcium-binding domain" FT CDS 9914..10828 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0007" FT /note="Rv0007, (MTCY10H4.05), len: 304 aa. Possible FT conserved membrane protein, highly similar to FT Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FT FASTA scores: opt: 812, E(): 1.6e-25, (54.2% identity in FT 319 aa overlap). C-terminal part highly similar to FT C-terminus of CAB92992.1|AL357152 putative integral FT membrane protein from Streptomyces coelicolor (185 aa); FT and N-terminal part highly similar to C-terminus of FT NP_302684.1|NC_002677 hypothetical protein from FT Mycobacterium leprae (123 aa)." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT tRNA 10887..10960 FT /gene="tRNA-Ile (GAT)" FT /anticodon=(pos:10921..10923,aa:Ile) FT /product="transfer RNA-Ile(GAT)" FT tRNA 11112..11184 FT /gene="tRNA-Ala(TGC)" FT /anticodon=(pos:11145..11147,aa:Ala) FT /product="transfer RNA-Ala (TGC)" FT CDS complement(11874..12311) FT /function="UNKNOWN" FT /locus_tag="Rv0008c" FT /note="Rv0008c, (MTCY10H4.07c), len: 145 aa. Possible FT membrane protein." FT /product="POSSIBLE MEMBRANE PROTEIN" FT CDS 12468..13016 FT /EC_number="5.2.1.8" FT /evidence=experimental FT /function="PPIASES ACCELERATE THE FOLDING OF PROTEINS FT [CATALYTIC ACTIVITY: CIS-TRANS ISOMERIZATION OF PROLINE FT IMIDIC PEPTIDE BONDS IN OLIGOPEPTIDES]." FT /gene="ppiA" FT /locus_tag="Rv0009" FT /note="Rv0009, (MTCY10H4.08), len: 182. Probable ppiA FT (alternate gene name: cfp22), iron-regulated FT peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8), FT equivalent to NP_301138.1|NC_002677 putative FT peptidyl-prolyl cis-trans isomerase from Mycobacterium FT leprae (182 aa), FASTA score: (90.1% identity in 182 aa FT overlap). Also highly similar to others e.g. T36725 from FT Streptomyces coelicolor (177 aa); T43805 from FT Halobacterium salinarum (180 aa); NP_219383.1|NC_000919 FT from Treponema pallidum (215 aa); etc. BELONGS TO THE FT CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon FT has been suggested." FT /product="PROBABLE IRON-REGULATED PEPTIDYL-PROLYL FT CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A)" FT /standard_name="cfp22" FT CDS complement(13133..13558) FT /function="UNKNOWN" FT /locus_tag="Rv0010c" FT /note="Rv0010c, (MTCY10H4.10c), len: 141 aa. Probable FT conserved membrane protein, equivalent to FT NP_301139.1|NC_002677 putative membrane protein from FT Mycobacterium leprae (137 aa); and similar to FT Rv1417|P71686|YE17_MYCTU HYPOTHETICAL 16.4 kDa PROTEIN FT from Mycobacterium tuberculosis (154 aa), FASTA scores: FT opt: 121, E(): 0.097, (29.6% identity in 81 aa overlap)." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS complement(13714..13995) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0011c" FT /note="Rv0011c, (MTCY10H4.11c), len: 93 aa. Probable FT conserved transmembrane protein, equivalent to FT NP_301140.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (93 aa); and similar to FT AL079308|SCH69_24 hypothetical protein from Streptomyces FT coelicolor (84 aa), FASTA scores: opt: 135, E(): 0.0068, FT (32.6% identity in 92 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 14089..14877 FT /function="UNKNOWN" FT /locus_tag="Rv0012" FT /note="Rv0012, (MTCY10H4.12), len: 262 aa. Probable FT conserved membrane protein, similar to FT AL079308|SCH69_23|T36722 hypothetical protein from FT Streptomyces coelicolor (237 aa), FASTA scores: opt: 506, FT E(): 1.9e-25, (39.8% identity in 236 aa overlap). Some FT similarity to BLU0|1958_35A2 DIVIB (fragment) (188 aa), FT FASTA scores: opt: 204, E(): 8.9e-07, (35.6% identity in FT 90 aa overlap); and G1129091|DDS cell division and FT sporulation protein from Bacillus subtilis (231 aa), FASTA FT scores: opt: 180, E(): 3.8e-05, (30.7% identity in 101 aa FT overlap). Also similar to Rv1823|MTCY1A11_20 from FT Mycobacterium tuberculosis FASTA score: (30.1% identity in FT 246 aa overlap); and MTCY1A11_18 FASTA score: (25.5% FT identity in 235 aa overlap). Contains probable N-terminal FT signal sequence." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS 14914..15612 FT /EC_number="4.1.3.27" FT /evidence=experimental FT /function="POSSIBLY INVOLVED IN BIOSYNTHESIS OF TRYPTOPHAN FT (AT THE FIRST STEP). SUPPOSED TETRAMER OF TWO COMPONENTS I FT AND TWO COMPONENTS II: COMPONENT I (Rv1609|trpE) CATALYZES FT THE FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN FT GLUTAMINE, WHEREAS COMPONENT II (Rv0013|trpG) PROVIDES FT GLUTAMINE AMIDOTRANSFERASE ACTIVITY. POSSIBLY PARTICIPATES FT IN THE TRYPTOPHAN-DEPENDENT INDOLE-3-ACETIC ACID FT PRODUCTION [CATALYTIC ACTIVITY: CHORISMATE + L-GLUTAMINE = FT ANTHRANILATE + PYRUVATE + L-GLUTAMATE]." FT /gene="trpG" FT /locus_tag="Rv0013" FT /note="Rv0013, (MTCY10H4.13), len: 232 aa. Possible trpG, FT anthranilate synthase component II (glutamine FT amidotransferase) (EC 4.1.3.27), equivalent to FT NP_301141.1|NC_002677 putative p-aminobenzoate synthase FT glutamine amidotransferase from Mycobacterium leprae (232 FT aa). Also highly similar to others e.g. P26922|TRPG_AZOBR FT Anthranilate synthase component II from Azospirillum FT brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40, FT (56.7% identity in 187 aa overlap); T36720 probable FT glutamine amidotransferase from Streptomyces coelicolor FT (212 aa); T44524 anthranilate synthase from Nitrosomonas FT europaea (199 aa); etc. Also similar to E235740 FT para-aminobenzoate synthase (232 aa), FASTA scores: opt: FT 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains FT PS00606 Beta-ketoacyl synthases active site; and PS00442 FT Glutamine amidotransferases class-I active site. FT SIMILARITY TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE FT DOMAINS. Note that previously known as pabA." FT /product="POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG FT (GLUTAMINE AMIDOTRANSFERASE)" FT /standard_name="pabA" FT misc_feature 15100..15150 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 15145..15180 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS complement(15590..17470) FT /EC_number="2.7.1.-" FT /evidence=experimental FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE CELL FT DIVISION/DIFFERENTIATION. CAN PHOSPHORYLATE THE PEPTIDE FT SUBSTRATE MYELIN BASIC PROTEIN (MBP) [CATALYTIC ACTIVITY: FT ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]." FT /gene="pknB" FT /locus_tag="Rv0014c" FT /note="Rv0014c, (MTCY10H4.14c), len: 626 aa. pknB, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citations below), equivalent to MLCB1770_9|T10009 FT probable serine/threonine-specific protein kinase from FT Mycobacterium leprae (622 aa), FASTA scores: opt: 3600, FT E(): 0, (86.4% identity in 626 aa overlap). Also similar FT (highly similar in N-terminus) to others e.g. T36717 from FT Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 FT from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 FT from Listeria monocytogenes (655 aa); E235741 protein FT kinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0, FT (90.8 identity in 305 aa overlap); etc. Contains PS00107 FT Protein kinases ATP-binding region signature, and PS00108 FT Serine/Threonine protein kinases active-site signature. FT Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FT FAMILY OF PROTEIN KINASES. Experimental studies show FT evidence of auto-phosphorylation on serine/threonine FT residues." FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B FT PKNB (PROTEIN KINASE B) (STPK B)" FT misc_feature complement(17033..17071) FT /note="PS00108 Serine/Threonine protein kinases FT active-site signature" FT misc_feature complement(17351..17422) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS complement(17467..18762) FT /EC_number="2.7.1.-" FT /evidence=experimental FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE MORPHOLOGICAL FT CHANGES ASSOCIATED WITH CELL DIVISION/DIFFERENTIATION FT PROCESS. PHOSPHORYLATES AT SERINE AND THREONINE RESIDUES FT [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A FT PHOSPHOPROTEIN]." FT /gene="pknA" FT /locus_tag="Rv0015c" FT /note="Rv0015c, (MTCY10H4.15c), len: 431 aa. pknA, FT transmembrane serine/threonine-protein kinase (EC FT 2.7.1.-), magnesium/manganese dependent (see citations FT below), equivalent to MLCB1770_10|NP_301143.1|NC_002677 FT putative serine/threonine protein kinase from FT Mycobacterium leprae (437 aa), FASTA scores: opt: 1883, FT E(): 0, (72.1% identity in 434 aa overlap). And also FT highly similar to other kinases from Mycobacterium leprae FT e.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Also FT similar to PKNA_MYCLE protein kinase (253 aa), FASTA FT scores: opt: 1525, E(): 0, (95.0% identity in 242 aa FT overlap); etc. Also highly similar in part to others e.g. FT N-terminus of NP_243370.1|NC_002570 from Bacillus FT halodurans (664 aa); N-terminus of T36717 from FT Streptomyces coelicolor (673 aa); etc. Also similar to FT others from Mycobacterium tuberculosis: MTCY10H4_15, FT MTV021_9, MTCY28_5, MTCY4C12_28, MTCY50_16, MTCY8D9_8, FT MTCY49_28, MTCY4C12_30, MTCY28_9, etc. Contains PS00108 FT Serine/Threonine protein kinases active-site signature. FT Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FT FAMILY OF PROTEIN KINASES. It has been shown that sodium FT orthovanadate inhibits the activity of the enzyme in FT vitro." FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A FT PKNA (PROTEIN KINASE A) (STPK A)" FT misc_feature complement(18316..18354) FT /note="PS00108 Serine/Threonine protein kinases FT active-site signature" FT CDS complement(18759..20234) FT /evidence=experimental FT /function="INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FT FINAL STAGES). CELL WALL FORMATION; PBPA IS SUPPOSED TO BE FT RESPONSIBLE FOR THE DETERMINATION OF THE ROD SHAPE OF THE FT CELL. ITS SYNTHESIZES CROSS-LINKED PEPTIDOGLYCAN FROM FT LIPID INTERMEDIATES." FT /gene="pbpA" FT /locus_tag="Rv0016c" FT /note="Rv0016c, (MTCY10H4.16c), len: 491 aa. Probable FT pbpA, penicillin-binding protein, equivalent to FT NP_301144.1|NC_002677 putative penicillin-binding protein FT from Mycobacterium leprae (492 aa); and highly similar to FT MLCB1770_1 penicillin binding protein from Mycobacterium FT leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% FT identity in 472 aa overlap). Also similar to others e.g. FT T36716 from Streptomyces coelicolor (490 aa); FT AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 FT aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum FT (482 aa); E235825|pbpA penicillin binding protein (325 FT aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in FT 323 aa overlap); etc. And also similar to MTCY270_5 and FT MTV003_8 from Mycobacterium tuberculosis." FT /product="PROBABLE PENICILLIN-BINDING PROTEIN PBPA" FT CDS complement(20231..21640) FT /function="THIS IS A SEPTUM-PEPTIDOGLYCAN BIOSYNTHETIC FT PROTEIN, INVOLVED IN CELL WALL FORMATION. PLAYS A ROLE IN FT THE STABILIZATION OF THE FTSZ RING DURING CELL DIVISION." FT /gene="rodA" FT /locus_tag="Rv0017c" FT /note="Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA FT (alternate gene name: ftsW), cell division protein, FT integral membrane protein, equivalent to FT MLCB1770_12|T10012 probable cell division protein from FT Mycobacterium leprae (465 aa), FASTA scores: opt: 2475, FT E(): 0, (81.9% identity in 469 aa overlap). Also highly FT similar to others e.g. T36715|SCH69.16 from Streptomyces FT coelicolor (479 aa); NP_243432.1|NC_002570 from Bacillus FT halodurans (366 aa); NP_347145.1|NC_003030 from FT Clostridium acetobutylicum (400 aa); etc. Also similar to FT MTCY270_14 from Mycobacterium tuberculosis FASTA score: FT (32.2% identity in 369 aa overlap). BELONGS TO THE FT FTSW/RODA/SPOVE FAMILY." FT /product="PROBABLE CELL DIVISION PROTEIN RODA" FT /standard_name="ftsW" FT CDS complement(21637..23181) FT /EC_number="3.1.3.16" FT /evidence=experimental FT /function="INVOLVED IN REGULATION (USING DEPHOSPHORYLATION FT OF A SPECIFIC PHOSPHORYLATED SUBSTRATE)." FT /gene="ppp" FT /locus_tag="Rv0018c" FT /note="Rv0018c, (MTCY10H4.18c), len: 514 aa. Possible ppp, FT serine/threonine phosphatase (EC 3.1.3.16), equivalent to FT MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE FT from Mycobacterium leprae (509 aa), FASTA scores: opt: FT 2517, E(): 0. Also highly similar to others e.g. T36714 FT probable protein phosphatase from Streptomyces coelicolor FT (515 aa); CAA10712.1|AJ132604 pppL protein from FT Lactococcus lactis (258 aa); NP_248765.1|NC_002516 FT probable phosphoprotein phosphatase from Pseudomonas FT aeruginosa (242 aa); etc. Also similar to BSUB0009_46 YLOO FT PROTEIN from Bacillus subtilis (254 aa), FASTA score: FT (34.0% identity in 250 aa overlap)." FT /product="POSSIBLE SERINE/THREONINE PHOSPHATASE PPP" FT repeat_unit complement(23173..23273) FT /note="101 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See Supply et al. (1997) Molecular Microbiology FT 26, 991-1003" FT CDS complement(23270..23737) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0019c" FT /note="Rv0019c, (MTCY10H4.19c), len: 155 aa. Conserved FT hypothetical protein, equivalent to FT MLCB1770_14|NP_301147.1|NC_002677 conserved hypothetical FT protein from Mycobacterium leprae (155 aa), FASTA scores: FT opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Also FT highly similar to T36713|AL079308|SCH69_14 from FT Streptomyces coelicolor (172 aa), FASTA scores: opt: 389, FT E(): 6e-21, (46.2% identity in 171 aa overlap); and FT similar in C-terminus to others e.g. NP_342559.1|NC_002754 FT Conserved hypothetical protein from Sulfolobus FT solfataricus (209 aa); etc. C-terminus also highly similar FT to C-terminal part of AAF07901.1|AF173844_2|AF173844 FT putative signal transduction protein GarA from FT Mycobacterium smegmatis (158 aa). Also similar to FT Rv1827|MTCY 1A11.16c from Mycobacterium tuberculosis ( 162 FT aa), FASTA score: (41.2% identity in 85 aa overlap); FT MTMOAIS_3; MAU66560_1 and MLCB1788_15." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(23861..25444) FT /evidence=experimental FT /function="UNKNOWN" FT /gene="TB39.8" FT /locus_tag="Rv0020c" FT /note="Rv0020c, (MTCY10H4.20c), len: 527 aa. TB39.8, FT conserved hypothetical protein, identified by proteomic FT study by the Statens Serum Institute, Denmark (spot FT TB39.8) (see citation below). Highly similar to FT NP_301148.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (488 aa); and FT Z70722|MLCB1770_15|T10015 hypothetical protein from FT Mycobacterium leprae (463 aa), FASTA scores: opt: 1213, FT E(): 2.2e-32, (72.3% identity in 506 aa overlap). FT Alternative start codon in position 24979 has been FT suggested (see citation below)." FT /product="CONSERVED HYPOTHETICAL PROTEIN TB39.8" FT tRNA 25644..25726 FT /gene="tRNA-Leu(CAG)" FT /anticodon=(pos:25677..25679,aa:Leu) FT /product="transfer RNA-Leu(CAG)" FT CDS complement(25913..26881) FT /function="UNKNOWN" FT /locus_tag="Rv0021c" FT /note="Rv0021c, (MTCY10H4.21c), len: 322 aa. Conserved FT hypothetical protein, similar to various proteins e.g. FT NP_464341.1|NC_003210 protein similar to oxidoreductases FT from Listeria monocytogenes (309 aa); FT NP_357973.1|NC_003098 Enoyl-acyl carrier protein(ACP) FT reductase from Streptococcus pneumoniae (324 aa); FT 2NPD_NEUCR|G726338 2-nitropropane dioxygenase precursor FT from Neurospora crassa (378 aa), FASTA scores: opt: 383, FT E(): 1.1e-16, (32.2% identity in 348 aa overlap); etc. FT Also similar to AE001747_25 from Thermotoga maritima FT section 59 (314 aa), FASTA scores: opt: 442, E(): 1.5e-19, FT (30.5% identity in 325 aa overlap). Also similar to other FT proteins from Mycobacterium tuberculosis e.g. Rv3553 (355 FT aa), FASTA scores: E(): 6.8e-15, (35.3 identity in 235 aa FT overlap); and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12, FT (34.4% identity in 262 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(27023..27442) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /gene="whiB5" FT /locus_tag="Rv0022c" FT /note="Rv0022c, (MTCY10H4.22c), len: 139 aa. Probable FT whiB5 (alternate gene name: whmG), WhiB-like regulatory FT protein (see citations below), similar to WhiB paralogue FT of Streptomyces coelicolor, wblE gene product (85 aa). FT Shows some similarity to FT O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID FT PROTEIN from Streptomyces coelicolor (112 aa), FASTA FT scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa FT overlap); and slight similarity to G466960|WHIB WHIB FT PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 FT identity in 67 aa overlap)." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT WHIB-LIKE WHIB5" FT /standard_name="whmG" FT CDS 27595..28365 FT /evidence=experimental FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0023" FT /note="Rv0023, (MTCY10H4.23),len: 256 aa. Possible FT transcriptional regulator, equivalent to FT CAB96432.1|AJ251434 hypothetical protein from FT Mycobacterium avium subsp. paratuberculosis (146 aa). FT N-terminus showing similarity with other transcriptional FT regulators e.g. AE0002|ECAE000240_9 from Escherichia coli FT strain K12 (178 aa), FASTA scores: opt: 149, E(): 0.0048, FT (33.3% identity in 84 aa overlap); etc. Contains probable FT helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 FT SD)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 28362..29207 FT /function="UNKNOWN. THE P60 PROTEIN IS A MAJOR FT EXTRACELLULAR PROTEIN MAY BE INVOLVED IN THE INVASION OF FT HOST CELLS." FT /locus_tag="Rv0024" FT /note="Rv0024, (MTCY10H4.24), len: 281 aa. Putative FT secreted protein, p60 homologue, similar in part to others FT and relatives proteins e.g. P60_LISIV|Q01837 protein p60 FT precursor (invasion-associated protein) from Listeria FT ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, FT (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 FT putative NPL/P60 family secreted protein from Streptomyces FT coelicolor (347 aa) ; etc. Similar to Mycobacterium FT tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. FT And several homologues in Streptomyces coelicolor e.g. FT AL049497|SC6G10_8|T35517 probable secreted protein (338 FT aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity FT in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / FT LISTERIA P60 FAMILY." FT /product="PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN" FT CDS 29245..29607 FT /function="UNKNOWN" FT /locus_tag="Rv0025" FT /note="Rv0025, (MTCY10H4.25), len: 120 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 FT aa), FASTA score: (37.6% identity in 101 aa overlap), and FT Rv0026 FASTA score: (35.4% identity in 113 aa overlap); FT etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 29722..31068 FT /function="UNKNOWN" FT /locus_tag="Rv0026" FT /note="Rv0026, (MTCY10H4.26), len: 448 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis: Rv0025 FASTA FT score: (35.4% identity in 113 aa overlap) and Rv0739 (268 FT aa), FASTA score: (32.4% identity in 142 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 31189..31506 FT /function="UNKNOWN" FT /locus_tag="Rv0027" FT /note="Rv0027, (MTCY10H4.27), len: 105 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 31514..31819 FT /function="UNKNOWN" FT /locus_tag="Rv0028" FT /note="Rv0028, (MTCY10H4.28), len: 101 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 32057..33154 FT /function="UNKNOWN" FT /locus_tag="Rv0029" FT /note="Rv0029, (MTCY10H4.29), len: 365 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis e.g. C-terminal FT region of Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa FT protein (721 aa), FASTA scores: opt: 453, E(): 1.2e-22, FT (38.5% identity in 265 aa overlap); Rv3899c|MTY15F10_12 FT HYPOTHETICAL 40.8 kDa PROTEIN (410 aa), FASTA score: FT (33.7% identity in 252 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 33224..33553 FT /function="UNKNOWN" FT /locus_tag="Rv0030" FT /note="Rv0030, (MTCY10H4.30), len: 109 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 33582..33794 FT /function="NORMALY, REQUIRED FOR THE TRANSPOSITION OF AN FT INSERTION ELEMENT." FT /locus_tag="Rv0031" FT /note="Rv0031, (MTCY10H4.31), len: 70 aa. Possible remnant FT of a transposase, showing partial similarity to FT mycobacterial transposases in a short overlap, e.g. FT Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity FT in 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc." FT /product="POSSIBLE REMNANT OF A TRANSPOSASE" FT CDS 34295..36610 FT /EC_number="2.3.1.47" FT /function="COULD BE INVOLVED IN BIOTIN BIOSYNTHESIS (AT FT THE FIRST STEP) [CATALYTIC ACTIVITY: 6-CARBOXYHEXANOYL-COA FT + L-ALANINE = 8-AMINO-7-OXONONANOATE + CoA + CO2]." FT /gene="bioF2" FT /locus_tag="Rv0032" FT /note="Rv0032, (MTCY10H4.32), len: 771 aa. Probable bioF2, FT 8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its FT C-terminal similar to others e.g. BIOF_BACSU|P53556 FT 8-amino-7-oxononanoate synthase from Bacillus subtilis FT (389 aa), FASTA scores: opt: 775, E(): 0, (37.9% identity FT in 346 aa overlap); P22806|BIOF_BACSH from Bacillus FT sphaericus (389 aa); etc. Also similar to FT BIOF1|Rv1569|MTCY336_35 from Mycobacterium tuberculosis FT (386 aa), AF041819_4 from Mycobacterium bovis, and FT BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa). FT Contains PS00599 Aminotransferases class-II FT pyridoxal-phosphate attachment site. BELONGS TO CLASS-II FT OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES." FT /product="POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 FT (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) FT (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP FT SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)" FT misc_feature 36128..36157 FT /note="PS00599 Aminotransferases class-II FT pyridoxal-phosphate attachment site" FT CDS 36607..36870 FT /function="KEY COMPONENT IN DE NOVO FATTY ACID FT BIOSYNTHESIS. THIS PROTEIN IS SUPPOSED TO BE THE CARRIER FT OF THE GROWING FATTY ACID CHAIN IN FATTY ACID FT BIOSYNTHESIS." FT /gene="acpA" FT /locus_tag="Rv0033" FT /note="Rv0033, (MTCY10H4.33), len: 87 aa. Probable acpA FT (alternate gene name: acpP), acyl carrier protein, similar FT to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) FT from Bacillus subtilis (77 aa), FASTA scores: opt: 149, FT E(): 0.00026, (41.4% identity in 70 aa overlap); FT NP_224500.1|NC_000922 Acyl Carrier Protein from FT Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 FT acyl carrier protein from Thermotoga maritima (81 aa); FT etc. Also similar to proteins of Mycobacterium FT tuberculosis Rv1344 and Rv2244 (31.5% identity in 73 aa FT overlap)." FT /product="PROBABLE ACYL CARRIER PROTEIN ACPA (ACP)" FT /standard_name="acpP" FT CDS 36867..37262 FT /function="UNKNOWN" FT /locus_tag="Rv0034" FT /note="Rv0034, (MTCY10H4.34), len: 131 aa. Conserved FT hypothetical protein, showing weak similarity to FT AE001980|AE001980_7 hypothetical protein from Deinococcus FT radiodurans (120 aa), FASTA scores: opt: 141, E(): 0.0028, FT (29.3% identity in 123 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 37259..38947 FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD34" FT /locus_tag="Rv0035" FT /note="Rv0035, (MTCY10H4.35), len: 562 aa. Probable FT fadD34, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to FT many e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium FT bovis (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. FT Also similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 FT aa), FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity FT in 573 aa overlap). Also similar to other proteins from FT Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: FT (32.3% identity in 468 aa overlap), MTCY349_40, FT MTCY4D9_17, MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30, FT MTCY24G1_8, MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21, FT MTCY19G5_7, MTCY9F9_39, etc." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD34 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT CDS complement(39056..39829) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0036c" FT /note="Rv0036c, (MTCY10H4.36c), len: 257 aa. Conserved FT hypothetical protein, highly similar to FT CAB95889.1|AL359988 conserved hypothetical protein from FT Streptomyces (276 aa). Also some similarity to FT Rv3099c|MTCY164_10 (283 aa), FASTA scores: E(): 3.3e-05, FT (25.9% identity in 205 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(39877..41202) FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF FT MACROLIDE ACROSS THE MEMBRANE." FT /locus_tag="Rv0037c" FT /note="Rv0037c, (MTCY10H4.37c), len: 441 aa. Probable FT conserved integral membrane protein, member of major FT facilitator superfamily (MFS) possibly involved in FT transport of macrolide, showing some similarity to FT Rv1258c|MTCY50_24 (419 aa), FASTA score: (25.2% identity FT in 408 aa overlap); and to AL049826|SCH24_20 from FT Streptomyces coelicolor (425 aa), FASTA scores: opt: 725, FT E(): 0, (36.1% identity in 418 aa overlap). Also FT similarity with several MACROLIDE-EFFLUX PROTEINS e.g. FT from S. pyogenes (405 aa), FASTA scores: E(): 1.3e-06, FT (22.8% identity in 416 aa overlap)." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 41304..41912 FT /function="UNKNOWN" FT /locus_tag="Rv0038" FT /note="Rv0038, (MTCY10H4.38), len: 202 aa. Conserved FT hypothetical protein, equivalent to FT MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from FT Mycobacterium leprae (202 aa), FASTA scores: opt: 1194, FT E(): 0, (88.6% identity in 202 aa overlap). Also highly FT similar or similar to other hypothetical proteins e.g. FT CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor FT (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 FT aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE FT from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI FT HYPOTHETICAL 20.7 kDa PROTEIN (187 aa), FASTA score: FT (29.5% identity in 166 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(42004..42351) FT /function="UNKNOWN" FT /locus_tag="Rv0039c" FT /note="Rv0039c, (MTCY21D4.02c, MTCY10H4.39c), len: 115 aa. FT Possible conserved transmembrane protein, highly similar FT to NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical FT protein from Mycobacterium leprae (113 aa), FASTA scores: FT opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa FT overlap)." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(42433..43365) FT /evidence=experimental FT /function="UNKNOWN" FT /gene="mtc28" FT /locus_tag="Rv0040c" FT /note="Rv0040c, (MTCY21D4.03c), len: 310 aa. mtc28, FT secreted proline rich 28 kDa antigen protein (has FT hydrophobic stretch at N-terminus) (see citation below). FT Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich FT 28 kDa antigen from Mycobacterium leprae (278 aa), FASTA FT scores: opt: 1007, E(): 0, (65.0% identity in 257 aa FT overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 FT putative lipoprotein from Mycobacterium leprae (218 aa). FT C-terminal part very similar to lipoprotein Rv1016c from FT Mycobacterium tuberculosis." FT /product="SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE FT RICH 28 KDA ANTIGEN)" FT CDS 43562..46471 FT /EC_number="6.1.1.4" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate FT + L-leucyl-tRNA(Leu)]." FT /gene="leuS" FT /locus_tag="Rv0041" FT /note="Rv0041, (MTCY21D4.04), len: 969 aa. Probable FT leucyl-tRNA synthetase (EC 6.1.1.4), equivalent to FT NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from FT Mycobacterium leprae (972 aa), FASTA score: (83.6% FT identity in 972 aa overlap); and highly similar to FT MLCB1770_20 from Mycobacterium leprae (824 aa), FASTA FT score: (82.8% identity in 824 aa overlap). Also highly FT similar to others e.g. CAB66249.1|AL136518 leucyl-tRNA FT synthetase from Streptomyces coelicolor (966 aa); FT NP_244147.1|NC_002570 leucyl-tRNA synthetase from Bacillus FT halodurans (806 aa); SYL_BACSU|P36430 leucyl-tRNA FT synthetase from Bacillus subtilis (804 aa), FASTA scores: FT opt: 714, E(): 3.1e-38, (43.7% identity in 938 aa FT overlap); etc. Contains PS00178 Aminoacyl-transfer RNA FT synthetases class-I signature. BELONGS TO CLASS-I FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /product="PROBABLE LEUCYL-tRNA SYNTHETASE LEUS FT (LEUCINE--tRNA LIGASE) (LEURS)" FT misc_feature 43799..43831 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT CDS complement(46581..47207) FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0042c" FT /note="Rv0042c, (MTCY21D4.05c), len: 208 aa. Possible FT transcriptional regulatory protein, MarR-family, highly FT similar except in N-terminus to CAC32228.1|AL583926 FT putative MarR-family regulatory protein from Mycobacterium FT leprae (243 aa). Also similar in part to others e.g. FT AB76343.1|AL158061 putative MarR-family transcriptional FT regulator from Streptomyces coelicolor (163 aa); FT NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR FT PROTEIN from Sinorhizobium meliloti (164 aa); FT NP_531782.1|NC_003304 transcriptional regulator, MarR FT family from Agrobacterium tumefaciens (151 aa); etc. Also FT some similarity to Mycobacterium tuberculosis proteins FT Rv2327, Rv0880, and Rv1404." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY MARR-FAMILY)" FT CDS complement(47366..48100) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0043c" FT /note="Rv0043c, (MTCY21D4.06c), len: 244 aa. Probable FT transcriptional regulator, GntR family, similar to others FT e.g. NP_420584.1|NC_002696 transcriptional regulator GntR FT family from Caulobacter crescentus (221 aa); FT NP_294539.1|NC_001263 transcriptional regulator GntR FT family from Deinococcus radiodurans (267 aa); FT YIN1_STRAM|P32425 hypothetical transcriptional regulatory FT protein from Streptomyces ambofaciens (236 aa), FASTA FT scores: opt: 170, E(): 9.8e-05, (27.6% identity in 127 aa FT overlap); etc. Similar also to SC9B10_7 from Streptomyces FT coelicolor FASTA score: E():0.00038; and Rv0165c|MTCI28_5 FT from Mycobacterium tuberculosis (264 aa), FASTA score: FT (27.7% identity in 130 aa overlap)." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT CDS complement(48233..49027) FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0044c" FT /note="Rv0044c, (MTCY21D4.07c), len: 264 aa. Possible FT oxidoreductase (EC 1.-.-.-), highly similar to FT AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase FT from Streptomyces lavendulae (264 aa). Also similar to FT Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c, FT Rv0791c, Rv0132c, etc." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS complement(49043..49939) FT /EC_number="3.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN LIPID FT BIOSYNTHESIS." FT /locus_tag="Rv0045c" FT /note="Rv0045c, (MTCY21D4.08c), len 298 aa. Possible FT hydrolase (EC 3.-.-.-), showing similarity with others eg FT NP_107230.1|NC_002678 putative hydrolase from FT Mesorhizobium loti (278 aa); CAB56730.1|AL121600 putative FT hydrolase from Streptomyces coelicolor (302 aa); FT NP_438361.1|NC_000907 putative esterase/lipase from FT Haemophilus influenzae Rd (287 aa); etc. Also similar to FT Mycobacterium tuberculosis proteins Rv3473c, Rv1123c, FT Rv1938, Rv3617, Rv3670, etc." FT /product="POSSIBLE HYDROLASE" FT CDS complement(50021..51124) FT /EC_number="5.5.1.4" FT /evidence=experimental FT /function="INVOLVED IN PHOSPHATIDYLINOSITOL (PI) FT BIOSYNTHETIC PATHWAY [CATALYTIC ACTIVITY: D-GLUCOSE FT 6-PHOSPHATE = 1L-MYO-INOSITOL 1-PHOSPHATE]." FT /gene="ino1" FT /locus_tag="Rv0046c" FT /note="Rv0046c, (MTCY21D4.09c), len: 367 aa. ino1 FT (alternate gene name: tbINO), myo-inositol-1-phosphate FT synthase (EC 5.5.1.4) (see citations below), equivalent to FT Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 FT HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae FT (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity FT in 366 aa overlap). N-terminus similar to N-terminus of FT myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 FT myo-inositol-1-phosphate synthase (510 aa), FASTA scores: FT opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); FT CAC21218.1|AJ401007 myo-inositol 1P synthase from FT Thermotoga sp. SG1 (335 aa); etc. Also highly similar to FT other hypothetical proteins e.g. AL049826|SCH24_21c FT hypothetical protein from Streptomyces coelicolor (360 FT aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in FT 360 aa overlap); AE000881_1 conserved protein from M. FT thermoautotrophicus (368 aa); etc." FT /product="MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol FT 1-phosphate synthetase) (D-glucose 6-phosphate FT cycloaldolase) (Glucose 6-phosphate cyclase) FT (Glucocycloaldolase)" FT /standard_name="tbINO" FT CDS complement(51185..51727) FT /function="UNKNOWN" FT /locus_tag="Rv0047c" FT /note="Rv0047c, (MTCY21D4.10c), len: 180 aa. Conserved FT hypothetical protein, equivalent to NP_302717.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (180 aa). Also showing strong similarity to other FT hypothetical proteins e.g. AL049826|SCH24_22|T36587 from FT Streptomyces coelicolor (225 aa), FASTA scores: opt: 583, FT E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some FT similarity to Rv1176c from Mycobacterium tuberculosis and FT to P94443|YFIO from Bacillus subtilis (182 aa), FASTA FT scores: E(): 0.00066, (24.9% identity in 177 aa overlap). FT Also some similarity to G1163121 MITHRAMYCIN RESISTANCE FT DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: FT opt: 143, E(): 0.0091, (29.4% identity in 180 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(51828..52697) FT /function="UNKNOWN" FT /locus_tag="Rv0048c" FT /note="Rv0048c, MTCY21D4.11c, len: 289 aa. Possible FT membrane protein." FT /product="POSSIBLE MEMBRANE PROTEIN" FT CDS 52831..53244 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0049" FT /note="Rv0049, (MTCY21D4.12), len: 137 aa. Conserved FT hypothetical protein, only equivalent to FT AL022118|MLCB1913_20 hypothetical protein from FT Mycobacterium leprae (138 aa), FASTA scores: opt: 768, FT E(): 0, (83.9% identity in 137 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 53663..55699 FT /EC_number="2.4.2.-" FT /EC_number="3.4.-.-" FT /evidence=experimental FT /function="INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FT FINAL STAGES), CELL WALL FORMATION. SYNTHESIS OF FT CROSS-LINKED PEPTIDOGLYCAN FROM THE LIPID INTERMEDIATES. FT THE ENZYME HAS A PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE FT N-TERMINAL DOMAIN (FORMATION OF LINEAR GLYCAN STRANDS) AND FT A PENICILLIN-SENSITIVE TRANSPEPTIDASE C-TERMINAL DOMAIN FT (CROSS-LINKING OF THE PEPTIDE SUBUNITS)." FT /gene="ponA1" FT /locus_tag="Rv0050" FT /note="Rv0050, (MTCY21D4.13), len: 678 aa. Probable ponA1, FT penicillin-binding protein (class A), bienzymatic protein FT with transglycosylase (EC 2.4.2.-) and transpeptidase (EC FT 3.4.-.-) activities (see Graham & Clark-Curtiss 1999), FT highly similar to many e.g. NP_302715.1|NC_002677 FT penicillin-binding protein from Mycobacterium leprae (708 FT aa); AAB53123.1|L39923 penicillin binding protein from FT Mycobacterium leprae (686 aa), FASTA scores: (82.3% FT identity in 679 aa overlap); FT Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 FT penicillin-binding protein 1 from Mycobacterium smegmatis FT (715 aa) (see Billman-Jacobe et al., 1999); FT CAB88838.1|AL353832 probable penicillin-binding protein FT from Streptomyces coelicolor (756 aa); etc. Also similar FT to ponA2|Rv3682|MTV025.030 BIFUNCTIONAL FT MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B from FT Mycobacterium tuberculosis (810 aa). BELONGS TO THE FT TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO FT THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION." FT /product="PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN FT 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): FT PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN FT TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE FT (DD-TRANSPEPTIDASE)" FT CDS 55696..57378 FT /function="UNKNOWN" FT /locus_tag="Rv0051" FT /note="Rv0051, (MTCY21D4.14), len:560 aa. Probable FT conserved transmembrane protein, equivalent to FT NP_302714.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (564 aa); and highly similar to FT C-terminus of AAF25828.1|AF187306_1|AF187306 putative FT transmembrane protein from Mycobacterium smegmatis (692 FT aa). Also highly similar to MSGDNAB_5|G886306|L222-ORF5 FT (418 aa), FASTA scores: opt: 2163, E(): 0, (78.4% identity FT in 412 aa overlap). Also similar to FT AL049826|SCH24_24|T36589 probable transmembrane protein FT from Streptomyces coelicolor (502 aa), FASTA scores: opt: FT 492, E(): 1.4e-23, (35.8% identity in 522 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 57410..57973 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0052" FT /note="Rv0052, (MTCY21D4.15), len: 187 aa. Conserved FT hypothetical protein, similar to others e.g. FT AL049587|SC5F2A_30S|T35272 hypothetical protein from FT Streptomyces coelicolor (211 aa), FASTA scores: opt: 531, FT E(): 3.4e-29, (49.5% identity in 182 aa overlap); FT NP_420588.1|NC_002696 ThiJ/PfpI family protein from FT Caulobacter crescentus (267 aa); etc. Some similarity to FT Escherichia coli G1100872|thiJ (198 aa), FASTA scores: FT opt: 178, E(): 6.1e-06, (29.9% identity in 137 aa FT overlap). Also similar to Rv1930c from Mycobacterium FT tuberculosis (174 aa). May be a membrane protein." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 58192..58482 FT /evidence=experimental FT /function="BINDS TOGETHER WITH S18 TO 16S RIBOSOMAL RNA." FT /gene="rpsF" FT /locus_tag="Rv0053" FT /note="Rv0053, (MTCY21D4.16), len: 96 aa. Probable 30S FT ribosomal protein S6, equivalent to RS6_MYCLE|P46389 30s FT ribosomal protein s6 from Mycobacterium leprae (96 aa), FT FASTA scores: opt: 570, E(): 1.1e-36, (91.7% identity in FT 96 aa overlap).Also highly similar to many e.g. FT Q9X8U2|RS6_STRCO 30S RIBOSOMAL PROTEIN S6 from FT Streptomyces coelicolor (96 aa); etc. Contains PS01048 FT Ribosomal protein S6 signature. BELONGS TO THE S6P FAMILY FT OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S6 RPSF" FT misc_feature 58318..58347 FT /note="PS01048 Ribosomal protein S6 signature" FT CDS 58586..59080 FT /evidence=experimental FT /function="THIS PROTEIN IS ESSENTIAL FOR REPLICATION OF FT THE CHROMOSOME. IT IS ALSO INVOLVED IN DNA RECOMBINATION FT AND REPAIR." FT /gene="ssb" FT /locus_tag="Rv0054" FT /note="Rv0054, (MTCY21D4.17), len: 164 aa. Probable ssb, FT single-strand binding protein (see Mizrahi & Andersen FT 1998), equivalent to highly similar to others e.g. FT SSB_MYCLE|P46390 single-strand binding protein from FT Mycobacterium leprae (140 aa), FASTA scores: opt: 792, FT E(): 0, (92.6% identity in 135 aa overlap); and FT AAK30583.1|AF349434 single-stranded DNA-binding protein FT from Mycobacterium smegmatis (165 aa). Also highly similar FT to others e.g. T36594 probable single-strand binding FT protein from Streptomyces coelicolor (199 aa); etc. Also FT similar to Rv2478c|MTV008_34c CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (161 aa), FASTA FT score: E (): 1.1e-06. BELONGS TO THE SSB FAMILY." FT /product="PROBABLE SINGLE-STRAND BINDING PROTEIN SSB FT (HELIX-DESTABILIZING PROTEIN)" FT CDS 59122..59376 FT /function="THIS PROTEIN HAS BEEN IMPLICATED IN FT AMINOACYL-TRANSFER RNA BINDING. IT APPEARS TO BE SITUATED FT AT THE DECODING SITE OF MESSENGER RNA." FT /gene="rpsR1" FT /locus_tag="Rv0055" FT /note="Rv0055, (MTCY21D4.18), len: 84 aa. Probable rpsR1, FT 30S ribosomal protein S18-1, equivalent to FT NP_302711.1|NC_002677|O53125|RS18_MYCLE 30S RIBOSOMAL FT PROTEIN from Mycobacterium leprae (84 aa). Also highly FT similar to others e.g. Q9X8U4|R18A_STRCO 30S RIBOSOMAL FT PROTEIN S18-1 from Streptomyces coelicolor (78 aa); FT RS18_B|ACST|P10806 30s ribosomal protein s18 (bs21) (77 FT aa), FASTA scores: opt: 220, E(): 4e-10, (52.2% identity FT in 67 aa overlap); etc. Also similar to MTCY63A_5 from FT Mycobacterium tuberculosis. BELONGS TO THE S18P FAMILY OF FT RIBOSOMAL PROTEINS. Note that previously known as rpsR." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S18-1 RPSR1" FT /standard_name="rpsR" FT CDS 59409..59867 FT /evidence=experimental FT /function="BINDS TO THE 23S RRNA." FT /gene="rplI" FT /locus_tag="Rv0056" FT /note="Rv0056, (MTCY21D4.19), len: 152 aa. Probable rplI, FT 50S ribosomal protein L9, equivalent to RL9_MYCLE|P46385 FT 50s ribosomal protein l9 from Mycobacterium leprae (152 FT aa), FASTA scores: opt: 847, E(): 0, (88.7% identity in FT 150 aa overlap). Also highly similar to others e.g. FT Q9X8U5|RL9_STRCO 50S RIBOSOMAL PROTEIN L9 from FT Streptomyces coelicolor (148 aa); etc. Contains PS00651 FT Ribosomal protein L9 signature. BELONGS TO THE L9P FAMILY FT OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L9 RPLI" FT misc_feature 59445..59528 FT /note="PS00651 Ribosomal protein L9 signature" FT CDS 59896..60417 FT /function="UNKNOWN" FT /locus_tag="Rv0057" FT /note="Rv0057, (MTCY21D4.20), len: 173 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 60396..63020 FT /EC_number="3.6.1.-" FT /function="PARTICIPATES IN INITIATION AND ELONGATION FT DURING CHROMOSOME REPLICATION; IT EXHIBITS DNA-DEPENDENT FT ATPASE ACTIVITY. THE INTEIN IS AN ENDONUCLEASE FT (POTENTIAL)." FT /gene="dnaB" FT /locus_tag="Rv0058" FT /note="Rv0058, (MTV030.01, MTCY21D4.21), len: 874 aa. FT Probable dnaB, replicative DNA helicase (EC 3.6.1.-). FT Contains an intein (position 61630..62838) similar to, and FT in the same position as, those in Sycnechocystis and FT Rhodothermus marinus (see citation below). Highly similar FT to others e.g. DNAB_SYNY3|Q55418 replicative dna helicase FT (872 aa), FASTA scores: opt: 533, E(): 0, (32.5% identity FT in 424 aa overlap). Also similar to intein FT recA|E1173867|AL008967 RECA INTEIN from Mycobacterium FT tuberculosis (442 aa), FASTA scores: E(): 3.8e-16, (27.0% FT identity in 426 aa overlap). C-terminal extein (position FT 62839..63015) similar to many dnaB proteins e.g. FT NP_302709.1|NC_002677|P46394|DNAB_MYCLE REPLICATIVE DNA FT HELICASE from Mycobacterium leprae (604 aa); FT DNAB_ECOLI|P03005 replicative dna helicase from FT Escherichia coli (471 aa), FASTA scores: opt: 148, E(): FT 1.5e-07, (37.9% identity in 58 aa overlap); etc. THIS FT PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A FT POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION FT (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE FT HELICASE FAMILY, DNAB SUBFAMILY. IN THE INTEIN SECTION; FT BELONGS TO THE HOMING ENDONUCLEASE FAMILY." FT /product="PROBABLE REPLICATIVE DNA HELICASE DNAB" FT misc_feature 61071..61094 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 63200..63892 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0059" FT /note="Rv0059, (MTV030.02), len: 230 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 63909..64967 FT /function="UNKNOWN" FT /locus_tag="Rv0060" FT /note="Rv0060, (MTV030.03), len: 352 aa. Conserved FT hypothetical protein, showing weak similarity to FT NP_104623.1|NC_002678 hypothetical protein from FT Mesorhizobium loti (155 aa); and AP000062|AP000062_92 FT hypothetical protein from Aeropyrum pernix (194 aa), FASTA FT scores: opt: 186, E(): 4.2e-05, (30.9% identity in 165 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 64991..65416 FT /function="UNKNOWN" FT /locus_tag="Rv0061" FT /note="Rv0061, (MTV030.04), len: 141 aa (questionable FT ORF). Hypothetical unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 65552..66694 FT /EC_number="3.2.1.4" FT /function="THE BIOLOGICAL CONVERSION OF CELLULOSE TO FT GLUCOSE GENERALLY REQUIRES THREE TYPES OF HYDROLYTIC FT ENZYMES: (1) ENDOGLUCANASES WHICH CUT INTERNAL FT BETA-1,4-GLUCOSIDIC BONDS; (2) EXOCELLOBIOHYDROLASES THAT FT CUT THE DISSACCHARIDE CELLOBIOSE FROM THE NONREDUCING END FT OF THE CELLULOSE POLYMER CHAIN; (3) BETA-1,4-GLUCOSIDASES FT WHICH HYDROLYZE THE CELLOBIOSE AND OTHER SHORT FT CELLO-OLIGOSACCHARIDES TO GLUCOSE [CATALYTIC FT ACTIVITY:Endohydrolysis of 1,4-beta-D-glucosidic linkages FT in cellulose]." FT /gene="celA1" FT /locus_tag="Rv0062" FT /note="Rv0062, (MTV030.05), len: 380 aa. Possible celA1, FT cellulase (EC 3.2.1.4), similar to many e.g. FT AB65568.1|AL136058 putative secreted endoglucanase FT (cellulase) from Streptomyces coelicolor (332 aa); FT P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from FT Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 FT endoglucanase 1 precursor (cellulase) from STREPTOMYCES FT HALSTEDII (321 aa), FASTA scores: opt: 702, E(): 1. 2e-27, FT (38.9% identity in 319 aa overlap); etc. SEEMS TO BELONG FT TO CELLULASE FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). FT Note that previously known as celA." FT /product="POSSIBLE CELLULASE CELA1 (ENDOGLUCANASE) FT (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL FT CELLULASE)" FT /standard_name="celA" FT CDS 66923..68362 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0063" FT /note="Rv0063, (MTV030.06), len: 479 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to many e.g. FT HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from FT Arthrobacter oxidans (458 aa), FASTA scores: opt: 343, FT E(): 3.4e-13, (27.4% identity in 467 aa overlap); FT AAD28454.1|AF127374_9|AF127374|MitR oxidase from FT Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM FT putative FAD-dependent oxygenase from FT Streptomycesmaritimus (464 aa); etc. Also similar to FT Mycobacterium tuberculosis proteins e.g. Rv3107c, Rv1257c, FT etc. Contains PS00862 Oxygen oxidoreductases covalent FT FAD-binding site." FT /product="POSSIBLE OXIDOREDUCTASE" FT misc_feature 67142..67243 FT /note="PS00862 Oxygen oxidoreductases covalent FAD-binding FT site" FT CDS 68620..71559 FT /function="UNKNOWN" FT /locus_tag="Rv0064" FT /note="Rv0064, (MTV030.07), len: 979 aa. Probable FT conserved transmembrane protein, highly similar to FT NP_301532.1| (NC_002677) putative integral membrane FT protein from Mycobacterium leprae (983 aa). Also similar FT to other hypothetical proteins from ARCHAEOGLOBUS FULGIDUS FT and Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 FT kDa PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA FT scores: opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 FT aa overlap); and CAC01334.1|AL390968 putative integral FT membrane protein (fragment) from Streptomyces coelicolor FT (815 aa); etc. Also similar to Rv3193c from Mycobacterium FT tuberculosis (992 aa), FASTA score: (50.3% identity in 985 FT aa overlap). Contains probable coiled-coil domain from aa FT 948 to 976." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 71821..72222 FT /function="UNKNOWN" FT /locus_tag="Rv0065" FT /note="Rv0065, (MTV030.08), len: 133 aa. Conserved FT hypothetical protein, similar to several hypothetical FT proteins from Mycobacterium tuberculosis: Rv0960 (127 aa), FT Rv1720c (129 aa), and Rv0549c (137 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(72274..74511) FT /EC_number="1.1.1.42" FT /evidence=experimental FT /function="INVOLVED IN THE KREBS CYCLE [CATALYTIC FT ACTIVITY: Isocitrate + NADP+ = 2-OXOGLUTARATE + CO(2) + FT NADPH]." FT /gene="icd2" FT /locus_tag="Rv0066c" FT /note="Rv0066c, (MTV030.09c), len: 745 aa. Probable icd2, FT isocitrate dehydrogenase NADP-dependent (EC 1.1.1.42), FT equivalent to NP_302705.1|NC_002677 isocitrate FT dehydrogenase [NADP] from Mycobacterium leprae (746 aa). FT Also highly similar to many members of the monomeric-type FT family of IDH e.g. NP_251314.1|NC_002516 isocitrate FT dehydrogenase from Pseudomonas aeruginosa (741 aa); FT IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from FT Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106, FT E(): 0, (61.4% identity in 735 aa overlap); FT NP_230786.1|NC_002505 isocitrate dehydrogenase from Vibrio FT cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FT FAMILY OF IDH." FT /product="PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 FT (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) FT (IDP)" FT CDS complement(74629..75198) FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0067c" FT /note="Rv0067c, (MTV030.10c), len: 189 aa. Possible FT transcriptional regulator, highly similar except in FT N-terminus to T44726 probable transcription regulator from FT Mycobacterium leprae (189 aa), FASTA scores: opt: 829, FT E(): 0, (68.3% identity in 189 aa overlap). And similar to FT others, often many members of the tetR family, e.g. T36918 FT probable transcription regulator from Streptomyces FT coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional FT regulator TetR family from Agrobacterium tumefaciens FT strain C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon FT repressor (gus operon repressor) from Escherichia coli FT (196 aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% FT identity in 186 aa overlap); etc. Also similar to FT MTCY8D5_28 from Mycobacterium tuberculosis cosmid (229 FT aa), FASTA score: (32.7% identity in 168 aa overlap). FT Contains probable helix-turn-helix motif from aa 34 to 55 FT (Score 1523, +4.37 SD)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT CDS 75301..76212 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0068" FT /note="Rv0068, (MTV030.11), len: 303 aa. Probable FT oxidoreductase (EC 1.-.-.-), equivalent to FT NP_301343.1|NC_002677 putative oxidoreductase from FT Mycobacterium leprae (304 aa). Also highly similar to many FT e.g. NP_485762.1|NC_003272 probable oxidoreductase from FT Nostoc sp. PCC 7120 (311 aa); NP_279536.1|NC_002607|YajO1 FT probable oxidoreductase from Halobacterium sp. NRC-1 (316 FT aa); OXIR_STRAT|Q03326 probable oxidoreductase from FT Streptomyces antibioticus (298 aa), FASTA scores: opt: FT 430, E(): 1.3e-16, (34.9% identity in 295 aa overlap); FT etc. Also highly similar to MTV037_3 and MTV022_13 from FT Mycobacterium tuberculosis." FT /product="PROBABLE OXIDOREDUCTASE" FT CDS complement(76237..77622) FT /EC_number="4.2.1.13" FT /function="INVOLVED IN GLUCONEOGENESIS FROM SERINE FT [CATALYTIC ACTIVITY: L-serine + H2O = pyruvate + NH3 + FT H2O]." FT /gene="sdaA" FT /locus_tag="Rv0069c" FT /note="Rv0069c, (MTV030.12c), len: 461 aa. Probable sdaA, FT L-serine dehydratase (EC 4.2.1.13), equivalent to FT NP_302203.1| NC_002677 L-serine dehydratase from FT Mycobacterium leprae (458 aa). Also highly similar to many FT e.g. NP_251133.1|NC_002516 L-serine dehydratase from FT Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO FT L-SERINE DEHYDRATASE from Streptomyces coelicolor (455 FT aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from FT Escherichia coli (454 aa), FASTA scores: opt: 1381, E(): FT 0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE FT IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. FT COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE)." FT /product="PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE FT DEAMINASE) (SDH) (L-SD)" FT CDS complement(77619..78896) FT /EC_number="2.1.2.1" FT /function="KEY ENZYME IN THE BIOSYNTHESIS OF PURINES, FT LIPIDS, OTHER COMPONENTS. INTERCONVERSION OF SERINE AND FT GLYCINE [CATALYTIC ACTIVITY: FT 5,10-methylenetetrahydrofolate + glycine + H2O = FT tetrahydrofolate + L-serine]." FT /gene="glyA2" FT /locus_tag="Rv0070c" FT /note="Rv0070c, (MTV030.13c), len: 425 aa. Probable glyA2, FT serine hydroxymethyltransferase (EC 2.1.2.1), equivalent FT to NP_302318.1|NC_002677 serine hydroxymethyltransferase FT from Mycobacterium leprae (426 aa). Also highly similar to FT many e.g. O86565|GLYA_STRCO SERINE FT HYDROXYMETHYLTRANSFERASE from Streptomyces coelicolor (420 FT aa); AAK60516.1|AF327063_1|AF327063 serine FT hydroxymethyltransferase from Corynebacterium glutamicum FT (434 aa); GLYA_ECOLI|P00477 serine FT hydroxymethyltransferase from Escherichia coli (417 aa), FT FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa FT overlap); etc. Also highly similar to MTV017_46 from FT Mycobacterium tuberculosis. Contains PS00096 Serine FT hydroxymethyltransferase pyridoxal-phosphate attachment FT site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL FT PHOSPHATE." FT /product="PROBABLE SERINE HYDROXYMETHYLTRANSFERASE GLYA2 FT (SERINE METHYLASE 2) (SHMT 2)" FT misc_feature complement(78183..78233) FT /note="PS00096 Serine hydroxymethyltransferase FT pyridoxal-phosphate attachment site" FT CDS 79486..80193 FT /function="UNKNOWN" FT /locus_tag="Rv0071" FT /note="Rv0071, (MTV030.14), len: 235 aa. Possible FT maturase, similar to many proteins of the group II intron FT maturase family e.g. P95451|U77945 MATURASE-RELATED FT PROTEIN from PSEUDOMONAS ALCALIGENES (297 aa), FASTA FT scores: opt: 395, E(): 1.7e-20, (43.5% identity in 147 aa FT overlap); N-terminus of AAD16434.1|AF101076 FT maturase-related protein from Pseudomonas putida (473 aa); FT N-terminus of NP_437373.1|NC_003078 putative reverse FT transcriptasematurase protein from Sinorhizobium meliloti FT (453 aa); etc. Also similar to MLCL581_1 from FT Mycobacterium leprae. Contains 5 VDP repeats at FT N-terminus, these are also found in two Streptococcus FT plasmid hypothetical proteins Q52246|X17092 and FT Q54942|X66468." FT /product="POSSIBLE MATURASE" FT repeat_region 79507..79551 FT /note="5 x 9 bp GTGGACCCG repeats" FT repeat_region 80236..80550 FT /note="(MTV030.15), len: 315 bp. Probable REP'-1 FT pseudogene fragment, similar to many Mycobacterium FT tuberculosis proteins inside REP13E12 elements e.g. FT Q50655|Z95390|MTCY13E12.20 (317 aa), FASTA scores; opt: FT 324 E(): 6.8e-17, 43.4% identity in 99 aa overlap, but no FT possible startsite." FT /rpt_type=DIRECT FT /label=REP'-1 FT CDS 80624..81673 FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT GLUTAMINE ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /locus_tag="Rv0072" FT /note="Rv0072, (MTV030.16), len: 349 aa. Probable FT glutamine-transport transmembrane protein ABC-transporter FT (see citation below), showing weak similarity to FT NP_465894.1|NC_003210 protein similar to putative FT ABC-transporter transmembrane subunit from Listeria FT monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 FT protein similar to putative ABC-transporter transmembrane FT subunit from Listeria innocua (367 aa); E1204111|AJ003195 FT MEMBRANE SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS FT (385 aa), FASTA scores: opt: 155, E(): 8.1e-07, (22.0% FT identity in 381 aa overlap). Also highly similar to FT Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium FT tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% FT identity in 349 aa overlap). Note that supposed act with FT near ORF Rv0073|MTV030.17 ATP-binding protein FT ABC-transporter." FT /product="PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE FT PROTEIN ABC TRANSPORTER" FT CDS 81676..82668 FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT GLUTAMINE ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /locus_tag="Rv0073" FT /note="Rv0073, (MTV030.17), len: 330 aa. Probable FT glutamine-transport ATP-binding protein ABC-transporter FT (see citation below), similar to many ATP-binding proteins FT e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding FT protein from Archaeoglobus fulgidus (231 aa); T34822 FT ABC-transporter ATP binding protein from Streptomyces FT coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC FT transporter ATP-binding protein from Escherichia coli (648 FT aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity FT in 233 aa overlap); etc. Also highly similar to FT Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter FT ATP-binding protein from Mycobacterium tuberculosis (330 FT aa), FASTA scores: E(): 0, (83.3% identity in 330 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), PS00211 ABC transporters family signature, and FT PS00889 Cyclic nucleotide-binding domain signature 2. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Note that supposed act with near ORF FT Rv0072|MTV030.16 transmembrane ABC-transporter." FT /product="PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER" FT misc_feature 81793..81816 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 82105..82149 FT /note="PS00211 ABC transporters family signature" FT misc_feature 82507..82560 FT /note="PS00889 Cyclic nucleotide-binding domain signature FT 2" FT CDS 82748..83983 FT /function="UNKNOWN" FT /locus_tag="Rv0074" FT /note="Rv0074, (MTV030.18), len: 411 aa. Conserved FT hypothetical protein, similar to Rv2915c|MTCY338.03c FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis, and showing some simlarity to various FT enzymes or hypothetical proteins from other organisms, eg FT NP_243801.1|NC_002570 aryldialkylphosphatase from Bacillus FT halodurans (394 aa); NP_421471.1|NC_002696 putativ Xaa-Pro FT dipeptidase from Caulobacter crescentus (429 aa); FT NP_343436.1|NC_002754 Prolidase (Xaa-Pro dipeptidase) FT (pepQ-like2) from Sulfolobus solfataricus (408 aa); FT Q50432|M91040 ORGANO PHOSPHATE ACID ANHYDRASE OPAB from FT MYCOBACTERIUM SP. (409 aa), FASTA scores: opt: 166, E(): FT 3.9e-11, (31.2% identity in 430 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 83996..85168 FT /EC_number="2.6.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0075" FT /note="Rv0075, (MTV030.19), len: 390 aa. Probable FT aminotransferase (EC 2.6.1.-), similar to many CLASS-II FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB FT SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase FT from Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 FT putative aminotransferase b from Bacillus subtilis (387 FT aa), FASTA scores: opt: 684, E(): 5.4e-33, (31.3% identity FT in 384 aa overlap); etc. Also similar to several FT cystathionine beta-lyase (beta C-S lyase) e.g. FT AAK69425.1|AF276227_1|AF276227 from Corynebacterium FT glutamicum (368 aa); etc. Also similar to other proteins FT from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c, FT etc." FT /product="PROBABLE AMINOTRANSFERASE" FT CDS complement(85183..85572) FT /function="UNKNOWN" FT /locus_tag="Rv0076c" FT /note="Rv0076c, (MTV030.20c), len: 129 aa. Probable FT membrane protein, with membrane-spanning domain at FT C-terminus." FT /product="PROBABLE MEMBRANE PROTEIN" FT CDS complement(85636..86466) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0077c" FT /note="Rv0077c, (MTV030.21c), len: 276 aa. Possible FT oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. FT CAC44600.1|AL596162 putative oxidoreductase from FT Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU FT NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC FT 1.11.1.-) from Streptomyces aureofaciens (275 aa); FT BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from FT Streptomyces aureofaciens (274 aa), FASTA scores: opt: FT 230, E(): 1.5e-07, (26.1% identity in 249 aa overlap); FT etc. Also similar to MTCY05A6_35 and MTCY1A11_10 from FT Mycobacterium tuberculosis. And shows some similarity in FT part with AAL17935.1|AY054120 putative epoxide hydrolase FT from Mycobacterium smegmatis (203 aa)." FT /product="PROBABLE OXIDOREDUCTASE" FT CDS 86528..87133 FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0078" FT /note="Rv0078, (MTV030.22), len: 201 aa. Probable FT transcriptional regulator, equivalent to FT NP_302706.1|NC_002677 putative TetR-family transcriptional FT regulator from Mycobacterium leprae (236 aa), FASTA FT scores: opt: 755, E(): 0, (71.4% identity in 175 aa FT overlap). Also similar to others e.g. FT NP_103770.1|NC_002678 probable transcriptional regulator FT from Mesorhizobium loti (208 aa); NP_384275.1|NC_003047 FT PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from FT Sinorhizobium meliloti (197 aa); NP_250960.1|NC_002516 FT probable transcriptional regulator from Pseudomonas FT aeruginosa (196 aa); etc. Also similar to FT TETC_ECOLI|P28815 transposon tn10 tetc protein from FT Escherichia coli (197 aa), FASTA scores: opt: 181, E(): FT 9.7e-05, (24.8% identity in 165 aa overlap). Contains FT probable helix-turn-helix motif from aa 35 to 56 (Score FT 1348, +3.78 SD)." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS complement(87208..87801) FT /function="UNKNOWN" FT /locus_tag="Rv0078A" FT /note="Rv0078A, len: 197 aa. Hypothetical unknown FT protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 88204..89025 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0079" FT /note="Rv0079, (MTV030.23), len: 273 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 89022..89480 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0080" FT /note="Rv0080, (MTV030.24), len: 152 aa. Conserved FT hypothetical protein, similar to several hypothetical FT proteins from Streptomyces coelicolor e.g. FT SCJ12.26|AL109989|SCJ12_24 from Streptomyces coelicolor FT cosmid J1 (137 aa), FASTA scores: opt: 291, E(): 4e-13, FT (46.5% identity in 129 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 89575..89919 FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0081" FT /note="Rv0081, (MTV030.25), len: 114 aa. Probable FT transcriptional regulator, highly similar to others e.g. FT AL078610|SCH35_52|T36657 probable transcription regulator FT from Streptomyces coelicolor (117 aa), FASTA scores: opt: FT 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); FT AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory FT protein from Streptomyces verticillus (113 aa); FT NP_435817.1|NC_003037 Putative transcriptional regulator FT from Sinorhizobium meliloti (115 aa); etc." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 89924..90403 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0082" FT /note="Rv0082, (MTV030.26), len: 159 aa. Probable FT oxidoreductase (EC 1.-.-.-), highly highly similar or FT similar to other various oxidoreductases e.g. FT NP_143304.1|NC_000961 NADH-ubiquinone oxidoreductase FT subunit from Pyrococcus horikoshii (173 aa); FT NP_126406.1|NC_000868 CO-induced hydrogenase related, FT subunit L from Pyrococcus abyssi (170 aa); FT HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from FT Escherichia coli (255 aa), FASTA scores: opt: 442, E(): FT 8e-29, (43.2% identity in 148 aa overlap); etc." FT /product="PROBABLE OXIDOREDUCTASE" FT CDS 90400..92322 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0083" FT /note="Rv0083, (MTV030.27, MTCY251.01), len: 640 aa. FT Probable oxidoreductase (EC 1.-.-.-), showing some FT similarity to other various oxidoreductases e.g. FT AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B FT from Burkholderia pseudomallei (668 aa); HYFB_ FT ECOLI|P23482 hydrogenase-4 component b from Escherichia FT coli strain K12 (672 aa), FASTA scores: opt: 995, E(): 0, FT (32.2% identity in 571 aa overlap); FT AAF13041.1|AF157639_1|AF157639 putative formate FT hydrogenlyase integral membrane subunit from FT Desulfitobacterium dehalogenans (637 aa); etc." FT /product="PROBABLE OXIDOREDUCTASE" FT CDS 92328..93278 FT /EC_number="1.-.-.-" FT /function="INVOLVED IN HYDROGEN METABOLISM; FHL PATHWAY." FT /gene="hycD" FT /locus_tag="Rv0084" FT /note="Rv0084, (MTCY251.02), len: 316 aa. Possible hycD FT (alternate gene name: hevD), formate hydrogenlyase (EC FT 1.-.-.-), integral membrane protein, similar to others FT e.g. HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 FT from Escherichia coli (307 aa), FASTA scores: opt: 570, FT E(): 2.1e-26, (33.8% identity in 305 aa overlap); FT AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase FT subunit 4 from Burkholderia pseudomallei (316 aa); FT NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from FT Salmonella enterica subsp. enterica serovar Typhi (307 FT aa); etc. Also similar to NUOH_ECOLI|P33603 NADH FT dehydrogenase I chain H from Escherichia coli (325 aa), FT FASTA scores: opt: 207, E(): 9.5e-06, (26.5% identity in FT 260 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 1 FT FAMILY." FT /product="POSSIBLE FORMATE HYDROGENLYASE HYCD (FHL)" FT /standard_name="hevD" FT CDS 93289..93951 FT /EC_number="1.-.-.-" FT /function="INVOLVED IN HYDROGEN METABOLISM." FT /gene="hycP" FT /locus_tag="Rv0085" FT /note="Rv0085, (MTCY251.03), len: 220 aa. Possible hycP, FT hydrogenase (EC 1.-.-.-), integral membrane protein, FT weakly similar to P77524|HYFE_ECOLI HYDROGENASE-4 FT COMPONENT E from Escherichia coli (216 aa), FASTA scores: FT opt: 204, E():1.2e-07, (25.5% identity in 216 aa FT overlap)." FT /product="POSSIBLE HYDROGENASE HYCP" FT CDS 93951..95417 FT /EC_number="1.-.-.-" FT /function="POSSIBLY INVOLVED IN HYDROGEN METABOLISM." FT /gene="hycQ" FT /locus_tag="Rv0086" FT /note="Rv0086, (MTCY251.04), len: 488 aa. Possible hycQ, FT hydrogenase (EC 1.-.-.-), integral membrane protein, FT weakly similar to P77437|HYFF_ECOLI HYDROGENASE-4 FT COMPONENT F from Escherichia coli (526 aa), FASTA scores: FT opt: 948, E(): 0, (35.9% identity in 493 aa overlap); and FT AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B FT from Burkholderia pseudomallei (668 aa). Also similar to FT d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L FT from Escherichia coli (613 aa), FASTA scores: opt: 360, FT E():3.2e-13, (27.9% identity in 488 aa overlap); and to FT NUON_ECOLI|P33608 NADH dehydrogenase I chain N from FT Escherichia coli (425 aa), FASTA scores: opt: 375, E(): FT 3.9e-14, (25.0% identity in 432 aa overlap)." FT /product="POSSIBLE HYDROGENASE HYCQ" FT CDS 95414..96892 FT /EC_number="1.-.-.-" FT /function="INVOLVED IN HYDROGEN METABOLISM; FHL PATHWAY." FT /gene="hycE" FT /locus_tag="Rv0087" FT /note="Rv0087, (MTCY251.05), len: 492 aa. Possible hycE FT (alternate gene name: hevE), formate hydrogenlyase (EC FT 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate FT hydrogenlyase subunit 5 from Escherichia coli (569 aa), FT FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in FT 449 aa overlap); NP_457243.1|NC_003198 formate FT hydrogenlyase subunit 5 from Salmonella enterica subsp. FT enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 FT formate hydrogenlyase subunit 5 from Methanothermobacter FT thermautotrophicus (370 aa); etc. Also some similarity FT with NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from FT Escherichia coli (407 aa), FASTA scores: opt: 245, E(): FT 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO FT THE COMPLEX I 49 kDa SUBUNIT FAMILY." FT /product="POSSIBLE FORMATE HYDROGENASE HYCE (FHL)" FT /standard_name="hevE" FT CDS 96927..97601 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0088" FT /note="Rv0088, (MTCY251.06), len: 224 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 97758..98351 FT /EC_number="2.1.1.-" FT /function="THOUGHT TO CAUSE METHYLATION." FT /locus_tag="Rv0089" FT /note="Rv0089, (MTCY251.07), len: 197 aa. Possible FT methyltransferase (EC 2.1.1.-), showing some weak FT similarity to others e.g. NP_299749.1|NC_002488 FT 3-demethylubiquinone-9 3-methyltransferase from Xylella FT fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative FT methyltransferase from Streptomyces coelicolor (285 aa); FT NP_111415.1|NC_002689 Predicted SAM-dependent FT methyltransferase from Thermoplasma volcanium (245 aa); FT etc. Also some similarity with many biotin biosynthesis FT proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS FT PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: FT 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); FT etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY." FT /product="POSSIBLE METHYLTRANSFERASE/METHYLASE" FT CDS 98480..99250 FT /function="UNKNOWN" FT /locus_tag="Rv0090" FT /note="Rv0090, (MTCY251.08), len: 256 aa. Possible FT membrane protein." FT /product="POSSIBLE MEMBRANE PROTEIN" FT CDS 99684..100451 FT /EC_number="3.2.2.16" FT /EC_number="3.2.2.9" FT /function="RESPONSIBLE FOR CLEAVAGE OF THE GLYCOSIDIC BOND FT IN BOTH 5'-METHYLTHIOADENOSINE (MTA) AND FT S-ADENOSYLHOMOCYSTEINE (SAH) [CATALYTIC ACTIVITY 1: FT Methylthioadenosine + H2O = adenine + FT 5-methylthio-D-ribose] [CATALYTIC ACTIVITY 2: FT S-adenosyl-L-homocysteine + H2O = adenine + FT S-D-ribosyl-L-homocysteine]." FT /gene="mtn" FT /locus_tag="Rv0091" FT /note="Rv0091, (MTCY251.10), len: 255 aa. Probable mtn FT (alternate gene name: pfs), FT methylthioadenosine/S-Adenosylhomocysteine nucleosidase FT (MTA/SAH nucleosidase), including 5'-methylthioadenosine FT nucleosidase (EC 3.2.2.16) and S-adenosylhomocysteine FT nucleosidase (EC 3.2.2.9), similar to others e.g. FT NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL PROTEIN FT (MTA/SAH NUCLEOSIDASE) (P46): 5'-METHYLTHIOADENOSINE FT NUCLEOSIDASE AND S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from FT Ralstonia solanacearum (261 aa); AAC45731.1|U55214 Pfs FT from Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH FT NUCLEOSIDASE from Treponema pallidum (269 aa); FT PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli FT (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5% FT identity in 246 aa overlap); etc. BELONGS TO THE MTN FT FAMILY." FT /product="PROBABLE BIFUNCTIONAL MTA/SAH NUCLEOSIDASE MTN: FT 5'-METHYLTHIOADENOSINE NUCLEOSIDASE (METHYLTHIOADENOSINE FT METHYLTHIORIBOHYDROLASE) + S-ADENOSYLHOMOCYSTEINE FT NUCLEOSIDASE (S-ADENOSYL-L-HOMOCYSTEINE FT HOMOCYSTEINYLRIBOHYDROLASE)" FT /standard_name="pfs" FT CDS 100583..102868 FT /EC_number="3.6.3.-" FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES FT THE TRANSPORT OF A CATION (POSSIBLY COPPER) WITH THE FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT CATION(IN) = ADP + PHOSPHATE + CATION(OUT)]." FT /gene="ctpA" FT /locus_tag="Rv0092" FT /note="Rv0092, (MTCY251.11), len: 761 aa. Probable ctpA, FT cation-transporting P-type ATPase A (transmembrane FT protein) (EC 3.6.3.-), highly similar to others e.g. FT CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from FT Mycobacterium leprae (780 aa), FASTA scores: opt: 3454, FT E(): 0, (74.4% identity in 741 aa overlap); FT CAB66270.1|AL136519 probable cation-transporting P-type FT ATPase from Streptomyces coelicolor (760 aa); FT NP_391230.1|NC_000964 protein similar to heavy FT metal-transporting ATPase from Bacillus subtilis (803 aa); FT etc. Also highly similar to MTCY251.22c from Mycobacterium FT tuberculosis, FASTA score: (68.3% identity in 742 aa FT overlap). Contains PS01047 Heavy-metal-associated domain, FT and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO FT THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), FT SUBFAMILY IB." FT /product="PROBABLE CATION TRANSPORTER P-TYPE ATPASE A FT CTPA" FT misc_feature 100640..100726 FT /note="PS01047 Heavy-metal-associated domain" FT misc_feature 101909..101929 FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT CDS complement(102815..103663) FT /function="UNKNOWN" FT /locus_tag="Rv0093c" FT /note="Rv0093c, (MTCY251.12c), len: 282 aa. Probable FT conserved membrane protein, equivalent only to FT CAC30943.1|AL583924 probable integral membrane protein FT from Mycobacterium leprae (237 aa)." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS complement(103710..104663) FT /function="UNKNOWN" FT /locus_tag="Rv0094c" FT /note="Rv0094c, (MTCY251.13c), len: 317 aa. Member of FT 13E12 repeat family, showing some similarity to FT U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA FT score: (49.4% identity in 79 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_region complement(103713..105215) FT /note="REP-2, len: 1503 bp. REP251, member of REP13E12 FT family." FT /rpt_type=DIRECT FT /label=REP-2 FT CDS complement(104805..105215) FT /function="UNKNOWN" FT /locus_tag="Rv0095c" FT /note="Rv0095c, (MTCY251.14c), len: 136 aa. Member of FT 13E12 repeat, also partially similar to AF0418|AF041819_8 FT from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% FT identity in 96 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 105324..106715 FT /function="UNKNOWN" FT /gene="PPE1" FT /locus_tag="Rv0096" FT /note="Rv0096, (MTCY251.15), len: 463 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to many FT e.g. Z46257|MLACEA_3 aceA gene for isocitrate L from FT Mycobacterium leprae (438 aa), FASTA scores: opt: 1207, FT E(): 0, (55.3% identity in 380 aa overlap). Also similar FT to Z97559|MTCY261_19 from Mycobacterium tuberculosis (473 FT aa), FASTA score: (40.2% identity in 478 aa overlap); FT YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein (517 aa), FT FASTA scores: opt: 365, E(): 4.6e-12, (37.6% identity in FT 178 aa overlap). Also similar to MTCY274.23c from FT Mycobacterium tuberculosis, FASTA score: (31.1% identity FT in 383 overlap). Some similarity also to MTCY31.06c and FT MTCY48.17 and other mycobacterial PPE family proteins." FT /product="PPE FAMILY PROTEIN" FT CDS 106734..107603 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0097" FT /note="Rv0097, (MTCY251.16), len: 289 aa. Possible FT oxidoreductase (EC 1.-.-.-), equivalent to FT NP_302343.1|NC_002677 putative oxidoreductase from FT Mycobacterium leprae (289 aa). Also highly similar to FT BAB69377.1|AB070955 putative oxidoreductase from FT Streptomyces avermitilis (296 aa); and weakly similar to FT others e.g. NP_518867.1|NC_003295 PUTATIVE FT ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE FT OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 FT aa); NP_286110.1|NC_002655 taurine dioxygenase FT (2-oxoglutarate-dependent) from Escherichia coli strain FT O157:H7 (283 aa); NP_252624.1|NC_002516 taurine FT dioxygenase from Pseudomonas aeruginosa (277 aa); FT ECAE00014310 (283 aa), FASTA scores: opt: 304, E(): FT 2.6e-13, (27.8% identity in 288 aa overlap); FT TFDA_ALCEU|P10088 2,4-dichlorophenoxyacetate monooxygenase FT from A. eutropha (287 aa), FASTA scores: opt: 188, E(): FT 3.5e-06, (26.6% identity in 188 aa overlap); etc. Contains FT PS00077 Cytochrome c oxidase subunit I, copper B binding FT region signature." FT /product="POSSIBLE OXIDOREDUCTASE" FT misc_feature 107474..107488 FT /note="PS00077 Cytochrome c oxidase subunit I, copper B FT binding region signature" FT CDS 107600..108151 FT /function="UNKNOWN" FT /locus_tag="Rv0098" FT /note="Rv0098, (MTCY251.17), len: 183 aa. Conserved FT hypothetical protein, equivalent to CAC30948.1|AL583924 FT conserved hypothetical protein from Mycobacterium leprae FT (183 aa). Also some similarity with BAB69378.1|AB070955 FT hypothetical protein from Streptomyces avermitilis (172 FT aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 108156..109778 FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION." FT /gene="fadD10" FT /locus_tag="Rv0099" FT /note="Rv0099, (MTCY251.18), len: 540 aa. Possible fadD10, FT fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to FT MLACEA_4|Q50176 LONG CHAIN FATTY ACID-CoA LIGASE from FT Mycobacterium leprae (532 aa), FASTA scores: opt: 2580, FT E(): 0, (74.6% identity in 531 aa overlap). Also similar FT to many e.g. BAB69379.1|AB070955 long-chain fatty FT acid--CoA ligase from Streptomyces avermitilis (518 aa); FT NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA FT ligase from Caulobacter crescentus (530 aa); FT NP_435326.1|NC_003037 probable long chain fatty acid CoA FT ligase from Sinorhizobium meliloti (508 aa); etc. Also FT similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase FT from Bacillus subtilis (572 aa), FASTA scores: opt: 415, FT E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains FT PS00455 putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /product="POSSIBLE FATTY-ACID-CoA LIGASE FADD10 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature 108675..108710 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS 109783..110019 FT /function="UNKNOWN" FT /locus_tag="Rv0100" FT /note="Rv0100, (MTCY251.19), len: 78 aa. Conserved FT hypothetical protein, equivalent only to FT CAC30950.1|AL583924 conserved hypothetical protein from FT Mycobacterium leprae (78 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 110001..117539 FT /EC_number="6.-.-.-" FT /function="INVOLVED IN LIPID METABOLISM." FT /gene="nrp" FT /locus_tag="Rv0101" FT /note="Rv0101, (MTCY251.20), len: 2512 aa. Probable nrp, FT peptide synthetase (EC 6.-.-.-), similar to others e.g. FT AAD44234.1|AF143772_40|PstB peptide synthetase from FT Mycobacterium avium (2552 aa); 7476034|S77657 cyclic FT peptide synthetase from Mycobacterium leprae (1401 aa), FT FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 FT aa overlap); part of CAB55600.1|AJ238027 peptide FT synthetase from Mycobacterium smegmatis (5990). Also FT similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF FT protein from Bacillus subtilis (2378 aa); FT SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587 FT aa), FASTA scores: opt: 1708, E(): 0, (30.6% identity in FT 1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop), 2 x PS00455 Putative AMP-binding FT domain signature, and PS00012 Phosphopantetheine FT attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING FT ENZYME FAMILY. THOUGHT TO BE NOT INVOLVED IN MYCOBACTIN FT BIOSYNTHESIS (see citation below)." FT /product="PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE FT SYNTHASE)" FT misc_feature 110070..110093 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 111729..111764 FT /note="PS00455 Putative AMP-binding domain signature" FT misc_feature 114906..114941 FT /note="PS00455 Putative AMP-binding domain signature" FT misc_feature 116040..116087 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 117714..119699 FT /function="UNKNOWN" FT /locus_tag="Rv0102" FT /note="Rv0102, (MTCY251.21), len: 661 aa. Probable FT conserved integral membrane protein, highly similar to FT P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible FT membrane protein from Mycobacterium leprae (659 aa), FT FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa FT overlap). Also similar to others e.g. CAC01497.1|AL391017 FT putative integral membrane protein from Streptomyces FT coelicolor (316 aa); etc. Contains PS00343 Gram-positive FT cocci surface proteins 'anchoring' hexapeptide." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT misc_feature 119085..119102 FT /note="PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT CDS complement(119915..122173) FT /EC_number="3.6.3.-" FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES FT THE TRANSPORT OF A CATION (POSSIBLY COOPPER) WITH THE FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT CATION(IN) = ADP + ORTHOPHOSPHATE + CATION(OUT)]." FT /gene="ctpB" FT /locus_tag="Rv0103c" FT /note="Rv0103c, (MTCY251.22c), len: 752 aa. Probable ctpB, FT cation-transporting P-type ATPase B (transmembrane FT protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 FT cation-transporting P-type ATPase B from Mycobacterium FT leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% FT identity in 752 aa overlap). Also highly similar to others FT e.g. CAB96031.1|AL360055 putative metal transporter ATPase FT from Streptomyces coelicolor (753 aa); FT NP_241423.1|NC_002570 copper-transporting ATPase from FT Bacillus halodurans (806 aa); etc. Also highly similar to FT Z46257|MLACEA_7 aceA gene for isocitrate L from FT Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, FT E():0, (76.5% identity in 752 aa overlap). And similar to FT MTCY251.11 from Mycobacterium tuberculosis, FASTA score: FT (68.3% identity in 742 aa overlap). Contains PS01047 FT Heavy-metal-associated domain, PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." FT /product="PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B FT CTPB" FT misc_feature complement(120818..120838) FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT misc_feature complement(122027..122113) FT /note="PS01047 Heavy-metal-associated domain" FT CDS 122317..123831 FT /function="UNKNOWN" FT /locus_tag="Rv0104" FT /note="Rv0104, (MTCY251.23), len: 504 aa. Conserved FT hypothetical protein, showing weak similarity with other FT cAMP-dependent protein kinases e.g. AAC37564.1|M65066 FT cAMP-dependent protein kinase RI-beta regulatory subunit FT from Homo sapiens (380 aa); etc ." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(123980..124264) FT /function="POSSIBLY INVOLVED IN A TRANSLATION MECHANISM." FT /gene="rpmB1" FT /locus_tag="Rv0105c" FT /note="Rv0105c, (MTCY251.24c), len: 94 aa. Probable rpmB1, FT 50S ribosomal protein L28-1, highly similar to others e.g. FT Q9X8K8|R28B_STRCO 50S RIBOSOMAL PROTEIN L28-2 from FT Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s FT ribosomal protein l28 from Escherichia coli (77 aa), FASTA FT scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa FT overlap); etc. Also similar to MTCY63A_2 from FT Mycobacterium tuberculosis. BELONGS TO THE L28P FAMILY OF FT RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L28-1 RPMB1" FT CDS 124374..125570 FT /function="UNKNOWN" FT /locus_tag="Rv0106" FT /note="Rv0106, (MTCY251.25), len: 398 aa. Conserved FT hypothetical protein, similar to others e.g. FT AL049841|SCE9_33 from Streptomyces coelicolor (370 aa), FT FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity in FT 381 aa overlap); etc. Some similarity to P94400 HOMOLOGUE FT TO NITRILE HYDRATASE REGION from Bacillus subtilis (397 FT aa), FASTA scores: opt: 226, E(): 5.4e-08, (26.4% identity FT in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FT FASTA score: (25.3% identity in 186 aa overlap); and FT P47K_PSECL|P31521 47 kDa protein (p47k) (419 aa), FASTA FT score: (25.9% identity in 401 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(125643..130541) FT /EC_number="3.6.3.-" FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES FT THE TRANSPORT OF A CATION (POSSIBLY MAGNESIUM) WITH THE FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT CATION(IN) = ADP + PHOSPHATE + CATION(OUT)]." FT /gene="ctpI" FT /locus_tag="Rv0107c" FT /note="Rv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa. FT Probable ctpI, cation-transporting ATPase I P-type (EC FT 3.6.3.-), highly similar to NP_302704.1|NC_002677 probable FT cation transport ATPase from Mycobacterium leprae (1609 FT aa); and similar to others e.g. CAB69720.1|AL137166 FT putative transport ATPase from Streptomyces coelicolor FT (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase FT pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: FT 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); FT etc. Also similar to MTCY39.21c and MTCY22G10.22c from FT Mycobacterium tuberculosis, FASTA score: (34.4% identity FT in 796 aa overlap). Contains PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES)." FT /product="PROBABLE CATION-TRANSPORTER ATPASE I CTPI" FT misc_feature complement(127365..127385) FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT CDS complement(130895..131104) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0108c" FT /note="Rv0108c, (MTV031.02c), len: 69 aa. Hypothetical FT unknown protein. TBparse score is 0.890." FT /product="HYPOTHETICAL PROTEIN" FT CDS 131382..132872 FT /function="UNKNOWN" FT /gene="PE_PGRS1" FT /locus_tag="Rv0109" FT /note="Rv0109, (MTV031.03c), len: 496 aa. Member of the M. FT tuberculosis PE family, PGRS subfamily of gly-rich FT proteins (see citation below), highly similar to many e.g. FT Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 kDa FT PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA FT scores: opt: 1772, E(): 0, (57.3% identity in 513 aa FT overlap); etc. TBparse score is 0.884." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 133020..133769 FT /function="UNKNOWN" FT /locus_tag="Rv0110" FT /note="Rv0110, (MTV031.04), len 249 aa. Probable conserved FT integral membrane protein, similar to many e.g. FT AL079308|SCH69_25 from Streptomyces coelicolor (297 aa), FT FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in FT 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD FT PROTEIN from Bacillus subtilis (507 aa), FASTA scores: FT opt: 320, E(): 4e-15, (32.4% identity in 210 aa overlap); FT etc. TBparse score is 0.915." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 133950..136007 FT /EC_number="2.3.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0111" FT /note="Rv0111, (MTV031.05), len: 685 aa. Possible FT transmembrane acyltransferase (EC 2.3.1.-), equivalent to FT AA22904.1|AL035300 putative acyltransferase from FT Mycobacterium leprae (696 aa). Also similar to others e.g. FT C69975 acyltransferase homolog yrhL from Bacillus subtilis FT (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% FT identity in 382 aa overlap). Very similar to Mycobacterium FT tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc." FT /product="POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE" FT CDS 136289..137245 FT /EC_number="4.2.1.47" FT /function="POSSIBLY INVOLVED IN SYNTHESIS OF A-BAND COMMON FT ANTIGEN LIPOPOLYSACCHARIDE. FIRST OF THE THREE STEPS IN FT THE BIOSYNTHESIS OF GDP-FUCOSE FROM GDP-MANNOSE [CATALYTIC FT ACTIVITY: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + FT H2O]." FT /gene="gca" FT /locus_tag="Rv0112" FT /note="Rv0112, (MTV031.06), len: 318 aa. Possible gca, FT GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to FT others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas FT aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21, FT (27.0% identity in 318 aa overlap). Similar to Rv3634c, FT Rv3784, etc from Mycobacterium tuberculosis. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature. SEEMS TO BELONG TO THE GDP-MANNOSE FT 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+)." FT /product="POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA FT (GDP-D-MANNOSE DEHYDRATASE)" FT misc_feature 136673..136759 FT /note="PS00061 Short-chain dehydrogenases/reductases FT family signature" FT CDS 137319..137909 FT /EC_number="5.-.-.-" FT /function="INVOLVED IN BIOSYNTHESIS OF FT NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE: SYNTHESIS OF FT GLYCEROMANNOHEPTOSE 7-PHOSPHATE (INNER CORE FT LIPOPOLYSACCHARIDE BIOSYNTHESIS) [CATALYTIC ACTIVITY: FT D-SEDOHEPTULOSE 7-PHOSPHATE = FT D-GLYCERO-ALPHA,BETA-D-MANNO-HEPTOSE 7-PHOSPHATE]." FT /gene="gmhA" FT /locus_tag="Rv0113" FT /note="Rv0113, (MTV031.07), len: 196 aa. Probable gmhA FT (alternate gene name: lpcA), sedoheptulose-7-phosphate FT isomerase (EC 5.-.-.-) (see citation below), similar to FT many e.g. AE0005|HPAE000596_11 from Helicobacter pylori FT (192 aa), FASTA scores: opt: 451, E(): 1.9e-24, (45.1% FT identity in 162 aa overlap). BELONGS TO THE SIS FAMILY, FT LPCA SUBFAMILY." FT /product="PROBABLE SEDOHEPTULOSE-7-PHOSPHATE ISOMERASE FT GMHA (PHOSPHOHEPTOSE ISOMERASE)" FT /standard_name="lpcA" FT CDS 137941..138513 FT /EC_number="2.-.-.-" FT /function="INVOLVED IN BIOSYNTHESIS OF FT NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE. INVOLVED IN FT TWO PATHWAYS, D-ALPHA-D PATHWAY [CATALYTIC ACTIVITY: FT D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 1,7-BIPHOSPHATE = FT D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 1-PHOSPHATE] AND L-BETA-D FT PATHWAY [CATALYTIC ACTIVITY: FT D-GLYCERO-BETA-D-MANNO-HEPTOSE 1,7-BIPHOSPHATE = FT D-GLYCERO-BETA-D-MANNO-HEPTOSE 1-PHOSPHATE]." FT /gene="gmhB" FT /locus_tag="Rv0114" FT /note="Rv0114, (MTV031.08), len: 190 aa. Possible gmhB, FT D-alpha,beta-D-heptose-1,7-biphosphate phosphatase (EC FT 2.-.-.-) (see citation below), similar to several FT hypothetical proteins and phosphatases e.g. FT HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase FT (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, (34.0 % FT identity in 141 aa overlap)." FT /product="POSSIBLE D-ALPHA,BETA-D-HEPTOSE-1,7-BIPHOSPHATE FT PHOSPHATASE GMHB (D-GLYCERO-D-MANNO-HEPTOSE 7-PHOSPHATE FT KINASE)" FT CDS 138513..139673 FT /EC_number="2.-.-.-" FT /function="INVOLVED IN BIOSYNTHESIS OF FT NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE (D-ALPHA-D FT PATHWAY) [CATALYTIC ACTIVITY: FT D-GLYCERO-ALPHA,BETA-D-MANNO-HEPTOSE 7-PHOSPHATE + ATP = FT D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 1,7-BIPHOSPHATE]." FT /gene="hddA" FT /locus_tag="Rv0115" FT /note="Rv0115, (MTV031.09), len: 386 aa. Possible hddA, FT D-alpha-D-heptose-7-phosphate kinase (EC 2.-.-.-) (see FT citation below), similar to several hypothetical proteins FT and sugar kinases e.g. AAK27850.1|AF324836_3 FT D-glycero-D-manno-heptose 7-phosphate kinase from FT Aneurinibacillus thermoaerophilus (341 aa); FT AAK80995.1|AE007802_11 Sugar kinase from Clostridium FT acetobutylicum (364 aa). TBparse score is 0.951." FT /product="POSSIBLE D-ALPHA-D-HEPTOSE-7-PHOSPHATE KINASE FT HDDA" FT misc_feature 139188..139220 FT /note="PS00435 Peroxidases proximal heme-ligand signature" FT CDS complement(140267..141022) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0116c" FT /note="Rv0116c, (MTV031.10c), len: 251 aa. Possible FT conserved membrane protein, showing similarity to several FT hypothetical mycobacterial proteins e.g. Rv1433 from FT Mycobacterium tuberculosis (271 aa); and FT Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 FT aa); to the C-terminal regions of others like Rv0192 from FT Mycobacterium tuberculosis (366 aa), FASTA scores: opt: FT 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and FT Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis FT cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% FT identity in 221 aa overlap). TBparse score is 0.932." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT CDS 141200..142144 FT /evidence=experimental FT /function="COULD EFFECT FUNCTIONS OF OXYR DURING FT EVOLUTION." FT /gene="oxyS" FT /locus_tag="Rv0117" FT /note="Rv0117, (MTV031.11), len: 314 aa. OxyS, oxidative FT stress response protein regulatory protein, LysR family FT (see citation below). Similar to many transcription FT regulators and OxyR, the oxidative stress response protein FT of many bacteria. Contains LysR family signature at FT N-terminus. Also contains helix-turn-helix motif at aa FT 16-37 (Score 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY FT OF TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE FT INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE FT GENES SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC." FT /product="OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN FT OXYS" FT misc_feature 141248..141340 FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS complement(142128..143876) FT /EC_number="4.1.1.8" FT /function="INVOLVED IN CATABOLISM OF OXALIC ACID FT [CATALYTIC ACTIVITY: Oxalyl-CoA = formyl-CoA + CO2]." FT /gene="oxcA" FT /locus_tag="Rv0118c" FT /note="Rv0118c, (MTV031.12c), Len: 582 aa. Probable oxcA, FT oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to FT many e.g. FT P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 FT PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli FT (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from FT Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124, FT E():0, (55.6% identity in 568 aa overlap). Also similar to FT mycobacterial IlvB proteins e.g. MLCB1788.46c unknown FT TPP-requiring enzyme from Mycobacterium leprae (548 aa); FT and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa), FT FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa FT overlap)." FT /product="PROBABLE OXALYL-CoA DECARBOXYLASE OXCA" FT CDS 144049..145626 FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD7" FT /locus_tag="Rv0119" FT /note="Rv0119, (MTV031.13-MTCI418B.01), len: 525 aa. FT Probable fadD7, fatty-acid-CoA synthetase (EC 6.2.1.-), FT similar to 4-coumarate:CoA ligase of many organisms e.g. FT U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus FT taedaxylem (537 aa), FASTA scores: opt: 483, E(): 8.3e-22, FT (28.2% identity in 440 aa overlap). Contains PS00455 FT Putative AMP-binding domain signature. TBscore is 0.896." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD7 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature 144562..144597 FT /note="PS00455 Putative AMP-binding domain signature, FT [LIVM FY].{2}[STG][STAG]G[ST][STEI][SG].[PASLIVM][KR], FT info count = 22.0" FT CDS complement(145627..147771) FT /evidence=experimental FT /function="INVOLVED IN TRANSLATION MECHANISM. THIS PROTEIN FT MAY PROMOTE THE GTP-DEPENDENT TRANSLOCATION OF THE NASCENT FT PROTEIN CHAIN FROM THE A-SITE TO THE P-SITE OF THE FT RIBOSOME." FT /gene="fusA2" FT /locus_tag="Rv0120c" FT /note="Rv0120c, (MTCI418B.02c), len: 714 aa. Probable FT fusA2 (alternate gene name: fus2), elongation factor G, FT highly similar to others e.g. EFG_ECOLI|P02996 elongation FT factor G (ef-g) from Escherichia coli (703 aa), FASTA FT scores: opt: 1049, E(): 0, (32.5% identity in 717 aa FT overlap). Also similar to fusA1|MTCY210.01 from FT Mycobacterium tuberculosis FASTA score: (39.1% identity in FT 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G FT (EF-G) from Mycobacterium leprae (701 aa), FASTA score: FT (31.7% identity in 710 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 FT SUBFAMILY." FT /product="PROBABLE ELONGATION FACTOR G FUSA2 (EF-G)" FT /standard_name="fus2" FT misc_feature complement(147661..147684) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(147908..148342) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0121c" FT /note="Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved FT hypothetical protein, showing some similarity with others FT proteins from Mycobacterium tuberculosis e.g. Rv1155, FT Rv1875, Rv2074, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 148491..148859 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0122" FT /note="Rv0122, (MTCI418B.04), len: 133 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 148856..149224 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0123" FT /note="Rv0123, (MTCI418B.05), len: 133 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 149533..150996 FT /function="UNKNOWN" FT /gene="PE_PGRS2" FT /locus_tag="Rv0124" FT /note="Rv0124, (MTCI418B.06), len: 487 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium FT tuberculosis (498 aa), FASTA scores: opt: 1730, E(): 0, FT (60.7% identity in 504 aa overlap)." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 151148..152215 FT /EC_number="3.4.21.-" FT /evidence=experimental FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS (SEEMS TO CLEAVE PREFERENTIALLY AFTER SERINE FT RESIDUES)." FT /gene="pepA" FT /locus_tag="Rv0125" FT /note="Rv0125, (MTCI418B.07, MTB32A), len: 355 aa. FT Probable pepA (alternate gene name: mtb32a), serine FT protease (EC 3.4.21.-) (see Skeiky et al., 1999), highly FT similar to other proteases e.g. HHOB_ECOLI|P31137 protease FT hhob precursor (355 aa), FASTA scores: opt: 400, E(): FT 3.8e-14, (32.4% identity in 346 aa overlap). Also similar FT to Q50320 34 kDa PROTEIN PRECURSOR from Mycobacterium FT tuberculosis (361 aa), FASTA scores: opt: 1689, E(): 0, FT (70.7% identity in 362 aa overlap). Contains PS00135 FT Serine proteases, trypsin family, serine active site. Has FT a putative signal sequence at the N-terminus. BELONGS TO FT THE SERINE PROTEASE FAMILY." FT /product="PROBABLE SERINE PROTEASE PEPA (SERINE FT PROTEINASE) (MTB32A)" FT /standard_name="mtb32a" FT misc_feature 151751..151786 FT /note="PS00135 Serine proteases, trypsin family, serine FT active site" FT CDS 152324..154129 FT /EC_number="5.4.99.-" FT /evidence=experimental FT /function="INVOLVED IN TREHALOSE BIOSYNTHESIS (PROTECTIVE FT EFFECT). CONVERTS MALTOSE TO TREHALOSE. Mycobacteria can FT produce trehalose from glucose 6-phosphate and UDP-glucose FT (the OtsA-OtsB pathway) from glycogen-like FT alpha(1-->4)-linked glucose polymers (the TreY-TreZ FT pathway) and from maltose (the TreS pathway)." FT /gene="treS" FT /locus_tag="Rv0126" FT /note="Rv0126, (MTCI418B.08), len: 601 aa. treS, trehalose FT synthase (EC 5.4.99.-) (see citation below), highly FT similar to others e.g. CAA04601.2|AJ001205 putative FT trehalose synthase from Streptomyces coelicolor (566 aa); FT S71450|1536814|BAA11303.1|D78198 trehalose synthase FT maltose-specific from Pimelobacter sp. strain R48 (573 FT aa). Also similar to MAL1_DROME|P07191 possible maltase FT precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% FT identity in 504 aa overlap); and similar to proteins FT associated with amino-acid transport e.g. Q64319 rat FT protein which stimulates transport of cystine and dibasic FT and neutral amino acids (683 aa), FASTA scores: opt: 839, FT E(): 0, (32.0% identity in 531 aa overlap). Also similar FT to several other Mycobacterium tuberculosis proteins e.g. FT Rv2471 FASTA score: (31.7% identity in 164 aa overlap)." FT /product="TREHALOSE SYNTHASE TRES" FT repeat_unit 154073..154125 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class III. See citation below." FT repeat_unit 154126..154178 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_unit 154179..154231 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 154232..155599 FT /function="UNKNOWN" FT /locus_tag="Rv0127" FT /note="Rv0127, (MTCI418B.09, MTCI5.01), len: 455 aa. FT Conserved hypothetical protein, highly similar to various FT proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from FT Streptomyces coelicolor A3(2) (464 aa), FASTA scores: opt: FT 412, E(): 1.1e-19, (40.6% identity in 485 aa overlap); FT AJ0012|SCJ001206_5 hypothetical protein from Streptomyces FT coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): FT 4.3 e-19, (36.5% identity in 455 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 155667..156446 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0128" FT /note="Rv0128, (MTCI5.02), len: 259 aa. Probable conserved FT transmembrane protein, with some similarity to Rv3064c and FT other bacterial proteins e.g. FT AAK85977.1|AE007957|AGR_C_254p from Agrobacterium FT tumefaciens (206 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(156578..157600) FT /EC_number="2.3.1.-" FT /evidence=experimental FT /function="PROTEINS OF THE ANTIGEN 85 COMPLEX ARE FT RESPONSIBLE FOR THE HIGH AFFINITY OF MYCOBACTERIA TO FT FIBRONECTIN. POSSESSES A MYCOLYLTRANSFERASE ACTIVITY FT REQUIRED FOR THE BIOGENESIS OF TREHALOSE DIMYCOLATE (CORD FT FACTOR), A DOMINANT STRUCTURE NECESSARY FOR MAINTAINING FT CELL WALL INTEGRITY." FT /gene="fbpC" FT /locus_tag="Rv0129c" FT /note="Rv0129c, (MT0137, MTCI5.03c), len: 340 aa. fbpC FT (alternate gene names: mpt45, 85C, fbpC2), secreted FT antigen 85c (fibronectin-binding protein C) (mycolyl FT transferase 85C) (EC 2.3.1.-) (see citations below), also FT highly similar to other Mycobacterial antigen precursors FT e.g. A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from FT Mycobacterium leprae (333 aa), FASTA scores: opt: 1937, FT E(): 0, (81.4% identity in 333 aa overlap); etc." FT /product="SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 FT COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) FT (FIBRONECTIN-BINDING PROTEIN C)" FT /standard_name="mpt45; 85C; fbpC2" FT CDS 157847..158302 FT /function="UNKNOWN" FT /locus_tag="Rv0130" FT /note="Rv0130, (MTCI5.04), len: 151 aa. Conserved FT hypothetical protein, most similar to AL096811|SCI30A_19 FT from Streptomyces coelicolor (153 aa), FASTA scores: opt: FT 639, E(): 0, (60.8% identity in 148 aa overlap). Also FT similar to NODN_RHILV|P08634 nodulation protein from FT Rhizobium leguminosarum bv. viciae plasmid pRL1JI (161 FT aa), FASTA scores: opt: 406, E(): 1e-21, (43.9% identity FT in 148 aa overlap; and to O30041 MONOAMINE OXIDASE FT REGULATORY PROTEIN (146 aa), FASTA scores: opt: 219, E(): FT 1.1e-08, (30.8% identity in 133 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(158315..159658) FT /EC_number="1.3.99.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE1" FT /locus_tag="Rv0131c" FT /note="Rv0131c, (MTCI5.05c), len: 447 aa. Probable fadE1, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain FT specific precursor (412 aa), FASTA scores: opt: 522, E(): FT 1.4e-23, (30.1% identity in 425 aa overlap). Also highly FT similar to MTCI5_28 from Mycobacterium tuberculosis." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE1" FT CDS complement(159700..160782) FT /EC_number="1.-.-.-" FT /function="CATALYZES OXIDATION OF GLUCOSE-6-PHOSPHATE TO FT 6-PHOSPHOGLUCONOLACTONE USING COENZYME F420 (AN FT *-HYDROXY-5-DEAZAFLAVIN DERIVATIVE) AS THE ELECTRON FT ACCEPTOR." FT /gene="fgd2" FT /locus_tag="Rv0132c" FT /note="Rv0132c, (MTCI5.06c), len: 360 aa. Putative fgd2, FT F420-dependent glucose-6-phosphate dehydrogenase (EC FT 1.-.-.-), highly similar to many from Mycobacteria e.g. FT AAD38167|g5031431 from Mycobacterium chelonae. Also FT similar to MJ1534|Q58929 N5,N10-METHYLENE FT TETRAHYDROMETHANOPTERIN REDUCTASE from METHANOCOCCUS FT JANNASCHII (342 aa), FASTA scores: opt: 285, E(): 7.9e-11, FT (28.4% identity in 292 aa overlap). And also similar to FT Rv0953c, Rv0791c, etc from Mycobacterium tuberculosis. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /product="PUTATIVE F420-DEPENDENT GLUCOSE-6-PHOSPHATE FT DEHYDROGENASE FGD2" FT misc_feature complement(160702..160734) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 160869..161474 FT /EC_number="2.3.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0133" FT /note="Rv0133, (MTCI5.07), len: 201 aa. Probable FT acetyltransferase (EC 2.3.1.-), highly similar to others FT e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 FT aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity FT in 201 aa overlap)." FT /product="PROBABLE ACETYLTRANSFERASE" FT CDS 161771..162673 FT /EC_number="3.3.2.3" FT /function="THOUGHT TO BE INVOLVED IN DETOXIFICATION FT REACTIONS FOLLOWING OXIDATIVE DAMAGE TO LIPIDS [CATALYTIC FT ACTIVITY: AN EPOXIDE + H(2)O = A GLYCOL]." FT /gene="ephF" FT /locus_tag="Rv0134" FT /note="Rv0134, (MTCI5.08), len: 300 aa. Possible ephE, FT epoxide hydrolase (EC 3.3.2.3) (see citation below), FT similar to others e.g. Q39856 epoxide hydrolase (341 aa), FT FASTA scores: opt: 369, E(): 4.6e-17, (27.2% identity in FT 335 aa overlap); ETC. Also similar to MTCY09F9.26c from FT Mycobacterium tuberculosis (29.5% identity in 346 aa FT overlap)." FT /product="POSSIBLE EPOXIDE HYDROLASE EPHF (EPOXIDE FT HYDRATASE) (ARENE-OXIDE HYDRATASE)" FT CDS complement(162644..163249) FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0135c" FT /note="Rv0135c, (MTCI5.09c), len: 201 aa. Possible FT transcriptional regulator, weakly similar to others e.g. FT P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR FT from Bacillus subtilis (191 aa), FASTA scores: opt: 145, FT E(): 0.0012, (21.0% identity in 162 aa overlap)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 163366..164691 FT /EC_number="1.14.-.-" FT /evidence=experimental FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /gene="cyp138" FT /locus_tag="Rv0136" FT /note="Rv0136, (MT0144, MTCI5.10), len: 441 aa. Probable FT cyp138, cytochrome P450 138 (EC 1.14.-.-), similar to FT others e.g. SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 FT aa), FASTA scores: opt: 315, E(): 1e-13, (25.7% identity FT in 416 aa overlap); etc. Also similar to MTV039_6 from FT Mycobacterium tuberculosis (472 aa), FASTA score: (38.2% FT identity in 442 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop); and PS00086 FT Cytochrome P450 cysteine heme-iron ligand signature. FT BELONGS TO THE CYTOCHROME P450 FAMILY." FT /product="PROBABLE CYTOCHROME P450 138 CYP138" FT misc_feature 163699..163722 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 164506..164535 FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(164712..165260) FT /EC_number="1.8.4.6" FT /function="HAS AN IMPORTANT FUNCTION AS A REPAIR ENZYME FT FOR PROTEINS THAT HAVE BEEN INACTIVATED BY OXIDATION. FT CATALYZES THE REVERSIBLE OXIDATION-REDUCTION OF METHIONINE FT SULFOXIDE IN PROTEINS TO METHIONINE [CATALYTIC ACTIVITY: FT Protein L-methionine + oxidized thioredoxin = protein FT L-methionine S-oxide + reduced thioredoxin]." FT /gene="msrA" FT /locus_tag="Rv0137c" FT /note="Rv0137c, (MTCI5.11c), len: 167 aa. Probable msrA, FT peptide methionine sulfoxide reductase (EC 1.8.4.6), FT equivalent to CAC32179.1|AL583926 putative peptide FT methionine sulfoxide from Mycobacterium leprae (177 aa). FT Highly similar to others e.g. CAC18703.1|AL451182 putative FT peptide methionine sulfoxide reductase from Streptomyces FT coelicolor (172 aa); PMSR_SCHPO|Q09859 putative peptide FT methionine sulfoxide reductase from Streptomyces (187 aa), FT FASTA scores: opt: 468, E(): 9.9e-26, (45.6% identity in FT 158 aa overlap); etc. BELONGS TO THE MSRA FAMILY." FT /product="PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE FT MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE FT MET(O) REDUCTASE)" FT CDS 165323..165826 FT /function="UNKNOWN" FT /locus_tag="Rv0138" FT /note="Rv0138, (MTCI5.12), len: 167 aa. Conserved FT hypothetical protein, showing weak similarity to FT Q10827|YT10_MYCTU HYPOTHETICAL 17.0 KDA PROTEIN from FT Mycobacterium tuberculosis (147 aa), FASTA scores: opt: FT 131, E(): 0.047, (31.15% identity in 106 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 165827..166849 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0139" FT /note="Rv0139, (MTCI5.13), len: 340 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to others e.g. FT O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa), FT FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity in FT 328 aa overlap); TRE_STRGR|P29782 dtdp-glucose FT 4,6-dehydratase (328 aa), FASTA scores: opt: 254, E(): FT 2.6e-10, (29.0% identity in 307 aa overlap)." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS 166910..167290 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0140" FT /note="Rv0140, (MTCI5.14), len: 126 aa. Conserved FT hypothetical protein, similar to others e.g. FT P74567|D90916_48 HYPOTHETICAL 20.8 KDP PROTEIN from FT Synechocystis sp. (180 aa), FASTA scores: opt: 229, E(): FT 4.7e-10, (36.1% identity in 108 aa overlap). Also similar FT to Rv1056 and Rv1670 from Mycobacterium tuberculosis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(167271..167681) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0141c" FT /note="Rv0141c, (MTCI5.15c), len: 136 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 167711..168637 FT /function="UNKNOWN" FT /locus_tag="Rv0142" FT /note="Rv0142, (MTCI5.16), len: 208 aa. Conserved FT hypothetical protein, similar, except in N-terminus, to FT AB88922.1|AL353862 hypothetical protein SCE34.20 from FT Streptomyces coelicolor (326 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(168704..170182) FT /function="UNKNOWN; POSSIBLY ION CHANNEL INVOLVED IN FT TRANSPORT OF CHLORIDE ACROSS THE MEMBRANE." FT /locus_tag="Rv0143c" FT /note="Rv0143c, (MTCI5.17c), len: 492 aa. Probable FT conserved transmembrane protein, CIC family possibly FT involved in transport of chloride, similar to others and FT hypothetical proteins e.g. O28857 PUTATIVE CHLORIDE FT CHANNEL from Archaeoglobus fulgidus (589 aa), FASTA FT scores: opt: 966, E(): 0, (37.7% identity in 453 aa FT overlap); YADQ_ECOLI|P37019 hypothetical 46.0 kDa protein FT (436 aa), FASTA scores: opt: 452, E(): 2.4e-20, (28.0% FT identity in 460 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 170284..171126 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0144" FT /note="Rv0144, (MTCI5.18), len: 280 aa. Probable FT transcriptional regulator, possibly tetR family. Has FT region similar to others e.g. FT Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON FT REPRESSOR (GUS OPERON) from Escherichia coli strains K12 FT and O157:H7 (196 aa), FASTA scores: opt: 214, E(): FT 1.1e-06, (26.0% identity in 196 aa overlap). Contains FT probable helix-turn helix motif from aa 109-130 (Score FT 1463, +4.17 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT CDS 171215..172168 FT /function="UNKNOWN" FT /locus_tag="Rv0145" FT /note="Rv0145, (MTCI5.19), len: 317 aa. Conserved FT hypothetical protein, highly similar to many e.g. FT CAC32172.1|AL583926 conserved hypothetical protein from FT Mycobacterium leprae (310 aa); and several Mycobacterium FT tuberculosis proteins e.g. Rv0726c, Rv0731c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 172211..173143 FT /function="UNKNOWN" FT /locus_tag="Rv0146" FT /note="Rv0146, (MTCI5.20), len: 310 aa. Conserved FT hypothetical protein, highly similar to others e.g. FT AC30975.1|AL583924 conserved hypothetical protein from FT Mycobacterium leprae (304 aa); and several Mycobacterium FT tuberculosis proteins e.g. Rv0726c, Rv0731c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 173238..174758 FT /EC_number="1.2.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: An aldehyde + NAD+ + H2O = FT an acid + NADH]." FT /locus_tag="Rv0147" FT /note="Rv0147, (MTCI5.21), len: 506 aa. Probable aldehyde FT dehydrogenase (NAD+) dependent (EC 1.2.1.-), similar to FT others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase FT (dimeric NADP-preferring) (452 aa), FASTA scores: opt: FT 1291, E(): 0, (43.9% identity in 453 aa overlap). Also FT similar to several Mycobacterium tuberculosis aledehyde FT dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 FT aldehyde dehydrogenases glutamic acid active site, and FT PS00070 aldehyde dehydrogenases cysteine active site. FT BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY." FT /product="PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) FT DEPENDENT" FT misc_feature 173994..174017 FT /note="PS00687 Aldehyde dehydrogenases glutamic acid FT active site" FT misc_feature 174078..174113 FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT CDS 174833..175693 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0148" FT /note="Rv0148, (MTCI5.22), len: 286 aa. Probable FT short-chain dehydrogenase (EC 1.-.-.-), similar to others, FT in particular Estradiol 17 beta-dehydrogenases (EC FT 1.1.1.62), e.g. DHB4_MOUSE|P51660 estradiol 17 FT beta-dehydrogenase 4 (735 aa), FASTA scores: opt: 952, FT E(): 0, (52.5% identity in 276 aa overlap). Contains FT PS00061 Short-chain alcohol dehydrogenase family FT signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT misc_feature 175283..175369 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 175700..176668 FT /EC_number="1.6.5.-" FT /function="POSSIBLY BINDS NADP AND ACTS THROUGH A FT ONE-ELECTRON TRANSFER PROCESS. QUINONES ARE SUPPOSED TO BE FT THE BEST SUBSTRATES. MAY ACT IN THE DETOXIFICATION OF FT XENOBIOTICS [CATALYTIC ACTIVITY: NADPH + quinone = NADP+ + FT semiquinone]" FT /locus_tag="Rv0149" FT /note="Rv0149, (MTCI5.23), len: 322 aa. Possible quinone FT oxidoreductase (EC 1.6.5.-), similar to others FT oxidoreductases e.g. Q08257 quinone oxidoreductase (EC FT 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18, FT (28.4% identity in 328 aa overlap); SCHCOADH_4 from FT Streptomyces coelicolor. Also similar to many proteins FT from Mycobacterium tuberculosis. Contains PS01162 Quinone FT oxidoreductase / zeta-crystallin signature. BELONG TO THE FT ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE FT OXIDOREDUCTASE SUBFAMILY." FT /product="POSSIBLE QUINONE OXIDOREDUCTASE (NADPH:QUINONE FT OXIDOREDUCTASE) (ZETA-CRYSTALLIN)" FT misc_feature 176117..176170 FT /note="PS01162 Quinone oxidoreductase / zeta-crystallin FT signature" FT CDS complement(176665..176952) FT /function="UNKNOWN" FT /locus_tag="Rv0150c" FT /note="Rv0150c, (MTCI5.24c), len: 95 aa. Conserved FT hypothetical protein, showing some similarity with FT C-terminus of O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN FT from Mycobacterium tuberculosis (655 aa), FASTA score: FT (36.5% identity in 104 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(177543..179309) FT /function="UNKNOWN" FT /gene="PE1" FT /locus_tag="Rv0151c" FT /note="Rv0151c, (MTCI5.25c), len: 588 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT with N-terminal region similar to others e.g. MTV032_2 FT PE_PGRS family from Mycobacterium tuberculosis (468 aa), FT FASTA scores: opt: 1125, E(): 0, (46.3% identity in 456 aa FT overlap); MTCY493_24 from Mycobacterium tuberculosis FASTA FT score: (42.5% identity in 558 aa overlap). Also similar to FT upstream ORF MTCI5.26c FASTA score: (54.7% identity in 464 FT aa overlap). Also shows similarity to C-terminal part of FT some PPE family proteins e.g. MTV049_21 from Mycobacterium FT tuberculosis FASTA score: (41.5% identity in 591 aa FT overlap)." FT /product="PE FAMILY PROTEIN" FT CDS complement(179319..180896) FT /function="UNKNOWN" FT /gene="PE2" FT /locus_tag="Rv0152c" FT /note="Rv0152c, (MTCI5.26c), len: 525 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to ORF downstream Z92770|MTCI5_25 (588 aa), FASTA FT scores: opt: 1492, E(): 0, (54.7% identity in 464 aa FT overlap); and to many other PE family type members." FT /product="PE FAMILY PROTEIN" FT CDS complement(181155..181985) FT /EC_number="3.1.3.48" FT /evidence=experimental FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT DEPHOSPHORYLATION). CAN DEPHOSPHORYLATED IN VITRO THE FT PHOSPHOTYROSINE RESIDUE OF MYELIN BASIC PROTEIN (MBP) AT FT pH 7.0. COULD BE INVOLVED IN VIRULENCE BY INTERFERING WITH FT PHOSPHOTYROSINE-MEDIATED SIGNALS IN MACROPHAGES [CATALYTIC FT ACTIVITY: Protein tyrosine phosphate + H(2)O = protein FT tyrosine + phosphate]." FT /gene="ptbB" FT /locus_tag="Rv0153c" FT /note="Rv0153c, (MTCI5.27c), len: 276 aa. ptbB (alternate FT gene name: MPtpB), protein-tyrosine-phosphatase (see FT citation below) (EC 3.1.3.48), showing some similarity to FT several protein-tyrosine phosphatases, polyketide synthase FT and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH FT PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune FT (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): FT 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed FT a secreted protein." FT /product="PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB FT (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)" FT /standard_name="MPtpB" FT CDS complement(181987..183198) FT /EC_number="1.3.99.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE2" FT /locus_tag="Rv0154c" FT /note="Rv0154c, (MTCI5.28c), len: 403 aa. Probable fadE2, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 FT aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in FT 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase FT (short-chain) (383 aa), FASTA score: (35.0% identity in FT 306 aa overlap). COULD BELONG TO THE ACYL-COA FT DEHYDROGENASES FAMILY." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE2" FT CDS 183622..184722 FT /EC_number="1.6.1.2" FT /evidence=experimental FT /function="THE TRANSHYDROGENATION BETWEEN NADH AND NADP IS FT COUPLED TO RESPIRATION AND ATP HYDROLYSIS AND FUNCTIONS AS FT A PROTON PUMP ACROSS THE MEMBRANE [CATALYTIC ACTIVITY: FT NADPH + NAD+ = NADP+ + NADH]." FT /gene="pntAa" FT /locus_tag="Rv0155" FT /note="Rv0155, (MTCI5.29), len: 366 aa. Probable pntAa, FT first part of NAD(P) transhydrogenase subunit alpha (EC FT 1.6.1.2), similar to N-terminus of others e.g. FT PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase FT subunit alpha from Escherichia coli strain K12 (510 aa), FT FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa FT overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1)." FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) FT PNTAA [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT ALPHA)" FT /standard_name="pntAA" FT CDS 184723..185055 FT /function="THE TRANSHYDROGENATION BETWEEN NADH AND NADP IS FT COUPLED TO RESPIRATION AND ATP HYDROLYSIS AND FUNCTIONS AS FT A PROTON PUMP ACROSS THE MEMBRANE [CATALYTIC ACTIVITY: FT NADPH + NAD+ = NADP+ + NADH]." FT /gene="pntAb" FT /locus_tag="Rv0156" FT /note="Rv0156, (MTCI5.30), len: 110 aa. Probable pntAb, FT second part of NAD(P) transhydrogenase subunit alpha, FT integral membrane protein, similar to C-terminus of others FT e.g. Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE FT SUBUNIT PNTAB (139 aa), FASTA scores: opt: 247, E(): FT 1.9e-11, (45.5% identity in 88 aa overlap)." FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) FT PNTAB [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE FT NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE FT NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA)" FT /standard_name="pntAB" FT CDS 185052..186479 FT /EC_number="1.6.1.1" FT /function="THE TRANSHYDROGENATION BETWEEN NADH AND NADP IS FT COUPLED TO RESPIRATION AND ATP HYDROLYSIS AND FUNCTIONS AS FT A PROTON PUMP ACROSS THE MEMBRANE [CATALYTIC ACTIVITY: FT NADPH + NAD+ = NADP+ + NADH]." FT /gene="pntB" FT /locus_tag="Rv0157" FT /note="Rv0157, (MTCI5.31), len: 475 aa. Probable pntB, FT pyridine nucleotide transhydrogenase (nicotinamide FT nucleotide transhydrogenase) subunit beta (EC 1.6.1.1), FT integral membrane protein, similar to others e.g. Q59763 FT PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM FT (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity FT in 472 aa overlap); FT P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) FT TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli FT strains K12 and O157:H7 (462 aa)." FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) FT PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA)" FT CDS complement(186495..186623) FT /function="UNKNOWN" FT /locus_tag="Rv0157A" FT /note="Rv0157A, len: 42 aa. Hypothetical protein (probably FT pseudogene), showing similarity to C-terminal part (aa FT 186-220) of O53976|Rv1975|MTV051.13 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA FT scores: opt: 173, E(): 3e-06, (62.5% identity in 40 aa FT overlap)." FT /product="HYPOTHETICAL PROTEIN (FRAGMENT)" FT /pseudo FT CDS 186785..187429 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0158" FT /note="Rv0158, (MTV032.01), len: 214 aa. Probable FT transcriptional regulator, possibly TetR family, showing FT weak similarity to various transcriptional activators and FT repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL FT TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis FT (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% FT identity in 191 aa overlap). Contains helix-turn-helix FT motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO FT THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. FT TBparse score is 0.897." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT CDS complement(187433..188839) FT /function="UNKNOWN" FT /gene="PE3" FT /locus_tag="Rv0159c" FT /note="Rv0159c, (MTV032.02c), len: 468 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to many other PE proteins e.g. O06828 from FT Mycobacterium tuberculosis (528 aa), FASTA scores: opt: FT 1163, E(): 0, (45.8% identity in 467 aa overlap). Also FT highly similar to upstream MTV032_3, and to MTCI5_25, FT MTCI5_26, MTV049_ 21, MTCY1A10_26, etc." FT /product="PE FAMILY PROTEIN" FT CDS complement(188931..190439) FT /function="UNKNOWN" FT /gene="PE4" FT /locus_tag="Rv0160c" FT /note="Rv0160c, (MTV032.03c), len: 502 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to many other PE proteins e.g. Z92770|MTCI5_26c FT from Mycobacterium tuberculosis (525 aa), FASTA scores: FT opt: 816, E(): 0, (41.4% identity in 367 aa overlap); FT C-terminal region of O06801|RV1768|MTCY28.34 from FT Mycobacterium tuberculosis (618 aa), FASTA scores: opt: FT 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). FT Also highly similar to downstream ORF MTV032_2." FT /product="PE FAMILY PROTEIN" FT CDS 190607..191956 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0161" FT /note="Rv0161, (MTCI28.01, MTV032.04), len 449 aa. FT Possible oxidoreductase (EC 1.-.-.-), similar to FT hypothetical proteins and various oxidoreductases e.g. FT AIP2_YEAST|P46681 actin interacting protein 2 (530 aa), FT FASTA scores: opt: 356, E (): 0, (33.3% identity in 357 aa FT overlap); DLD1_YEAST|P32891 d-lactate dehydrogenase FT (cytochrome) (587 aa), FASTA scores: opt: 311, E(): FT 2.5e-20, (27.9% identity in 366 aa overlap). Also similar FT to other Mycobacteria proteins e.g. MTCY339.30c from FT Mycobacterium tuberculosis FASTA score: (29.4% identity in FT 357 aa overlap); MLCL622.30c from Mycobacterium FT tuberculosis (449 aa)." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS complement(191984..193135) FT /EC_number="1.1.1.1" FT /function="DEHYDROGENESES A ALCOHOL (OXIDO-REDUCTION) FT [CATALYTIC ACTIVITY: An alcohol + NAD+ = an aldehyde or FT ketone + NADH]." FT /gene="adhE1" FT /locus_tag="Rv0162c" FT /note="Rv0162c, (MTCI28.02c), len: 383 aa. Probable adhE1, FT zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to FT others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha FT chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% FT identity in 363 aa overlap). Also similar to other alcohol FT dehydrogenases from Mycobacterium tuberculosis e.g. FT MTCY369.06c FASTA score: (34.0% identity in 365 aa FT overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa FT overlap). Contains PS00059 Zinc-contain ingalcohol FT dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING FT ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: FT ZINC." FT /product="PROBABLE ZINC-TYPE ALCOHOL DEHYDROGENASE (E FT SUBUNIT) ADHE" FT misc_feature complement(192854..192898) FT /note="PS00059 Zinc-containing alcohol dehydrogenases FT signature" FT CDS 193117..193572 FT /function="UNKNOWN" FT /locus_tag="Rv0163" FT /note="Rv0163, (MTCI28.03), len: 151 aa. Conserved FT hypothetical protein, similar to others e.g. Q44017 FT HYPOTHETICAL 16.6 KDA PROTEIN IN GBD 5'REGION (ORF6)from FT Alcaligenes eutrophus (145 aa), FASTA scores: opt: 155, FT E(): 0.0002, (26.6% identity in 139 aa overlap). Also weak FT similary with MTV008.31c|Rv2475c|B70867 from Mycobacterium FT tuberculosis (138 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 193626..194111 FT /evidence=experimental FT /function="UNKNOWN" FT /gene="TB18.5" FT /locus_tag="Rv0164" FT /note="Rv0164, (MTCI28.04), len: 161 aa. TB18.5, conserved FT hypothetical protein, equivalent to CAB08818.1|Z95398 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FT FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa FT overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from FT Mycobacterium tuberculosis. Alternative start codon has FT been suggested. 3' part corrected since first submission FT (-24 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN TB18.5" FT CDS complement(194144..194938) FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0165c" FT /note="Rv0165c, (MTCI28.05c), len: 264 aa. Possible FT transcriptional regulator, GntR family, showing some FT similarity to several e.g. NTRA_CHELE|P54988 nta operon FT transcriptional regulator (231 aa), FASTA scores: opt: FT 154, E(): 0.00058, (32.0% identity in 125 aa overlap); FT P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL FT REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU FT GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 FT aa). Also similar to Rv0043c from Mycobacterium FT tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT CDS 194993..196657 FT /EC_number="6.2.1.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD5" FT /locus_tag="Rv0166" FT /note="Rv0166, (MTCI28.06), len: 554 aa. Probable fadD5, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg FT LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 FT aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in FT 534 aa overlap). Also similar to many other fatty-acid-CoA FT ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FT FASTA score: (35.3% identity in 487 aa overlap), FT MTV013_10, MTY25D10_30, etc. Contains PS00455 putative FT AMP-binding domain signature." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD5 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature 195554..195589 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS 196861..197658 FT /function="UNKNOWN." FT /gene="yrbE1A" FT /locus_tag="Rv0167" FT /note="Rv0167, (MTCI28.07), len: 265 aa. yrbE1A, FT hypothetical unknown integral membrane protein, part of FT mce1 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly FT similar or similar to conserved hypothetical integral FT membrane proteins of yrbEA type, e.g. FT NP_302654.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 FT hypothetical protein from Haemophilus influenzae (261 aa), FT FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in FT 244 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE1A" FT CDS 197660..198529 FT /function="UNKNOWN." FT /gene="yrbE1B" FT /locus_tag="Rv0168" FT /note="Rv0168, (MTCI28.08), len: 289 aa. yrbE1B, FT hypothetical unknown integral membrane protein, part of FT mce1 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 FT conserved membrane protein from Mycobacterium leprae (289 FT aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from FT Haemophilus influenzae (261 aa), FASTA scores: opt: 223, FT E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE1B" FT CDS 198534..199898 FT /evidence=experimental FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION (ENTRY AND SURVIVAL INSIDE MACROPHAGES)." FT /gene="mce1A" FT /locus_tag="Rv0169" FT /note="Rv0169, (MTCI28.09), len: 454 aa. mce1A; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins FT O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); FT O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also FT highly similar to others e.g. FT AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry FT protein from Mycobacterium bovis BCG (454 aa); FT NP_302656.1|NC_002677 putative cell invasion protein from FT Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene FT product from Mycobacterium avium (88 aa) (similarity on FT C-terminus); CAC12798.1|AL445327 putative secreted protein FT from Streptomyces coelicolor (418 aa); etc. Note that FT equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 FT Mcep protein from Mycobacterium tuberculosis (432 aa). FT Contains a very hydrophobic region around residues 20-35. FT Note that previously known as mce1." FT /product="MCE-FAMILY PROTEIN MCE1A" FT /standard_name="mce1" FT CDS 199895..200935 FT /evidence=experimental FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce1B" FT /locus_tag="Rv0170" FT /note="Rv0170, (MTCI28.10), len: 346 aa. mce1B (alternate FT gene name: mceD); belongs to 24-membered Mycobacterium FT tuberculosis Mce protein family (see citations below), FT highly similar to Mycobacterium tuberculosis proteins FT O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); FT O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly FT similar to others e.g. NP_302657.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (346 aa); FT CAC12797.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (354 aa); etc. Contains FT hydrophobic region in N-terminal 30 residues. In FT Escherichia coli, N-terminal part is functional and FT directs export of a leaderless beta-lactamase into the FT periplasm (see Chubb et al., 1998)." FT /product="MCE-FAMILY PROTEIN MCE1B" FT /standard_name="mceD" FT CDS 200932..202479 FT /evidence=experimental FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce1C" FT /locus_tag="Rv0171" FT /note="Rv0171, (MTCI28.11), len: 515 aa. mce1C; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 FT aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also FT highly similar to others e.g. NP_302658.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (519 FT aa); CAC12796.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (351 aa); etc. Weakly similar to FT downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA FT score: (24.6% identity in 552 aa overlap). Contains FT possible signal sequence and highly proline-rich FT C-terminus." FT /product="MCE-FAMILY PROTEIN MCE1C" FT CDS 202476..204068 FT /evidence=experimental FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce1D" FT /locus_tag="Rv0172" FT /note="Rv0172, mce1D (MTCI28.12), len: 530 aa. mce1D; FT belongs to 24-membered Mycobacterium tuberculosis Mce FT protein family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); FT O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly FT similar to others e.g. NP_302659.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (531 aa); FT CAC12795.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (337 aa); etc. Hydrophobic region FT at N-terminus." FT /product="MCE-FAMILY PROTEIN MCE1D" FT CDS 204065..205237 FT /evidence=experimental FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="lprK" FT /locus_tag="Rv0173" FT /note="Rv0173, (MTCI28.13), len: 390 aa. Possible lprK FT (alternate gene name: mce1E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E FT (402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); FT etc. Also highly similar to others e.g. FT NP_302660.1|NC_002677 putative lipoprotein from FT Mycobacterium leprae (392 aa); CAC12794.1|AL445327 FT putative secreted protein from Streptomyces coelicolor FT (413 aa); etc. Contains PS00013 prokaryotic membrane FT lipoprotein lipid attachment site." FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY FT LIPOPROTEIN MCE1E)" FT /standard_name="mce1E" FT misc_feature 204125..204157 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 205231..206778 FT /evidence=experimental FT /function="UNKNOWN, BUT THOUGHT INVOLVED IN HOST CELL FT INVASION." FT /gene="mce1F" FT /locus_tag="Rv0174" FT /note="Rv0174, (MTCI28.14), len: 515 aa. mce1F; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), similar to Mycobacterium FT tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F FT (516 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. FT Also highly similar to others e.g. NP_302661.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (516 FT aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from FT Mycobacterium avium (80 aa) (similarity on C-terminus); FT CAC12793.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (433 aa); etc. Has hydrophobic FT stretch, possibly a signal peptide at the N-terminus." FT /product="MCE-FAMILY PROTEIN MCE1F" FT repeat_unit 206812..206850 FT /note="39 bp direct repeat 1, FT AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG" FT CDS 206814..207455 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0175" FT /note="Rv0175, (MTCI28.15), len: 213 aa. Probable FT conserved Mce-associated membrane protein, equivalent, but FT longer in N-terminus, to CAC32127.1|AL583926 possible FT membrane protein from Mycobacterium leprae (182 aa). Also FT similar to mce-associated proteins from Mycobacterium FT tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Contains FT two 12 residue direct repeats at N-terminus." FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT repeat_unit 206869..206907 FT /note="39 bp direct repeat 2, FT AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG" FT CDS 207452..208420 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0176" FT /note="Rv0176, (MTCI28.16), len: 322 aa. Probable FT conserved Mce-associated transmembrane protein. Contains FT short region of similarity to PRA_MYCLE|P41484 FT proline-rich antigen (36 kDa antigen) from Mycobacterium FT leprae (249 aa) (outside the proline-rich region), FASTA FT scores: opt: 165, E(): 2.9e-05, (40.0% identity in 65 aa FT overlap). Also similar to mce-associated proteins from FT Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv3493c, FT etc." FT /product="PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE FT PROTEIN" FT CDS 208417..208971 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0177" FT /note="Rv0177, (MTCI28.17), len: 184 aa. Probable FT conserved Mce-associated protein, equivalent to FT CAC32129.1|AL583926 conserved membrane protein from FT Mycobacterium leprae (184 aa). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv1973, Rv3493c, etc." FT /product="PROBABLE CONSERVED MCE ASSOCIATED PROTEIN" FT CDS 208938..209672 FT /function="UNKNOWN" FT /locus_tag="Rv0178" FT /note="Rv0178, (MTCI28.18), len: 244 aa. Probable FT conserved Mce-associated membrane protein, highly similar FT in C-terminus to CAC32130.1|AL583926 putative secreted FT protein from Mycobacterium leprae (184 aa). Also similar FT to mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 FT aa overlap with the upstream ORF." FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT CDS complement(209703..210812) FT /function="UNKNOWN" FT /gene="lprO" FT /locus_tag="Rv0179c" FT /note="Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO, FT lipoprotein (visibly not conserved). Contains possible FT N-terminal signal sequence and PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site." FT /product="POSSIBLE LIPOPROTEIN LPRO" FT misc_feature complement(210708..210740) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(210892..212250) FT /function="UNKNOWN" FT /locus_tag="Rv0180c" FT /note="Rv0180c, (MTCI28.20c), len: 452 aa. Probable FT conserved transmembrane protein, equivalent to FT CAC32132.1|AL583926 probable conserved membrane protein FT from Mycobacterium leprae (465 aa). Shows some similarity FT with others membrane proteins e.g. AL096849|SCI11_29 from FT Streptomyces coelicolor (354 aa), FASTA scores: opt: 190, FT E(): 0.00067, (25.9% identity in 409 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(212277..213011) FT /function="UNKNOWN" FT /locus_tag="Rv0181c" FT /note="Rv0181c, (MTCI28.21c), len: 244 aa. Conserved FT hypothetical protein, highly similar to other hypothetical FT proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd FT protein from Escherichia coli (231 aa), FASTA scores: opt: FT 479, E(): 1.2e-29, (37.3% identity in 233 aa overlap); FT P73623|SLL1773 HYPOTHETICAL 25.7 kDa PROTEIN from FT Synechocystis sp. strain PCC 6803 (232 aa), FASTA score: FT (39.1% identity in 233 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(213028..214140) FT /evidence=experimental FT /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT FT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC FT INITIATION SITES AND THEN IS RELEASED." FT /gene="sigG" FT /locus_tag="Rv0182c" FT /note="Rv0182c, (MTCI28.22c), len: 370 aa (start site FT uncertain; first of several possibles was chosen, but note FT that this overlaps the upstream ORF). Probable sigG, FT alternative RNA polymerase sigma subunit (see citations FT below), similar to many e.g. Q45585|SIGW_BACSU RNA FT POLYMERASE SIGMA FACTOR from Bacillus subtilis (187 aa). FT Also similar to nine other ECF sigma factors from FT Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc. FT Contains PS01063 Sigma-70 factors ECF subfamily signature FT and probable helix-turn helix motif from aa 205-226 (Score FT 1181, +3.21 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, FT ECF SUBFAMILY." FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR)" FT misc_feature complement(213856..213894) FT /note="PS01063 Sigma-70 factors ECF subfamily signature" FT CDS 214088..214927 FT /EC_number="3.1.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0183" FT /note="Rv0183, (MTCI28.23), len: 279 aa. Possible FT lysophospholipase (EC 3.1.-.-), similar to several FT (especially eukaryotic enzymes, weaker with Escherichia FT coli), e.g. U67963|HSU67963_1 Human lysophospholipase FT homolog from Homo sapiens (313 aa), FASTA scores: opt: FT 569, E(): 2.6e-29, (37.1% identity in 259 aa overlap); FT P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia FT coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start FT changed based on similarity to AE001997_8 from Deinococcus FT radiodurans (282 aa), FASTA scores: opt: 510, E(): FT 1.4e-25, (34.8% identity in 282 aa overlap). Also shows FT some similarity to epoxide hydrolases from Mycobacterium FT tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in FT 114 aa overlap); and FT O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa)." FT /product="POSSIBLE LYSOPHOSPHOLIPASE" FT CDS 214969..215718 FT /function="UNKNOWN" FT /locus_tag="Rv0184" FT /note="Rv0184, (MTCI28.24), len: 249 aa. Conserved FT hypothetical protein, equivalent to CAC32136.1|AL583926 FT conserved hypothetical protein from Mycobacterium lepra FT (249 aa); and C-terminus highly similar to FT CAB08793.1|Z95398 conserved hypothetical protein from FT Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2 FT identity in 145 aa overlap). Also similar to FT 049841|SCE9_39|T36358 hypothetical protein from FT Streptomyces coelicolor (418 aa), FASTA scores: opt: 231, FT E(): 8.1e-08, (30.4% identity in 270 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 215715..216224 FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN A CELLULAR FT METABOLISM." FT /locus_tag="Rv0185" FT /note="Rv0185, (MTCI28.25a), len: 169 aa. Conserved FT hypothetical protein, equivalent to FT CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 FT aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in FT 165 aa overlap). Contains PS00142 Neutral zinc FT metallopeptidases, zinc-binding region signature." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature 216069..216098 FT /note="PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature" FT CDS 216269..218344 FT /EC_number="3.2.1.21" FT /function="POSSIBLY INVOLVED IN DEGRADATION [CATALYTIC FT ACTIVITY: Hydrolysis of terminal, non-reducing FT beta-D-glucose residues with release of beta-D-glucose]." FT /gene="bglS" FT /locus_tag="Rv0186" FT /note="Rv0186, (MTCI28.25b), len: 691 aa. Probable bglS, FT beta-glucosidase (EC 3.2.1.21), highly similar to many FT e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium FT tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0, FT (32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FT FAMILY 3 OF GLYCOSYL HYDROLASES." FT /product="PROBABLE BETA-GLUCOSIDASE BGLS (GENTIOBIASE) FT (CELLOBIASE) (BETA-D-GLUCOSIDE GLUCOHYDROLASE)" FT CDS 218705..219367 FT /EC_number="2.1.1.-" FT /function="THOUGHT TO BE INVOLVED IN TRANSFER OF METHYL FT GROUP." FT /locus_tag="Rv0187" FT /note="Rv0187, (MTCI28.26), len: 220 aa. Probable FT O-methyltransferase (EC 2.1.1.-), similar to many e.g. FT AB93458.1|AL357591 putative O-methyltransferase from FT Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 FT O-methyltransferase from Streptomyces mycarofaciens (221 FT aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity FT in 192 aa overlap). Also similar to Rv1703c, Rv1220c from FT Mycobacterium tuberculosis." FT /product="PROBABLE O-METHYLTRANSFERASE" FT CDS 219486..219917 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0188" FT /note="Rv0188, (MTCI28.27), len: 143 aa. Probable FT conserved transmembrane protein, similar to FT T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable FT membrane protein from Streptomyces coelicolor (147 aa), FT FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in FT 141 aa overlap); N-terminus of P80185|MTRC_METTH FT TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC FT 2.1.1.86) from Methanobacterium thermoautotrophicum strain FT Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): FT 0.033, (31.6% identity in 98 aa overlap). Also similar to FT Rv3635 from Mycobacterium tuberculosis." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(219996..221723) FT /EC_number="4.2.1.9" FT /function="INVOLVED IN VALINE AND ISOLEUCINE BIOSYNTHESIS FT (AT THE FOURTH STEP) [CATALYTIC ACTIVITY: FT 2,3-DIHYDROXY-3-METHYLBUTANOATE = 3-METHYL-2- OXOBUTANOATE FT + H(2)O]." FT /gene="ilvD" FT /locus_tag="Rv0189c" FT /note="Rv0189c, (MTCI28.28c), len: 575 aa. Probable ilvD, FT dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many FT e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) FT from Lactococcus lactis (subsp. lactis) (Streptococcus FT lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% FT identity in 561 aa overlap). Also similar to FT ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID FT DEHYDRATASE from Mycobacterium leprae (564 aa). Contains FT PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases FT signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR: FT BINDS 1 4FE-4S CLUSTER (POTENTIAL)." FT /product="PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)" FT misc_feature complement(221283..221315) FT /note="PS00886 Dihydroxy-acid and 6-phosphogluconate FT dehydratases signature 1" FT CDS 221871..222161 FT /function="UNKNOWN" FT /locus_tag="Rv0190" FT /note="Rv0190, (MTCI28.29), len: 96 aa. Conserved FT hypothetical protein, highly similar to several FT hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 FT hypothetical 18.9 kDa protein from Synechocystis (167 aa), FT FASTA scores: opt: 237, E(): 5.8e-16, (39.4% identity in FT 94 aa overlap). Also highly similar to FT Z95398|MLCL622_7|O06070 from Mycobacterium leprae (135 FT aa), FASTA score: (82.6% identity in 92 aa overlap). Also FT similar to hypothetical proteins from Mycobacterium FT tuberculosis e.g. Rv0967, Rv0030, Rv1766 (42.5% identity FT in 80 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 222289..223530 FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF DRUG FT ACROSS THE MEMBRANE." FT /locus_tag="Rv0191" FT /note="Rv0191, (MTCI28.30), len: 413 aa. Probable FT conserved integral membrane protein, member of major FT facilitator superfamily (MFS) possibly involved in FT transport of drug, similar to several hypothetical FT proteins e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd FT protein from Escherichia coli (396 aa), FASTA scores: opt: FT 475, E(): 4.2e-33, (29.7% identity in 381 aa overlap); and FT to several chloramphenicol resistance proteins e.g. FT CMLR_STRLI|P31141 chloramphenicol resistance protein from FT stremtomyces lividans (392 aa), FASTA scores: opt: 394, FT E(): 6.7e-12, (28.2% identity in 383 aa overlap). Also FT similar to SVU09991_1 from Mycobacterium tuberculosis." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 223564..224664 FT /function="UNKNOWN" FT /locus_tag="Rv0192" FT /note="Rv0192, (MTCI28.31), len: 366 aa. Conserved FT hypothetical protein. Has Gly- Arg-rich region followed by FT highly Pro-rich repetitive region near N-terminus. Similar FT in C-terminus to other hypothetical proteins e.g. FT Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 FT aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity FT in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 FT hypothetical 47.9 kDa protein from Mycobacterium FT tuberculosis (451 aa), FASTA scores: opt: 330, E(): FT 3.2e-13, (35.1% identity in 271 aa overlap). Also similar FT to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium FT tuberculosis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 223607..223909 FT /function="UNKNOWN" FT /locus_tag="Rv0192A" FT /note="Rv0192A, len: 100 aa. Probable N-terminal part of FT Rv0192, which is member of family P5.17 with Rv0116c, FT Rv1433, Rv2518c, Rv0483. These are all predicted to be FT exported/membrane proteins. Rv0192A has typical N-terminal FT signal peptide which is functional and was identified by FT PhoA fusion screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT FT 45 AA) (see citation below). Since Rv0192 misses a signal FT peptide this suggests that there is a frameshift in the FT region of the overlap with Rv0192 but none found on FT reinspection of sequence." FT /product="CONSERVED SECRETED PROTEIN" FT CDS complement(224724..226571) FT /function="UNKNOWN" FT /locus_tag="Rv0193c" FT /note="Rv0193c, (MTV033.01c-MTCI28.32), len: 615 aa. FT Hypothetical unknown protein. TBparse score is 0.924." FT /product="HYPOTHETICAL PROTEIN" FT CDS 226878..230462 FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /locus_tag="Rv0194" FT /note="Rv0194, (MTV033.02), len: 1194 aa. Probable FT drugs-transport transmembrane protein ATP binding protein FT ABC transporter (see citation below), highly similar to FT many e.g. U62129|STU62129_2|T30293 ABC transport protein FT homolog from Salmonella typhi (1218 aa), FASTA scores: FT opt: 1116, E(): 0, (36.3% identity in 1209 aa overlap); FT CAB66302.1|AL136519 ABC transporter protein ATP-binding FT component from Streptomyces coelicolor (1243 aa); I84547 FT mdl protein from Escherichia coli (1143 aa); etc. Also FT similar to MTCY50_9 and MTCY50_10 from Mycobacterium FT tuberculosis, FASTA score: (33.8% identity in 574 aa FT overlap). Contains two PS00017 ATP/GTP-binding site motif FT A (P-loop) and one PS00211 ABC transporters family FT signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS). Alternative start possible at FT 1823 but no RBS." FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT misc_feature 227976..227999 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 228288..228332 FT /note="PS00211 ABC transporters family signature" FT misc_feature 229803..229826 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 230899..231534 FT /function="POSSIBLY SENSOR PART OF A TWO COMPONENT FT REGULATORY SYSTEM." FT /locus_tag="Rv0195" FT /note="Rv0195, (MTV033.03), len: 211 aa. Possible FT two-component response regulator, luxR family, similar to FT many e.g. U00008|ECOHU49_15 regulatory protein narP from FT Escherichia coli strain K12 (225 aa), FASTA scores: opt: FT 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). FT Start chosen by similarity. Contains probable FT helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 FT SD). TBparse score is 0.931." FT /product="POSSIBLE TWO COMPONENT TRANSCRIPTIONAL FT REGULATORY PROTEIN (PROBABLY LUXR-FAMILY)" FT CDS 231647..232231 FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0196" FT /note="Rv0196, (MTV033.04), len: 194 aa. Possible FT transcriptional regulatory protein, similar to two FT Bacillus subtilis regulators: P42105|YXAF_BACSU FT HYPOTHETICAL 21.0 kDa PROTEIN (191 aa), FASTA scores: opt: FT 323, E(): 2.1e-15, (30.9% identity in 181 aa overlap); and FT Z99105|BSUB0002_9 negative regulator of the lincomycin FT operon (188 aa), FASTA scores: opt: 255, E(): 1e-10, (25.9 FT identity in 185 aa overlap). TBparse score is 0.885." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 232231..234519 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0197" FT /note="Rv0197, (MTV033.05), len: 762 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to others e.g. FT 9948789|AAG06102.1|AE004699_7|B83307 probable FT molybdopterin oxidoreductase from Pseudomonas aeruginosa FT strain PAO1 (769 aa); 5441785|CAB46809.1|AL096811|T36812 FT probable dehydrogenase from Streptomyces coelicolor (747 FT aa), FASTA scores: opt: 617, E(): 9.8e-30, (29.9% identity FT in 762 aa overlap); BAB04334.1|AP001509 assimilatory FT nitrate reductase (catalytic subunit) from Bacillus FT halodurans (743 aa); etc. TBparse score is 0.911." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS complement(234516..236507) FT /EC_number="3.4.24.-" FT /function="UNKNOWN; HYDROLYZES PEPTIDES AND/OR PROTEINS." FT /locus_tag="Rv0198c" FT /note="Rv0198c, (MTV033.06c), len: 663 aa. Probable zinc FT metalloprotease (EC 3.4.24.-), equivalent to FT Z95398|MLCL622.12c from Mycobacterium leprae (667 aa), FT FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 FT aa overlap). Also similar to many other metalloproteases FT e.g. members of the eukaryotic neprilysin family: FT P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA FT scores: opt: 872, E(): 0, (31.1% identity in 692 aa FT overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from FT Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): FT 0, (30.0% identity in 654 aa overlap). Contains PS00142 FT Neutral zinc metallopeptidases, zinc-binding region FT signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC FT METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY. FT TBparse score is 0.905." FT /product="PROBABLE ZINC METALLOPROTEASE" FT misc_feature complement(235011..235040) FT /note="PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature" FT CDS 236550..237209 FT /function="UNKNOWN" FT /locus_tag="Rv0199" FT /note="Rv0199, (MTV033.07), len: 219 aa. Probable FT conserved membrane protein, equivalent to FT Z95398|MLCL622.13 from Mycobacterium leprae (224 aa), FT FASTA scores: opt: 920, E(): 0, (67.7% identity in 220 aa FT overlap). Also some similarity to Mce-associated membrane FT proteins from Mycobacterium tuberculosis e.g. Rv0178, FT Rv0175, etc. TBparse score is 0.918." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS 237206..237895 FT /function="UNKNOWN" FT /locus_tag="Rv0200" FT /note="Rv0200, (MTV033.08), len: 229 aa. Possible FT conserved transmembrane protein, equivalent to FT Z95398|MLCL622.14 from Mycobacterium leprae (229 aa), FT FASTA scores: opt: 1147, E(): 0, (74.7% identity in 229 aa FT overlap). Also some similarity to Rv1973 from FT Mycobacterium tuberculosis (160 aa); and FT Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA scores: opt: FT 134, E(): 0.063, (25.8% identity in 159 aa overlap). FT TBparse score is 0.906." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(237892..238395) FT /function="UNKNOWN" FT /locus_tag="Rv0201c" FT /note="Rv0201c, (MTV033.09c), len: 167 aa. Conserved FT hypothetical protein, equivalent to Z95398|MLCL622.15c FT from Mycobacterium leprae (170 aa), FASTA scores: opt: FT 646, E(): 0, (63.9% identity in 158 aa overlap). TBparse FT score is 0.909." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(238392..241292) FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /gene="mmpL11" FT /locus_tag="Rv0202c" FT /note="Rv0202c, (MTV033.10c), len: 966 aa. Probable FT mmpL11, conserved transmembrane transport protein (see FT citation below), equivalent to Z95398|MLCL622.16c from FT Mycobacterium leprae (1014 aa), FASTA scores: opt: 4076, FT E(): 0, (72.8% identity in 1017 aa overlap). Member of RND FT superfamily, similar to several putative transport FT proteins e.g. P96687 from Bacillus subtilis (724 aa), FT FASTA scores: opt: 594, E(): 9.1e-29, (26.9% identity in FT 717 aa overlap); etc. BELONGS TO THE MMPL FAMILY. TBparse FT score is 0.913." FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL11" FT CDS 241514..241924 FT /function="UNKNOWN" FT /locus_tag="Rv0203" FT /note="Rv0203, (MTV033.11), len: 136 aa. Possible exported FT protein (has hydrophobic stretch near N-terminus). Some FT similarity to part of U02459|LDU02459_1 hypothetical FT protein from Leishmania donovani (741 aa), FASTA score: FT opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap). FT TBparse score is 0.901." FT /product="POSSIBLE EXPORTED PROTEIN" FT CDS complement(241976..243214) FT /function="UNKNOWN" FT /locus_tag="Rv0204c" FT /note="Rv0204c, (MTV033.12c), len: 412 aa. Probable FT conserved transmembrane protein (see citation below), FT equivalent, but has C-terminal extension, to FT Z95398|MLCL622.17c from Mycobacterium leprae (367 aa), FT FASTA scores: opt: 2002, E(): 0, (82.4% identity in 374 aa FT overlap). Some similarity to Rv0585c from Mycobacterium FT tuberculosis. TBparse score is 0.908." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 243384..244487 FT /function="UNKNOWN" FT /locus_tag="Rv0205" FT /note="Rv0205, (MTV033.13), len: 367 aa. Possible FT conserved transmembrane protein, similar to hypothetical FT proteins from many bacteria e.g. AL0209|SC4H8_6 from FT Streptomyces coelicolor (402 aa), FASTA scores: opt: 436, FT E(): 1.7e-21, (27.2% identity in 349 aa overlap); FT Z99117|BSUB0014_221 from Bacillus subtilis (353 aa), FASTA FT scores: opt: 394, E(): 8.6e-19, (28.7% identity in 324 aa FT overla). TBparse score is 0.885." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(244484..247318) FT /evidence=experimental FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /gene="mmpL3" FT /locus_tag="Rv0206c" FT /note="Rv0206c, (MTV033.14c, MTCY08D5.01c), len: 944 aa. FT Possible mmpL3, conserved transmembrane transport protein FT (see Tekaia et al., 1999), equivalent to FT Z95398|MLCL622.18c from Mycobacterium leprae (955 aa), FT FASTA scores: opt: 806, E(): 1.8e-21, (57.2% identity in FT 243 aa overlap). Member of RND superfamily, similar to FT others. BELONGS TO THE MMPL FAMILY. TBparse score is FT 0.928." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL3" FT CDS complement(247384..248112) FT /function="UNKNOWN" FT /locus_tag="Rv0207c" FT /note="Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved FT hypothetical protein, equivalent to Z95398|MLCL622_19 from FT Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 FT identity in 199 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(248115..248906) FT /EC_number="2.1.1.-" FT /function="CAUSES METHYLATION." FT /locus_tag="Rv0208c" FT /note="Rv0208c, (MTCY08D5.03c), len: 263 aa. Hypothetical FT methyltransferase (EC 2.1.1.-), equivalent to FT Z95398|MLCL622_20 from Mycobacterium leprae (279 aa), FT FASTA score: (64.2% identity in 246 aa overlaps). Also FT similar to others e.g. FT 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c FT HYPOTHETICAL METHLYTRANSFERASE from Streptomyces FT coelicolor (271 aa). Could start at aa 7." FT /product="HYPOTHETICAL METHLYTRANSFERASE (METHYLASE)" FT CDS 249038..250123 FT /function="UNKNOWN" FT /locus_tag="Rv0209" FT /note="Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 250120..251598 FT /function="UNKNOWN" FT /locus_tag="Rv0210" FT /note="Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical FT unknown protein. Possibly membrane protein; has FT hydrophobic stretches around aa 333 - 381." FT /product="HYPOTHETICAL PROTEIN" FT CDS 251782..253602 FT /EC_number="4.1.1.32" FT /evidence=experimental FT /function="RATE-LIMITING GLUCONEOGENIC ENZYME [CATALYTIC FT ACTIVITY: GTP + OXALOACETATE = GDP + PHOSPHOENOLPYRUVATE + FT CO2]." FT /gene="pckA" FT /locus_tag="Rv0211" FT /note="Rv0211, (MTCY08D5.06), len: 606 aa. Probable pckA FT (alternate gene names: pckG and pck1), iron-regulated FT phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32), FT equivalent to Z95398|MLCL622_21 PROBABLE FT PHOSPHOENOLPYRUVATE CARBOXYKINASE from Mycobacterium FT leprae (609 aa), FASTA score: (86.1% identity in 605 aa FT overlap). Also highly similar to others e.g. FT PPCK_NEOFR|P22130 phosphoenolpyruvate carboxykinase [GTP] FT (608 aa), FASTA scores: opt: 2287, E(): 0, (55.9% identity FT in 598 aa overlap). Contains PS00505 Phosphoenolpyruvate FT carboxykinase (GTP) signature. BELONGS TO THE FT PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FAMILY." FT /product="PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE FT CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) FT (PEPCK)(PEP CARBOXYKINASE)" FT /standard_name="pckG; pck1" FT misc_feature 252586..252612 FT /note="PS00505 Phosphoenolpyruvate carboxykinase (GTP) FT signature" FT CDS complement(253669..254640) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /gene="nadR" FT /locus_tag="Rv0212c" FT /note="Rv0212c, (MTCY08D5.07c), len: 323 aa. Possible nadR FT (alternate gene name: nadI), transcriptional regulator, FT similar to others e.g. NADR_ECOLI|P27278 transcriptional FT regulator from Escherichia coli (410 aa), FASTA scores: FT opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR FT (PROBABLY ASNC-FAMILY)" FT /standard_name="nadI" FT misc_feature complement(254143..254166) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(254637..255950) FT /EC_number="2.1.1.-" FT /function="CAUSES METHYLATION." FT /locus_tag="Rv0213c" FT /note="Rv0213c, (MTCY08D5.08c), len: 437 aa. Possible FT methyltransferase (EC 2.1.1.-), weakly similar to others FT methyltransferases e.g. AF127374_30|LINA from Streptomyces FT lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19, FT (27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 FT methyltransferase (553 aa), FASTA scores: opt: 267, E(): FT 1.2e-13, (29.3% identity in 351 aa overlap)." FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT CDS 256064..257677 FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD4" FT /locus_tag="Rv0214" FT /note="Rv0214, (MTCY08D5.09), len: 537 aa. Probable fadD4, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. 4CL_PINTA|P41636 4-coumarate--CoA ligase (EC FT 6.2.1.12) (537 aa), FASTA scores: opt: 622, E(): 1e-31, FT (30.0% identity in 514 aa overlap). Also similar to others FT from Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA FT score: (30.7% identity in 501 aa overlap); MTCY493_27, FT MTCY07A7_11, MTCI28_6. Contains PS00455 putative FT AMP-binding domain signature." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD4 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature 256628..256663 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(257783..258856) FT /EC_number="1.3.99.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE3" FT /locus_tag="Rv0215c" FT /note="Rv0215c, (MTCY08D5.10c), len: 357 aa. Probable FT fadE3, acyl- dehydrogenase (EC 1.3.99.-), similar to many FT e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. FT subtilis (EC 1.3.99.-) (379 aa), FASTA scores: opt: 812, FT E(): 0, (39.5% identity in 354 aa overlap)." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE3" FT CDS 258913..259926 FT /function="UNKNOWN" FT /locus_tag="Rv0216" FT /note="Rv0216, (MTCY08D5.11), len: 337 aa. Conserved FT hypothetical protein, equivalent to Z95398|MLCL622_22 from FT Mycobacterium leprae (339 aa), FASTA scores: E(): 0, (73.7 FT identity in 338 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(259923..260831) FT /EC_number="3.1.1.-" FT /function="UNKNOWN; LIPOLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM." FT /gene="lipW" FT /locus_tag="Rv0217c" FT /note="Rv0217c, (MTCY08D5.12c), len: 302 aa. Possible FT esterase (EC 3.1.1.-), showing similarity with others e.g. FT EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt: FT 320, E(): 3.2e-13, (29.2% identity in 274 aa overlap)." FT /product="POSSIBLE ESTERASE LIPW" FT CDS 260924..262252 FT /function="UNKNOWN" FT /locus_tag="Rv0218" FT /note="Rv0218, (MTCY08D5.13), len: 442 aa. Probable FT conserved transmembrane protein, some similarity with FT sulfite oxidases (EC 1.8.3.1) e.g. SUOX_HUMAN|P51687 FT sulfite oxidase precursor (488 aa), FASTA scores: opt: FT 153, E(): 0.0087, (28.6% identity in 161 aa overlap); and FT with some nitrate reductases (EC 1.6.6.3) e.g. FT NIA_FUSOX|P39863 nitrate reductase (NADPH) (905 aa), FASTA FT scores: opt: 143, E(): 0.06, (29.3% identity in 92 aa FT overlap). Also similar to BSUB0017_86 from Mycobacterium FT tuberculosis." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 262254..262802 FT /function="UNKNOWN" FT /locus_tag="Rv0219" FT /note="Rv0219, (MTCY08D5.14), len: 182 aa. Probable FT conserved transmembrane protein, showing similarity with FT CAB76992.1|AL159178 putative lipoprotein from Streptomyces FT coelicolor (163 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 262812..264023 FT /EC_number="3.1.1.-" FT /function="UNKNOWN; LIPOLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM." FT /gene="lipC" FT /locus_tag="Rv0220" FT /note="Rv0220, (MTCY08D5.15), len: 403 aa. Probable FT esterase (EC 3.1.1.-), similar to others proteins and FT esterases from various organisms and Mycobacterium FT tuberculosis e.g. Q50681 (431 aa), FASTA scores: opt: 841, FT E(): 0, (38.2% identity in 408 aa overlap); Rv1426c, FT Rv1399c, etc. Contains PS00122 Carboxylesterases type-B FT serine active site." FT /product="PROBABLE ESTERASE LIPC" FT misc_feature 263481..263528 FT /note="PS00122 Carboxylesterases type-B serine active FT site" FT CDS 264067..265476 FT /function="UNKNOWN" FT /locus_tag="Rv0221" FT /note="Rv0221, (MTCY08D5.16), len: 469 aa. Conserved FT hypothetical protein, similar to others proteins from FT Mycobacterium tuberculosis e.g. FT Q50680|Rv2285|MT2343|MTCY339.25c hypothetical 47.7 kDa FT protein (445 aa), FASTA scores: opt: 455, E(): 8.1e-23, FT (26.7% identity in 461 aa overlap); Rv3740c, Rv3734c, FT etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 265507..266295 FT /EC_number="4.2.1.17" FT /evidence=experimental FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + FT H(2)O]." FT /gene="echA1" FT /locus_tag="Rv0222" FT /note="Rv0222, (MTCY08D5.17), len: 262 aa. Probable echA1, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. FT AAC77915.1|AF063588 enoyl CoA hydratase from Rhodococcus FT fascians (275 aa); etc." FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA1 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT CDS complement(266301..267764) FT /EC_number="1.2.1.-" FT /function="THOUGHT TO OXIDIZE A WIDE VARIETY OF ALIPHATIC FT AND AROMATIC ALDEHYDES." FT /locus_tag="Rv0223c" FT /note="Rv0223c, (MTCY08D5.18), len: 487 aa. Probable FT aldehyde dehydrogenase (EC 1.2.1.-), similar to others FT e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde FT dehydrogenase from Deinococcus radiodurans strain R1 (495 FT aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent FT from Gluconobacter oxydans (498 aa), FASTA scores: opt: FT 1157, E (): 0, (42.1% identity in 482 aa overlap); etc. FT Also similar to Rv0768, Rv2858c, etc from Mycobacterium FT tuberculosis. Contains PS00687 Aldehyde dehydrogenases FT glutamic acid active site; and PS00070 Aldehyde FT dehydrogenases cysteine active site. BELONGS TO THE FT ALDEHYDE DEHYDROGENASES FAMILY." FT /product="PROBABLE ALDEHYDE DEHYDROGENASE" FT misc_feature complement(266889..266924) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT misc_feature complement(266985..267008) FT /note="PS00687 Aldehyde dehydrogenases glutamic acid FT active site" FT CDS complement(267863..268627) FT /EC_number="2.1.1.-" FT /function="CAUSES METHYLATION" FT /locus_tag="Rv0224c" FT /note="Rv0224c, (MTCY08D5.19c), len: 254 aa. Possible FT methyltransferase (EC 2.1.1.-), showing weak similarity FT with other methyltransferases e.g. P74388 FT STEROL-C-METHYLTRANSFERASE (318 aa), FASTA scores: opt: FT 190, E(): 3.6e-05, (33.3% identity in 114 aa overlap). FT Equivalent to AL022486|MLCB1883_1 from Mycobacterium FT leprae (269 aa), FASTA scores: opt: 1456, E(): 0, (82.9% FT identity in 252 aa overlap). Also some similarity with FT MTCY21B4.22c from Mycobacterium tuberculosis FASTA score: FT (30.1% identity in 136 aa overlap)." FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT CDS 268663..269817 FT /function="POSSIBLY INVOLVED IN LPS BIOSYNTHESIS." FT /locus_tag="Rv0225" FT /note="Rv0225, (MTCY08D5.20), len: 384 aa. Possible FT conserved protein involved in LPS biosynthesis, similar to FT O26275 LPS BIOSYNTHESIS RFBU RELATED PROTEIN (382 aa), FT FASTA scores: opt: 426, E(): 1.2e-20, (28.2% identity in FT 394 aa overlap). Some similarity with Rv3032 from FT Mycobacterium tuberculosis FASTA score: (31.6% identity in FT 228 aa overlap)." FT /product="POSSIBLE CONSERVED PROTEIN" FT CDS complement(269834..271564) FT /function="UNKNOWN" FT /locus_tag="Rv0226c" FT /note="Rv0226c, (MTCY08D5.21c), len: 576 aa. Probable FT conserved transmembrane protein, equivalent, except in FT N-terminal part, to AC32114.1|AL583926 conserved membrane FT protein from Mycobacterium leprae (600 aa), FASTA scores: FT opt: 2086, E(): 0, (70.3% identity in 579 aa overlap). FT Also similar to AL021411|SC7H1_20 from Streptomyces FT coelicolor (483 aa), FASTA scores: opt: 180, E(): 0.00028, FT (26.5 identity in 388 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(271574..272839) FT /function="UNKNOWN" FT /locus_tag="Rv0227c" FT /note="Rv0227c, (MTCY08D5.22c), len: 421 aa. Possible FT conserved membrane protein, equivalent to FT AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa), FT FASTA scores: opt: 2148, E(): 0, (76.6% identity in 423 aa FT overlap)." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT repeat_unit complement(272855..272955) FT /note="101 bp Mycobacterial Interspersed Repetitive Unit, FT class III" FT CDS 273055..274278 FT /EC_number="2.3.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0228" FT /note="Rv0228, (MTCY08D5.23), len: 407 aa. Probable FT integral membrane acyltransferase (EC 2.3.1.-), equivalent FT to 3063875|CAA18555.1|AL022486|T44870 ACYLTRANSFERASE from FT Mycobacterium leprae (384 aa), FASTA scores: opt: 2004, FT E(): 0, (79.3% identity in 381 aa overlap). Also similar FT to others e.g. Q11064 PROBABLE ACYLTRANSFERASE CY50.28C FT (383 aa), FASTA scores: opt: 372, E(): 2.6e-16, (35.9% FT identity in 359 aa overlap); Q00718|MDMB_STRMY FT ACYLTRANSFERASE. Very similar to Rv0111, Rv1254, etc from FT Mycobacterium tuberculosis." FT /product="PROBABLE INTEGRAL MEMBRANE ACYLTRANSFERASE" FT CDS complement(274306..274986) FT /function="UNKNOWN" FT /locus_tag="Rv0229c" FT /note="Rv0229c, (MTCY08D5.24c), len: 226 aa. Possible FT conserved membrane protein, similar to several proteins FT from Mycobacterium tuberculosis. Other possible start FT sites and could be shorter as C-terminal region has some FT similarity with Rv2757c|D70880 from Mycobacterium FT tuberculosis (138 aa), FASTA scores: E(): 1e-15, (45.3% FT identity in 137 aa overlap), and Rv0301, Rv2546, etc. Also FT some similarity with Q48177 virulence associated protein C FT (132 aa), FASTA scores: opt: 101, E(): 0.6, (24.3% FT identity in 136 aa overlap). Contains PS00626 Regulator of FT chromosome condensation (RCC1) signature 2." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT misc_feature complement(274393..274425) FT /note="PS00626 Regulator of chromosome condensation (RCC1) FT signature 2" FT CDS complement(274983..275963) FT /EC_number="3.1.8.1" FT /function="ENZYMATIC ACTIVITY IS NOT YET KNOWN [CATALYTIC FT ACTIVITY: Aryl dialkyl phosphate + H2O = dialkyl phosphate FT + an aryl alcohol]." FT /gene="php" FT /locus_tag="Rv0230c" FT /note="Rv0230c, (MTCY08D5.26c), len: 326 aa. Probable php, FT phosphotriesterase (EC 3.1.8.1), similar to others e.g. FT AAK42653.1|AE006849 putative aryldialkylphosphatase FT (phosphotriesterase) (paraoxonase) from Sulfolobus FT solfataricus (314 aa); PHP_ECOLI|P45548 PHOSPHOTRIESTERASE FT HOMOLOGY PROTEIN from Escherichia coli (292 aa), FASTA FT scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa FT overlap ); OPD_FLASP|P16648 parathion hydrolase precursor FT (365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5% FT identity in 333 aa overlap); etc. BELONGS TO THE FT PHOSPHOTRIESTERASE FAMILY. COFACTOR: CONTAINS 2 MOLES OF FT ZINC PER SUBUNIT." FT /product="PROBABLE PHOSPHOTRIESTERASE PHP (PARATHION FT HYDROLASE) (PTE) (ARYLDIALKYLPHOSPHATASE) (PARAOXONASE) FT (A-ESTERASE) (ARYLTRIPHOSPHATASE) (PARAOXON HYDROLASE)" FT CDS 276058..277764 FT /EC_number="1.3.99.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE4" FT /locus_tag="Rv0231" FT /note="Rv0231, (MTCY08D5.27), len: 568 aa. Probable fadE4, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT O29752 ACYL-CoA DEHYDROGENASE (ACD-3) from Archaeoglobus FT fulgidus (576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% FT identity in 577 aa overlap); ACDB_BACSU|P45857 acyl-coa FT dehydrogenase from Bacillus subtilis (379 aa), FASTA FT scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa FT overlap)." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE4" FT CDS 277899..278588 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0232" FT /note="Rv0232, (MTCY08D5.28), len: 229 aa. Probable FT transcriptional regulatory protein, tetR/AcrR family, FT similar to others e.g. YIXD_BACSU|P32398 hypothetical FT transcriptional regulator (191 aa), FASTA scores: opt: FT 149, E(): 0.0014, (21.5% identity in 158 aa overlap). Also FT similar to MTV030_11 from Mycobacterium tuberculosis. FT Contains PS01081 Bacterial regulatory proteins, tetR FT family signature, and probable helix-turn helix motif from FT aa 33-54 (Score 1142, +3.08 SD). BELONGS TO THE TETR/ACRR FT FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR/ACRR-FAMILY)" FT misc_feature 277983..278075 FT /note="PS01081 Bacterial regulatory proteins, tetR family FT signature" FT CDS 278585..279529 FT /EC_number="1.17.4.1" FT /function="INVOLVED IN THE DNA REPLICATION PATHWAY (FIRST FT REACTION). PROVIDES THE PRECURSORS NECESSARY FOR DNA FT SYNTHESIS [CATALYTIC ACTIVITY: 2'-deoxyribonucleoside FT diphosphate + oxidized thioredoxin + H2O = ribonucleoside FT diphosphate + reduced thioredoxin]." FT /gene="nrdB" FT /locus_tag="Rv0233" FT /note="Rv0233, (MTCY08D5.29), len: 314 aa. Probable nrdB FT (alternate gene name: rnrS) ribonucleoside-diphosphate FT reductase, beta chain (EC 1.17.4.1), similar to others FT e.g. RIR2_SCHPO|P36603 ribonucleoside-diphosphate FT reductase (391 aa), FASTA scores: opt: 168, E(): 0.00018, FT (26.1% identity in 199 aa overlap); etc. BELONGS TO THE FT RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY. FT COFACTOR: BINDS 2 IRON IONS." FT /product="PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE FT (BETA CHAIN) NRDB (RIBONUCLEOTIDE REDUCTASE SMALL CHAIN)" FT /standard_name="rnrS" FT CDS complement(279605..281140) FT /EC_number="1.2.1.16" FT /evidence=experimental FT /function="INVOLVED IN 4-AMINOBUTYRATE (GABA) DEGRADATION FT PATHWAY [CATALYTIC ACTIVITY: SUCCINATE SEMIALDEHYDE + FT NAD(P)(+) + H(2)O = SUCCINATE + NAD(P)H]." FT /gene="gabD1" FT /locus_tag="Rv0234c" FT /note="Rv0234c, (MTCY08D5.30c), len: 511 aa. Probable FT gabD1, succinate-semialdehyde dehydrogenase [NADP+] FT dependent (EC 1.2.1.16), equivalent to AL022486|MLCB1883_6 FT PROBABLE ALDEHYDE DEHYDROGENASE from Mycobacterium leprae FT (457 aa), FASTA scores: opt: 2617, E(): 0, (85.7% identity FT in 455 aa overlap). Also highly similar to FT Q55585|GABD|SLR0370 PROBABLE SUCCINATE-SEMIALDEHYDE FT DEHYDROGENASE from Synechocystis sp. strain PCC 6803 (454 FT aa), FASTA scores: opt: 1676, E(): 0, (55.8% identity in FT 455 aa overlap); and similar to others e.g. FT GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase FT from Escherichia coli (482 aa), FASTA scores: opt: 929, FT E(): 0, (36.5% identity in 452 aa overlap); etc. Note that FT similar to other cytosolic aldehyde dehydrogenases with EC FT number: 1.2.1.3. Also similar to Rv0768|aldA semialdehyde FT dehydrogenase from Mycobacterium tuberculosis (489 aa); FT and gabD2|Rv1731|MTCY04C12.16 POSSIBLE FT SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT FT from Mycobacterium tuberculosis (518 aa). Contains PS00070 FT aldehyde dehydrogenases cysteine active site. BELONGS TO FT THE ALDEHYDE DEHYDROGENASES FAMILY. Could start at FT different site by homology. Note that previously known as FT gabD2." FT /product="PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE FT [NADP+] DEPENDENT (SSDH) GABD1" FT /standard_name="gabD2" FT misc_feature complement(280172..280207) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT CDS complement(281166..282614) FT /function="UNKNOWN" FT /locus_tag="Rv0235c" FT /note="Rv0235c, (MTCY08D5.31c), len: 482 aa. Probable FT conserved transmembrane protein, highly similar to FT AL133278|CAB61913.1|SCM11_2 putative integral membrane FT protein from Streptomyces coelicolor (470 aa), FASTA FT scores: opt: 2116, E(): 0, (61.8% identity in 474 aa FT overlap); and similar to hypothetical proteins from other FT organisms e.g. Q13392|384D8_7 hypothetical protein (579 FT aa), FASTA scores: opt: 355, E(): 6.9e-17, (28.5% identity FT in 569 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(282649..286851) FT /function="UNKNOWN" FT /locus_tag="Rv0236c" FT /note="Rv0236c, (MTV034.01c, MTV034.02c, MTCY08D5.32c), FT len: 1400 aa. Probable conserved transmembrane protein, FT equivalent to AL022486|CAC32102.1|MLCB1883_7 possible FT integral membrane protein from Mycobacterium leprae (1440 FT aa), FASTA scores: opt: 7491, E(): 0, (78.8% identity in FT 1397 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(286898..287071) FT /function="UNKNOWN" FT /locus_tag="Rv0236A" FT /note="Rv0236A, len: 57 aa. Small secreted protein." FT /product="SMALL SECRETED PROTEIN" FT CDS 287186..288352 FT /function="UNKNOWN" FT /gene="lpqI" FT /locus_tag="Rv0237" FT /note="Rv0237, (MTV034.03), len: 388 aa. Probable lpQI, FT conserved lipoprotein, equivalent to FT AL022486|MLCB1883_8|T44873 probable secreted hydrolase FT from Mycobacterium leprae (387 aa), FASTA scores: opt: FT 1831, E(): 0, (73.3% identity in 390 aa overlap). Also FT similar to other lipoproteins and various hydrolases e.g. FT P40406|2126897|YBBD_BACSU|I39839 HYPOTHETICAL 70.6 KDA FT LIPOPROTEIN from Bacillus subtilis (642 aa); FT P48823|HEXA_ALTSO BETA-HEXOSAMINIDASE A PRECURSOR from FT ALTEROMONAS SP. (598 aa), FASTA scores: opt: 415, E(): FT 5.8e-17, (31.2% identity in 343 aa overlap); FT PCC6803|P74340 BETA-GLUCOSIDASE from Synechocystis sp. FT (538 aa), FASTA scores: opt: 414, E(): 6.1e-17, (30.6 FT identity in 320 aa overlap). Contains signal sequence and FT appropriately positioned PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQI" FT misc_feature 287213..287245 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 288428..289042 FT /evidence=experimental FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0238" FT /note="Rv0238, (MTV034.04), len: 204 aa. Possible FT transcriptional regulatory protein, TetR family, FT equivalent to AL022486|MLCB1883_9|T44874 probable FT transcription regulator from Mycobacterium leprae (208 FT aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in FT 199 aa overlap). Also similar to others e.g. FT CAB77290.1|AL160312 putative tetR-family regulatory FT protein from Streptomyces coelicolor (240 aa). Also FT similar to Mycobacterium tuberculosis proteins FT Z95120|Rv3208 (228 aa), FASTA scores: opt: 266, E(): FT 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 FT (197 aa)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT CDS 289104..289337 FT /function="UNKNOWN" FT /locus_tag="Rv0239" FT /note="Rv0239, (MTV034.05), len: 77 aa. Conserved FT hypothetical protein, weakly similar to FT Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis FT (87 aa), FASTA scores: opt: 88, E(): 5, (40.0% identity in FT 45 aa overlap). TBparse score is 0.922." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 289345..289782 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0240" FT /note="Rv0240, (MTV034.06), len: 145 aa. Conserved FT hypothetical protein, weak similarity with Rv3697c from FT Mycobacterium tuberculosis (145 aa), FASTA scores: opt: FT 145, E(): 7.6e-05, (28.0% identity in 143 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(289812..290654) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0241c" FT /note="Rv0241c, (MTV034.07c), len: 280 aa. Conserved FT hypothetical protein, highly similar to FT MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical FT protein from Mycobacterium leprae (280 aa), FASTA scores: FT opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and FT CAC32097.1|AL583926 conserved hypothetical protein from FT Mycobacterium leprae (300 aa). Also similar to proteins FT from other organisms e.g. CAB77291.1|AL160312 putative FT dehydratase from Streptomyces coelicolor (291 aa); part of FT BAA92930.1|AB032743 fatty acid synthetase beta subunit FT from Pichia angusta (2060 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(290665..292029) FT /EC_number="1.1.1.100" FT /evidence=experimental FT /function="INVOLVED IN THE FATTY ACID BIOSYNTHESIS PATHWAY FT (FIRST REDUCTION STEP) [CATALYTIC ACTIVITY: FT (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = FT 3-oxoacyl-[acyl-carrier protein] + NADPH]." FT /gene="fabG4" FT /locus_tag="Rv0242c" FT /note="Rv0242c, (MTV034.08c), len: 454 aa. Probable fabG4, FT 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100), FT equivalent to FT 3063883|CAA18568.1|AL022486|MLCB1883_13|T44878 FT 3-oxoacyl-[acyl-carrier protein] reductase homolog from FT Mycobacterium leprae (454 aa), FASTA scores: opt: 2486, FT E(): 0, (84.8% identity in 454 aa overlap). C-terminal FT part highly similar to many FabG proteins e.g. FT U39441|VHU3944 1_2 from Vibrio harveyi (244 aa), FASTA FT scores: opt: 562, E(): 3.4e-28, (40.2% identity in 241 aa FT overlap); U91631|PAU91631_3 from Pseudomonas aeruginosa FT (247 aa), FASTA scores: opt: 584, E(): 1.5e-29, (44.4% FT identity in 241 aa overlap). Has N-terminal extension of FT ~200 aa and C-terminal part contains PS00061 Short-chain FT dehydrogenases/reductases family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /product="PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE FABG4 (3-KETOACYL-ACYL CARRIER PROTEIN FT REDUCTASE)" FT misc_feature complement(290905..290991) FT /note="PS00061 Short-chain dehydrogenases/reductases FT family signature" FT CDS 292171..293493 FT /EC_number="2.3.1.16" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION FT [CATALYTIC ACTIVITY: Acyl-CoA + acetyl-CoA = CoA + FT 3-oxoacyl-CoA]." FT /gene="fadA2" FT /locus_tag="Rv0243" FT /note="Rv0243, (MTV034.09), len: 440 aa. Probable fadA2, FT acetyl-CoA acyltransferase (3-acyl-CoA thiolase) (EC FT 2.3.1.16), equivalent, but shorter 17 aa, to FT AL022486|MLCB1883_14T44879 acetyltransferase from FT Mycobacterium leprae (457 aa), FASTA scores: opt: 250 7, FT E(): 0, (87.6% identity in 435 aa overlap). Also highly FT similar to many e.g. G83046|PA478 probable acyl-CoA FT thiolase from Pseudomonas aeruginosa (425 aa); FT AB77293.1|AL160312 putative ketoacyl CoA thiolase from FT Streptomyces coelicolor (428 aa); FT P76503|7449731|YFCY_ECOLI|D65007|B2342 PROBABLE FT 3-KETOACYL-CoA THIOLASE (ACETYL-CoA ACYLTRANSFERASE) FT (BETA-KETOTHIOLASE) from Escherichia coli strain K-12 (436 FT aa), FASTA scores: opt: 914, E(): 0, (38.2% identity in FT 434 aa overlap); P55084|ECHB_HUMAN MITOCHONDRIAL FT TRIFUNCTONAL ENZYME (474 aa), FASTA scores: opt: 881, E(): FT 0, (37.7 identity in 451 aa overlap). Contains PS00099 FT Thiolases active site. BELONGS TO THE THIOLASE FAMILY." FT /product="PROBABLE ACETYL-CoA ACYLTRANSFERASE FADA2 FT (3-KETOACYL-CoA THIOLASE) (BETA-KETOTHIOLASE)" FT misc_feature 293434..293475 FT /note="PS00099 Thiolases active site" FT CDS complement(293798..295633) FT /EC_number="1.3.99.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE5" FT /locus_tag="Rv0244c" FT /note="Rv0244c, (MTV034.10c), len: 611 aa. Probable fadE5, FT acyl-CoA dehydrogenase (EC 1.3.99.-), equivalent to FT AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa), FT FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa FT overlap). Also highly similar to AL0211|MTV007.14 from FT Mycobacterium tuberculosis (609 aa), FASTA scores: opt: FT 2576, E(): 0, (64.6% identity in 611 aa overlap); and to FT various other bacterial proteins described as putative FT acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from FT Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229, FT E(): 6.8e-08, (29.8% identity in 409 aa overlap); etc." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE5" FT CDS 296005..296493 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0245" FT /note="Rv0245, (MTV034.11), len: 162 aa. Possible FT oxidoreductase (EC 1.-.-.-), equivalent to FT AL022486|MLCB1883_17|T44882 probable oxidoreductase from FT Mycobacterium leprae (162 aa), FASTA scores: opt: 860, FT E(): 0, (83.4% identity in 157 aa overlap). Also similar FT to several hypothetical proteins and various FT oxidoreductases e.g. AAK24246.1|AE005898 NADH:riboflavin FT 5'-phosphate oxidoreductase from Caulobacter crescentus FT (174 aa); Q02058|DIM6_STRCO|CAA45048.1 ACTINORHODIN FT POLYKETIDE DIMERASE from STREPTOMYCES COELICOLOR (177 aa), FT FASTA scores: opt: 308, E(): 3. 2e-15, (37.8% identity in FT 143 aa overlap). Also similar to FT Z84498|Rv1939|MTCY09F9.25c from Mycobacterium tuberculosis FT (171 aa), FASTA scores: opt: 517, E(): 3.5e-30, (49.4% FT identity in 158 aa overlap)." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS 296809..298119 FT /function="UNKNOWN" FT /locus_tag="Rv0246" FT /note="Rv0246, (MTV034.12), len: 436 aa (start uncertain). FT Probable conserved integral membrane protein, similar to FT Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from FT Mycobacterium tuberculosis (512 aa), FASTA scores: opt: FT 712, E(): 0, (33.2% identity in 422 aa overlap)." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS complement(298116..298862) FT /EC_number="1.3.99.1" FT /evidence=experimental FT /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND FT SUCCINATE (AEROBIC RESPIRATION) [CATALYTIC ACTIVITY: FT SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]." FT /locus_tag="Rv0247c" FT /note="Rv0247c, (MTV034.13c), len: 248 aa. Probable FT succinate dehydrogenase, iron-sulfur subunit (EC FT 1.3.99.1), highly similar to CAC44313.1|AL596043 putative FT succinate dehydrogenase iron-sulfur subunit from FT Streptomyces coelicolor (259 aa); and similar to FT iron-sulphur protein subunits of fumarate reductase or FT succinate dehydrogenases from many bacteria e.g. FT NP_147618.1|7521083|B72691 fumarate reductase iron-sulfur FT protein from Aeropyrum pernix (305 aa); FT NP_069516.1|2649932|AAB90556.1|AE001057 succinate FT dehydrogenase iron-sulfur subunit B (sdhB) from FT Archaeoglobus fulgidus (236 aa); etc. Also similar to FT Q10761|FRDB_MYCTU|7431693|F70762 FUMARATE REDUCTASE FT IRON-SULFUR PROTEIN from Mycobacterium tuberculosis (247 FT aa), FASTA scores: opt: 358, E():1e-16, (31.3% identity in FT 214 aa overlap). Contains PS00197 2Fe-2S ferredoxins, FT iron-sulfur binding region signature. NOTE THAT SUCCINATE FT DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX FT CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN FT IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR FT PROTEINS (Rv0249c ?)." FT /product="PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR FT SUBUNIT] (SUCCINIC DEHYDROGENASE)" FT misc_feature complement(298680..298706) FT /note="PS00197 2Fe-2S ferredoxins, iron-sulfur binding FT region signature" FT CDS complement(298863..300803) FT /EC_number="1.3.99.1" FT /evidence=experimental FT /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND FT SUCCINATE (AEROBIC RESPIRATION) [CATALYTIC ACTIVITY: FT SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]." FT /locus_tag="Rv0248c" FT /note="Rv0248c, (MTV034.14c), len: 646 aa. Probable FT succinate dehydrogenase, flavoprotein subunit (EC FT 1.3.99.1), highly similar to flavoprotein subunit of FT various succinate dehydrogenases e.g. M88696|RIRSDHA_1 FT flavoprotein from Rickettsia prowazekii (596 aa), FASTA FT scores: opt: 651, E(): 0, (34.6 % identity in 598 aa FT overlap). Also similar to truncated U00022_17 flavoprotein FT from Mycobacterium leprae (401 aa), FASTA scores: opt: FT 677, E(): 0, (39.0% identity in 423 aa overlap). NOTE THAT FT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME FT COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c FT ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR FT PROTEINS (Rv0249c ?)." FT /product="PROBABLE SUCCINATE DEHYDROGENASE [IRON-SULFUR FT SUBUNIT] (SUCCINIC DEHYDROGENASE)" FT misc_feature complement(299583..299618) FT /note="PS00141 Eukaryotic and viral aspartyl proteases FT active site" FT misc_feature complement(300159..300182) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(300834..301655) FT /evidence=experimental FT /function="COULD BE INVOLVED IN INTERCONVERSION OF FT FUMARATE AND SUCCINATE (AEROBIC RESPIRATION). THIS FT HYDROPHOBIC COMPONENT MAY BE REQUIRED TO ANCHOR THE FT CATALYTIC COMPONENTS OF THE SUCCINATE DEHYDROGENASE FT COMPLEX TO THE CYTOPLASMIC MEMBRANE." FT /locus_tag="Rv0249c" FT /note="Rv0249c, (MTV034.15c), len: 273 aa. Probable FT succinate dehydrogenase, membrane-anchor subunit for FT succinate dehydrogenase encoded by Rv0247c and Rv0248c. FT Highly similar to AC44315.1|AL596043 putative integral FT membrane protein from Streptomyces coelicolor (278 aa). FT NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF FT AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN FT (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO FT HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?)." FT /product="PROBABLE SUCCINATE DEHYDROGENASE [MEMBRANE FT ANCHOR SUBUNIT] (SUCCINIC DEHYDROGENASE)" FT CDS complement(301735..302028) FT /evidence=experimental FT /function="UNKNOWN. POSSIBLY DOWN-REGULATED BY FT HSPR|Rv0353." FT /locus_tag="Rv0250c" FT /note="Rv0250c, (MTV034.16c), len: 97 aa. Conserved FT hypothetical protein, equivalent to FT MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 FT hypothetical protein from Mycobacterium leprae (98 aa), FT FASTA scores: opt: 478, E(): 4.4e-28, (72.6% identity in FT 95 aa overlap). Also similar to C-terminus of FT AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein FT from Streptomyces coelicolor (146 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(302173..302652) FT /evidence=experimental FT /function="THOUGHT TO BE INVOLVED IN THE INITIATION STEP FT OF TRANSLATION AT HIGH TEMPERATURE. BOUNDED TO 30S FT RIBOSOMAL SUBUNIT. POSSIBLY A MOLECULAR CHAPERONE. SEEMS FT TO BE REGULATED POSITIVELY BY SIGE|Rv1221 AND NEGATIVELY FT BY HSPR|Rv0353." FT /gene="hsp" FT /locus_tag="Rv0251c" FT /note="Rv0251c, (MTV034.17c), len: 159 aa. hsp (alternate FT gene name: hsp20, hrpA, acr2), heat-stress-induced FT ribosome-binding protein A (see citations below). Highly FT similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 FT from Mycobacterium smegmatis (145 aa), FASTA scores: opt: FT 479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and FT similar to many bacterial and eukaryotic hsp proteins e.g. FT P12811|HS2C_CHLRE CHLOROPLAST HEAT SHOCK 22KD PROTEIN from FT CHLAMYDOMONAS REINHARDTII (157 aa), FASTA scores: opt: FT 184, E(): 1.2e-05, (32.4% identity in 142 aa overlap). FT Also similar to PCC6803 Spore protein sp21 from FT Synechocystis sp. (146 aa), FASTA scores: opt: 213, E(): FT 1.2e-07, (30.3 identity in 145 aa overlap). Also similar FT to P30223|14KD_MYCTU 14 KDA ANTIGEN (16 KDA ANTIGEN) 19K FT major membrane protein (HSP 16.3) from Mycobacterium FT tuberculosis (144 aa). BELONG TO THE SMALL HEAT SHOCK FT PROTEIN (HSP20) FAMILY." FT /product="HEAT SHOCK PROTEIN HSP (HEAT-STRESS-INDUCED FT RIBOSOME-BINDING PROTEIN A)" FT /standard_name="hsp 20; hrpA; acr2" FT CDS 302866..305427 FT /EC_number="1.6.6.4" FT /function="INVOLVED IN NITRATE ASSIMILATION FT (DENITRIFICATION) (AT THE SECOND STEP). THIS ENZYME IS A FT FAD FLAVOPROTEIN THAT ALSO CONTAINS A SIROHEME AND ONE FT 2FE-2S IRON-SULFUR CENTER [CATALYTIC ACTIVITY: 3 NAD(P)H + FT nitrite = 3 NAD(P)+ + NH4OH + H2O.]" FT /gene="nirB" FT /locus_tag="Rv0252" FT /note="Rv0252, (MTV034.18), len: 853 aa. Probable nirB FT (alternate gene name: nasB), nitrite reductase [NAD(P)H] FT large subunit (EC 1.6.6.4), flavoprotein containing FT siroheme and a 2FE-2S iron-sulfur centre. Highly similar FT to many others bacterial enzymes e.g. P08201|NIRB_ECOLI FT NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia FT coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0, FT (49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN FT NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA FT scores: opt: 2902, E(): 0, (54.2% identity in 827 aa FT overlap). Contains PS00365 Nitrite and sulfite reductases FT iron-sulfur/siroheme-binding site. HOMODIMER WHICH FT ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; FT Siroheme. TBparse score is 0.903." FT /product="PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE FT SUBUNIT [FAD FLAVOPROTEIN] NIRB" FT /standard_name="nasB" FT misc_feature 304939..304989 FT /note="PS00365 Nitrite and sulfite reductases FT iron-sulfur/siroheme-binding site" FT CDS 305453..305809 FT /EC_number="1.6.6.4" FT /function="INVOLVED IN NITRATE ASSIMILATION FT (DENITRIFICATION); REQUIRED FOR ACTIVITY OF THE REDUCTASE FT [CATALYTIC ACTIVITY: 3 NAD(P)H + nitrite = 3 NAD(P)+ + FT NH4OH + H2O.]" FT /gene="nirD" FT /locus_tag="Rv0253" FT /note="Rv0253, (MTV034.19), len: 118 aa. Probable nirD, FT nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4), FT similar to others e.g. FT P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia FT coli strains K12 and O157:H7 (108 aa), FASTA scores: opt: FT 271, E():1.7e-12, (41.9% identity in 105 aa overlap). FT ASSOCIATES WITH NIRB|Rv0252. TBparse score is 0.913." FT /product="PROBABLE NITRITE REDUCTASE [NAD(P)H] SMALL FT SUBUNIT NIRD" FT CDS complement(305825..306349) FT /EC_number="2.-.-.-" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS." FT /gene="cobU" FT /locus_tag="Rv0254c" FT /note="Rv0254c, (MTV034.20), len: 174 aa. Probable cobU, FT cobalamin biosynthesis protein including a cobinamide FT kinase (EC 2.-.-.-) and cobinamide phosphate FT guanylyltransferase (EC 2.-.-.-). Highly similar to many FT e.g. Q05599|COBU_SALTY COBINAMIDE KINASE / COBINAMIDE FT PHOSPHATE GUANYLYLTRANSFERASE from Salmonella typhimurium FT (181 aa), FASTA scores: opt: 308, E(): 1.1e-14, (38.7% FT identity in 181 aa overlap); FT P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional FT cobalamin biosynthesis protein cobU from Escherichia coli FT strains K12 and O157:H7 (181 aa); part of FT AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa), FT FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in FT 176 aa overlap); etc. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop)." FT /product="PROBABLE BIFUNCTIONAL COBALAMIN BIOSYNTHESIS FT PROTEIN COBU: COBINAMIDE KINASE + COBINAMIDE PHOSPHATE FT GUANYLYLTRANSFERASE" FT misc_feature complement(306308..306331) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(306374..307858) FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS" FT /gene="cobQ1" FT /locus_tag="Rv0255c" FT /note="Rv0255c, (MTV034.21c), len: 494 aa. Probable cobQ1, FT cobyric acid synthase, similar to many e.g. FT Z46611|RCBLUGNS_8 COBYRIC ACID SYNTHASE from R.capsulatus FT (483 aa), FASTA scores: opt: 1239, E(): 0, (47.1% identity FT in 493 aa overlap); P29932|COBQ_PSEDE COBYRIC ACID FT SYNTHASE from Pseudomonas denitrificans (484 aa), FASTA FT scores: opt: 1168, E():0, (44.9% identity in 490 aa FT overlap); etc. TBparse score is 0.893. BELONGS TO THE FT COBB/COBQ FAMILY, COBQ SUBFAMILY. Note that previously FT known as cobQ." FT /product="PROBABLE COBYRIC ACID SYNTHASE COBQ1" FT /standard_name="cobQ" FT CDS complement(307877..309547) FT /evidence=experimental FT /function="UNKNOWN" FT /gene="PPE2" FT /locus_tag="Rv0256c" FT /note="Rv0256c, (MTV034.22c), len: 556 aa. Member of the FT M. tuberculosis PPE family, similar to many e.g. Rv0280, FT Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from FT Mycobacterium leprae (572 aa), FASTA scores: opt: 1837, FT E(): 0, (62.9% identity in 461 aa overlap)." FT /product="PPE FAMILY PROTEIN" FT CDS 309699..310073 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0257" FT /note="Rv0257, len: 124 aa. Hypothetical protein, FT orthologue of ML1828A conserved hypothetical protein from FT Mycobacterium leprae. Replaced Rv0257c (older FT annotation)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(310294..310749) FT /function="UNKNOWN" FT /locus_tag="Rv0258c" FT /note="Rv0258c, (MTCY06A4.02c), len: 151 aa (alternative FT start possible). Conserved hypothetical protein, showing FT some similarity to Rv1685c|MTCI125_6 from Mycobacterium FT tuberculosis (207 aa), FASTA scores: E(): 9.3e-07, (32.1% FT identity in 140 aa overlap). Also some similarity with FT AL049819|SCE7_13|T36295 probable transcription regulator FT from Streptomyces coelicolor (204 aa), FASTA scores: opt: FT 158, E(): 0.00052, (27.0% identity in 111 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(310774..311517) FT /function="UNKNOWN" FT /locus_tag="Rv0259c" FT /note="Rv0259c, (MTCY06A4.03c), len: 247 aa. Conserved FT hypothetical protein, showing some similarity to FT Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis FT (281 aa), FASTA scores: E(): 9.5e-16, (33.6 % identity in FT 235 aa overlap). Also some similarity with FT CAC33938.1|AL589708 putative secreted protein from FT Streptomyces coelicolor (248 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(311514..312659) FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0260c" FT /note="Rv0260c, (MTCY0A4.04c), len: 381 aa. Possible FT two-component response regulator, highly similar to FT CAB72204.1|AL138851 putative transcriptional regulator FT from Streptomyces coelicolor (395 aa); and similar to FT O34394|D69851|YJJA conserved hypothetical protein from FT Bacillus subtilis (270 aa), FASTA scores: opt: 312, E(): FT 7.4e-14, (25.8% identity in 267 aa overlap). Also some FT similarity to regulatory proteins at C-terminal region FT e.g. CUTR_STRLI|Q03756 transcriptional regulatory protein FT (217 aa), FASTA scores: opt: 138, E(): 0.02, (30.6% FT identity in 111 aa overlap)." FT /product="POSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS complement(312759..314168) FT /function="INVOLVED IN EXCRETION OF NITRITE PRODUCED BY FT THE DISSIMILATORY REDUCTION OF NITRATE. RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /gene="narK3" FT /locus_tag="Rv0261c" FT /note="Rv0261c, (MTCY06A4.05c), len: 469 aa. Probable FT nirK3, nitrite extrusion protein, integral membrane FT protein possibly member of major facilitator superfamily FT (MFS), equivalent to AAB41700.1|U72744 nitrite extrusion FT protein from Mycobacterium fortuitum (471 aa); and FT 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein FT homolog from Mycobacterium leprae (517 aa; longer in FT N-terminus). Also similar to other nitrite extrusion FT proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion FT protein 1 from Escherichia coli strain K12 (463 aa), FASTA FT scores: opt: 755, E(): 0, (35.0% identity in 466 aa FT overlap). BELONGS TO THE NARK/NASA FAMILY OF FT TRANSPORTERS." FT /product="PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION FT PROTEIN NARK3 (NITRITE FACILITATOR)" FT CDS complement(314309..314854) FT /EC_number="2.3.1.-" FT /evidence=experimental FT /function="CONFERS RESISTANCE TO AMINOGLYCOSIDES FT (GENTAMICIN, TOBRAMYCIN, DIBEKACIN, NETILMICIN, AND FT 6'-N-ETHYLNETILMICIN)." FT /gene="aac" FT /locus_tag="Rv0262c" FT /note="Rv0262c, (MTCY06A4.06c), len: 181 aa. aac, FT aminoglycoside 2'-N-acetyltransferase (aac(2')-IC) (EC FT 2.3.1.-) (see citation below), highly similar to FT NP_302635.1|NC_002677 aminoglycoside FT 2'-N-acetyltransferase from Mycobacterium leprae (182 aa); FT Q49157|AAC2_MYCFO|AAC aminoglycoside FT 2'-N-acetyltransferase from Mycobacterium fortuitum (195 FT aa), FASTA scores: opt: 884, E(): 0, (69.1% identity in FT 181 aa overlap); and P94968|AAC2_MYCSM|AAC aminoglycoside FT 2'-N-acetyltransferase from Mycobacterium smegmatis (210 FT aa) (see also citation below). Also similar to FT Q52424|AAC2_PROST AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE FT from Providencia stuartii (178 aa). BELONGS TO THE FT AAC(2')-I FAMILY OF ACETYLTRANSFERASES. Note that FT previously known as aac(2')-IC." FT /product="AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE AAC FT (AAC(2')-IC)" FT /standard_name="aac(2')-IC" FT CDS complement(314864..315766) FT /function="UNKNOWN" FT /locus_tag="Rv0263c" FT /note="Rv0263c, (MTCY06A4.07c), len: 300 aa. Conserved FT hypothetical protein, equivalent to NP_302634.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (305 aa). Also similar to others e.g. AL121596|SC51A_21 FT hypothetical protein from Streptomyces coelicolor (285 FT aa), FASTA scores: opt: 714, E(): 0, (45.3% identity in FT 289 aa overlap); NP_233164.1|NC_002506 conserved FT hypothetical protein from Vibrio cholerae (309 aa); FT NP_406216.1|NC_003143 conserved hypothetical protein from FT Yersinia pestis (316 aa); YH30_HAEIN|P44298|hi1730 FT hypothetical protein from Haemophilus influenzae (309 aa), FT FASTA scores: opt: 430, E(): 3e-20, (29.6% identity in 284 FT aa overlap); etc. Also similar to carboxylases eg FT NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative FT carboxylase from Escherichia coli strain K12 (310 aa), FT FASTA score: (34.6% identity in 286 aa overlap); FT NP_459698.1|NC_003197 putative carboxylase from Salmonella FT typhimurium (310 aa); and to middle part of FT NP_420636.1|NC_002696 urea amidolyase-related protein from FT Caulobacter crescentus (1207 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(315783..316415) FT /function="UNKNOWN" FT /locus_tag="Rv0264c" FT /note="Rv0264c, (MTCY06A4.08c), len: 320 aa. Conserved FT hypothetical protein, equivalent to CAC32080.1|AL583926 FT conserved hypothetical protein from Mycobacterium leprae FT (222 aa). Also similar to others hypothetical proteins FT e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252 FT aa), FASTA scores: opt: 420, E(): 2.7e-20, (41.7% identity FT in 204 aa overlap); P75744|YBGJ_ECOLI HYPOTHETICAL 23.9 KD FT PROTEIN from Escherichia coli (218 aa), FASTA scores: E(): FT 2.1e-14, (35.7% identity in 182 aa overlap); FT YH31_HAEIN|P44299|hi173 hypothetical protein from FT Haemophilus influenzae (213 aa), FASTA scores: opt: 252, FT E(): 8.3e-10, (31.1% identity in 183 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(316511..317503) FT /function="THOUGHT TO BE INVOLVED IN IRON TRANSPORT ACROSS FT THE MEMBRANE (IMPORT)." FT /locus_tag="Rv0265c" FT /note="Rv0265c, (MTCY06A4.09c), len: 330 aa. Probable FT iron-transport lipoprotein, most similar to FT T36412|5763945|CAB53324.1|AL109974 probable FT iron-siderophore binding lipoprotein from Streptomyces FT coelicolor (350 aa); and (N-terminus may be incorrect) to FT T14166|3560508|AAC82551.1|AF027770 fxuD protein from FT Mycobacterium smegmatis (420 aa), FASTA scores: opt: 385, FT E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also FT similar to AAB97475.1|U02617 DtxR/iron regulated FT lipoprotein precursor from Corynebacterium diphtheriae FT (355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding FT periplasmic protein (300 aa), FASTA scores: opt: 191, E(): FT 2.3e-05, (26.5% identity in 196 aa overlap). Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site. Note that previously known as fecB2." FT /product="PROBABLE PERIPLASMIC IRON-TRANSPORT LIPOPROTEIN" FT /standard_name="fecB2" FT misc_feature complement(317426..317458) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(317525..321154) FT /EC_number="3.5.2.9" FT /function="CATALYZES THE CLEAVAGE OF 5-OXO-L-PROLINE TO FT FORM L-GLUTAMATE COUPLED TO THE HYDROLYSIS OF ATP TO ADP FT AND INORGANIC PHOSPHATE [CATALYTIC ACTIVITY: ATP + FT 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate]." FT /gene="oplA" FT /locus_tag="Rv0266c" FT /note="Rv0266c, (MTCY06A4.10c), len: 1209 aa. Probable FT oplA, 5-oxoprolinase (EC 3.5.2.9), highly similar to FT others or to hypothetical proteins e.g. FT AAK24340.1|AE005906 hydantoinase/oxoprolinase from FT Caulobacter crescentus (1196 aa); FT NP_103129.1|14022305|BAB48915.1|AP002997 5-oxoprolinase FT from Mesorhizobium loti (1210 aa); CAC48426.1|AL603642 FT CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti FT (1205 aa); S77037|slr0697|1006579|BAA10729.1|D6400 FT HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC FT 6803 (1252 aa), FASTA scores: opt: 2016, E(): 0, (51.4% FT identity in 1247 aa overlap); FT P97608|OPLA_RAT|T42756|11278797 5-OXOPROLINASE FT (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) from Rattus FT norvegicus (1288 aa); etc. BELONGS TO THE OXOPROLINASE FT FAMILY." FT /product="PROBABLE 5-OXOPROLINASE OPLA (5-OXO-L-PROLINASE) FT (PYROGLUTAMASE) (5-OPASE)" FT CDS 321331..322722 FT /function="INVOLVED IN EXCRETION OF NITRITE PRODUCED BY FT THE DISSIMILATORY REDUCTION OF NITRATE. RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /gene="narU" FT /locus_tag="Rv0267" FT /note="Rv0267, (MTCY06A4.11), len: 463 aa. Probable narU, FT nitrite extrusion protein, integral membrane protein FT possibly member of major facilitator superfamily (MFS), FT similar to other nitrite extrusion proteins e.g. FT NARU_ECOLI|P37758 nitrite extrusion protein 2 from FT Escherichia coli (462 aa), FASTA scores: opt: 630, E(): FT 4.4e-33, (38.9% identity in 463 aa overlap); and FT NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from FT Escherichia coli strain K12 (463 aa), FASTA scores: opt: FT 607, E(): 1.3e-31, (42.0% identity in 457 aa overlap). FT Also similar to Rv0261c, Rv2329c, Rv1737c, and to FT MLCB22_25 from Mycobacterium leprae (517 aa), FASTA score: FT (35.1 identity in 459 aa overlap). BELONGS TO THE FT NARK/NASA FAMILY OF TRANSPORTERS." FT /product="PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION FT PROTEIN NARU (NITRITE FACILITATOR)" FT CDS complement(322764..323273) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0268c" FT /note="Rv0268c, (MTCY06A4.12c), len: 169 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(323338..324531) FT /function="UNKNOWN" FT /locus_tag="Rv0269c" FT /note="Rv0269c, (MTCY06A4.13c), len: 397 aa. Conserved FT hypothetical protein, highly similar to AL079355|SC4C6_19 FT hypothetical protein from Streptomyces coelicolor (341 FT aa), FASTA scores: opt: 1019, E(): 0, (46.5% identity in FT 344 aa overlap), and similar to other proteins e.g. FT CAC49016.1|AL603644 putative ATP-dependent DNA ligase FT protein from Sinorhizobium meliloti (636 aa); O34398 YKOU FT PROTEIN from Bacillus subtilis (611 aa), FASTA score: FT (27.2% identity in 283 aa overlap). Also similar to FT proteins from Mycobacterium tuberculosis e.g. Rv3062, FT Rv3731 (both DNA ligases), and Rv0938, Rv3730c." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 324567..326249 FT /EC_number="6.2.1.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD2" FT /locus_tag="Rv0270" FT /note="Rv0270, (MTCY06A4.14), len: 560 aa. Probable fadD2, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase FT from Escherichia coli (561 aa), FASTA scores: opt: 544, FT E(): 2.9e-26, (27.7% identity in 535 aa overlap). Also FT similar to others from Mycobacterium tuberculosis e.g. FT MTCY493_2, MTCY8D5_9, MTCY6G11_8, etc. Contains PS00455 FT Putative AMP-binding domain signature." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD2 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature 325236..325271 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(326266..328461) FT /EC_number="1.3.99.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE6" FT /locus_tag="Rv0271c" FT /note="Rv0271c, (MTCY06A4.15c), len: 731 aa. Probable FT fadE6, acyl-CoA dehydrogenase (EC 1.3.99.-), with FT C-terminal half similar to many e.g. ACDS_HUMAN|P16219 FT acyl-CoA dehydrogenase (short-chain) from Homo sapiens FT (412 aa), FASTA scores: opt: 339, E(): 1.3e-13, (28.1% FT identity in 288 aa overlap)." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE6" FT CDS complement(328575..329708) FT /function="UNKNOWN" FT /locus_tag="Rv0272c" FT /note="Rv0272c, (MTCY06A4.16c), len: 377 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(329705..330325) FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0273c" FT /note="Rv0273c, (MTV035.01c), len: 206 aa (start FT uncertain). Possible transcriptional regulator, showing FT some similarity to hypothetical regulators from FT Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c FT (216 aa); O08377|Rv1534|MTCY07A7A.03 (225 aa), FASTA FT scores: opt: 123, E(): 3.2e-06, (28.5% identity in 172 aa FT overlap). TBparse score is 0.945." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 330422..331003 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0274" FT /note="Rv0274, (MTV035.02), len: 193 aa. Conserved FT hypothetical protein, highly similar to FT AAK25058.1|AE005973 conserved hypothetical protein from FT Caulobacter crescentus (174 aa). Shows also some FT similarity to others hypothetical proteins e.g. FT AJ002571|BSAJ2571_7 from Bacillus subtilis (316 aa), FASTA FT scores: opt: 138, E(): 0.033, (27.1% identity in 133 aa FT overlap). Previous hits with Q56415|M85195 FT FOSFOMYCIN-RESISTANCE PROTEIN from SERRATIA MARCESCENS FT (141 aa), FASTA scores: opt: 82, E(): 1.1e -08, (29.1% FT identity in 151 aa overlap). Contains PS00082 Extradiol FT ring-cleavage dioxygenases signature near C-terminus. FT TBparse score is 0.914." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature 330842..330907 FT /note="PS00082 Extradiol ring-cleavage dioxygenases FT signature" FT CDS complement(330933..331658) FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0275c" FT /note="Rv0275c, (MTV035.03c), len: 241 aa. Possible FT transcriptional regulator, tetR family, similar to others FT e.g. Q9RJE7|SCF81.04c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Streptomyces coelicolor (219 aa); FT Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Streptomyces coelicolor (213 aa); FT Q9I2Q9|PA1836 PROBABLE TRANSCRIPTIONAL REGULATOR from FT Pseudomonas aeruginosa (193 aa); etc. Also shows some FT similarity with Rv0825c from Mycobacterium tuberculosis FT (213 aa), FASTA scores: opt: 230, E(): 2.7e-07, (32.6% FT identity in 190 aa overlap). SEEMS TO BELONG TO THE FT TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS (M. FT tuberculosis regulatory protein family with many TetR FT orthologues)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT CDS 331748..332668 FT /function="UNKNOWN" FT /locus_tag="Rv0276" FT /note="Rv0276, (MTV035.04), len: 306 aa. Conserved FT hypothetical protein, similar to Rv2237|Z70692|MTCY427.18 FT from Mycobacterium tuberculosis (296 aa), FASTA scores: FT opt: 874, E(): 0, (49.6% identity in 282 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(332708..333136) FT /function="UNKNOWN" FT /locus_tag="Rv0277c" FT /note="Rv0277c, (MTV035.05c), len: 152 aa. Conserved FT hypothetical protein, highly similar to FT Rv0749|H70824|2911023|CAA17516.1|AL021958 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (142 FT aa); and similar to several other hypothetical FT Mycobacterium tuberculosis proteins: Rv0277c, Rv2530c, FT etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(333437..336310) FT /function="UNKNOWN" FT /gene="PE_PGRS3" FT /locus_tag="Rv0278c" FT /note="Rv0278c, (MTV035.06c), len: 957 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT PGRS subfamily of gly-rich proteins, similar to many e.g. FT Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis FT (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity FT in 903 aa overlap). Contains PS00583 pfkB family of FT carbohydrate kinases signature 1." FT /product="PE-PGRS FAMILY PROTEIN" FT misc_feature complement(334136..334207) FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1" FT CDS complement(336560..339073) FT /function="UNKNOWN" FT /gene="PE_PGRS4" FT /locus_tag="Rv0279c" FT /note="Rv0279c, (MTV035.07c), len: 837 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to many FT e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium FT tuberculosis (914 aa), FASTA scores: opt: 2677, E(): 0, FT (64.5% identity in 926 aa overlap)." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 339364..340974 FT /function="UNKNOWN" FT /gene="PPE3" FT /locus_tag="Rv0280" FT /note="Rv0280, (MTV035.08), len: 536 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to others FT e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium FT tuberculosis (539 aa), FASTA scores: opt: 1131, E(): 0, FT (51.7% identity in 540 aa overlap)." FT /product="PPE FAMILY PROTEIN" FT CDS 340998..341906 FT /function="UNKNOWN" FT /locus_tag="Rv0281" FT /note="Rv0281, (MTV035.09), len: 302 aa. Conserved FT hypothetical protein; member of Mycobacterium tuberculosis FT protein family that includes Rv0726c, Rv0731c, Rv3399, FT Rv1729c, etc. MTCY31_23 (325 aa), FASTA scores: opt: 1386, FT E(): 0, (69. 1% identity in 301 aa overlap). Contains FT possible N-terminal signal sequence." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 342130..344025 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0282" FT /note="Rv0282, (MTV035.10), len: 631 aa. Conserved FT hypothetical protein, similar to Y14967|MLCB628.18c FT hypothetical protein from Mycobacterium leprae (573 aa), FT FASTA scores: opt: 916, E(): 0, (38.7% identity in 568 aa FT overlap). Also similar to Mycobacterium tuberculosis FT proteins e.g. Z94121|MTY15F10.26 (619 aa), FASTA scores: FT opt: 743, E(): 0, (29.9% identity in 612 aa overlap). FT Member of CFXQ, CBXP family - 9 members in Mycobacterium FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature 343282..343305 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 344022..345638 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0283" FT /note="Rv0283, (MTV035.11), len: 538 aa. Possible FT conserved membrane protein, similar to several FT hypothetical mycobacterial proteins e.g. FT Z94121|MTY15F10_16|Rv3895c from Mycobacterium FT tuberculosis (495 aa), FASTA scores: opt: 698, E(): 0, FT (37.6% identity in 492 aa overlap); Rv1782; Rv3450c; FT Rv3869; and Y14967|MLCB628_16|MLCB628.17c from FT Mycobacterium leprae (481 aa), FASTA scores: opt: 672, FT E(): 1.5e-31, (37.2% identity in 506 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT misc_feature 344931..344954 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 345635..349627 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0284" FT /note="Rv0284, (MTV035.12), len: 1330 aa. Possible FT conserved membrane protein, similar to products of two FT adjacent Mycobacterium leprae genes, MLCB628.16c (744 aa) FT and MLCB628.15c (597 aa); and throughout its length to FT several large Mycobacterium tuberculosis proteins: FT Rv3447c, Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FT FASTA scores: opt: 942, E(): 0, (33.8% identity in 730 aa FT overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt: FT 613, E(): 3.1e-30, (31.7% identity in 615 aa overlap); FT Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, FT E(): 2.2e-32, (35.4% identity in 1321 aa overlap); FT Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): FT 2.2e-32, (35.4% identity in 1321 aa overlap). Contains FT three PS00017 ATP/GTP-binding site motif A (P-loop)." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT misc_feature 347069..347092 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 348119..348142 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 348953..348976 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 349624..349932 FT /evidence=experimental FT /function="UNKNOWN" FT /gene="PE5" FT /locus_tag="Rv0285" FT /note="Rv0285, (MTV035.13), len: 102 aa. Member of the FT Mycobacterium tuberculosis PE family (see Brennan & Delogu FT 2002), similar to others e.g. AL0212|MTV012_37 from FT Mycobacterium tuberculosis (105 aa), FASTA scores: opt: FT 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); FT Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 FT aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity FT in 102 aa overlap); etc." FT /product="PE FAMILY PROTEIN" FT CDS 349935..351476 FT /evidence=experimental FT /function="UNKNOWN" FT /gene="PPE4" FT /locus_tag="Rv0286" FT /note="Rv0286, (MTV035.14), len: 513 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to others FT e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 FT aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in FT 522 aa overlap)." FT /product="PPE FAMILY PROTEIN" FT CDS 351525..351818 FT /evidence=experimental FT /function="UNKNOWN" FT /gene="esxG" FT /locus_tag="Rv0287" FT /note="Rv0287, (MTV035.15), len: 97 aa. esxG, ESAT-6 like FT protein. PE-family related protein; distant member of the FT Mycobacterium tuberculosis PE family, similar to FT Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: 564, FT E(): 0, (91.8% identity in 97 aa overlap). Contains FT probable helix-turn-helix motif at aa 14-35 (Score 144, FT +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see Gey FT Van Pittius et al., 2001). Note that previously known as FT TB9.8." FT /product="ESAT-6 LIKE PROTEIN ESXG (CONSERVED HYPOTHETICAL FT PROTEIN TB9.8)" FT /standard_name="TB9.8" FT CDS 351848..352138 FT /db_xref="O53693" FT /evidence=experimental FT /function="UNKNOWN. MAY BE INVOLVED IN VIRULENCE." FT /gene="esxH" FT /locus_tag="Rv0288" FT /note="Rv0288, (MT0301, MTV035.16), len: 96 aa. esxH, low FT molecular weight protein antigen 7 (10 kDa antigen) FT (CFP-7) (Protein TB10.4) (see citations below), ala-rich FT protein; member of mycobacterial protein family containing FT ESAT-6, very similar to MTV012_33 from Mycobacterium FT tuberculosis (96 aa), FASTA scores: opt: 566, E(): 0, FT (84.4% identity in 96 aa overlap). Alternative start codon FT possible position 351878 (see Rosenkrands et al., 2000). FT BELONG TO THE ESAT6 FAMILY (see Skjot et al., 2000; 2002; FT Gey Van Pittius et al., 2001). Note that previously known FT as cfp7 (alternate gene name: TB10.4)." FT /product="LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7 ESXH (10 FT kDa ANTIGEN) (CFP-7) (PROTEIN TB10.4)" FT /standard_name="cfp7, TB10.4" FT CDS 352149..353036 FT /function="UNKNOWN" FT /locus_tag="Rv0289" FT /note="Rv0289, (MTV035.17), len: 295 aa. Conserved FT hypothetical protein, equivalent to CAC32061.1|AL583926 FT possible DNA-binding protein from Mycobacterium leprae FT (289 aa); and showing some similarity to FT Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from FT Mycobacterium tuberculosis (276 aa), FASTA scores: opt: FT 149, E(): 0.0035, (27.7% identity in 289 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 353083..354501 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0290" FT /note="Rv0290, (MTV035.18), len: 472 aa. Probable FT conserved transmembrane protein, similar to several others FT in mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from FT Mycobacterium tuberculosis (467 aa), FASTA scores: opt: FT 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); FT Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c FT from Mycobacterium leprae (480 aa), FASTA scores: opt: FT 269, E(): 3.1e-09, (26.0% identity in 503 aa overlap). FT TBparse score is 0.892." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 354498..355883 FT /EC_number="3.4.21.-" FT /evidence=experimental FT /function="THOUGHT TO HAVE PROTEOLYTIC ACTIVITY." FT /gene="mycP3" FT /locus_tag="Rv0291" FT /note="Rv0291, (MTV035.19), len: 461 aa. Probable mycP3, FT membrane-anchored serine protease (mycosin) (EC 3.4.21.-) FT (see Brown et al., 2000), similar to several others in FT mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from FT Mycobacterium tuberculosis (446 aa), FASTA scores: opt: FT 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; FT Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from FT Mycobacterium leprae (446 aa), FASTA scores: opt: 1159, FT E(): 0, (43.5 identity in 446 aa overlap). Has signal FT sequence and hydrophobic stretch at C-terminus, followed FT by short positively charged segment, that seems to act as FT a membrane anchor. Contains PS00137 Serine proteases, FT subtilase family, histidine active site signature. BELONGS FT TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FT FAMILY), PYROLYSIN SUBFAMILY." FT /product="PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE FT PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) FT (MYCOSIN-3)" FT misc_feature 354873..354905 FT /note="PS00137 Serine proteases, subtilase family, FT histidin e active site" FT CDS 355880..356875 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0292" FT /note="Rv0292, (MTV035.20), len: 331 aa. Probable FT conserved transmembrane protein (has two hydrophobic FT segments at N-terminal end), equivalent to FT CAC32058.1|AL583926 conserved membrane protein from FT Mycobacterium leprae (339 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(356862..358064) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0293c" FT /note="Rv0293c, (MTV035.21c), len: 400 aa. Conserved FT hypothetical protein, similar in C-terminal part to FT Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 FT aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity FT in 299 aa overlap). TBparse score is 0.922." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 358171..358956 FT /EC_number="2.1.1.-" FT /function="POSSIBLY CATALYZES THE S-ADENOSYLMETHIONINE FT MONOMETHYL ESTERIFICATION OF TRANS-ACONITATE AT HIGH FT AFFINITY AND OF CIS-ACONITATE, ISOCITRATE, AND CITRATE AT FT LOWER VELOCITIES AND AFFINITIES." FT /gene="tam" FT /locus_tag="Rv0294" FT /note="Rv0294, (MTV035.22), len: 261 aa. Probable tam, FT trans-aconitate methyltransferase (EC 2.1.1.-), similar to FT others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 FT TRANS-ACONITATE METHYLTRANSFERASE from Escherichia coli FT strain K12 (252 aa), FASTA scores: opt: 649, E(): 0, (39.3 FT identity in 252 aa overlap). BELONGS TO THE FT METHYLTRANSFERASE SUPERFAMILY." FT /product="PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM" FT CDS complement(358945..359748) FT /function="UNKNOWN" FT /locus_tag="Rv0295c" FT /note="Rv0295c, (MTV035.23c), len: 267 aa. Conserved FT hypothetical protein, showing weak similarity with FT CAC46877.1|AL591790 CONSERVED HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (213 aa); and FT NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak FT similarity to NodH from Mesorhizobium loti (257 aa). FT TBparse score is 0.915." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(359758..361155) FT /EC_number="3.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0296c" FT /note="Rv0296c, (MTCY63.01c, MTV035.24c), len: 465 aa. FT Probable sulfatase, possibly an aryl-/steryl-sulfatase (EC FT 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) FT (EC 3.10.1.-). Similar to various hydrolases e.g. FT AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from FT Mus musculus (502 aa); FT NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 FT N-sulfoglucosamine sulfohydrolase (sulfamidase) FT (sulphamidase) from Mus musculus (502 aa); FT AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase FT from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 FT STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID FT SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE FT C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727 FT arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA FT scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa FT overlap). Also similarity with 4 others sulfatases in FT Mycobacterium tuberculosis. Contains sulfatases signature FT 1 (PS00523). Note that previously known as atsG." FT /product="PROBABLE SULFATASE" FT /standard_name="atsG" FT misc_feature complement(360952..360990) FT /note="PS00523 Sulfatases signature 1" FT CDS 361334..363109 FT /function="UNKNOWN" FT /gene="PE_PGRS5" FT /locus_tag="Rv0297" FT /note="Rv0297, (MTCY63.02), len: 591 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT others e.g. Y03A_MYCTU|Q10637 from Mycobacterium FT tuberculosis (603 aa), FASTA scores: opt: 1884, E(): 0, FT (53.7% identity in 635 aa overlap). TBparse score is FT 0.850." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 363252..363479 FT /function="UNKNOWN" FT /locus_tag="Rv0298" FT /note="Rv0298, (MTCY63.03), len: 75 aa. Hypothetical FT unknown protein. TBparse score is 0.891." FT /product="HYPOTHETICAL PROTEIN" FT CDS 363476..363778 FT /function="UNKNOWN" FT /locus_tag="Rv0299" FT /note="Rv0299, (MTCY63.04), len: 100 aa. Hypothetical FT unknown protein. Equivalent to AAK44536.1 from FT Mycobacterium tuberculosis strain CDC1551 (49 aa) but FT longer 51 aa." FT /product="HYPOTHETICAL PROTEIN" FT CDS 363826..364047 FT /function="UNKNOWN" FT /locus_tag="Rv0300" FT /note="Rv0300, (MTCY63.05), len: 73 aa. Conserved FT hypothetical protein, similar to FT Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 FT aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in FT 38 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 364044..364469 FT /function="UNKNOWN" FT /locus_tag="Rv0301" FT /note="Rv0301, (MTCY63.06), len: 141 aa. Conserved FT hypothetical protein, similar to other hypothetical FT Mycobacterium tuberculosis proteins e.g. Rv2757c, Rv0229c, FT Rv2546, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 364605..365237 FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0302" FT /note="Rv0302, (MTCY63.07), len: 210 aa. Probable FT transcription regulatory protein, TetR family (see FT citation below), with its N-terminus similar to N-terminus FT of several repressors and regulatory proteins of TetR/AcrR FT family e.g. ACRR_ECOLI|P34000 potential acraB operon FT repressor from Escherichia coli (215 aa), FASTA scores: FT opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa FT overlap). Also similar in N-terminus to N-terminus of FT MTCY07A7.24 hypothetical regulator from Mycobacterium FT tuberculosis FASTA score: (38.7% identity in 62 aa FT overlap). Contains probable helix-turn helix motif from aa FT 35-56 (Score 1728, +5.07 SD). TBparse score is 0.896." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR/ACRR-FAMILY)" FT CDS 365234..366142 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0303" FT /note="Rv0303, (MTCY63.08), len: 302 aa. Possible FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT NADPH dehydrogenases and other NADPH oxidoreductases e.g. FT O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE FT REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) FT (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from FT Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE FT (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): FT 3.8e-16, (35.4% identity in 319 aa overlap). TBparse score FT is 0.905." FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT CDS complement(366150..372764) FT /function="UNKNOWN" FT /gene="PPE5" FT /locus_tag="Rv0304c" FT /note="Rv0304c, (MTCY63.9c), len: 2204 aa. Member of the FT Mycobacterium tuberculosis PE family (PPE, MPTR), similar FT to others e.g. Z95324|MTY13E10_16 from Mycobacterium FT tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% FT identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from FT Mycobacterium tuberculosis (734 aa), FASTA scores: opt: FT 989, E(): 0, (42.3% identity in 522 aa overlap)." FT /product="PPE FAMILY PROTEIN" FT CDS complement(372820..375711) FT /function="UNKNOWN" FT /gene="PPE6" FT /locus_tag="Rv0305c" FT /note="Rv0305c, (MTCY63.10c), len: 963 aa. Member of the FT Mycobacterium tuberculosis PE family (PPE, MPTR), similar FT to others e.g. Y04H_MYCTU|Q10778 from Mycobacterium FT tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0, FT (40.9% identity in 815 aa overlap)." FT /product="PPE FAMILY PROTEIN" FT CDS 375914..376585 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0306" FT /note="Rv0306, (MTCY63.11), len: 223 aa. Putative FT oxidoreductase (EC 1.-.-.-), highly similar to FT H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved FT hypothetical protein from Pseudomonas aeruginosa strain FT PAO1 (218 aa); and to other putative oxidoreductases e.g. FT middle part of CAB76073.1|AL157953 putative nitroreductase FT from Streptomyces coelicolor (1212 aa); Q52685|BLUB FT protein involved in cobalamin (vitamin B12) synthesis from FT Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318, FT E(): 2e-15, (35.6% identity in 191 aa overlap). TBparse FT score is 0.900." FT /product="PUTATIVE OXIDOREDUCTASE" FT CDS complement(376573..377055) FT /function="UNKNOWN" FT /locus_tag="Rv0307c" FT /note="Rv0307c, (MTCY63.12c), len: 160 aa. Hypothetical FT unknown protein. TBparse score is 0.901." FT /product="HYPOTHETICAL PROTEIN" FT CDS 377113..377829 FT /function="UNKNOWN" FT /locus_tag="Rv0308" FT /note="Rv0308, (MTCY63.13), len: 238 aa. Probable FT conserved integral membrane protein, with C-terminus FT highly similar to C-terminus of other integral membrane FT proteins or phosphatases e.g. FT AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 FT putative phosphatase from Streptococcus pyogenes (201 aa); FT Q06074 HYPOTHETICAL 24.9 kDa PROTEIN (216 aa), FASTA FT scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa FT overlap). Could be a phosphatase. TBparse score is 0.961." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 377931..378587 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0309" FT /note="Rv0309, (MTCY63.14), len: 218 aa. Possible FT conserved exported protein (has putative N-terminal signal FT sequence), equivalent to AC32053.1|AL583926 putative FT secreted protein from Mycobacterium leprae (218 aa). Also FT similar to others e.g. AB76092.1|AL157956 putative FT secreted protein from Streptomyces coelicolor (238 aa)." FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT CDS complement(378657..379148) FT /function="UNKNOWN" FT /locus_tag="Rv0310c" FT /note="Rv0310c, (MTCY63.15c), len: 163 aa. Conserved FT hypothetical protein, similar to some bile acid FT dehydratases e.g. FT P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 FT BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp FT (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% FT identity in 134 aa overlap); AAF22847.1|AF210152_4 bile FT acid 7a-dehydratase from Clostridium sp. (168 aa). TBparse FT score is 0.863." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 379172..380401 FT /function="UNKNOWN" FT /locus_tag="Rv0311" FT /note="Rv0311, (MTCY63.16), len: 409 aa. Hypothetical FT unknown protein. Contains PS00881 Protein splicing FT signature. TBparse score is 0.903." FT /product="HYPOTHETICAL PROTEIN" FT misc_feature 380132..380149 FT /note="PS00881 Protein splicing signature" FT CDS 380556..382418 FT /function="UNKNOWN" FT /locus_tag="Rv0312" FT /note="Rv0312, (MTCY63.17), len: 620 aa. Conserved FT hypothetical protein with highly Pro-, Thr-rich FT C-terminus. Similar to Pro-,Thr-rich region in FT Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis FT (592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity FT in 627 aa overlap). Also some similarity with Rv0350|dnaK FT from Mycobacterium tuberculosis. Possibly membrane FT protein; has hydrophobic stetch in its middle part." FT /product="CONSERVED HYPOTHETICAL PROLINE AND THREONINE FT RICH PROTEIN" FT CDS 382490..382876 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0313" FT /note="Rv0313, (MTCY63.18), len: 128 aa. Conserved FT hypothetical protein, equivalent only to FT CAC32049.1|AL583926 conserved hypothetical protein from FT Mycobacterium leprae (130 aa). TBparse score is 0.877." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(382879..383541) FT /function="UNKNOWN" FT /locus_tag="Rv0314c" FT /note="Rv0314c, (MTCY63.19c), len: 220 aa. Possible FT conserved membrane protein, with hydrophobic stretch from FT residues ~75-100. Similar in C-terminal part to FT Mycobacterium tuberculosis proteins Rv0679c and Rv0680c." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT CDS 383602..384486 FT /EC_number="3.2.1.-" FT /function="POSSIBLY HYDROLYZES SPECIFIC SUGAR FT (HYDROLYZATION OF GLYCOSIDIC BOND) AND COULD BE INVOLVED FT IN EXOPOLYSACCHARIDE BIOSYNTHESIS/DEGRADATION. COULD ALSO FT HAVE A LYTIC ACTIVITY AGAINST CELL WALLS." FT /locus_tag="Rv0315" FT /note="Rv0315, (MTCY63.20), len: 294 aa. Possible FT beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic FT stretch in its N-terminal part), similar to others e.g. FT Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia FT xanthineolytica (306 aa), FASTA scores: opt: 76, E(): FT 3e-14, (34.1% identity in 302 aa overlap); and FT AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia FT xanthineolytica (435 aa). Contains glycosyl hydrolases FT family 16 active site signature (PS01034). TBparse score FT is 0.908." FT /product="POSSIBLE BETA-1,3-GLUCANASE PRECURSOR" FT misc_feature 384112..384147 FT /note="PS01034 Glycosyl hydrolases family 16 active sites" FT CDS 384535..385149 FT /EC_number="5.3.3.-" FT /function="COULD BE INVOLVED IN THE CATABOLISM OF CATECHOL FT TO SUCCINATE- AND ACETYL-CoA IN THE BETA-KETOADIPATE FT PATHWAY (AT THE THIRD STEP) [CATALYTIC ACTIVITY: FT 2,5-dihydro-5-oxofuran-2-acetate = FT 3,4-dihydro-5-oxofuran-2-acetate]." FT /locus_tag="Rv0316" FT /note="Rv0316, (MTCY63.21), len: 204 aa. Possible FT muconolactone isomerase (EC 5.3.3.-), showing weak FT similarity with some muconolactone isomerases e.g. FT O33947|CTC1_ACILW MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE FT 1)(96 aa), FASTA scores: opt: 179, E(): 3.9e-05, (32.6% FT identity in 92 aa overlap). TBparse score is 0.882." FT /product="POSSIBLE MUCONOLACTONE ISOMERASE" FT CDS complement(385173..385943) FT /EC_number="3.1.4.46" FT /function="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE FT HYDROLYZES DEACYLATED PHOSPHOLIPIDS TO G3P AND THE FT CORRESPONDING ALCOHOLS [CATALYTIC ACTIVITY: A FT GLYCEROPHOSPHODIESTER + H(2)O = AN ALCOHOL + SN-GLYCEROL FT 3-PHOSPHATE]." FT /gene="glpQ2" FT /locus_tag="Rv0317c" FT /note="Rv0317c, (MTCY63.22c), len: 256 aa (start FT uncertain, chosen by homology). Possible glpQ2, FT glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), FT similar to others e.g. FT E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl FT diester phosphodiesterase from Deinococcus radiodurans FT (285 aa); P10908|UGPQ_ECOLI from Escherichia coli (247 FT aa), FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity FT in 250 aa overlap). Also similar to MTCY01A6.27 from FT Mycobacterium tuberculosis FASTA score: (27.5% identity in FT 247 aa overlap). TBparse score is 0.906." FT /product="POSSIBLE GLYCEROPHOSPHORYL DIESTER FT PHOSPHODIESTERASE GLPQ2 (GLYCEROPHOSPHODIESTER FT PHOSPHODIESTERASE)" FT tRNA complement(386204..386274) FT /gene="tRNA-Gly(CCC)" FT /anticodon=(pos:386240..386242,aa:Gly) FT /product="transfer RNA-Gly(CCC)" FT CDS complement(386305..387099) FT /function="UNKNOWN" FT /locus_tag="Rv0318c" FT /note="Rv0318c, (MTCY63.23c), len: 258 aa. Probable FT conserved integral membrane protein, with some similarity FT to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: FT opt: 157, E (): 0.0032, (28.3% identity in 198 aa FT overlap). Also similar to O26573 CONSERVED PROTEIN from FT Methanobacterium thermoauto (259 aa), FASTA scores: opt: FT 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap)." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 387148..387816 FT /EC_number="3.4.19.3" FT /function="REMOVES 5-OXOPROLINE FROM VARIOUS PENULTIMATE FT AMINO ACID RESIDUES EXCEPT L-PROLINE [CATALYTIC ACTIVITY: FT 5-oxoprolyl-peptide + H2O = 5-oxoproline + peptide]." FT /gene="pcp" FT /locus_tag="Rv0319" FT /note="Rv0319, (MTCY63.24), len: 222 aa. Probable pcp, FT pyrrolidone-carboxylate peptidase (EC 3.4.19.3), highly FT similar to others e.g. PCP_PSEFL|P42673 FT pyrrolidone-carboxylate peptidase from Pseudomonas FT fluorescens (213 aa), FASTA scores: opt: 478, E(): FT 7.5e-25, (40.2% identity in 219 aa overlap). BELONGS TO FT PEPTIDASE FAMILY C15 (THIOL PROTEASE). TBparse score is FT 0.902." FT /product="PROBABLE PYRROLIDONE-CARBOXYLATE PEPTIDASE PCP FT (5-OXOPROLYL-PEPTIDASE) (PYROGLUTAMYL-PEPTIDASE I) (PGP-I) FT (PYRASE)" FT CDS 387888..388550 FT /function="UNKNOWN" FT /locus_tag="Rv0320" FT /note="Rv0320, (MTCY63.25), len: 220 aa. Possible FT conserved exported protein, similar to some hypothetical FT proteins and to the middle part of a peptidase: FT NP_066789.1|10657900|AAG21739.1|AF116907 putative FT peptidase from Rhodococcus equi (546 aa). Also similar to FT Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 FT aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity FT in 225 aa overlap). TBparse score is 0.943." FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT CDS 388582..389154 FT /EC_number="3.5.4.13" FT /function="INVOLVED IN INTERCONVERSION OF dCTP AND dUTP FT [CATALYTIC ACTIVITY: dCTP + H2O = dUTP + NH3]." FT /gene="dcd" FT /locus_tag="Rv0321" FT /note="Rv0321, (MTCY63.26), len: 190 aa. Probable dcd FT (alternate gene names: dus or paxA), deoxycytidine FT triphosphate deaminase (EC 3.5.4.13), equivalent to FT CAC32024.1|AL583925 probable deoxycytidine triphosphate FT deaminase from Mycobacterium leprae (190 aa). Also highly FT similar to others e.g. FT Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE FT TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191 FT aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE FT TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12 FT (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1% FT identity in 188 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP FT DEAMINASE FAMILY. TBparse score is 0.907. The FT transcription of this CDS seems to be activated FT specifically in host granulomas (see citation below)." FT /product="PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE FT DCD (DCTP DEAMINASE)" FT /standard_name="dus; paxA" FT misc_feature 388864..388887 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 389260..390591 FT /EC_number="1.1.1.22" FT /function="POSSIBLY INVOLVED IN POLYSACCHARIDE FT BIOSYNTHESIS [CATALYTIC ACTIVITY: UDP-glucose + 2 NAD+ + FT H2O = UDP-glucuronate + 2 NADH]." FT /gene="udgA" FT /locus_tag="Rv0322" FT /note="Rv0322, (MTCY63.27), len: 443 aa. Probable udg FT (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase FT (EC 1.1.1.22), highly similar to others e.g. FT CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase FT from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE FT DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA FT scores: opt: 713, E(): 0, (41.9% identity in 351 aa FT overlap); etc. Also similar to several GDP-mannose FT 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE FT DEHYDROGENASES FAMILY. TBparse score is 0.905." FT /product="PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA FT (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH)" FT /standard_name="rkpK" FT misc_feature 389599..389622 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(390580..391251) FT /function="UNKNOWN" FT /locus_tag="Rv0323c" FT /note="Rv0323c, (MTCY63.28c), len: 223 aa. Conserved FT hypothetical protein, similar to others e.g. FT YPJG_BACSU|P42981 hypothetical 24.8 kDa protein from FT Bacillus subtilis (224 aa), FASTA scores: opt: 182, E(): FT 1.3e-05, (27.5% identity in 211 aa overlap). Also some FT similarity to MLU15183_8 from Mycobacterium tuberculosis FT FASTA score: (32.0% identity in 147 aa overlap). TBparse FT score is 0.932." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 391352..392032 FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0324" FT /note="Rv0324, (MTCY63.29), len: 226 aa. Possible FT transcriptional regulator, arsR family, with its FT N-terminus similar to the N-terminus of other DNA-binding FT proteins e.g. P30346|MERR_STRLI probable mercury FT resistance operon from Streptomyces lividans (125 aa), FT FASTA scores: opt: 154, E(): 0.002, (32.2% identity in 90 FT aa overlap)), and its C-terminal part similar to FT hypothetical bacterial proteins e.g. P54510|YQHL_BACSU FT hypothetical 14.6 kDa protein from Bacillus subtilis (126 FT aa), FASTA scores: opt: 159, E(): 0.00097, (35.5% identity FT in 76 aa overlap)). Most similar to AJ005575|SPE005575_2 FT ORF1 required for antibiotic production from Streptomyces FT peucetius (226 aa), FASTA scores: opt: 816, E(): 0, (60.7% FT identity in 211 aa overlap). Also similar in C-terminus to FT MTCY164.26 molybdopterin biosynthesis moeb protein from FT Mycobacterium tuberculosis FASTA score: (36.8% identity in FT 114 aa overlap)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY ARSR-FAMILY)" FT CDS 392039..392263 FT /function="UNKNOWN" FT /locus_tag="Rv0325" FT /note="Rv0325, (MTCY63.30), len: 74 aa. Hypothetical FT unknown protein. TBparse score is 0.915." FT /product="HYPOTHETICAL PROTEIN" FT CDS 392273..392728 FT /function="UNKNOWN" FT /locus_tag="Rv0326" FT /note="Rv0326, (MTCY63.31), len: 151 aa. Hypothetical FT unknown protein. TBparse score is 0.929." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(392696..394045) FT /EC_number="1.14.-.-" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /gene="cyp135A1" FT /locus_tag="Rv0327c" FT /note="Rv0327c, (MT0342, MTCY63.32c), len: 449 aa. FT Possible cyp135A1, cytochrome P450 (EC 1.14.-.-), similar FT to cytochrome P-450 monoxygenases and other cytochrome FT P-450 related enzymes e.g. FQ12609 PUTATIVE P450 FT MONOOXYGENASE (EC 1.14.14.1) (506 aa), FASTA scores: opt: FT 276, E() : 1.7e-11, (27.9% identity in 433 aa overlap). FT Also similar to other Mycobacterium tuberculosis proteins FT e.g. MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); FT MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in FT 434 aa overlap). Contains cytochrome P450 cysteine FT heme-iron ligand signature (PS00086). BELONGS TO THE FT CYTOCHROME P450 FAMILY. Alternative start possible at FT 33706 but no RBS." FT /product="POSSIBLE CYTOCHROME P450 135A1 CYP135A1" FT misc_feature complement(392891..392920) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT si gnature" FT CDS 394111..394713 FT /function="POSSIBLY INVOLVED IN A TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0328" FT /note="Rv0328, (MTCY63.33), len: 200 aa. Possible FT transcription regulator, tetR/acrR family, similar in part FT to various hypothetical transcriptional regulators e.g. FT T36696|4726006|CAB41735.1|AL049731 probable regulatory FT protein from Streptomyces coelicolor (197 aa). Also some FT similarity with YX44_MYCTU|Q10829 hypothetical FT transcriptional regulator from Mycobacterium tuberculosis FT (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% FT identity in 202 aa overlap). Contains probable helix-turn FT helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO FT BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL FT REGULATORS. TBparse score is 0.910." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR/ACRR-FAMILY)" FT CDS complement(394694..395320) FT /function="UNKNOWN" FT /locus_tag="Rv0329c" FT /note="Rv0329c, (MTCY63.34c), len: 208 aa. Conserved FT hypothetical protein, showing some similarity with others FT hypothetical proteins and methyltransferases e.g. FT MitM|AF127374_14 methyltransferase from Streptomyces FT lavendulae (283 aa), FASTA scores: opt: 242, E(): 1.8e-08, FT (37.2% identity in 145 aa overlap); Q48938 from FT Methanosarcina barkeri (262 aa), FASTA scores: opt: 194, FT E(): 3.6e-06, (31.1% identity in 119 aa overlap). TBparse FT score is 0.923." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(395347..396087) FT /function="UNKNOWN" FT /locus_tag="Rv0330c" FT /note="Rv0330c, (MTCY63.35c), len: 246 aa. Hypothetical FT unknown protein. TBparse score is 0.898." FT /product="HYPOTHETICAL PROTEIN" FT CDS 396201..397367 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0331" FT /note="Rv0331, (MTCY63.36), len: 388 aa. Possible FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases e.g. FT NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein FT reductase from Mesorhizobium loti (377 aa); NP_147681.1 FT predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum FT pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase FT (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% FT identity in 348 aa overlap). TBparse score is 0.906." FT /product="POSSIBLE DEHYDROGENASE/REDUCTASE" FT CDS 397442..398227 FT /function="UNKNOWN" FT /locus_tag="Rv0332" FT /note="Rv0332, (MTCY63.37), len: 261 aa. Conserved FT hypothetical protein, similar to several conserved FT hypothetical proteins from Streptomyces coelicolor e.g. FT SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein FT (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% FT identity in 251 aa overlap). TBparse score is 0.905." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 398254..398628 FT /function="UNKNOWN" FT /locus_tag="Rv0333" FT /note="Rv0333, (MTCY63.38), len: 124 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 398658..399524 FT /EC_number="2.7.7.24" FT /evidence=experimental FT /function="DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O FT ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE FT BIOSYNTHESIS [CATALYTIC ACTIVITY: dTTP + alpha-D-glucose FT 1-phosphate = diphosphate + dTDP-glucose]." FT /gene="rmlA" FT /locus_tag="Rv0334" FT /note="Rv0334, (MTCY279.01), len: 288 aa. rmlA (alternate FT gene name: rfbA), alpha-D-glucose-1-phosphate FT thymidylyl-transferase (EC 2.7.7.24) (see citations FT below), equivalent to CAC32020.1|AL583925 FT glucose-1-phosphate thymidyltransferase from Mycobacterium FT leprae (288 aa). Also highly similar to others e.g. FT AAG29804.1|AF235050 glucose-1-phosphate FT thymidylyltransferase from Streptomyces rishiriensis (296 FT aa); RBA1_ECOLI|P37744 glucose-1-phosphate FT thymidylyltransferase from Escherichia coli strain K12 FT (293 aa), FASTA scores: opt: 1199, E(): 0, (62.0% identity FT in 284 aa overlap). BELONGS TO THE GLUCOSE-1-PHOSPHATE FT THYMIDYLYLTRANSFERASE FAMILY." FT /product="ALPHA-D-GLUCOSE-1-PHOSPHATE FT THYMIDYLYLTRANSFERASE RMLA (DTDP-GLUCOSE SYNTHASE) FT (DTDP-GLUCOSE PYROPHOSPHORYLASE)" FT /standard_name="rfbA" FT CDS complement(399535..400050) FT /evidence=experimental FT /function="UNKNOWN" FT /gene="PE6" FT /locus_tag="Rv0335c" FT /note="Rv0335c, (MTCY279.02c), len: 171 aa. Member of the FT Mycobacterium tuberculosis PE family (see Brennan & Delogu FT 2002); contains short region of similarity to part of the FT unique N-terminus of the Mycobacterium tuberculosis PGRS FT family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 FT hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA FT scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa FT overlap)." FT /product="PE FAMILY PROTEIN" FT CDS 400192..401703 FT /evidence=experimental FT /function="UNKNOWN. THOUGHT TO BE REGULATED BY FT Rv2720|LEXA." FT /locus_tag="Rv0336" FT /note="Rv0336, (MTCY279.03), len: 503 aa. Part of FT Mycobacterium tuberculosis 13E12 repeat family; almost FT identical to Rv0515|MTCY20G10.05 hypothetical protein from FT Mycobacterium tuberculosis FASTA scores: (99.8% identity FT in 503 aa overlap), possibly due to a recent gene FT duplication. Also similar to other Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv1148c, Rv1945, FT etc." FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT CDS complement(401873..403162) FT /EC_number="2.6.1.1" FT /function="GENERATES OXALOACETATE AND L-GLUTAMATE FROM FT L-ASPARTATE AND 2-OXOGLUTARATE [CATALYTIC ACTIVITY: FT L-ASPARTATE + 2-OXOGLUTARATE = OXALOACETATE + FT L-GLUTAMATE]." FT /gene="aspC" FT /locus_tag="Rv0337c" FT /note="Rv0337c, (MTCY279.04c), len: 429 aa. Probable aspC, FT aspartate aminotransferase (transaminase A) (EC 2.6.1.1), FT equivalent to CAC32019.1|AL583925 probable aspartate FT aminotransferase from Mycobacterium leprae (437 aa). Also FT highly similar to many e.g. Q48143|U32823 aspartate FT aminotransferase (404 aa), FASTA scores: opt: 1646, E(): FT 0, (57.2% identity in 404 aa overlap). Also some FT similarity to Rv3565|MTCY06G11.12 from Mycobacterium FT tuberculosis FASTA score: (27.2% identity in 383 aa FT overlap). BELONGS TO CLASS-I OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: FT PYRIDOXAL PHOSPHATE." FT /product="PROBABLE ASPARTATE AMINOTRANSFERASE ASPC FT (TRANSAMINASE A) (ASPAT)" FT CDS complement(403193..405841) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0338c" FT /note="Rv0338c, (MTCY279.05c), len: 882 aa. Probable FT iron-sulphur-binding reductase (EC 1.-.-.-), possibly FT membrane-bound, equivalent to CAC32018.1|AL583925 probable FT iron-sulphur-binding reductase from Mycobacterium leprae FT (880 aa). Also highly similar to others e.g. FT T36608|5019323|CAB44376.1|AL078610 probable FT iron-sulfur-binding reductase from Streptomyces coelicolor FT (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity FT in 772 aa overlap); BAB07521.1|AP001520 FT iron-sulphur-binding reductase from Bacillus halodurans FT (700 aa). Contains PS00070 Aldehyde dehydrogenases FT cysteine active site and two of PS00198 4Fe-4S FT ferredoxins, iron-sulfur binding region signature. First FT of several possible start sites chosen." FT /product="PROBABLE IRON-SULFUR-BINDING REDUCTASE" FT misc_feature complement(404276..404311) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT misc_feature complement(404633..404668) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding FT regi on signature" FT misc_feature complement(404924..404959) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding FT regi on signature" FT CDS complement(405950..408448) FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0339c" FT /note="Rv0339c, (MTCY279.06c), len: 832 aa. Possible FT transcriptional regulator, showing very weak similarity FT with parts of others. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop ); and probable helix-turn helix FT motif from aa 778-799 (Score 1041, +2.73 SD)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT misc_feature complement(408281..408304) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 408634..409173 FT /function="UNKNOWN" FT /locus_tag="Rv0340" FT /note="Rv0340, (MTCY279.07), len: 179 aa. Conserved FT hypothetical protein; MEME-MAST analysis shows similarity FT to product of downstream gene, Rv0341|iniB." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 409362..410801 FT /evidence=experimental FT /function="UNKNOWN." FT /gene="iniB" FT /locus_tag="Rv0341" FT /note="Rv0341, iniB, (MTCY13E10.01), len: 479 aa. iniB, FT isoniazid-inducible gene, (see citations below). Protein FT very Gly-, Ala-rich, similar to cell wall proteins e.g. FT P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN FT from A.thaliana (338 aa), FASTA scores: opt: 532, E(): FT 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST FT analysis shows similarity to product of upstream gene, FT Rv0340." FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIB" FT CDS 410838..412760 FT /evidence=experimental FT /function="UNKNOWN." FT /gene="iniA" FT /locus_tag="Rv0342" FT /note="Rv0342, iniA, (MTCY13E10.02), len: 640 aa. iniA, FT isoniazid-inducible gene, (see citations below). Shows FT slight similarity to some hypothetical bacterial proteins FT e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA FT scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa FT overlap). Also some similarity to downstream ORF FT Rv0343|iniC. Possible transmembrane stretch around residue FT 490. Alternative translational start at 410824. Contains a FT phosphopantetheine attachment site motif suggestive of an FT acyl carrier protein. Note that the iniA gene is also FT induced by the antibiotic ethambutol, an agent that FT inhibits cell wall biosynthesis by a mechanism that is FT distinct from isoniazid." FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIA" FT CDS 412757..414238 FT /function="UNKNOWN." FT /gene="iniC" FT /locus_tag="Rv0343" FT /note="Rv0343, (MTCY13E10.03), len: 493 aa. iniC, FT isoniazid-inducible gene, (see citations below). Shows FT slight similarity to P40983|YOR6_THER8 hypothetical FT protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05, FT (25.9% identity in 228 aa overlap). Also some similarity FT to upstream ORF Rv0342|iniA. Contains (PS00017) FT ATP/GTP-binding site motif A (P-loop). Note that the iniA FT gene is also induced by the antibiotic ethambutol, an FT agent that inhibits cell wall biosynthesis by a mechanism FT that is distinct from isoniazid." FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIC" FT misc_feature 412907..412930 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(414381..414941) FT /function="UNKNOWN" FT /gene="lpqJ" FT /locus_tag="Rv0344c" FT /note="Rv0344c, (MTCY13E10.04c), len: 186 aa. Probable FT lipoprotein, without homology. Has an appropriately FT positioned prokaryotic lipoprotein signature (PS00013)." FT /product="PROBABLE LIPOPROTEIN LPQJ" FT misc_feature complement(414873..414905) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attac hment site" FT CDS 415050..415460 FT /function="UNKNOWN" FT /locus_tag="Rv0345" FT /note="Rv0345, (MTCY13E10.05), len: 136 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from FT Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, FT E(): 1.5e-05, (41.0% identity in 117 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(415502..416965) FT /evidence=experimental FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF FT L-ASPARAGINE ACROSS THE MEMBRANE. RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /gene="ansP2" FT /locus_tag="Rv0346c" FT /note="Rv0346c, (MTCY13E10.06c), len: 487 aa. Possible FT ansP2, L-asparagine permease, integral membrane protein FT belonging to family containing many amino acid permeases, FT highly similar to FT G467030|B2126_F2_85|NP_301937.1|NC_002677 probable FT L-asparagine permease from Mycobacterium leprae (498 aa); FT and NP_301938.1|NC_002677 probable L-asparagine permease FT from Mycobacterium leprae (505 aa). Also highly similar to FT others e.g. P77610|ANSP_ECOLI L-ASPARAGINE PERMEASE from FT Escherichia coli strain K-12 (499 aa). Also highly similar FT to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 PROBABLE FT L-ASPARAGINE PERMEASE from Mycobacterium tuberculosis (489 FT aa), FASTA score: (72.1% identity in 473 aa overlap). And FT shows some similarity to MTCY3G12.14 from Mycobacterium FT tuberculosis. BELONGS TO THE AMINO ACID PERMEASE FAMILY FT (APC FAMILY). Note that previously known as aroP2." FT /product="POSSIBLE L-ASPARAGINE PERMEASE ANSP2 FT (L-ASPARAGINE TRANSPORT PROTEIN)" FT /standard_name="aroP2" FT CDS 417304..418290 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0347" FT /note="Rv0347, (MTCY13E10.07), len: 328 aa (alternative FT start possible). Probable conserved membrane protein, FT similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium FT tuberculosis (271 aa), FASTA scores: E(): 9.6e-21, (33.1% FT identity in 266 aa overlap)." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS 418293..418946 FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0348" FT /note="Rv0348, (MTCY13E10.08), len: 217 aa. Possible FT transcriptional regulator, showing some similarity to FT O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (115 aa), FASTA score: FT (30.0% identity in 100 aa overlap). Contains probable FT helix-turn helix motif from aa 89-110 (Score 1407, +3.98 FT SD)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 418949..419608 FT /function="UNKNOWN" FT /locus_tag="Rv0349" FT /note="Rv0349, (MTCY13E10.09), len: 219 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 419835..421712 FT /EC_number="3.6.1.-" FT /evidence=experimental FT /function="ACTS AS A CHAPERONE. INVOLVED IN INDUCTION BY FT STRESS CONDITIONS e.g. HEAT SHOCK. POSSIBLY HAS AN ATPASE FT ACTIVITY. SEEMS TO BE REGULATED POSITIVELY BY SIGH FT (Rv3223c PRODUCT) AND NEGATIVELY BY HSPR (Rv0353 FT PRODUCT)." FT /gene="dnaK" FT /locus_tag="Rv0350" FT /note="Rv0350, (MTCY13E10.10), len: 625 aa. Probable dnaK FT (alternate gene name: hsp70), 70 kDa heat shock protein FT (see citations below), equivalent to FT AAA25362.1|M95576|1924344A|738248 heat shock protein 70 FT from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488 FT (623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity FT in 625 aa overlap). Also highly similar to others e.g. FT Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 CHAPERONE FT PROTEIN DNAK from Streptomyces coelicolor (618 aa). Has FT probably an ATPase activity (EC 3.6.1.-). Note that this FT sequence differs from DNAK_MYCTU|P32723 (609 aa), due to a FT frameshift near the N-terminus. BELONGS TO THE HEAT SHOCK FT PROTEIN 70 FAMILY." FT /product="PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK FT PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70)" FT /standard_name="hsp70" FT CDS 421709..422416 FT /evidence=experimental FT /function="STIMULATES, JOINTLY WITH DNAJ|Rv0352, THE FT ATPASE ACTIVITY OF DNAK|Rv0350. HELPS TO RELEASE ADP FROM FT DNAK THUS ALLOWING DNAK TO RECYCLE MORE EFFICIENTLY. SEEMS FT TO BE REGULATED NEGATIVELY BY HSPR (Rv0353 PRODUCT)." FT /gene="grpE" FT /locus_tag="Rv0351" FT /note="Rv0351, (MTCY13E10.11), len: 249 aa. Probable grpE FT protein (HSP-70 COFACTOR), equivalent to FT CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium FT leprae (229 aa). Also highly similar to others eg FT Q05562|GRPE_STRCO|2127521|PN0643 GRPE PROTEIN from FT Streptomyces coelicolor (225 aa). Contains grpE protein FT signature (PS01071). BELONGS TO THE GRPE FAMILY." FT /product="PROBABLE GRPE PROTEIN (HSP-70 COFACTOR)" FT misc_feature 422132..422266 FT /note="PS01071 grpE protein signature" FT CDS 422452..423639 FT /evidence=experimental FT /function="ACTS AS A CO-CHAPERONE. STIMULATES, JOINTLY FT WITH GRPE|Rv0351, THE ATPASE ACTIVITY OF DNAK|Rv0350. FT SEEMS TO BE REGULATED NEGATIVELY BY HSPR (Rv0353 FT PRODUCT)." FT /gene="dnaJ1" FT /locus_tag="Rv0352" FT /note="Rv0352, (MTCY13E10.12), len: 395 aa. Probable FT dnaJ1, chaperone protein, equivalent to AAA25363.1|M95576 FT DNA J heatshock protein from Mycobacterium leprae (389 FT aa). Also highly similar to others. Contains both DnaJ FT signatures (PS00636, and PS00637). BELONGS TO THE DNAJ FT FAMILY. COFACTOR: BINDS TWO ZINC IONS PER MONOMER. Note FT that sequence differs from DNAJ_MYCTU|P07881 due to a FT frameshift at the N-terminus. Note that previously known FT as dnaJ." FT /product="PROBABLE CHAPERONE PROTEIN DNAJ1" FT /standard_name="dnaJ" FT misc_feature 422605..422664 FT /note="PS00636 Nt-dnaJ domain signature" FT misc_feature 422980..423054 FT /note="PS00637 CXXCXGXG dnaJ domain signature" FT CDS 423639..424019 FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL REGULATION FT (REPRESSION) OF HEAT SHOCK PROTEINS e.g. DNAK|Rv0350, FT GRPE|Rv0351, DNAJ1|Rv0352. BINDS TO THREE INVERTED REPEATS FT (IR1-IR3) IN THE PROMOTER REGION OF THE DNAK OPERON. FT INDUCTION: BY HEAT SHOCK." FT /gene="hspR" FT /locus_tag="Rv0353" FT /note="Rv0353, (MTCY13E10.13), len: 126 aa. Probable hspR, FT heat shock regulatory protein (see Stewart et al., 2001), FT merR family, highly similar to others e.g. HspR|P40183 FT heat shock regulatory protein from Streptomyces coelicolor FT (151 aa), FASTA scores: E(): 4.9e-22, (55.7% identity in FT 140 aa overlap), that binds to three inverted repeats FT (IR1-IR3) in the promoter region of the dnaK operon. Has FT possible coiled coil region in C-terminal half. BELONGS TO FT THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /product="PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL FT REPRESSOR HSPR (MERR FAMILY)" FT CDS complement(424269..424694) FT /evidence=experimental FT /function="UNKNOWN" FT /gene="PPE7" FT /locus_tag="Rv0354c" FT /note="Rv0354c, (MTCY13E10.14c), len: 141 aa. Member of FT the Mycobacterium tuberculosis PPE family, similar to FT others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 FT aa), FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa FT overlap). Possible continuation of ORF upstream, but no FT sequence error apparent." FT /product="PPE FAMILY PROTEIN" FT CDS complement(424777..434679) FT /function="UNKNOWN" FT /gene="PPE8" FT /locus_tag="Rv0355c" FT /note="Rv0355c, (MTCY13E10.15c, MTCY13E10.16c, FT MTCY13E10.17c) len: 3300 aa. Member of the Mycobacterium FT tuberculosis PPE family, similar to others e.g. FT AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 FT aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in FT 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity FT in 3531 aa overlap); etc. Gene contains large number of FT clustered Major Polymorphic Tandem Repeats (MPTR). Related FT to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; FT MTCY48.17, E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): FT 0; MTCY98.0031c, E(): 0; MTCY31.06c, E(): 5.6e-17; FT MTCY359.33, E(): 2.3e-16." FT /product="PPE FAMILY PROTEIN" FT CDS complement(434830..435474) FT /function="UNKNOWN" FT /locus_tag="Rv0356c" FT /note="Rv0356c, (MTCY13E10.18c), len: 214 aa. Conserved FT hypothetical protein, equivalent to AL023514|MLCB4_12 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae FT (218 aa), FASTA scores: opt: 1067, E(): 0, (73.4% identity FT in 214 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(435471..436769) FT /EC_number="6.3.4.4" FT /function="INVOLVED IN AMP BIOSYNTHESIS (FIRST COMMITTED FT STEP). PLAYS AN IMPORTANT ROLE IN THE DE NOVO PATHWAY OF FT PURINE NUCLEOTIDE BIOSYNTHESIS [CATALYTIC ACTIVITY: GTP + FT IMP + L-aspartate = GDP + phosphate + adenylosuccinate]." FT /gene="purA" FT /locus_tag="Rv0357c" FT /note="Rv0357c, (MTCY13E10.19c), len: 432 aa. Probable FT purA, adenylosuccinate synthase (EC 6.3.4.4), equivalent FT to AL023514|MLCB4_13 from ADENYLOSUCCINATE SYNTHETASE FT Mycobacterium leprae (432 aa), FASTA scores: opt: 2555, FT E(): 0, (87.9% identity in 431 aa overlap). Also highly FT similar to many bacterial adenylosuccinates synthetases FT e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from FT Escherichia coli (431 aa), FASTA scores: E(): 0, (51.1% FT identity in 425 aa overlap); etc. BELONGS TO THE FT ADENYLOSUCCINATE SYNTHETASE FAMILY." FT /product="PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA FT (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)" FT CDS 436860..437507 FT /function="UNKNOWN" FT /locus_tag="Rv0358" FT /note="Rv0358, (MTCY13E10.20), len: 215 aa. Conserved FT hypothetical protein, highly similar to FT ML0281|AL023514|MLCB4_14 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (229 aa), FASTA scores: opt: FT 852, E(): 0, (62.9% identity in 229 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 437518..438297 FT /function="UNKNOWN" FT /locus_tag="Rv0359" FT /note="Rv0359, (MTCY13E10.21), len: 259 aa. Probable FT conserved integral membrane protein, highly similar to FT hypothetical or other membrane proteins e.g. FT AL133220|SCC75A_6|T50569 probable membrane protein from FT Streptomyces coelicolor (265 aa), FASTA scores: opt: 642, FT E(): 0, (43.1% identity in 248 aa overlap); P70995 FT HYPOTHETICAL 24.7 kDa PROTEIN from Bacillus subtilis (219 FT aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa FT overlap). Contains neutral zinc metallopeptidases, FT zinc-binding region signature (PS00142)." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT misc_feature 437686..437715 FT /note="PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature" FT CDS complement(438302..438739) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0360c" FT /note="Rv0360c, (MTCY13E10.22c), len: 145 aa. Conserved FT hypothetical protein, equivalent to FT AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c FT hypothetical protein from Mycobacterium leprae (137 aa), FT FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa FT overlap). And similar to AL049754|SCH10_25c|T36537 FT hypothetical protein from Streptomyces coelicolor (143 FT aa), FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity FT in 138 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 438822..439649 FT /function="UNKNOWN" FT /locus_tag="Rv0361" FT /note="Rv0361, (MTCY13E10.23), len: 275 aa. Probable FT conserved membrane protein (has hydrophobic stretch from FT residues 132-156), equivalent to FT AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane FT protein from Mycobacterium leprae (292 aa), FASTA scores: FT opt: 1044, E(): 0, (58.6% identity in 292 aa overlap)." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS 439871..441253 FT /function="THOUGHT TO BE INVOLVED IN Mg2+ TRANSPORT. FT RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS FT THE MEMBRANE." FT /gene="mgtE" FT /locus_tag="Rv0362" FT /note="Rv0362, (MTCY13E10.24), len: 460 aa. Possible mgtE, FT magnesium (Mg2+) transport transmembrane protein; FT C-terminal region is highly similar to MGTE|G780283 FT putative Mg2+ transporter from Providencia stuarti (314 FT aa), FASTA scores: E(): 0, (47.2% identity in 307 aa FT overlap) (N-terminus extends approx. 150 aa further FT upstream compared to P. stuarti ORF). Also similar in part FT to others e.g. AAK20879.1|AF334760_1|AF334760 putative FT Mg2+ transporter from Aeromonas hydrophila (455 aa); FT NP_231292.1|NC_002505 magnesium transporter from Vibrio FT cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport FT protein from Mesorhizobium loti (454 aa); etc. Also FT similar to Rv1232c|MTV006.04c from Mycobacterium FT tuberculosis (435 aa). Extended hydrophobic segment FT spanning last 130 residues. BELONG TO THE MGTE FAMILY." FT /product="POSSIBLE Mg2+ TRANSPORT TRANSMEMBRANE PROTEIN FT MGTE" FT CDS complement(441265..442299) FT /EC_number="4.1.2.13" FT /evidence=experimental FT /function="INVOLVED IN GLYCOLYSIS (AT THE SIXTH STEP) FT [CATALYTIC ACTIVITY: D-FRUCTOSE 1,6-BISPHOSPHATE = FT GLYCERONE PHOSPHATE + D-GLYCERALDEHYDE 3-PHOSPHATE]." FT /gene="fba" FT /locus_tag="Rv0363c" FT /note="Rv0363c, (MTCY13E10.25c), len: 344 aa. Probable fba FT (alternate gene name: fda), fructose bisphosphate aldolase FT (EC 4.1.2.13), equivalent to FT AL023514|MLCB4_18|O69600|ALF_MYCLE FRUCTOSE-BISPHOSPHATE FT ALDOLASE from Mycobacterium leprae (345 aa), FASTA scores: FT opt: 1995, E(): 0, (87.7% identity in 342 aa overlap). FT Also highly similar to others. BELONGS TO CLASS II FT FRUCTOSE-BISPHOSPHATE ALDOLASE FAMILY. COFACTOR: ZINC." FT /product="PROBABLE FRUCTOSE-BISPHOSPHATE ALDOLASE FBA" FT /standard_name="fda" FT CDS 442395..443078 FT /function="UNKNOWN" FT /locus_tag="Rv0364" FT /note="Rv0364, (MTCY13E10.26), len: 227 aa. Possible FT conserved transmembrane protein, equivalent to FT O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLC FT B4 _19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium FT leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% FT identity in 227 aa overlap). Shows strong similarity to FT DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia FT coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa FT overlap). Similar also to Mycobacterium tuberculosis DedA FT protein Rv2637|MTCY441.0." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(443067..444197) FT /evidence=experimental FT /function="UNKNOWN: MAY BE INVOLVED IN THE ABILITY TO FT SURVIVE IN MACROPHAGES." FT /locus_tag="Rv0365c" FT /note="Rv0365c, (MTCY13E10.27c), len: 376 aa (start FT uncertain). Conserved hypothetical protein (see citation FT below), very similar to G388212|CAA35191.1, a truncated FT ORF immediately upstream of the Corynebacterium glutamicum FT fda gene encoding fructose-1,6-biphosphate aldolase (304 FT aa), FASTA scores: E(): 7.1e-19, (42.2% identity in 296 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(444222..444815) FT /function="UNKNOWN" FT /locus_tag="Rv0366c" FT /note="Rv0366c, (MTV036.01c), len: 197 aa. Conserved FT hypothetical protein, showing weak similarity to FT HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from FT Haemophilus influenzae (140 aa), FASTA scores: opt: 152, FT E(): 0.0015, (27.0% identity in 126 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 FT Glycine radical signature. TBparse score is 0.891." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature complement(444525..444551) FT /note="PS00850 Glycine radical signature" FT misc_feature complement(444768..444791) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(444844..445233) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0367c" FT /note="Rv0367c, (MTV036.02c), len: 129 aa. Hypothetical FT unknown protein. TBparse score is 0.850." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(445314..446525) FT /function="UNKNOWN" FT /locus_tag="Rv0368c" FT /note="Rv0368c, (MTV036.03c), len: 403 aa. Conserved FT hypothetical protein, showing some similarity to FT AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium FT japonicum (422 aa), FASTA scores: opt: 341, E(): 4.3e-13, FT (27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 FT hypothetical protein from Mycobacterium tuberculosis FASTA FT score: (30.7% identity in 238 aa overlap). Contains FT PS00213 Lipocalin signature. TBparse score is 0.909." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature complement(445995..446036) FT /note="PS00213 Lipocalin signature" FT CDS complement(446531..447046) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0369c" FT /note="Rv0369c, (MTV036.04c), len: 171 aa. Possible FT membrane protein oxidoreductase (EC 1.-.-.-), similar to FT ORF 4 of the Pseudomonas thermocarboxydovorans protein of FT cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from FT Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: FT opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa FT overlap). Also similar to MTV036.05, MTV036.08, MTV036.09, FT and MTV026.10." FT /product="POSSIBLE MEMBRANE OXIDOREDUCTASE" FT CDS complement(447147..448043) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0370c" FT /note="Rv0370c, (MTV036.05c), len: 298 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to many hypothetical FT proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 FT Protein of coxMSL gene cluster from FT Pseudomonas/Oligotropha carboxidovorans (295 aa), FASTA FT scores: opt: 851, E(): 0, (48.2% identity in 282 aa FT overlap); AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium FT japonicum (302 aa), FASTA scores: opt: 881, E(): 0, (47.6% FT identity in 290 aa overlap). Also highly similar to FT MTCY428_21 from Mycobacterium tuberculosis. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). TBparse FT score is 0.921." FT /product="POSSIBLE OXIDOREDUCTASE" FT misc_feature complement(447897..447920) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(448040..448633) FT /function="UNKNOWN" FT /locus_tag="Rv0371c" FT /note="Rv0371c, (MTV036.06c), len: 197 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 FT hypothetical protein from Streptomyces coelicolor (207 FT aa), FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity FT in 195 aa overlap). Also weak similarity with FT YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE FT from Bacillus subtilis (197 aa), FASTA scores: opt: 217, FT E(): 2.5e-08, (27.0% identity in 174 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(448630..449385) FT /function="UNKNOWN" FT /locus_tag="Rv0372c" FT /note="Rv0372c, (MTV036.07c), len: 251 aa. Conserved FT hypothetical protein, showing some similarity with FT CAB76248.1|X82447|COXF CoxF protein from FT Pseudomonas/Oligotropha carboxidovorans (280 aa); FT AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum FT (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% FT identity in 95 aa overlap). Also similar to upstream ORF FT Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA FT scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap). FT TBparse score is 0.862." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(449404..451803) FT /EC_number="1.2.99.2" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: CO + H(2)O + acceptor = FT CO(2) + reduced acceptor]." FT /locus_tag="Rv0373c" FT /note="Rv0373c, (MTV036.08c), len: 799 aa. Probable carbon FT monoxide dehydrogenase, large chain (EC 1.2.99.2), highly FT similar to others e.g. AAD00363.1| U80806|CUTL carbon FT monoxide dehydrogenase large subunit CutL protein from FT Hydrogenophaga pseudoflava (803 aa); FT S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA FT carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) FT (cut operon) from Pseudomonas thermocarboxydovorans (842 FT aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL FT carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) FT (cluster coxMSL) from Pseudomonas/Oligotropha FT carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0, FT (56.0% identity in 804 aa overlap); etc." FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE FT CHAIN)" FT CDS complement(451800..452279) FT /EC_number="1.2.99.2" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: CO + H(2)O + acceptor = FT CO(2) + reduced acceptor]." FT /locus_tag="Rv0374c" FT /note="Rv0374c, (MTV036.09c), len: 159 aa. Probable carbon FT monoxide dehydrogenase, small chain (EC 1.2.99.2), highly FT similar to others e.g. FT B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide FT dehydrogenase small chain (EC 1.2.99.2) from FT Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA FT scores: opt: 662, E(): 0, (59.3% identity in 150 aa FT overlap); CAA12063.1|AJ224684 putative carbon monoxide FT dehydrogenase small subunit from Bradyrhizobium japonicum FT (161 aa); S49123|509390|CAA54901.1|X77931|CUTC FT carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) FT from Pseudomonas thermocarboxydovorans (163 aa); etc. FT TBparse score is 0.918." FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL FT CHAIN)" FT CDS complement(452294..453154) FT /EC_number="1.2.99.2" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: CO + H(2)O + acceptor = FT CO(2) + reduced acceptor]." FT /locus_tag="Rv0375c" FT /note="Rv0375c, (MTV036.10c), len: 286 aa. Probable carbon FT monoxide dehydrogenase, medium chain (EC 1.2.99.2), FT similar to others e.g. AAD00361.1|U80806|CUTM carbon FT monoxide dehydrogenase middle subunit from Hydrogenophaga FT pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB FT carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) FT from Pseudomonas thermocarboxydovorans (287 aa); FT A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH FT carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) FT from Pseudomonas/Oligotropha carboxydovorans (288 aa), FT FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa FT overlap); etc." FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM FT CHAIN)" FT CDS complement(453230..454372) FT /function="UNKNOWN" FT /locus_tag="Rv0376c" FT /note="Rv0376c, (MTV036.11c), len: 380 aa. Conserved FT hypothetical protein, highly similar to FT T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical FT protein from Streptomyces coelicolor (395 aa); and FT AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from FT Arthrobacter nicotinovorans (377 aa). And similar to other FT conserved hypothetical proteins e.g. FT NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical FT protein from Mesorhizobium loti (245 aa). Note that FT C-terminus shows similarity with C-termini of FT CAB76248.1|X82447|COXF CoxF protein from FT Pseudomonas/Oligotropha carboxidovorans (280 aa); FT CAB76250.1|X82447|COXI CoxI protein from FT Pseudomonas/Oligotropha carboxidovorans (330 aa); and FT AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum FT (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in FT 138 aa overlap). Also some partial similarity with FT AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum FT (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% FT identity in 92 aa overlap); E1184330|Z99120|YURF YURF FT PROTEIN from Bacillus subtilis (330 aa), FASTA scores: FT opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa FT overlap). Also similar to downstream ORF Rv0372c from FT Mycobacterium tuberculosis (251 aa), FASTA scores: E(): FT 2.1e-06, (30.7% identity in 277 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 454421..455386 FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0377" FT /note="Rv0377, (MTV036.12), len: 321 aa. Probable FT transcription regulator, lysR family, showing similarity FT with many hypothetical transcriptional regulators lysR FT homolog e.g. P32484|YEIE_ECOLI|M89774 HYPOTHETICAL FT TRANSCRIPTIONAL REGULATOR from Escherichia coli (293 aa), FT FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity in FT 266 aa overlap). Also similar to Rv2282c from FT Mycobacterium tuberculosis. Contains PS00044 bacterial FT regulatory protein lysR family signature. SEEMS TO BELONG FT TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse FT score is 0.903." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LYSR-FAMILY)" FT misc_feature 454469..454561 FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS 455637..455858 FT /function="UNKNOWN" FT /locus_tag="Rv0378" FT /note="Rv0378, (MTV036.13), len: 73 aa. Conserved FT hypothetical gly-rich protein, showing some similarity to FT Mycobacterium tuberculosis PE_PGRS family; also similar to FT MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD FT protein (1011 aa), FASTA scores: opt: 237, E(): 0.0032, FT (58.7% identity in 63 aa overlap); MTV043_25. TBparse FT score is 0.860." FT /product="CONSERVED HYPOTHETICAL GLYCINE RICH PROTEIN" FT CDS 455977..456192 FT /function="THOUGHT TO BE INVOLVED IN PROTEIN TRANSPORT FT (EXPORT)." FT /gene="secE2" FT /locus_tag="Rv0379" FT /note="Rv0379, (MTV036.14), len: 71 aa. Possible secE2, FT protein transport protein, showing similarity with FT P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT FT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) FT from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: FT 79, E(): 4.7. (30.3% identity in 66 aa overlap); and FT hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL FT PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); FT Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (71 aa); etc. Also highly similar to FT U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis FT protein from a patient isolate (116 aa), FASTA scores: FT opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). FT Note that for Rv0379|MTV036.14, a translation initiation FT region different to the one in U85467|MTU85467_1 was FT chosen. COULD BE A PART OF THE PROKARYOTIC PROTEIN FT TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, FT SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND FT SECY|Rv0732." FT /product="POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2" FT CDS complement(456268..456819) FT /EC_number="2.1.1.-" FT /function="POSSIBLY CAUSES METHYLATION OF RNA." FT /locus_tag="Rv0380c" FT /note="Rv0380c, (MTV036.15c), len: 183 aa. Possible RNA FT methyltransferase (EC 2.1.1.-), equivalent to FT CAC32002.1|AL583925 possible RNA methyltransferase from FT Mycobacterium leprae (182 aa). Also some similarity with FT others methyltransferases e.g. FT P19396|TRMH_ECOLI|78514|JV0043 TRNA FT (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA FT METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA FT scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa FT overlap). Also similar to Rv0881, Rv3579c, Rv1644 from FT Mycobacterium tuberculosis." FT /product="POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE)" FT CDS complement(456915..457823) FT /function="UNKNOWN" FT /locus_tag="Rv0381c" FT /note="Rv0381c, (MTV036.16c), len: 302 aa. Hypothetical FT unknown protein. Equivalent to AAK44616.1 from FT Mycobacterium tuberculosis strain CDC1551 (254 aa) but FT longer 48 aa. TBparse score is 0.902." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(457841..458380) FT /EC_number="2.4.2.10" FT /function="INVOLVED IN PYRIMIDINE BIOSYNTHESIS (AT THE FT FIFTH STEP) [CATALYTIC ACTIVITY: Orotidine 5'-phosphate + FT diphosphate = orotate + 5-phospho-alpha-D-ribose FT 1-diphosphate]." FT /gene="pyrE" FT /locus_tag="Rv0382c" FT /note="Rv0382c, (MTV036.17c), len: 179 aa. Probable pyrE, FT orotate phosphoribosyltransferase (EC 2.4.2.10), FT equivalent to CAC32004.1|AL583925 probable FT purine/pyrimidine phosphoribosyltransferase from FT Mycobacterium leprae (179 aa). Also highly similar to many FT others e.g. T36540|4753874|CAB42037.1|AL049754|SCH10.28c FT probable orotate phosphoribosyltransferase from FT Streptomyces coelicolor (182 aa); FT H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable FT orotate phosphoribosyltransferase from Methanobacterium FT thermoautotrophicum (180 aa), FASTA scores: opt: 389, E(): FT 2.7e-20, (40.7% identity in 172 aa overlap); FT O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 OROTATE FT PHOSPHORIBOSYLTRANSFERASE from Sulfolobus acidocaldarius FT (197 aa); etc. Note that also similar to other puridine FT 5'-monophosphate synthases (umpA genes; UMP synthases), FT generally in N-terminus that corresponds to orotate FT phosphoribosyltransferase activity. Contains PS00589 PTS FT HPR component serine phosphorylation site signature. FT BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FT FAMILY. Note that previously known as umpA." FT /product="PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE FT (OPRT) (OPRTASE)" FT /standard_name="umpA" FT misc_feature complement(457850..457897) FT /note="PS00589 PTS HPR component serine phosphorylation FT site signature" FT CDS complement(458461..459315) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0383c" FT /note="Rv0383c, (MTV036.18c), len: 284 aa. Possible FT conserved secreted protein, with hydrophobic stretch in FT N-terminus and Pro-rich C-terminus. Equivalent to FT CAC32006.1|AL583925 possible secreted protein from FT Mycobacterium leprae (286 aa). TBparse score is 0.900." FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT CDS complement(459456..462002) FT /EC_number="3.-.-.-" FT /evidence=experimental FT /function="THOUGHT TO BE AN ATPASE SUBUNIT OF AN FT INTRACELLULAR ATP-DEPENDENT PROTEASE. SEEMS TO BE FT REGULATED POSITIVELY BY SIGH (Rv3223c PRODUCT) AND FT NEGATIVELY BY HSPR (Rv0353 PRODUCT)." FT /gene="clpB" FT /locus_tag="Rv0384c" FT /note="Rv0384c, (MTV036.19c), len: 848 aa. Probable clpB FT (alternate gene name: htpM), endopeptidase ATP-binding FT protein, chain B (EC 3.-.-.-), equivalent to FT AC32007.1|AL583925 heat shock protein from Mycobacterium FT leprae (848 aa). Also highly similar to others e.g. FT P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 FT CLPB PROTEIN (heat-inducible expression) from FT Corynebacterium glutamicum (852 aa), FASTA scores: opt: FT 4113, E(): 0, (74.5% identity in 846 aa overlap); FT T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c FT probable ATP-dependent proteinase ATP-binding chain from FT Streptomyces coelicolor (853 aa); FT P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN FT (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains FT K12 and O157:H7 (857 aa); etc. Also similar to FT Rv3596c|ClpC from Mycobacterium tuberculosis. Contains FT PS00870 and PS00871 Chaperonins clpA/B signatures and two FT PS000017 ATP/GTP-binding site motives A (P-loop). BELONGS FT TO THE CLPA/CLPB FAMILY. Contains probable coiled-coil FT domain from aa 411-503." FT /product="PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN FT (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)" FT /standard_name="htpM" FT misc_feature complement(460050..460106) FT /note="PS00871 Chaperonins clpA/B signature 2" FT misc_feature complement(460161..460184) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(461082..461120) FT /note="PS00870 Chaperonins clpA/B signature 1" FT misc_feature complement(461364..461387) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 462135..463307 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0385" FT /note="Rv0385, (MTV036.20), len: 390 aa. Probable FT monooxygenase (EC 1.-.-.-), similar to FT T37003|5738846|CAB52917.1|AL109949 probable FT flavohemoprotein from Streptomyces coelicolor (435 aa); FT and similar in part (C-termini) to various monooxygenases FT e.g. P19734|DMPP_PSESP|94993|F37831 PHENOL HYDROXYLASE P5 FT PROTEIN (PHENOL 2-MONOOXYGENASE P5 COMPONENT) (EC FT 1.14.13.7) from Pseudomonas putida (353 aa), FASTA scores: FT opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa FT overlap); S47292|2120861|pir|S70085 phenol 2-monooxygenase FT (EC 1.14.13.7) chain mopP from Acinetobacter calcoaceticus FT (350 aa); P21394|XYLA_PSEPU|94933|B37316 XYLENE FT MONOOXYGENASE ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) FT [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from FT Pseudomonas putida plasmid pWW0 (350 aa); FT AAC38360.1|AF043544|NtnMA|ntnA reductase component of FT 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 FT aa); etc. TBparse score is 0.898." FT /product="PROBABLE MONOOXYGENASE" FT CDS 463411..466668 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0386" FT /note="Rv0386, (MTV036.21), len: 1085 aa. Probable FT regulatory protein, LuxR/uhpA family, highly similar to FT CAC30706.1|AL583923 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also similar in part FT to other regulatory proteins e.g. CAB95788.1|AL359949 FT putative multi-domain regulatory protein from Streptomyces FT coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 FT putative AfsR-like regulatory protein from Streptomyces FT coelicolor (1114 aa); N-terminus of FT NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional FT regulator from Mesorhizobium loti (952 aa); FT AFSR_STRCO|P25941 regulatory protein afsr from FT Streptomyces coelicolor (993 aa), FASTA scores: opt: 224, FT E() : 1.1e-06, (26.1% identity in 867 aa overlap); etc. FT Also similar to many putative Mycobacterium tuberculosis FT regulatory proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA FT scores: opt: 3756, E(): 0, (56.7% identity in 1089 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), PS00622 Bacterial regulatory proteins, luxR FT family signature and probable helix-turn-helix motif at aa FT 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE FT LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse FT score is 0.910." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LUXR/UHPA-FAMILY)" FT misc_feature 464071..464094 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 466531..466614 FT /note="PS00622 Bacterial regulatory proteins, luxR family FT signature" FT CDS complement(466672..467406) FT /function="UNKNOWN" FT /locus_tag="Rv0387c" FT /note="Rv0387c, (MTV036.22c), len: 244 aa. Conserved FT hypothetical protein, showing some similarity to FT MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon FT 1, Elastin (687 aa), FASTA scores: opt: 193, E(): 0.35, FT (34.4% identity in 189 aa overlap). TBparse score is FT 0.915." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(467459..468001) FT /function="UNKNOWN" FT /gene="PPE9" FT /locus_tag="Rv0388c" FT /note="Rv0388c, (MTV036.23c), len: 180 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT others e.g. MTCY10G2_10|Z92539 from Mycobacterium FT tuberculosis (391 aa), FASTA scores: opt: 667, E(): 0, FT (58.3% identity in 180 aa overlap) but much shorter." FT /product="PPE FAMILY PROTEIN" FT CDS 468335..469594 FT /EC_number="2.1.2.-" FT /function="INVOLVED IN THIRD STEP (FIRST OF TWO FT TRANSFORMYLATION REACTIONS) IN DE NOVO PURINE FT BIOSYNTHESIS. THIS IS AN ALTERNATIVE ENZYME TO THE FT PURN|Rv0956 GAR TRANSFORMYLASE FT (5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE). FT CATALYZES TWO REACTIONS: THE FIRST ONE IS THE PRODUCTION FT OF BETA-FORMYL GLYCINAMIDE RIBONUCLEOTIDE (GAR) FROM FT FORMATE, ATP AND BETA GAR; THE SECOND, A SIDE REACTION, IS FT THE PRODUCTION OF ACETYL PHOSPHATE AND ADP FROM ACETATE FT AND ATP [CATALYTIC ACTIVITY: FORMATE + ATP + FT 5'-PHOSPHO-RIBOSYLGLYCINAMIDE = FT 5'-PHOSPHORIBOSYL-N-FORMYLGLYCINAMIDE + ADP + FT PYROPHOSPHATE]." FT /gene="purT" FT /locus_tag="Rv0389" FT /note="Rv0389, (MTCY04D9.01, MTV036.24), len: 419 aa. FT Probable purT, phosphoribosylglycinamide formyltransferase FT 2 (EC 2.1.2.-), similar to others e.g. FT P33221|PURT_ECOLI|B1849 phosphoribosylglycinamide FT formyltransferase 2 from Escherichia coli strain K-12 (391 FT aa), FASTA scores: opt: 481, E(): 1.3e-22, (40.1% identity FT in 379 aa overlap); etc. BELONGS TO THE PURK / PURT FT FAMILY. COFACTOR: MAGNESIUM." FT /product="PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FT FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) FT (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) FT (FORMATE-DEPENDENT GAR TRANSFORMYLASE)" FT CDS 469591..470013 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0390" FT /note="Rv0390, (MTCY04D9.02), len: 140 aa. Conserved FT hypothetical protein, equivalent to FT AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein FT from Mycobacterium leprae (147 aa), FASTA scores: opt: FT 778, E(): 0, (79.0% identity in 138 aa overlap). Also FT similar to hypothetical proteins from several Rickettsia FT species." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 470010..471230 FT /EC_number="4.2.99.-" FT /function="INVOLVED IN METHIONINE BIOSYNTHESIS. CONVERTS FT O-SUCCINYLHOMOSERINE INTO HOMOCYSTEINE." FT /gene="metZ" FT /locus_tag="Rv0391" FT /note="Rv0391, (MTCY04D9.03), len: 406 aa. Probable metZ, FT O-succinylhomoserine sulfhydrylase (EC 4.2.99.-), FT equivalent, but shorter 20 aa in N-terminus, to FT AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from FT Mycobacterium leprae (426 aa). Also highly similar to FT others e.g. METZ_PSEAE|P55218 o-succinylhomoserine FT sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA FT scores: opt: 1175, E(): 0, (47.2% identity in 392 aa FT overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FT FAMILY. Could also be a cystathionine gamma-synthase (EC FT 4.2.99.9)." FT /product="PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ FT (OSH SULFHYDRYLASE)" FT CDS complement(471227..472639) FT /EC_number="1.6.99.3" FT /function="TRANSFER OF ELECTRONS FROM NADH TO THE FT RESPIRATORY CHAIN. THE IMMEDIATE ELECTRON ACCEPTOR FOR THE FT ENZYME IS BELIEVED TO BE UBIQUINONE. DOES NOT COUPLE THE FT REDOX REACTION TO PROTON TRANSLOCATION [CATALYTIC FT ACTIVITY: NADH + acceptor = NAD+ + reduced acceptor]." FT /gene="ndhA" FT /locus_tag="Rv0392c" FT /note="Rv0392c, (MTCY04D9.04c), len: 470 aa. Probable FT ndhA, membrane NADH dehydrogenase (EC 1.6.99.3), FT equivalent to many e.g. AF038423|AF038423_1 NADH FT dehydrogenase from Mycobacterium smegmatis (457 aa), FASTA FT scores: opt: 1991, E(): 0, (67.9% identity in 458 aa FT overlap); MLCB1788_3 NADH dehydrogenase from Mycobacterium FT leprae (466 aa), FASTA score: (62.5% identity in 467 aa FT overlap). Also similar to others from several organisms FT e.g. P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH FT DEHYDROGENASE from Escherichia coli (434 aa); and FT Rv0392c|ndhB from Mycobacterium tuberculosis. Has FT hydrophobic stretch in C-terminus. BELONGS TO THE NADH FT DEHYDROGENASE FAMILY." FT /product="PROBABLE MEMBRANE NADH DEHYDROGENASE NDHA" FT CDS 472781..474106 FT /function="UNKNOWN" FT /locus_tag="Rv0393" FT /note="Rv0393, (MTCY04D9.05), len: 441 aa. Member of FT Mycobacterium tuberculosis 13E12 repeat family of FT conserved proteins, similar to many e.g. Rv1148c, Rv1945, FT Rv3467, Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, FT (61.1% identity in 347 aa overlap)." FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT CDS complement(474122..474841) FT /function="UNKNOWN" FT /locus_tag="Rv0394c" FT /note="Rv0394c, (MTCY04D9.06c), len: 239 aa. Possible FT secreted protein, sharing no homology with other proteins. FT Has hydrophobic stretch at its N-terminus." FT /product="POSSIBLE SECRETED PROTEIN" FT CDS 474940..475344 FT /function="UNKNOWN" FT /locus_tag="Rv0395" FT /note="Rv0395, (MTCY04D9.07), len: 134 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 475350..475742 FT /function="UNKNOWN" FT /locus_tag="Rv0396" FT /note="Rv0396, (MTCY04D9.08), len: 130 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 475816..476184 FT /function="UNKNOWN" FT /locus_tag="Rv0397" FT /note="Rv0397, (MTCY04D9.09), len: 122 aa. Part of 13E12 FT repeat family of conserved Mycobacterium tuberculosis FT proteins, similar to downstream Rv0393|Z84725|MTCY4D9_5 FT CONSERVED 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA FT scores: E(): 0, (87.7% identity in 122 aa overlap)." FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT CDS complement(476679..477320) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0398c" FT /note="Rv0398c, (MTCY04D9.10c), len: 213 aa. Possible FT secreted protein, sharing no homology with other proteins. FT Has potential signal sequence with hydrophobic stretch FT from aa 7-25." FT /product="POSSIBLE SECRETED PROTEIN" FT CDS complement(477327..478556) FT /function="UNKNOWN" FT /gene="lpqK" FT /locus_tag="Rv0399c" FT /note="Rv0399c, (MTCY04D9.11c), len: 409 aa. Possible FT lpqK, conserved lipoprotein, showing some similarity to FT penicillin binding proteins and various peptidases e.g. FT DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase FT protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16, FT (29.2% identity in 301 aa overlap). Also similar to other FT Mycobacterium tuberculosis PBPs and esterases. Has FT possible N-terminal signal sequence and appropriately FT positioned prokaryotic lipoprotein lipid attachment site FT (PS00013)." FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPQK" FT CDS complement(478566..479753) FT /EC_number="1.3.99.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE7" FT /locus_tag="Rv0400c" FT /note="Rv0400c, (MTCY04D9.12c), len: 395 aa. Probable FT fadE7, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. CAC12923.1|AL445403 putative acyl CoA FT dehydrogenase from Streptomyces coelicolor (397 aa); FT G624219 GLUTARYL-CoA DEHYDROGENASE PRECURSOR (438 aa), FT FASTA scores: opt: 1161, E(): 0, (48.1% identity in 391 aa FT overlap); etc." FT /product="ACYL-CoA DEHYDROGENASE FADE7" FT CDS 479789..480160 FT /function="UNKNOWN" FT /locus_tag="Rv0401" FT /note="Rv0401, (MTCY04D9.14), len: 129 aa. Probable FT conserved transmembrane protein, equivalent to FT AL023514|MLCB4_9 putative integral membrane protein from FT Mycobacterium leprae (122 aa), FASTA scores: opt: 548, FT E(): 4.4e-32, (66.9% identity in 121 aa overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(480355..483231) FT /evidence=experimental FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /gene="mmpL1" FT /locus_tag="Rv0402c" FT /note="Rv0402c, (MTCY04D9.15c), len: 958 aa. Probable FT mmpL1, conserved transmembrane transport protein (see FT Tekaia et al., 1999), member of RND superfamily, highly FT similar to other Mycobacterial proteins e.g. FT YV34_MYCTU|Q11171 hypothetical 106.2 kDa membrane protein FT from Mycobacterium tuberculosis (968 aa), FASTA scores: FT opt: 3551, E(): 0, (55.4% identity in 933aa overlap); FT YV34_MYCLE|P54881 hypothetical 105.2 kDa protein from FT Mycobacterium leprae (959 aa), FASTA scores: opt: 3615, FT E(): 0, (55.5% identity in 941 aa overlap); etc. Highly FT similar to many other mycobacterial MmpL proteins from FT Mycobacterium tuberculosis and Mycobacterium leprae e.g. FT Rv0450c, Rv0676c, Rv0507, etc. BELONGS TO THE MMPL FT FAMILY." FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL1" FT CDS complement(483228..483656) FT /function="UNKNOWN." FT /gene="mmpS1" FT /locus_tag="Rv0403c" FT /note="Rv0403c, (MTCY04D9.16c), len: 142 aa. Probable FT mmpS1, conserved membrane protein (see citation below), FT highly similar to other Mycobacterial proteins e.g. FT YV33_MYCLE|P54880 hypothetical 16.9 kDa protein from FT Mycobacterium leprae (154 aa), FASTA scores: opt: 458, FT E(): 1.6e-26, (46.9% identity in 143 aa overlap); FT YV33_MYCTU|Q11170 hypothetical 15 .9 kDa protein from FT Mycobacterium tuberculosis (147 aa), FASTA scores: opt: FT 362, E(): 1.1e-19, (42.1% identity in 140 aa overlap); FT etc. Also similar to other MmpS proteins from FT Mycobacterium tuberculosis e.g. Rv0677c, Rv0451c, etc. FT BELONGS TO THE MMPS FAMILY." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS1" FT CDS 483977..485734 FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD30" FT /locus_tag="Rv0404" FT /note="Rv0404, (MTCY04D9.17-MTCY22G10.00), len: 585 aa. FT Probable fadD30, fatty-acid-CoA synthetase (EC 6.2.1.-), FT similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA FT synthase from Mycobacterium bovis (582 aa); FT MASC_MYCLE|P54200 masc protein from Mycobacterium leprae FT (372 aa), FASTA scores: opt: 888, E(): 0, (44.2% identity FT in 342 aa overlap). Also similar to Y06J_MYCTU|Q10976 FT hypothetical 67.9 kDa protein (626 aa), FASTA scores: opt: FT 1463, E(): 0, (42.4% identity in 568 aa overlap)." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD30 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT CDS 485731..489939 FT /function="POLYKETIDE SYNTHASE POSSIBLY INVOLVED IN LIPID FT SYNTHESIS." FT /gene="pks6" FT /locus_tag="Rv0405" FT /note="Rv0405, (MTCY22G10.01), len: 1402 aa. Probable FT pks6, membrane-bound polyketide synthase (see citation FT below), highly similar to others e.g. CAC29643.1|AL583917 FT putative polyketide synthase from Mycobacterium leprae FT (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase FT (1876 aa), FASTA scores: opt: 2303, E(): 0, (38.7% FT identity in 1232 aa overlap); etc. Contains PS00606 FT Beta-ketoacyl synthases active site, 2 x PS00017 FT ATP/GTP-binding site motif A (P-loop), and PS00012 FT Phosphopantetheine attachment site." FT /product="PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE FT PKS6" FT misc_feature 486505..486555 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 486811..486834 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 487366..487389 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 488869..488916 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS complement(489887..490705) FT /function="UNKNOWN" FT /locus_tag="Rv0406c" FT /note="Rv0406c, (MTCY22G10.02c), len: 272 aa. FT Beta-lactamase-like protein, equivalent to FT AAD38170.1|AF152397_1 beta-lactamase-like protein from FT Mycobacterium phlei (243 aa); AL023514|MLCB4_8 FT hypothetical protein from Mycobacterium leprae (251 aa), FT FASTA scores: opt: 1284, E(): 0, (74.9% identity in 243 aa FT overlap); and AAD38164.1|AF152394_2 beta-lactamase-like FT protein from Mycobacterium avium (247 aa), FASTA scores: FT opt: 1301, E(): 0, (74.2% identity in 244 aa overlap); FT etc. Also slight similarity to others beta-lactamases and FT hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349 FT METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE FT II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa), FT FASTA scores: (34.4% identity in 96 aa overlap)." FT /product="BETA LACTAMASE LIKE PROTEIN" FT CDS 490783..491793 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="CATALYZES OXIDATION OF GLUCOSE-6-PHOSPHATE TO FT 6-PHOSPHOGLUCONOLACTONE USING COENZYME F420 (AN FT *-HYDROXY-5-DEAZAFLAVIN DERIVATIVE) AS THE ELECTRON FT ACCEPTOR." FT /gene="fgd1" FT /locus_tag="Rv0407" FT /note="Rv0407, (MTCY22G10.03), len: 336 aa. Probable FT fgd1, F420-dependent glucose-6-phosphate dehydrogenase (EC FT 1.-.-.-), equivalent to others from Mycobacteria e.g. FT AAD38165.1|AF152394_3 from Mycobacterium avium (336 aa), FT FASTA scores: opt: 2082, E(): 0, (89.9% identity in 336 aa FT overlap); AL023514|MLCB 4_7 from Mycobacterium leprae (336 FT aa), FASTA scores: opt: 2069, E(): 0, (89.0% identity in FT 336 aa overlap). Also similar to other dehydrogenases e.g. FT CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase FT from Methanofollis liminatans (330 aa). Also similar to FT many proteins from Mycobacterium tuberculosis e.g. FT Rv0953c, Rv0791c, etc. Note that previously known as fgd." FT /product="PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE FT DEHYDROGENASE FGD1" FT /standard_name="fgd" FT CDS 491786..493858 FT /EC_number="2.3.1.8" FT /function="INVOLVED AT THE LAST STEP (OF TWO) IN THE FT CONVERSION OF ACETATE TO ACETYL-CoA [CATALYTIC ACTIVITY: FT Acetyl-CoA + phosphate = CoA + acetyl phosphate]." FT /gene="pta" FT /locus_tag="Rv0408" FT /note="Rv0408, (MTCY22G10.04), len: 690 aa. Probable pta, FT phosphate acetyltransferase (EC 2.3.1.8), highly similar FT to others e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 FT phosphate acetyltransferase from Escherichia coli strain FT K12 (713 aa), FASTA scores: opt: 1303, E(): 0, (38.0% FT identity in 718 aa overlap); etc. BELONGS TO THE PHOSPHATE FT ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY." FT /product="PROBABLE PHOSPHATE ACETYLTRANSFERASE PTA FT (PHOSPHOTRANSACETYLASE)" FT CDS 493851..495008 FT /EC_number="2.7.2.1" FT /function="INVOLVED AT THE FIRST STEP (OF TWO) IN THE FT CONVERSION OF ACETATE TO ACETYL-CoA [CATALYTIC ACTIVITY: FT ATP + acetate = ADP + acetyl phosphate]." FT /gene="ackA" FT /locus_tag="Rv0409" FT /note="Rv0409, (MTCY22G10.05), len: 385 aa. Probable ackA, FT acetate kinase (EC 2.7.2.1), highly similar to others e.g. FT ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis FT (395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity FT in 393 aa overlap); etc. Contains PS01075 Acetate and FT butyrate kinases family signature 1, PS00758 ArgE / dapE / FT ACY1/ CPG2 / yscS family signature 1. BELONGS TO THE FT ACETOKINASE FAMILY." FT /product="PROBABLE ACETATE KINASE ACKA (ACETOKINASE)" FT misc_feature 493863..493898 FT /note="PS01075 Acetate and butyrate kinases family FT signature 1" FT misc_feature 494748..494777 FT /note="PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family FT signature 1" FT CDS complement(495062..497314) FT /EC_number="2.7.1.-" FT /evidence=experimental FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE AMINO-ACID UPTAKE FT AND STATIONARY-PHASE METABOLISM. PHOSPHORYLATES THE FT PEPTIDE SUBSTRATE MYELIN BASIC PROTEIN (MBP) AT SERINE FT RESIDUES [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A FT PHOSPHOPROTEIN]." FT /gene="pknG" FT /locus_tag="Rv0410c" FT /note="Rv0410c, (MTCY22G10.06c), len: 750 aa. pknG, FT serine/threonine-protein kinase (EC 2.7.1.-) (see FT citations below), equivalent to FT PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE FT SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae FT (767 aa). Also similar to others e.g. AB76890.1|AL159139 FT putative serine/threonine protein kinase from Streptomyces FT coelicolor (774 aa); etc. Contains PS00108 FT Serine/Threonine protein kinases active-site signature. FT Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FT FAMILY OF PROTEIN KINASES." FT /product="SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN FT KINASE G) (STPK G)" FT misc_feature complement(496463..496501) FT /note="PS00108 Serine/Threonine protein kinases FT active-site signature" FT CDS complement(497314..498300) FT /function="INVOLVED IN ACTIVE TRANSPORT OF GLUTAMINE FT ACROSS THE MEMBRANE (IMPORT). INTERACTS WITH THE FT GLUTAMINE-TRANSPORT SYSTEM." FT /gene="glnH" FT /locus_tag="Rv0411c" FT /note="Rv0411c, (MTCY22G10.07c), len: 328 aa. Probable FT glnH, glutamine-binding protein, membrane-bound FT lipoprotein (see citation below), equivalent to FT AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 FT glutamine-binding protein homolog from Mycobacterium FT leprae (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% FT identity in 328 aa overlap). Also similar to others e.g. FT GLNH_BACST|P27676 glutamine-binding protein precursor from FT Bacillus stearothermophilus (262 aa), FASTA scores: opt: FT 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); FT etc. Contains PS00013 Prokaryotic membrane lipoprotein FT lipid attachment site, PS01039 Bacterial extracellular FT solute-binding proteins, family 3 signature. BELONGS TO FT THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY FT 3. Presumed attached to the membrane by a lipid anchor." FT /product="PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH FT (GLNBP)" FT misc_feature complement(497911..497952) FT /note="PS01039 Bacterial extracellular solute-binding FT proteins, family 3 signature" FT misc_feature complement(498223..498255) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(498300..499619) FT /function="UNKNOWN" FT /locus_tag="Rv0412c" FT /note="Rv0412c, (MTCY22G10.08c), len: 439 aa. Possible FT conserved membrane protein, equivalent to FT AL035159|MLCB1450_16|T44737 probable membrane protein from FT Mycobacterium leprae (403 aa), FASTA scores: opt: 2027, FT E(): 0, (80.4% identity in 403 aa overlap). Also some FT similarity with CAB71201.1|AL138538 putative secreted FT protein from Streptomyces coelicolor (429 aa)." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT CDS 499713..500366 FT /EC_number="3.6.1.-" FT /function="POSSIBLY INVOLVED IN THE GO SYSTEM RESPONSIBLE FT FOR REMOVING AN OXIDATIVELY DAMAGED FORM OF GUANINE FT (7,8-DIHYDRO-8-OXOGUANINE) FROM DNA AND THE NUCLEOTIDE FT POOL. 8-OXO-DGTP IS INSERTED OPPOSITE DA AND DC RESIDUES FT OF TEMPLATE DNA WITH ALMOST EQUAL EFFICIENCY THUS LEADING FT TO A.T TO G.C TRANSVERSIONS. MUTT SPECIFICALLY DEGRADES FT 8-OXO-DGTP TO THE MONOPHOSPHATE [CATALYTIC ACTIVITY: FT 8-OXO-DGTP + H2O = 8-OXO-DGMP + PYROPHOSPHATE]." FT /gene="mutT3" FT /locus_tag="Rv0413" FT /note="Rv0413, (MTCY22G10.10), len: 217 aa. Possible FT mutT3, mutator protein (EC 3.6.1.-) (see citation below), FT showing some similarity with e.g. MUTT_PROVU|P32090 FT mutator mutt protein from Proteus vulgaris (112 aa), FASTA FT scores: opt: 151, E(): 0.0008, (40.7% identity in 59 aa FT overlap). SEEMS TO BELONG TO THE NUDIX HYDROLASE FAMILY." FT /product="POSSIBLE MUTATOR PROTEIN MUTT3 FT (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) FT (DGTP PYROPHOSPHOHYDROLASE)" FT CDS complement(500350..501018) FT /EC_number="2.5.1.3" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. CONDENSES FT 4-METHYL-5-(BETA-HYDROXYETHYL)-THIAZOLE MONOPHOSPHATE FT (THZ-P) AND 4-AMINO-5-HYDROXYMETHYL PYRIMIDINE FT PYROPHOSPHATE (HMP-PP) TO FORM THIAMINE MONOPHOSPHATE FT (TMP) [CATALYTIC ACTIVITY: FT 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + FT 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate FT + thiamine monophosphate]." FT /gene="thiE" FT /locus_tag="Rv0414c" FT /note="Rv0414c, (MTCY22G10.11c), len: 222 aa. Probable FT thiE, thiamin phosphate pyrophosphorylase (EC 2.5.1.3), FT equivalent to Q9ZBL5|AL035159|MLCB1450_17 PROBABLE FT THIAMINE-PHOSPHATE PYROPHOSPHORYLASE from Mycobacterium FT leprae (235 aa), FASTA scores: opt: 1095, E(): 0, (78.0% FT identity in 223 aa overlap). Also similar to others e.g. FT T34974|5689976|CAB52013.1|AL109663 probable thiamin FT phosphate pyrophosphorylase from Streptomyces coelicolor FT (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia FT coli strain K12 (211 aa), FASTA scores: opt: 275, E(): FT 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS FT TO THE TMP-PPASE FAMILY." FT /product="PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE FT THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) FT (THIAMINE-PHOSPHATE SYNTHASE)" FT CDS 501148..502170 FT /EC_number="1.-.-.-" FT /function="POSSIBLY INVOLVED IN THIAMINE BIOSYNTHESIS." FT /gene="thiO" FT /locus_tag="Rv0415" FT /note="Rv0415, (MTCY22G10.12), len: 340 aa. Possible thiO, FT thiamine biosynthesis oxidoreductase (EC 1.-.-.-), FT equivalent to FT T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 FT hypothetical protein from Mycobacterium leprae (340 aa), FT FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa FT overlap). Shows some similarity to other thiO proteins FT e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis FT oxidoreductase from Rhizobium etli plasmid pb (327 aa) FT (see citation below); AAG31046.1|AF264948_8|THIO putative FT amino acid oxidase flavoprotein ThiO from Erwinia FT amylovora (349 aa); FT NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE FT BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti FT (333 aa); etc." FT /product="POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE FT THIO" FT CDS 502167..502373 FT /function="POSSIBLY INVOLVED IN THIAMINE BIOSYNTHESIS." FT /gene="thiS" FT /locus_tag="Rv0416" FT /note="Rv0416, (MTCY22G10.13), len: 68 aa. Possible thiS FT protein, equivalent to FT T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 FT hypothetical protein from Mycobacterium leprae (74 aa), FT FASTA scores: opt: 303, E(): 2e-18, (71.6% identity in 74 FT aa overlap). Shows weak similarity with FT O32583|THIS_ECOLI|THIG1|B3991.1 THIS PROTEIN from FT Escherichia coli strain K12 (66 aa), FASTA scores: opt: FT 103, E(): 0.052, (30.9% identity in 68 aa overlap)." FT /product="POSSIBLE PROTEIN THIS" FT CDS 502366..503124 FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. Required for FT the synthesis of the thiazole moiety of thiamine." FT /gene="thiG" FT /locus_tag="Rv0417" FT /note="Rv0417, (MTCY22G10.14), len: 252 aa. Probable thiG, FT thiamin biosynthesis protein, equivalent to FT AL035159|MLCB1450_20|T44741|THIG probable thiamin FT biosynthesis protein from Mycobacterium leprae (261 aa), FT FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa FT overlap). Also highly similar to others e.g. FT SCOEDB|SC6E10.03|T35490|THIG probable thiazole FT biosynthesis protein from Streptomyces coelicolor (264 FT aa); F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG FT thiamin biosynthesis protein thiG from Xylella fastidiosa FT (275 aa); FT P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 FT THIG PROTEIN thiamin biosynthesis protein from Escherichia FT coli strain K-12 (281 aa); etc. BELONGS TO THE THIG FT FAMILY." FT /product="PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG FT (THIAZOLE BIOSYNTHESIS PROTEIN)" FT CDS 503496..504998 FT /EC_number="3.4.11.-" FT /function="UNKNOWN; HYDROLYZES PEPTIDES AND/OR PROTEINS." FT /gene="lpqL" FT /locus_tag="Rv0418" FT /note="Rv0418, (MTCCY22G10.15), len: 500 aa. Probable FT lpqL, lipoprotein aminopeptidase (EC 3.4.11.-), similar to FT others e.g. FT B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 FT probable aminopeptidase from Pseudomonas aeruginosa (536 FT aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC FT 3.4.11.-) from Streptomyces griseus (284 aa) (homology FT only with C-terminus of Rv0418); FT P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC FT 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /product="PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL" FT misc_feature 503538..503570 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 505086..506582 FT /EC_number="3.4.11.-" FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS." FT /gene="lpqM" FT /locus_tag="Rv0419" FT /note="Rv0419, (MTCY22G10.16), len: 498 aa. Possible lpqM, FT lipoprotein peptidase (EC 3.4.-.-); has potential FT N-terminal signal peptide and contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site, PS00142 FT Neutral zinc metallopeptidases, zinc-binding region FT signature." FT /product="POSSIBLE LIPOPROTEIN PEPTIDASE LPQM" FT misc_feature 505170..505202 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 505614..505643 FT /note="PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature" FT CDS complement(506561..506971) FT /function="UNKNOWN" FT /locus_tag="Rv0420c" FT /note="Rv0420c, (MTCY22G10.17c), len: 136 aa. Possible FT transmembrane protein; has potential transmembrane domains FT aa 53-99 and aa 100-122." FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT CDS complement(507132..507761) FT /function="UNKNOWN" FT /locus_tag="Rv0421c" FT /note="Rv0421c, (MTCY22G10.18c), len: 209 aa. Conserved FT hypothetical protein, showing similarity with FT NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical FT protein from Mesorhizobium loti (214 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(507758..508555) FT /EC_number="2.7.4.7" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. CATALYZES FT THE PHOSPHORYLATION OF HMP-P TO HMP-PP [CATALYTIC FT ACTIVITY: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine FT = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine]." FT /gene="thiD" FT /locus_tag="Rv0422c" FT /note="Rv0422c, (MTCY22G10.19c), len: 265 aa. Probable FT thiD, phosphomethylpyrimidine kinase (EC 2.7.4.7), FT equivalent to AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE FT KINASE from Mycobacterium leprae (279 aa), FASTA scores: FT opt: 1386, E(): 0, (77.8% identity in 266 aa overlap). FT Also highly similar to others e.g. FT HIU32725_3|P44697|THID_HAEIN PHOSPHOMETHYLPYRIMIDINE FT KINASE from Haemophilus influenzae (269 aa), FASTA scores: FT opt: 605, E(): 0, (42.1% identity in 259 aa overlap). FT BELONGS TO THE THID FAMILY." FT /product="PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID FT (HMP-PHOSPHATE KINASE) (HMP-P KINASE)" FT CDS complement(508582..510225) FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. REQUIRED FOR FT THE SYNTHESIS OF THE HYDROMETHYLPYRIMIDINE (HMP) MOIETY OF FT THIAMINE (4-AMINO-2-METHYL-5-HYDROXYMETHYLPYRIMIDINE)." FT /gene="thiC" FT /locus_tag="Rv0423c" FT /note="Rv0423c, (MTCY22G10.20c), len: 547 aa. Probable FT thiC, thiamin biosynthesis protein, equivalent to FT Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 FT THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae FT (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity FT in 547 aa overlap). Also highly similar to others e.g. FT P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from FT Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): FT 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI FT THIC PROTEIN from Escherichia coli strain K12 (631 aa), FT FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa FT overlap); etc. BELONGS TO THE THIC FAMILY." FT /product="PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC" FT CDS complement(510377..510652) FT /function="UNKNOWN" FT /locus_tag="Rv0424c" FT /note="Rv0424c, (MTCY22G10.21c), len: 91 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(510702..515321) FT /EC_number="3.6.1.-" FT /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY FT CATALYZES THE TRANSPORT OF UNDETERMINATED METAL CATION FT WITH HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE + FT UNDETERMINATED METAL CATION(OUT)]." FT /gene="ctpH" FT /locus_tag="Rv0425c" FT /note="Rv0425c, (MTCY22G10.22c), len: 1539 aa. Possible FT ctpH, metal cation-transporting P-type ATPase FT (transmembrane protein) (EC 3.6.1.-), showing some FT similarity with FT CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative FT cation-transporting ATPase from Mycobacterium leprae (1609 FT aa). Also similar to others ATPases e.g. AE000873_1 FT CATION-TRANSPORTING P-ATPASE from Methanobacterium FT thermoautotrop (844 aa), FASTA score: (30.5% identity in FT 827 aa overlap); AB69720.1|AL137166 putative transport FT ATPase from Streptomyces coelicolor (1472 aa); etc. FT C-terminal region similar to other ATPases from FT Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative FT cation-transporting ATPase C (855 aa), FASTA scores: opt: FT 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap)." FT /product="POSSIBLE METAL CATION TRANSPORTING P-TYPE ATPASE FT CTPH" FT CDS complement(515373..515816) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0426c" FT /note="Rv0426c, (MTCY22G10.23c), len: 147 aa. Possible FT transmembrane protein; has potential transmembrane domains FT aa 19-41, and aa 61-83." FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT CDS complement(516017..516892) FT /EC_number="3.1.11.2" FT /function="INVOLVED IN BASE EXCISION REPAIR. FT APURINIC-APYRIMIDINIC ENDONUCLEASE. SUPPOSED TO REMOVE THE FT DAMAGED DNA AT CYTOSINES AND GUANINES BY CLEAVING AT THE FT 3' SIDE OF THE AP SITE BY A BETA-ELIMINATION REACTION. FT POSSIBLY EXHIBITES 3'-5'-EXONUCLEASE, FT 3'-PHOSPHOMONOESTERASE, 3'-REPAIR DIESTERASE AND FT RIBONUCLEASE H ACTIVITIES [CATALYTIC ACTIVITY: Degradation FT of double-stranded DNA. It acts progressively in a 3'- to FT 5'-direction, releasing 5'-phosphomononucleotides]." FT /gene="xthA" FT /locus_tag="Rv0427c" FT /note="Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable FT xthA (alternate gene name: xth), exodeoxyribonuclease III FT protein (EC 3.1.11.2) (see citation below), similar to FT others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from FT Escherichia Coli strain K12 (268 aa), FASTA scores: opt: FT 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); FT etc. BELONGS TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES." FT /product="PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA FT (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)" FT /standard_name="xth" FT CDS complement(516895..517803) FT /function="UNKNOWN" FT /locus_tag="Rv0428c" FT /note="Rv0428c, (MTCY22G10.25c), len: 302 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(517803..518396) FT /EC_number="3.5.1.31" FT /function="REMOVES THE FORMYL GROUP FROM THE N-TERMINAL FT MET OF NEWLY SYNTHESIZED PROTEINS [CATALYTIC ACTIVITY: FT N-formyl-L-methionine + H2O = formate + L-methionine]." FT /gene="def" FT /locus_tag="Rv0429c" FT /note="Rv0429c, (MTCY22G10.26c), len: 197 aa. Probable FT def, polypeptide deformylase (EC 3.5.1.31), equivalent to FT CAC30884.1|AL583923 polypeptide deformylase from FT Mycobacterium leprae (197 aa). Also similar to others e.g. FT DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from FT Escherichia coli (169 aa), FASTA scores: opt: 179, E(): FT 1.8e-05, (34.6% identity in 162 aa overlap); etc. BELONGS FT TO THE POLYPEPTIDE DEFORMYLASE FAMILY. COFACTOR: BINDS 1 FT ZINC ION." FT /product="PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) FT (FORMYLMETHIONINE DEFORMYLASE)" FT CDS 518733..519041 FT /function="UNKNOWN" FT /locus_tag="Rv0430" FT /note="Rv0430, (MTCY22G10.27), len: 102 aa. Conserved FT hypothetical protein, equivalent to AC30882.1|AL583923 FT conserved hypothetical protein from Mycobacterium leprae FT (102 aa). Also highly similar to FT CAB93047.1|SCD95A.20|AL357432 hypothetical protein from FT Streptomyces coelicolor (84 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 519073..519567 FT /function="UNKNOWN." FT /locus_tag="Rv0431" FT /note="Rv0431, (MTCY22G10.28), len: 164 aa. Putative FT tuberculin related peptide; almost identical to FT D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis FT (172 aa), FASTA score: (99.4% identity in 163 aa overlap). FT Highly similar to to CAC30881.1|AL583923 tuberculin FT related peptide (AT103) from Mycobacterium leprae (167 FT aa). Some similarity to G550415|HRPC (282 aa), FASTA FT scores: opt: 120, E(): 0.36, (33.3% identity in 111 aa FT overlap). Potential transmembrane domain at aa 19-37." FT /product="PUTATIVE TUBERCULIN RELATED PEPTIDE" FT CDS 519600..520322 FT /EC_number="1.15.1.1" FT /function="DESTROYS RADICALS WHICH ARE NORMALLY PRODUCED FT WITHIN THE CELLS AND ARE TOXIC TO BIOLOGICAL SYSTEMS FT [CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2]." FT /gene="sodC" FT /locus_tag="Rv0432" FT /note="Rv0432, (MTCY22G10.29), len: 240 aa. Probable sodC, FT periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1), FT equivalent to CAC30880.1|AL583923 superoxide dismutase FT precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and FT AAK20038.1|AF326234_1 copper zinc superoxide dismutase FT from Mycobacterium avium subsp. paratuberculosis (226 aa). FT Also similar to others e.g. SODC_PHOLE|P00446 superoxide FT dismutase precursor (cu-zn) from Photobacterium leiognathi FT (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% FT identity in 181 aa overlap). Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site. BELONGS TO THE FT CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in FT periplasm, membrane-bound." FT /product="PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE FT [CU-ZN] SODC" FT misc_feature 519666..519698 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 520324..521454 FT /function="UNKNOWN" FT /locus_tag="Rv0433" FT /note="Rv0433, (MTCY22G10.30), len: 376 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD FT protein from Escherichia coli strain K12 (372 aa), FASTA FT scores: opt: 555, E(): 2e-30, (28.2% identity in 365 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 521514..522167 FT /function="UNKNOWN" FT /locus_tag="Rv0434" FT /note="Rv0434, (MTCY22G10.31), len: 217 aa. Conserved FT hypothetical protein, similar to AE002052_2 from FT Deinococcus radiodurans (213 aa), FASTA scores: opt: 258, FT E(): 4e-10, (31.9% identity in 213 aa overlap); FT SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from FT Synechocystis (214 aa), FASTA scores: opt: 156, E(): FT 0.00041, (28.4% identity in 204 aa overlap); FT MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 FT from Myxococcus xanthus (826 aa), FASTA scores: opt: 160, FT E(): 0.00068, (28.4% identity in 197 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(522347..524533) FT /EC_number="3.6.1.-" FT /function="ATPASE; POSSIBLY CATALYZES THE TRANSPORT OF FT UNDETERMINATED SUBSTRATE WITH HYDROLYSE OF ATP [CATALYTIC FT ACTIVITY: ATP + H(2)O + UNDETERMINATED SUBSTRATE(IN) = ADP FT + PHOSPHATE + UNDETERMINATED SUBSTRATE(OUT)]." FT /locus_tag="Rv0435c" FT /note="Rv0435c, (MTCY22G10.32c), len: 728 aa. Putative FT conserved ATPase (EC 3.6.1.-), similar to others e.g. FT SAV_SULAC|Q07590 sav protein involved in cell division FT from sulfolobus acidocaldarius (780 aa), FASTA scores: FT opt: 897, E(): 0, (34.5% identity in 693 aa overlap); FT NP_148637.1|7435761|B72479 transitional endoplasmic FT reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also FT similar to Rv3610c and Rv2115c from Mycobacterium FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop), and PS00674 AAA-protein family signature." FT /product="PUTATIVE CONSERVED ATPASE" FT misc_feature complement(522674..522730) FT /note="PS00674 AAA-protein family signature" FT misc_feature complement(522998..523021) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(524530..525390) FT /EC_number="2.7.8.8" FT /function="INVOLVED IN PHOSPHOLIPID BIOSYNTHESIS. FT GENERATES PHOSPHATIDYLSERINE [CATALYTIC ACTIVITY: FT CDP-diacylglycerol + L-serine = CMP + FT O-Sn-phosphatidyl-L-serine]." FT /gene="pssA" FT /locus_tag="Rv0436c" FT /note="Rv0436c, (MTCY22G10.33c), len: 286 aa. Probable FT pssA, PS synthase (CDP-diacylglycerol--serine FT O-phosphatidyltransferase) (EC 2.7.8.8) (see citation FT below), integral membrane protein, equivalent to FT AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 FT aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in FT 285 aa overlap). Also highly similar to others e.g. FT NP_108059.1|14027250|BAB54204.1|AP003012 FT phosphatidylserine synthase from Mesorhizobium loti (248 FT aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine FT o-phosphatidyltransferase from Bacillus subtilis (177 aa), FT FASTA scores: opt: 277, E(): 9.9e-12, (33.3% identity in FT 183 aa overlap); etc. Contains PS00379 CDP-alcohol FT phosphatidyltransferases signature. BELONGS TO THE FT CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY." FT /product="PROBABLE CDP-DIACYLGLYCEROL--SERINE FT O-PHOSPHATIDYLTRANSFERASE PSSA (PS SYNTHASE) FT (PHOSPHATIDYLSERINE SYNTHASE)" FT misc_feature complement(525154..525222) FT /note="PS00379 CDP-alcohol phosphatidyltransferases FT signature" FT CDS complement(525387..526082) FT /EC_number="4.1.1.65" FT /function="UNKNOWN, BUT INVOLVED IN LIPID METABOLISM FT [CATALYTIC ACTIVITY: PHOSPHATIDYL-L-SERINE = FT PHOSPHATIDYLETHANOLAMINE + CO(2)]." FT /gene="psd" FT /locus_tag="Rv0437c" FT /note="Rv0437c, (MTV037.01c), len: 231 aa (start FT uncertain). Possible psd, phosphatidylserine decarboxylase FT (EC 4.1.1.65), equivalent to CAC29819.1|AL583918 conserved FT hypothetical protein from Mycobacterium leprae (243 aa); FT and highly similar to FT MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 FT hypothetical protein from Mycobacterium leprae (202 aa), FT FASTA score: (74.6% identity in 197 aa overlap). Also FT similar to other phosphatidylserine decarboxylases e.g. FT NP_108058.1|14027249|BAB54203.1|AP003012 FT phosphatidylserine decarboxylase from Mesorhizobium loti FT (232 aa); AAK86872|g15156090|AGR_C_1963 phosphatidylserine FT decarboxylase from Agrobacterium tumefaciens (244 aa); FT AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase FT from Chlorobium tepidum (216 aa); etc. TBparse score is FT 0.890." FT /product="POSSIBLE PHOSPHATIDYLSERINE DECARBOXYLASE PSD FT (PS DECARBOXYLASE)" FT CDS complement(526143..527360) FT /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS: FT INVOLVED IN THE BIOSYNTHESIS OF A DEMOLYBDO-COFACTOR FT (MOLYBDOPTERIN), NECESSARY FOR MOLYBDO-ENZYMES (BY FT SIMILARITY)." FT /gene="moeA2" FT /locus_tag="Rv0438c" FT /note="Rv0438c, (MTV037.02c), len: 405 aa. Probable moeA2, FT molybdenum cofactor biosynthesis protein, highly similar FT to many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 FT aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in FT 398 aa overlap); etc. Also similar to FT MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN FT BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 FT aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity FT in 425 aa overlap). TBparse score is 0.889. Note that FT previously known as moeA3." FT /product="PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN FT MOEA2" FT /standard_name="moeA3" FT CDS complement(527379..528314) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0439c" FT /note="Rv0439c, (MTV037.03c), len: 311 aa. Probable FT dehydrogenase/reductase (EC 1.-.-.-), equivalent to FT AL035159|MLCB1450_6|T44727 probable oxidoreductase from FT Mycobacterium leprae (304 aa), FASTA scores: opt: 1360, FT E(): 0, (69.2% identity in 302 aa overlap). Also highly FT similar to various oxidoreductases, generally FT dehydrogenases/reductases e.g. FT PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 FT probable short chain dehydrogenase from Pseudomonas FT aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE FT OXIDOREDUCTASE from Streptomyces antibioticus (298 aa), FT FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in FT 298 aa overlap); etc. TBparse score is 0.903." FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT CDS 528608..530230 FT /evidence=experimental FT /function="PREVENTS MISFOLDING AND PROMOTES THE REFOLDING FT AND PROPER ASSEMBLY OF UNFOLDED POLYPEPTIDES GENERATED FT UNDER STRESS CONDITIONS." FT /gene="groEL2" FT /locus_tag="Rv0440" FT /note="Rv0440, (MTV037.04), len: 539 aa. groEL2 (alternate FT gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa FT chaperonin 2 (see Shinnick 1987). PURIFIED 65 kDa ANTIGEN FT CAN ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION FT IN EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. FT THIS PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS FT OF THE MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT FT ARE COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains FT PS00296 Chaperonins cpn60 signature. BELONGS TO THE FT CHAPERONIN (HSP60) FAMILY. TBparse score is 0.847." FT /product="60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) FT (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) FT (CELL WALL PROTEIN A) (ANTIGEN A)" FT /standard_name="groL2; groEL-2; hsp65; hsp60" FT misc_feature 529814..529849 FT /note="PS00296 Chaperonins cpn60 signature" FT CDS complement(530296..530724) FT /function="UNKNOWN" FT /locus_tag="Rv0441c" FT /note="Rv0441c, (MTV037.05c), len: 142 aa. Hypothetical FT unknown protein. TBparse score is 0.897." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(530751..532214) FT /function="UNKNOWN" FT /gene="PPE10" FT /locus_tag="Rv0442c" FT /note="Rv0442c, (MTV037.06c), len: 487 aa. Member of the FT Mycobacterium tuberculosis PPE family, nearly identical to FT hypothetical protein from Mycobacterium tuberculosis FT (strain Erdman) and to AN5S46909_1 protein fragment from FT Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU FT HYPOTHETICAL 50.6 kDa PROTEIN (517 aa), FASTA scores: opt: FT 3144, E(): 0, (98.4 identity in 492 aa overlap); and FT S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0, FT (98.0% identity in 302 aa overlap). TBparse score is FT 0.903." FT /product="PPE FAMILY PROTEIN" FT CDS 532396..532911 FT /function="UNKNOWN" FT /locus_tag="Rv0443" FT /note="Rv0443, (MTV037.07), len: 171 aa. Conserved FT hypothetical protein, highly similar to FT AL049863|SC5H1_23|T35339 hypothetical protein from FT Streptomyces coelicolor (171 aa), FASTA scores: opt: 561, FT E(): 2.3e-32, (49.7% identity in 165 aa overlap); and FT CAC42482.1|AJ318385 hypothetical protein from FT Amycolatopsis mediterranei (163 aa). TBparse score is FT 0.915." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(533091..533789) FT /function="UNKNOWN" FT /locus_tag="Rv0444c" FT /note="Rv0444c, (MTV037.08c), len: 232 aa. Conserved FT hypothetical protein; C-terminus similar to FT P12752|Y24K_STRGR HYPOTHETICAL 24.7 kDa PROTEIN from FT Streptomyces griseus (238 aa), FASTA scores: opt: 207, FT E(): 2.2e-05, (32.9% identity in 158 aa overlap). TBparse FT score is 0.914." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(533833..534396) FT /function="INVOLVED IN TRANSCRIPTION MECHANISM. THE SIGMA FT FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF FT THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN FT IS RELEASED." FT /gene="sigK" FT /locus_tag="Rv0445c" FT /note="Rv0445c, (MTV037.09c), len: 187 aa. Probable sigK, FT alternative RNA polymerase sigma factor (see citations FT below), highly similar to others e.g. FT 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase FT sigma factor from Streptomyces coelicolor (185 aa); FT NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase FT sigma factor from Mesorhizobium loti (179 aa); FT 1654108|AAB17906.1|U11283|A58883 probable transcription FT initiation factor sigma E from Rhodobacter phaeroides (168 FT aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity FT in 168 aa overlap); Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FT FACTOR SIGW from Bacillus subtilis (187 aa), FASTA scores: FT opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa FT overlap); etc. TBparse score is 0.900." FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGK" FT CDS complement(534445..535215) FT /function="UNKNOWN" FT /locus_tag="Rv0446c" FT /note="Rv0446c, (MTV037.10c), len: 256 aa. Possible FT conserved transmembrane protein, similar at N-terminus to FT U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 FT aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity FT in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 FT from Streptomyces coelicolor (226 aa), FASTA scores: opt: FT 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). FT Also similar to others hypothetical proteins e.g. FT AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from FT Lactococcus lactis subsp. lactis (257 aa). TBparse score FT is 0.920." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(535224..536507) FT /EC_number="2.1.1.79" FT /function="TRANSFERS A METHYLENE GROUP FROM FT S-ADENOSYL-L-METHIONINE TO THE CIS DOUBLE BOND OF AN FT UNSATURATED FATTY ACID CHAIN RESULTING IN THE REPLACEMENT FT OF THE DOUBLE BOND WITH A METHYLENE BRIDGE [CATALYTIC FT ACTIVITY: S-adenosyl-L-methionine + phospholipid olefinic FT fatty acid = S-adenosyl-L-homocysteine + phospholipid FT cyclopropane fatty acid]." FT /gene="ufaA1" FT /locus_tag="Rv0447c" FT /note="Rv0447c, (MTV037.11c), len: 427 aa (start FT uncertain). Probable ufaA1, FT cyclopropane-fatty-acyl-phospholipid synthase (EC FT 2.1.1.79), similar to others e.g. FT NP_102178.1|14021351|BAB47964.1|AP002994 FT cyclopropane-fatty-acyl-phospholipid synthase from FT Mesorhizobium loti (378 aa); FT B82240|9655593|AAF94281.1|AE004192 FT cyclopropane-fatty-acyl-phospholipid synthase from Vibrio FT cholerae (432 aa); P30010|CFA_ECOLI FT CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from FT Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 FT LPD-3 from P.putida (394 aa), FASTA scores: opt: 556, E(): FT 2.8e-30, (33.3% identity in 387 aa overlap); FT AE0005|HPAE000557_9 from Helicobacter pylori (389 aa), FT FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in FT 382 aa overlap). TBparse score is 0.919." FT /product="PROBABLE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID FT SYNTHASE UFAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA FT SYNTHASE)" FT CDS complement(536504..537169) FT /function="UNKNOWN" FT /locus_tag="Rv0448c" FT /note="Rv0448c, (MTV037.12c), len: 221 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa), FT FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity in FT 197 aa overlap); etc. Some similarity to FT U15183|MLU15183_38 from Mycobacterium leprae (82 aa), FT FASTA scores: opt: 134, E(): 0.014, (71.0% identity in 31 FT aa overlap). TBparse score is 0.934." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(537229..538548) FT /function="UNKNOWN" FT /locus_tag="Rv0449c" FT /note="Rv0449c, (MTV037.13c), len: 439 aa. Conserved FT hypothetical protein, some similarity with several FT hypothetical proteins and various enzymes e.g. FT AAK24569.1|AE005927 amine oxidase, flavin-containing from FT Caulobacter crescentus (454 aa); BAB02771.1|AB023036 FT mycolic acid methyl transferase-like protein from FT Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein FT which contains similarity to cyclopropane fatty acid FT synthase from Arabidopsis thaliana (793 aa); etc. Has FT hydrophobic stretch at N-terminus. TBparse score is FT 0.903." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(538588..541491) FT /evidence=experimental FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /gene="mmpL4" FT /locus_tag="Rv0450c" FT /note="Rv0450c, (MTV037.14c), len: 967 aa. Probable mmpL4, FT conserved transmembrane transport protein (see citations FT below), member of RND superfamily, equivalent to FT U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN FT from Mycobacterium leprae (959 aa), FASTA scores: opt: FT 5051, E(): 0, (78.4% identity in 962 aa overlap). Also FT highly similar to other proteins from Mycobacterium FT tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: FT opt: 3917, E(): 0, (61.3% identity in 950 aa overlap), FT MTCY20G9.34, etc. Contains PS00211 ABC transporters family FT signature. BELONGS TO THE MMPL FAMILY. TBparse score is FT 0.948." FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL4" FT misc_feature complement(540445..540489) FT /note="PS00211 ABC transporters family signature" FT CDS complement(541488..541910) FT /evidence=experimental FT /function="UNKNOWN." FT /gene="mmpS4" FT /locus_tag="Rv0451c" FT /note="Rv0451c, (MTV037.15c), len: 140 aa. Probable mmpS4, FT conserved membrane protein (see citations below), FT equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 FT kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA FT scores: opt: 727, E(): 0, (75.9% identity in 137 aa FT overlap). Also similar to other Mycobacterial proteins FT e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis FT (142 aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% FT identity in 138 aa overlap); etc. BELONGS TO THE MMPS FT FAMILY. TBparse score is 0.953." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4" FT CDS 542142..542852 FT /evidence=experimental FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0452" FT /note="Rv0452, (MTV037.16), len: 236 aa. Possible FT transcriptional regulator, similar to several putative FT TetR-family transcriptional regulators from Streptomyces FT coelicolor. Also similar in N-terminus to FT U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 FT aa), FASTA score: (76.1% identity in 67 aa overlap). FT Contains probable helix-turn-helix motif at aa 44-65 FT (Score 1727, +5.07 SD). TBparse score is 0.914." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 543174..544730 FT /function="UNKNOWN" FT /gene="PPE11" FT /locus_tag="Rv0453" FT /note="Rv0453, (MTV037.17), len: 518 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to many FT e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 FT aa), FASTA scores: opt: 882, E(): 7e-31, (41.8% identity FT in 514 aa overlap). TBparse score is 0.922." FT /product="PPE FAMILY PROTEIN" FT CDS 544835..545185 FT /function="UNKNOWN" FT /locus_tag="Rv0454" FT /note="Rv0454, (MTV037.18), len: 116 aa (start uncertain). FT Conserved hypothetical protein, showing similarity with FT AAA63007.1|U15183 hypothetical protein from Mycobacterium FT leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019, FT (31.5% identity in 89 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(545375..545821) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0455c" FT /note="Rv0455c, (MTV037.19c), len: 148 aa. Conserved FT hypothetical protein, equivalent to CAC31896.1|AL583925 FT possible secreted protein from Mycobacterium leprae (153 FT aa). Has hydrophobic stretch at N-terminus. TBparse score FT is 0.947." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(545889..546803) FT /EC_number="4.2.1.17" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + FT H(2)O]." FT /gene="echA2" FT /locus_tag="Rv0456c" FT /note="Rv0456c, (MTCI429A.02, MTV037.20c), len 304 aa. FT Probable echA2, enoyl-CoA hydratase (EC 4.2.1.17), similar FT to other enoyl-CoA hydratases e.g. Q13011 PEROXISOMAL FT ENOYL-CoA HYDRATASE-LIKE PROTEIN (328 aa), FASTA scores: FT opt: 209, E(): 5.3e-07, (31.7% identity in 142 aa FT overlap). Also similar to several other proteins from FT Mycobacterium tuberculosis e.g. MTCY09F9.29 FASTA score: FT (32.9% identity in 146 aa overlap); and MTI376.01c." FT /product="ENOYL-CoA HYDRATASE ECHA2 (ENOYL HYDRASE) FT (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT CDS complement(547076..547357) FT /function="UNKNOWN" FT /locus_tag="Rv0456A" FT /note="Rv0456A, len: 93 aa. Conserved hypothetical FT protein; N-terminus highly similar to N-terminal part of FT P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA FT scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa FT overlap). Also some similarity in part with other FT hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid FT maintenance protein from Xylella fastidiosa (108 aa), FT FASTA scores: opt: 169, E(): 3.9e-05, (50.820% identity in FT 61 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_unit complement(547488..547517) FT /note="3 copies of a 10 bp near-perfect direct repeat, FT ATTACTACCTATTACTACGTATTACTATCT" FT CDS complement(547586..549607) FT /EC_number="3.4.-.-" FT /function="UNKNOWN; HYDROLYZES PEPTIDES AND/OR PROTEINS." FT /locus_tag="Rv0457c" FT /note="Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. FT Probable peptidase (EC 3.4.-.-), similar to many e.g. FT NP_102851.1|14022026|BAB48637.1 probable endopeptidase FT from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 FT probable peptidase (EC 3.4.21.-) (726 aa), FASTA scores: FT opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). FT Also similar to Mycobacterium tuberculosis protein FT MTCY369.26 FASTA score: (33.8% identity in 299 aa FT overlap)." FT /product="PROBABLE PEPTIDASE" FT CDS 549675..551198 FT /EC_number="1.2.1.3" FT /function="INTERCONVERSION ALDEHYDE AND ACID [CATALYTIC FT ACTIVITY: An aldehyde + NAD+ + H2O = an acid + NADH]." FT /locus_tag="Rv0458" FT /note="Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde FT dehydrogenase (EC 1.2.1.3), highly similar to many, FT closest to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE FT DEHYDROGENASE from Rhodococcus erythropolis (506 aa), FT FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa FT overlap); AAC13641.1|AF029733 chloroacetaldehyde FT dehydrogenase from Xanthobacter autotrophicus (505 aa), FT FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa FT overlap); Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE FT DEHYDROGENASE from Streptomyces coelicolor (507 aa). Also FT similar to other semialdehyde dehydrogenases in FT Mycobacterium tuberculosis e.g. Rv0768, Rv2858c. BELONGS FT TO THE ALDEHYDE DEHYDROGENASES FAMILY. TBparse score is FT 0.866." FT /product="PROBABLE ALDEHYDE DEHYDROGENASE" FT CDS 551198..551689 FT /function="UNKNOWN" FT /locus_tag="Rv0459" FT /note="Rv0459, (MTV038.03), len: 163 aa. Conserved FT hypothetical protein, highly similar to other hypothetical FT proteins. Note that highly similar to products of FT unidentified ORFs in Xanthobacter autotrophicus, FT AF029733_2 (139 aa), and Rhodococcus erythropolis, REREUTP FT BC_1 (186 aa). Like MTV038.03, these ORF's are linked to FT aldehyde dehydrogenase genes. FASTA scores: FT AF0297|AF029733_2 (139 aa), opt: 439, E(): 6.2e-24, (50.0% FT identity in 126 aa overlap); and L24492|REREUTPBC_1 (186 FT aa), opt: 347, E(): 2.1e-17, (52.7% identity in 169 aa FT overlap). N-terminus also highly similar to FT AAA63041.1|U15183 ethanolamine permease (eutP) match from FT Mycobacterium leprae (53 aa). TBparse score is 0.894." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 551749..551988 FT /function="UNKNOWN" FT /locus_tag="Rv0460" FT /note="Rv0460, (MTV038.04), len: 79 aa. Conserved FT hydrophobic protein, highly similar AAA63024.1|U15183 FT hypothetical protein from Mycobacterium leprae (56 aa), FT FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity in FT 47 aa overlap). TBparse score is 0.896." FT /product="CONSERVED HYDROPHOBIC PROTEIN" FT CDS 552026..552550 FT /function="UNKNOWN" FT /locus_tag="Rv0461" FT /note="Rv0461, (MTV038.05), len: 174 aa (start uncertain). FT Probable transmembrane protein. TBparse score is 0.917." FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT CDS 552614..554008 FT /EC_number="1.8.1.4" FT /evidence=experimental FT /function="INVOLVED IN ENERGY METABOLISM. LIPOAMIDE FT DEHYDROGENASE IS A COMPONENT OF THE ALPHA-KETOACID FT DEHYDROGENASE COMPLEXE [CATALYTIC ACTIVITY: FT DIHYDROLIPOAMIDE + NAD(+) = LIPOAMIDE + NADH]." FT /gene="lpd" FT /locus_tag="Rv0462" FT /note="Rv0462, (MTV038.06), len: 464 aa. lpd (alternate FT gene name: TB49.2), dihydrolipoamide dehydrogenase (EC FT 1.8.1.4) (see Argyrou & Blanchard 2001), equivalent to FT AAA63016.1|U15183 lipoamide dehydrogenase from FT Mycobacterium leprae (467 aa), FASTA scores: opt: 2583, FT E(): 0, (83.1% identity in 467 aa overlap). Also similar FT to to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1 FT DIHYDROLIPOAMIDE DEHYDROGENASE from Z.mobilis (466 aa), FT FASTA scores: opt: 1198, E(): 0, (42.4 % identity in 465 FT aa overlap); etc. BELONG TO THE PYRIDINE FT NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. TBparse FT score is 0.897." FT /product="DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE FT REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL FT DEHYDROGENASE) (DIAPHORASE)" FT /standard_name="TB49.2" FT CDS 554016..554309 FT /function="UNKNOWN" FT /locus_tag="Rv0463" FT /note="Rv0463, (MTV038.07), len: 97 aa. Probable conserved FT transmembrane protein, highly similar to AAA63017.1|U15183 FT hypothetical protein from Mycobacterium leprae (101 aa), FT FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 FT aa overlap). TBparse score is 0.893." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS complement(554313..554885) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0464c" FT /note="Rv0464c, (MTV038.08c), len: 190 aa. Conserved FT hypothetical protein, highly similar to FT CAC31982.1|AL583925 conserved hypothetical protein from FT Mycobacterium leprae (188 aa). Also some similarity with FT Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from FT Mycobacterium tuberculosis (188 aa), FASTA scores: E(): FT 9.6e-10, (30.9% identity in 175 aa overlap). TBparse score FT is 0.925." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(554882..556306) FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0465c" FT /note="Rv0465c, (MTV038.09c), len: 474 aa. Probable FT transcriptional regulator, highly similar to FT AC44331.1|AL596102 putative DNA-binding protein from FT Streptomyces coelicolor (489 aa); and similar to several FT hypothetical proteins and others transcriptional FT regulators. Some similarity in N-terminal region (1-100 FT aa) with repressors e.g. P06153|RPC_BPPH1 IMMUNITY FT REPRESSOR PROTEIN (144 aa), FASTA scores: opt: 130, E(): FT 0.084,(27.0% identity in 100 aa overlap). Very similar to FT Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium FT tuberculosis (486 aa), FASTA scores: opt: 1475, E(): 0, FT (47.4% identity in 468 aa overlap). Contains probable FT helix-turn-helix motif at aa 19-40 (1827, +5.41 SD). FT TBparse score is 0.896." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 556458..557252 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0466" FT /note="Rv0466, (MTV038.10), len: 264 aa. Conserved FT hypothetical protein, equivalent to CAC31980.1|AL583925 FT conserved hypothetical protein from Mycobacterium leprae FT (264 aa). Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL FT 28.7 KDA PROTEIN from Mycobacterium tuberculosis (250 aa), FT FASTA scores: opt: 592, E(): 0, (38.0% identity in 263 aa FT overlap). Some similarity to several THIOESTERASES e.g. FT Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER FT from A. thaliana (362 aa), FASTA scores: E(): 0.0092, FT (24.4% identity in 197 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 557527..558813 FT /EC_number="4.1.3.1" FT /evidence=experimental FT /function="INVOLVED IN GLYOXYLATE BYPASS (AT THE FIRST FT STEP), AN ALTERNATIVE TO THE TRICARBOXYLIC ACID CYCLE (IN FT BACTERIA, PLANTS, AND FUNGI) [CATALYTIC ACTIVITY: FT ISOCITRATE = SUCCINATE + GLYOXYLATE]. INVOLVED IN THE FT PERSISTENCE IN THE HOST." FT /gene="icl" FT /locus_tag="Rv0467" FT /note="Rv0467, (MTV038.11), len: 428 aa. icl (previously FT known as aceA), isocitrate lyase (EC 4.1.3.1) (see FT citations below), highly similar to many, closest to FT Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: FT opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). FT BELONGS TO THE ISOCITRATE LYASE FAMILY. TBparse score is FT 0.860." FT /product="ISOCITRATE LYASE ICL (ISOCITRASE) FT (ISOCITRATASE)" FT /standard_name="aceA" FT CDS 558895..559755 FT /EC_number="1.1.1.157" FT /evidence=experimental FT /function="BUTYRATE/BUTANOL-PRODUCING PATHWAY [CATALYTIC FT ACTIVITY: (S)-3-hydroxybutanoyl-CoA + NADP+ = FT 3-acetoacetyl-CoA + NADPH]" FT /gene="fadB2" FT /locus_tag="Rv0468" FT /note="Rv0468, (MTV038.12), len: 286 aa. Probable fadB2, FT 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), FT equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA FT dehydrogenase from Mycobacterium leprae (287 aa). Also FT similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. FT U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A FT dehydrogenase from Bradyrhizobium japonicum (293 aa), FT FASTA scores: opt: 771, E(): 0, (45.7% identity in 282 aa FT overlap). BELONGS TO THE 3-HYDROXYACYL-CoA DEHYDROGENASE FT FAMILY. TBparse score is 0.894." FT /product="PROBABLE 3-HYDROXYBUTYRYL-CoA DEHYDROGENASE FT FADB2 (BETA-HYDROXYBUTYRYL-CoA DEHYDROGENASE) (BHBD)" FT CDS 559888..560748 FT /EC_number="2.-.-.-" FT /function="Involved in mycolic acid modification or FT synthesis." FT /gene="umaA" FT /locus_tag="Rv0469" FT /note="Rv0469, (MTV038.13), len: 286 aa. Possible umaA, FT mycolic acid synthase (EC 2.-.-.-) (see citations below), FT highly similar to CAC30854.1|AL583923 methyl mycolic acid FT synthase 1 from Mycobacterium leprae (286 aa); and FT CAC31976.1|AL583925 Mycolic acid synthase from FT Mycobacterium leprae (295 aa), FASTA scores: opt: 1402, FT E(): 0, (69.6% identity in 286 aa overlap). Also very FT similar to mycobacterial methyltransferases e.g. FT U77466|CmaD|MBU77466_1 (286 aa); FT MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar FT to CFA1_MYCTU|Q11195|U66108|MTU66108_1 FT cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa), FT FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa FT overlap) (see citation below); and very similar also to FT methoxy mycolic acid synthase 1 from Mycobacterium FT tuberculosis e.g. MTU66108_1 (286 aa). TBparse score is FT 0.944. Note that previously known as umaA1." FT /product="POSSIBLE MYCOLIC ACID SYNTHASE UMAA" FT /standard_name="umaA1" FT CDS complement(560848..561711) FT /EC_number="2.-.-.-" FT /evidence=experimental FT /function="INVOLVED IN THE MYCOLIC ACID MODIFICATION OR FT SYNTHESIS; ESSENTIAL FOR THE CYCLOPROPANATION FUNCTION. FT REQUIRED FOR CORDING AND MYCOLIC ACID CYCLOPROPANE RING FT SYNTHESIS IN THE CELL WALL." FT /gene="pcaA" FT /locus_tag="Rv0470c" FT /note="Rv0470c, (MTV038.14), len: 287 aa. pcaA (previously FT known as umaA2), mycolic acid synthase (cyclopropane FT synthase) (EC 2.-.-.-) (see citations below), equivalent FT to CAC31976.1|AL583925 Mycolic acid synthase from FT Mycobacterium leprae (295 aa); and highly similar to FT S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical FT protein from Mycobacterium leprae (308 aa); FT Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID FT SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) FT (see Glickman et al., 2000); U27357|MTU27357_1 FT cyclopropane mycolic acid synthase from Mycobacterium FT tuberculosis (287 aa), FASTA scores: opt: 1415, E(): 0, FT (72.8% identity in 287 aa overlap); and related enzymes FT e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA FT scores: opt: 1387, E(): 0, (72.5% identity in 287 aa FT overlap). TBparse score is 0.893." FT /product="MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE FT SYNTHASE)" FT /standard_name="umaA2" FT CDS complement(561854..562294) FT /function="UNKNOWN" FT /locus_tag="Rv0470A" FT /note="Rv0470A, len: 146 aa. Hypothetical unknown protein. FT GC plot suggests CDS for Cys-rich protein, could possibly FT be continuation of Rv0471c but no frameshift found to FT allow this. Sequence same in Mycobacterium bovis and FT Mycobacterium tuberculosis strain CDC1551. Weak hits to FT Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for FT NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: FT 132, E(): 1.1, (39.35% identity in 61 aa overlap)." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(562225..562713) FT /function="UNKNOWN" FT /locus_tag="Rv0471c" FT /note="Rv0471c, (MTV038.15c), len: 162 aa. Hypothetical FT unknown protein. TBparse score is 0.937." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(562723..563427) FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0472c" FT /note="Rv0472c, (MTV038.16c), len: 234 aa. Probable FT regulatory protein, possibly tetR family, equivalent to FT CAC31974.1|AL583925 possible TetR-family transcriptional FT regulator from Mycobacterium leprae (233 aa). Also similar FT to CAC01492.1|AL391017 putative transcriptional regulatory FT protein from Streptomyces coelicolor (218 aa); and FT CAC01371.1|AL390975 putative tetR-family transcriptional FT regulator from Streptomyces coelicolor (228 aa). Also FT similar to AL0212|MTV012_65 from Mycobacterium FT tuberculosis (246 aa), FASTA scores: opt: 327, E(): FT 1.8e-15, (31.0% identity in 232 aa overlap); and FT Z95120|MTCY07D11.18c (228 aa), FASTA scores: opt: 190, FT E(): 4.4e-06, (23.1% identity in 186 aa overlap). Contains FT probable helix-turn-helix doimain at aa 45-66 (Score 1429, FT +4.05 SD). TBparse score is 0.898." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT CDS 563564..564934 FT /function="UNKNOWN" FT /locus_tag="Rv0473" FT /note="Rv0473, (MTV038.17), len: 456 aa. Possible FT conserved transmembrane protein, showing some similarity FT to hypothetical proteins e.g. FT NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical FT protein from Mesorhizobium loti (431 aa); FT P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 kDa PROTEIN FT (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia FT coli strain K12 (426 aa), FASTA scores: opt: 396, E(): FT 9.8e-19, (31.8 % identity in 424 aa overlap); etc. TBparse FT score is 0.899." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 565021..565443 FT /evidence=experimental FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0474" FT /note="Rv0474, (MTV038.18), len: 140 aa. Probable FT transcriptional regulator, highly similar to others e.g. FT CAC04034.1|AL391406 putative DNA-binding protein from FT Streptomyces coelicolor (141 aa); N-terminus of FT NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional FT regulator from Mesorhizobium loti (219 aa); N-terminus of FT A83618|PA0225 probable transcription regulator from FT Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr FT protein from Bacillus subtilis (111 aa), FASTA scores: FT opt: 147, E(): 8.9e-06, (30.6% identity in 111 aa FT overlap). Also similar to other hypothetical proteins e.g. FT X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa), FT FASTA scores: opt: 280, E(): 4.8e-12, (43.6% identity in FT 117 aa overlap). Also similar to Rv2745c from FT Mycobacterium tuberculosis. Contains probable FT helix-turn-helix domain at aa 35-56 (Score 1709, +5.01 FT SD). TBparse score is 0.903." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 565797..566396 FT /evidence=experimental FT /function="REQUIRED FOR EXTRAPULMONARY DISSEMINATION. FT MEDIATES ADHERENCE TO EPITHELIAL CELLS BY BINDING TO FT SULFATED GLYCOCONJUGATES PRESENT AT THE SURFACE OF THESE FT CELLS; BINDS HEPARIN, DEXTRAN SULFATE, FUCOIDAN AND FT CHONDROITIN SULFATE. PROMOTES HEMAGGLUTINATION OF FT ERYTHROCYTES OF CERTAIN HOST SPECIES. INDUCES FT MYCOBACTERIAL AGGREGATION." FT /gene="hbhA" FT /locus_tag="Rv0475" FT /note="Rv0475, hbhA (MTCY20G9.01), len: 199 aa. hbhA, FT iron-regulated heparin-binding hemagglutinin (see FT citations below), equivalent to CAC31971.1|AL583925 FT possible hemagglutinin from Mycobacterium leprae (188 aa). FT Contains possible N-terminal signal sequence and K-A-rich FT region at C-terminus: SUBCELLULAR LOCATION: SURFACE FT ASSOCIATED." FT /product="IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ FT HBHA (ADHESIN)" FT CDS 566508..566771 FT /function="UNKNOWN" FT /locus_tag="Rv0476" FT /note="Rv0476, (MTCY20G9.02), len: 87 aa. Possible FT conserved transmembrane protein, equivalent to FT CAC31970.1|AL583925 conserved membrane protein from FT Mycobacterium leprae (95 aa). Also highly similar to FT CAC04036.1|AL391406 putative membrane protein from FT Streptomyces coelicolor (113 aa). Contains PS00606 FT Beta-ketoacyl synthases active site." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT misc_feature 566676..566726 FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS 566776..567222 FT /function="UNKNOWN" FT /locus_tag="Rv0477" FT /note="Rv0477, (MTCY20G9.03), len: 148 aa. Possible FT conserved secreted protein, equivalent to FT CAC31969.1|AL583925 hypothetical protein from FT Mycobacterium leprae (123 aa). Also similar to FT G83406|PA1914 conserved hypothetical protein from FT Pseudomonas aeruginosa (408 aa). Contains possible FT N-terminal signal sequence." FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT CDS 567222..567896 FT /EC_number="4.1.2.4" FT /function="INVOLVED IN NUCLEOTIDE AND DEOXYRIBONUCLEOTIDE FT CATABOLISM [CATALYTIC ACTIVITY: 2-deoxy-D-ribose FT 5-phosphate = D-glyceraldehyde 3-phosphate + FT acetaldehyde]." FT /gene="deoC" FT /locus_tag="Rv0478" FT /note="Rv0478, (MTCY20G9.04), len: 224 aa. Probable deoC, FT deoxyribose-phosphate aldolase (EC 4.1.2.4), equivalent to FT Q9CB45|DEOC_MYCLE DEOXYRIBOSE-PHOSPHATE ALDOLASE from FT Mycobacterium leprae (226 aa). Also highly similar to FT others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214 FT aa), FASTA scores: opt: 543, E(): 1.4e-26, (45.9% identity FT in 209 aa overlap); etc. BELONGS TO THE DEOC/FBAB FAMILY FT OF ALDOLASES, DEOC SUBFAMILY." FT /product="PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC FT (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE)" FT CDS complement(567921..568967) FT /function="UNKNOWN" FT /locus_tag="Rv0479c" FT /note="Rv0479c, (MTCY20G9.04c), len: 348 aa. Probable FT conserved membrane protein, equivalent to FT CAC31967.1|AL583925 possible secreted protein from FT Mycobacterium leprae (254 aa); and C-terminus highly FT similar to AAF74996.1|AF143402_1|AF143402 putative FT multicopper oxidase from Mycobacterium avium (149 aa). FT Contains hydrophobic domain in centre of protein." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS complement(568964..569806) FT /EC_number="3.-.-.-" FT /function="UNKNOWN; HYDROLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM." FT /locus_tag="Rv0480c" FT /note="Rv0480c, (MTCY20G9.06c), len: 280 aa. Possible FT amidohydrolase (EC 3.-.-.-), highly similar to FT NP_302587.1|NC_002677|CAC31966.1|AL583925 putative FT hydrolase from Mycobacterium leprae (271 aa). Also similar FT to other hydrolases and hypothetical proteins e.g. FT NP_601985.1|NC_003450 Predicted amidohydrolase from FT Corynebacterium glutamicum (266 aa); NP_459623.1|NC_003197 FT putative hydrolase from Salmonella typhimurium LT2 (262 FT aa); AL096822|SCGD3_8|NP_627996.1|NC_003888 probable FT hydrolase from Streptomyces coelicolor (264 aa), FASTA FT scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa FT overlap); YAUB_SCHPO|Q10166 hypothetical 35.7 kDa protein FT c26a3.11 from S. pombe (322 aa), FASTA scores: opt: 338, FT E():1.4e-13, (30.3% identity in 277 aa overlap); etc. FT Start changed since first submission (-60 aa)." FT /product="POSSIBLE AMIDOHYDROLASE" FT CDS complement(569988..570512) FT /function="UNKNOWN" FT /locus_tag="Rv0481c" FT /note="Rv0481c, (MTCY20G9.07c), len: 174 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 570539..571648 FT /EC_number="1.1.1.158" FT /function="INVOLVED IN CELL WALL FORMATION; PEPTIDOGLYCAN FT BIOSYNTHESIS [CATALYTIC ACTIVITY: UDP-N-acetylmuramate + FT NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + FT NADPH]." FT /gene="murB" FT /locus_tag="Rv0482" FT /note="Rv0482, (MTCY20G9.08), len: 369 aa. Probable murB, FT UDP-N-acetylenolpyruvoylglucosamine reductase (EC FT 1.1.1.158) (see citation below), equivalent to FT CAC31964.1|AL583925 UDP-N-acetylenolpyruvoylglucosamine FT reductase from Mycobacterium leprae (367 aa). Also highly FT similar to others e.g. MURB_ECOLI|P08373 FT UDP-N-acetylenolpyruvoylglucosamine reductase from FT Escherichia coli (342 aa), FASTA scores: opt: 292, E(): FT 6.3e-12, (33.5% identity in 355 aa overlap); etc. BELONGS FT TO THE MURB FAMILY. COFACTOR: FAD." FT /product="PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE FT REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE)" FT CDS 571710..573065 FT /function="UNKNOWN" FT /gene="lprQ" FT /locus_tag="Rv0483" FT /note="Rv0483, (MTCY20G9.09), len: 451 aa. Probable lprQ, FT conserved lipoprotein, equivalent to FT CAC31963.1|AL583925|ML2446 possible lipoprotein from FT Mycobacterium leprae (441 aa); appears longer than ML2446, FT so start may be further downstream. Shows also similarity FT with MLCL383_24|O07707 HYPOTHETICAL 43.6 kDa PROTEIN from FT Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). FT Similar to others lipoproteins from other organisms. Also FT similar to several Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains FT potential N-terminal signal sequence and appropriately FT positioned PS00013 prokaryotic membrane lipoprotein lipid FT attachment site." FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRQ" FT CDS complement(573046..573801) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0484c" FT /note="Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable FT short-chain oxidoreductase (EC 1.-.-.-), highly similar to FT others e.g. T36118|4678912|CAB41284.1|AL049707 probable FT oxidoreductase from Streptomyces coelicolor (260 aa); FT YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR FT family) from Haemophilus influenzae (252 aa), FASTA FT scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa FT overlap); etc. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY, FT TO BACTERIAL YDFG HOMOLOGS." FT /product="PROBABLE SHORT-CHAIN TYPE OXIDOREDUCTASE" FT CDS 573984..575300 FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0485" FT /note="Rv0485, (MTCY20G9.11), len: 438 aa. Possible FT transcriptional repressor, member of the NAGC/XYLR FT repressor FAMILY; similar to several e.g. FT D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor FT from Vibrio cholerae (404 aa), FASTA scores: opt: 378, FT E(): 1.2e-17, (26.9% identity in 350 aa overlap); FT NAGC_ECOLI|P15301 N-acetylglucosamine repressor from FT Escherichia coli (406 aa), FASTA scores: opt: 305, E(): FT 1.8e-12, (21.8% identity in 357 aa overlap); etc." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 575348..576790 FT /EC_number="2.4.1.-" FT /function="THOUGHT TO BE INVOLVED IN POLYPRENOLMANNOSE FT SYNTHESIS." FT /locus_tag="Rv0486" FT /note="Rv0486, (MTCY20G9.12), len: 480 aa. FT Mannosyltransferase (EC 2.4.1.-) (see citations below), FT highly similar to P54138|Y486_MYCLE|ML2443 possible FT glycosyl transferase from Mycobacterium leprae (428 aa); FT and S72892|B2168_C2_201 probable hexosyltransferase (EC FT 2.4.1.-) from Mycobacterium leprae (409 aa), FASTA scores: FT opt: 2375, E(): 0, (86.4% identity in 413 aa overlap). FT Also highly similar to CAC04040.1|AL391406 putative FT transferase from Streptomyces coelicolor (496 aa); and FT similar to various transferases e.g. NP_437172.1|NC_003078 FT putative membrane-anchored glycosyltransferase protein FT from Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS FT BIOSYNTHESIS RELATED PROTEIN from Methanococcus jannaschii FT (411 aa), FASTA score: (25.3% identity in 387 aa overlap); FT etc. Also similar to CAC87824.1|AJ316594 putative FT sucrose-phosphate synthase from Nostoc punctiforme (422 FT aa). Contains PS00039 DEAD-box subfamily ATP-dependent FT helicases signature." FT /product="MANNOSYLTRANSFERASE" FT misc_feature 575963..575989 FT /note="PS00039 DEAD-box subfamily ATP-dependent helicases FT signature" FT CDS 576787..577338 FT /function="UNKNOWN" FT /locus_tag="Rv0487" FT /note="Rv0487, (MTCY20G9.13), len: 183 aa. Conserved FT hypothetical protein, highly similar to FT P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA FT PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: FT opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa FT overlap). Also highly similar to CAC04041.1|AL391406 FT conserved hypothetical protein from Streptomyces FT coelicolor (168 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 577664..578269 FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF FT LYSINE ACROSS THE MEMBRANE." FT /locus_tag="Rv0488" FT /note="Rv0488, (MTCY20G9.14), len: 201 aa. Probable FT conserved integral membrane protein, LysE family possibly FT involved in transport of Lysine, similar to others and FT conserved hypothetical proteins e.g. AB93746.1|AL357613 FT putative membrane transport protein from Streptomyces FT coelicolor (204 aa); D83100|PA4365 probable transporter FT from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 FT hypothetical 21.7 kDa protein from Escherichia coli (197 FT aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity FT in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER FT PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% FT identity in 219 aa overlap). Also similar to Rv1986 from FT Mycobacterium tuberculosis." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 578426..579175 FT /EC_number="5.4.2.1" FT /function="INVOLVED IN GLYCOLYSIS [CATALYTIC ACTIVITY: FT 1,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE = FT 2,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE]." FT /gene="gpm1" FT /locus_tag="Rv0489" FT /note="Rv0489, (MTCY20G9.15), len: 249 aa. Probable gpm1, FT phosphoglycerate mutase 1 (EC 5.4.2.1), equivalent to FT P53531|PMGY_MYCLE PHOSPHOGLYCERATE MUTASE from FT Mycobacterium leprae (247 aa). Also highly similar to FT others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt: FT 805, E(): 0, (51.4% identity in 245 aa overlap); etc. FT Contains PS00175 Phosphoglycerate mutase family FT phosphohistidine signature, and PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE PHOSPHOGLYCERATE FT MUTASE FAMILY. Note that previously known as gpm." FT /product="PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 FT (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)" FT /standard_name="gpm" FT misc_feature 578450..578479 FT /note="PS00175 Phosphoglycerate mutase family FT phosphohistidine signature" FT misc_feature 578933..578956 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 579349..580581 FT /EC_number="2.7.3.-" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM. PROBABLY FORMS PART OF A TWO-COMPONENT REGULATORY FT SYSTEM SENX3/REGX3; PHOSPHORYLATES REGX3." FT /gene="senX3" FT /locus_tag="Rv0490" FT /note="Rv0490, (MTCY20G9.16), len: 410 aa. Putative senX3, FT two-component sensor histidine kinase (EC 2.7.3.-), FT transmembrane protein (see citations below), equivalent to FT O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from FT Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0, FT (99.5% identity in 410 aa overlap); and highly similar to FT P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from FT Mycobacterium leprae (443 aa), FASTA score: (83.8% FT identity in 408 aa overlap). Also highly similar, except FT in N-terminus, to CAC31957.1|AL583925 probable FT two-component system sensor histidine kinase from FT Mycobacterium leprae (441 aa). Also highly similar to FT sensor kinase proteins from other organisms e.g. FT CAB77323.1|AL160331 putative sensor kinase protein from FT Streptomyces coelicolor (426 aa)." FT /product="PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE FT SENX3" FT repeat_unit 580578..580654 FT /note="77 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See citation below." FT repeat_unit 580655..580731 FT /note="77 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See citation below." FT repeat_unit 580732..580808 FT /note="77 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See citation below." FT CDS 580809..581492 FT /function="TRANSCRIPTIONAL REGULATORY PROTEIN PART OF THE FT TWO COMPONENT REGULATORY SYSTEM REGX3/SENX3." FT /gene="regX3" FT /locus_tag="Rv0491" FT /note="Rv0491, (MTCY20G9.17), len: 227 aa. regX3, response FT regulator protein (sensory transduction protein) (see FT citations below), equivalent to O07130|RGX3_MYCBO|REGX3 FT SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG FT (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response FT regulator from Mycobacterium smegmatis (228 aa); FT equivalent to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION FT PROTEIN from Mycobacterium leprae (198 aa), FASTA scores : FT E(): 0, (95.4% identity in 197 aa overlap). Also highly FT similar to other response regulators e.g. FT AAG43239.1|AF123314_2 |AF123314 putative response FT regulator from Corynebacterium glutamicum (232 aa)." FT /product="TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 FT (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY FT LUXR-FAMILY)" FT CDS complement(581489..583378) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0492c" FT /note="Rv0492c, (MT0511/MT0512, MTCY20G9.18c), len: 629 FT aa. Probable oxidoreductase GMC type (EC 1.-.-.-), similar FT to others except in N-terminus e.g. FT P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL GMC-TYPE FT OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA scores: FT opt: 873, E():0, (34.3% identity in 502 aa overlap); FT YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kDa GMC-TYPE FT OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FT FASTA score: (25.7% identity in 521 aa overlap); FT YTH2_RHOSO|P46371 hypothetical 53.0 kDa gmc-type FT oxidoreductase from Rhodococcus erythropolis (493 aa), FT FASTA score: (25.7% identity in 521 aa overlap); FT NP_085596.1|NC_002679 probable oxidoreductase from FT Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC FT oxidoreductase from Deinococcus radiodurans (722 aa); FT NP_249055.1|NC_002516 probable oxidoreductase from FT Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 FT 4Fe-4S ferredoxins, iron-sulfur binding region signature, FT and PS00624 GMC oxidoreductases signature 2. BELONGS TO FT THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY FT SIMILARITY). Note that start changed since first FT submission (previously 684 aa)." FT /product="PROBABLE OXIDOREDUCTASE GMC-TYPE" FT misc_feature complement(582197..582241) FT /note="PS00624 GMC oxidoreductases signature 2" FT misc_feature complement(582428..582463) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding FT region signature" FT CDS complement(583375..583704) FT /function="UNKNOWN" FT /locus_tag="Rv0492A" FT /note="Rv0492A, len: 109 aa. Hypothetical unknown protein. FT GC plot suggests CDS." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(583701..584690) FT /function="UNKNOWN" FT /locus_tag="Rv0493c" FT /note="Rv0493c, (MTCY20G9.19), len: 329 aa. Conserved FT hypothetical protein, showing some similarity to FT U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FT FASTA scores: opt: 166, E(): 0.00077, (35.9% identity in FT 131 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 584695..585423 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0494" FT /note="Rv0494, (MTCY20G9.20), len: 242 aa. Probable FT transcriptional regulator, GntR family, with C-terminal FT part highly similar to S72893|B2168_C2_205 hypothetical FT protein from Mycobacterium leprae (105 aa). Also similar FT to other transcription regulators e.g. PDHR_ECOLI|P06957 FT pyruvate dehydrogenase complex repressor PDHR or GENA from FT Escherichia coli (254 aa), FASTA scores: opt: 284, E(): FT 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains FT PS00043 Bacterial regulatory proteins, gntR family FT signature, and probable helix-turn helix motif from aa FT 50-71 (Score 1229, +3.37 SD)." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT misc_feature 584827..584892 FT /note="PS00043 Bacterial regulatory proteins, gntR family FT signature" FT CDS complement(585424..586314) FT /function="UNKNOWN" FT /locus_tag="Rv0495c" FT /note="Rv0495c, (MTCY20G9.21c), len: 296 aa. Conserved FT hypothetical protein, highly similar to S72915|B2168_F1_37 FT hypothetical protein from Mycobacterium leprae (323 aa), FT FASTA scores: opt: 1615, E(): 0, (82.7% identity in 271 aa FT overlap); and FT P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 FT conserved hypothetical protein from Mycobacterium leprae FT (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 FT aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 586394..587380 FT /function="UNKNOWN" FT /locus_tag="Rv0496" FT /note="Rv0496, (MTCY20G9.22), len: 328 aa. Conserved FT hypothetical protein, highly similar to FT S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC FT 3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA FT scores: opt: 1902, E(): 0, (86.6% identity in 343 aa FT overlap); and FT P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 FT HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae FT (339 aa). Also highly similar to hypothetical proteins and FT exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 FT aa). C-terminal region similar to CGU31224_1|Q46054 FT protein similar to ppx gene product of Mycobacterium FT leprae from Cornybacterium glutamicum (140 aa), FASTA FT scores: opt: 615, E(): 2.7e-33, (70.9% identity in 134 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 587377..588309 FT /function="UNKNOWN" FT /locus_tag="Rv0497" FT /note="Rv0497, (MTCY20G9.23), len: 310 aa. Probable FT conserved transmembrane protein, equivalent (but shorter FT in C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL FT 37.9 KDA PROTEIN from Mycobacterium leprae (355 aa). FT N-terminus highly similar to S72922|B2168_C1_166|467074 FT hypothetical protein from Mycobacterium leprae (118 aa), FT FASTA scores: opt: 350, E(): 1.4e-12, (57.9% identity in FT 114 aa overlap); and hydrophobic C-terminus, highly FT similar to S72895|B2168_C2_209|467047 hypothetical protein FT from Mycobacterium leprae (241 aa), FASTA scores: opt: FT 473, E(): 8e-19, (53.9% identity in 241 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 588325..589167 FT /function="UNKNOWN" FT /locus_tag="Rv0498" FT /note="Rv0498, (MTCY20G9.24), len: 280 aa. Conserved FT hypothetical protein, highly similar to FT P54581|Y498_MYCLE|ML2432 HYPOTHETICAL 30.5 KDA PROTEIN FT from Mycobacterium leprae (280 aa); and FT S72896|B2168_C2_210 hypothetical protein from FT Mycobacterium leprae (244 aa), FASTA scores: opt: 1486, FT E():0, (89.3% identity in 244 aa overlap). Also similar to FT Q9X8H0|Y714_STRCO|SCE7.14c HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 589183..590058 FT /function="UNKNOWN" FT /locus_tag="Rv0499" FT /note="Rv0499, (MTCY20G9.25), len: 291 aa. Conserved FT hypothetical protein, showing some similarity to FT AL031184|SC2A11_16|T34762 hypothetical protein from FT Streptomyces coelicolor (340 aa), FASTA scores: opt: 240, FT E(): 1.8e-07, (28.9% identity in 270 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 590083..590970 FT /EC_number="1.5.1.2" FT /function="INVOLVED AT THE TERMINAL (THIRD) STEP IN FT PROLINE BIOSYNTHESIS [CATALYTIC ACTIVITY: L-proline + FT NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H]." FT /gene="proC" FT /locus_tag="Rv0500" FT /note="Rv0500, (MTCY20G9.26), len: 295 aa. Probable proC, FT Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (see FT citation below), equivalent to P46725|PROC_MYCLE FT PYRROLINE-5-CARBOXYLATE REDUCTASE from Mycobacterium FT leprae (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4% FT identity in 295 aa overlap). Also similar to others e.g. FT P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE from FT Corynebacterium glutamicum (270 aa); FT T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate FT reductase from Streptomyces coelicolor (284 aa); etc. FT BELONGS TO THE PYRROLINE-5-CARBOXYLATE REDUCTASE FAMILY." FT /product="PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC FT (P5CR) (P5C REDUCTASE)" FT CDS 591111..591347 FT /function="UNKNOWN" FT /locus_tag="Rv0500A" FT /note="Rv0500A, len: 78 aa. Conserved hypothetical FT protein, similar to proteins from Mycobacterium leprae and FT Streptomyces coelicolor e.g. U00018_25 from Mycobacterium FT leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): FT 1.3e-27, (82.6% identity in 86 aa overlap); FT AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 FT (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 FT identity in 54 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 591475..591576 FT /function="UNKNOWN" FT /locus_tag="Rv0500B" FT /note="Rv0500B, len: 33 aa. Conserved hypothetical FT protein. Basic protein 18 of the 33 aa are Arg or Lys, FT with strong similarity to AL079345|SCE68_25 protein from FT Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores: FT opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap). FT Same gene arrangement in both actinomycetes." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 591654..592784 FT /EC_number="5.1.3.2" FT /function="INVOLVED IN GALACTOSE METABOLISM [CATALYTIC FT ACTIVITY: UDP-GLUCOSE = UDP-GALACTOSE]." FT /gene="galE2" FT /locus_tag="Rv0501" FT /note="Rv0501, (MTCY20G9.28), len: 376 aa. Possible galE2, FT UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar FT (except in N-terminus) to CAC31944.1|AL583925 possible FT glucose epimerase/dehydratase from Mycobacterium leprae FT (364 aa). N-terminus highly similar to FT S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical FT protein from Mycobacterium leprae (180 aa), FASTA scores: FT opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and FT C-terminus highly similar to FT S72898|467050|AAA17234.1|U00018 hypothetical protein from FT Mycobacterium leprae (168 aa), FASTA scores: opt: 928, FT E(): 0, (82.7% identity in 168 aa overlap). Also highly FT similar to T36274|5123671|CAB45360.1|AL079345 probable FT epimerase from Streptomyces coelicolor (353 aa); and FT similar in part to other epimerases e.g. GALE_ECOLI|P09147 FT UDP-glucose 4-epimerase from Escherichia coli (338 aa), FT FASTA scores: opt: 241, E(): 6.7e-09, (28.2% identity in FT 294 aa overlap); etc. BELONGS TO THE SUGAR EPIMERASE FT FAMILY. COFACTOR: NAD. Note that previously known as FT galE1." FT /product="POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 FT (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHO-GALACTOSE 4-EPIMERASE)" FT /standard_name="galE1" FT CDS 592791..593867 FT /function="UNKNOWN" FT /locus_tag="Rv0502" FT /note="Rv0502, (MTCY20G9.29), len: 358 aa. Conserved FT hypothetical protein, equivalent to FT P54878|Y502_MYCLE|ML2427 HYPOTHETICAL 40.5 KDA PROTEIN FT from Mycobacterium leprae (367 aa), FASTA scores: opt: FT 2042, E(): 0, (84.1% identity in 365 aa overlap). Also FT similar to T36273|SCE68.23c hypothetical protein from FT Streptomyces coelicolor (355 aa). C-terminal similar to FT AL021529|SC10A5_4|T34572 hypothetical protein from FT Streptomyces coelicolor (295 aa), FASTA score: (57.8% FT identity in 263 aa overlap); and to hypothetical proteins FT from Mycobacterium tuberculosis Rv1920|G70808 (287 aa); FT and Rv1428c|G70914 (275 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(593871..594779) FT /EC_number="2.1.1.79" FT /evidence=experimental FT /function="ESSENTIAL FOR THE CYCLOPROPANATION FUNCTION. FT TRANSFERS A METHYLENE GROUP FROM S-ADENOSYL-L-METHIONINE FT TO THE CIS DOUBLE BOND OF AN UNSATURATED FATTY ACID CHAIN FT RESULTING IN THE REPLACEMENT OF THE DOUBLE BOND WITH A FT METHYLENE BRIDGE. MYCOLIC ACIDS, WHICH REPRESENT THE MAJOR FT CONSTITUENT OF MYCOBACTERIAL CELL WALL COMPLEX, ACT AS FT SUBSTRATES [CATALYTIC ACTIVITY: S-adenosyl-L-methionine + FT phospholipid olefinic fatty acid = FT S-adenosyl-L-homocysteine + phospholipid cyclopropane FT fatty acid]." FT /gene="cmaA2" FT /locus_tag="Rv0503c" FT /note="Rv0503c, (MTCY20G9.30c), len: 302 aa. cmaA2 FT (alternate gene name: cma2), FT cyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic FT acid trans-cyclopropane synthetase) (EC 2.1.1.79) (see FT citations below). Note that this protein has 302 aa and FT not 322 aa: we have chosen a different initiation codon on FT the basis of homology). Equivalent to S72886|B2168_F3_130 FT hypothetical protein from Mycobacterium leprae (308 aa), FT FASTA score: (78.9% identity in 303 aa overlap); and FT highly similar to other proteins from Mycobacterium FT leprae. Also similar to other proteins from Mycobacterium FT tuberculosis and Mycobacterium bovis BCG e.g. FT MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID FT SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in FT 297 aa overlap)." FT /product="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 FT CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) FT (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID FT TRANS-CYCLOPROPANE SYNTHETASE)" FT /standard_name="cma2" FT CDS complement(594802..595302) FT /function="UNKNOWN" FT /locus_tag="Rv0504c" FT /note="Rv0504c, (MTCY20G9.31c), len: 166 aa. Conserved FT hypothetical protein, equivalent to FT P54879|Y504_MYCLE|ML2425 HYPOTHETICAL 18.7 KDA PROTEIN FT from Mycobacterium leprae (166 aa), FASTA scores: opt: FT 884, E(): 0, (83.1% identity in 166 aa overlap); and FT highly similar to other proteins from Mycobacterium FT leprae. Also highly similar to FT CAB77410.1|AL160431|SCD82.07 hypothetical protein from FT Streptomyces coelicolor (150 aa). Also similar to M. FT tuberculosis hypothetical proteins Rv0635|H70612 (158 aa); FT and Rv0637|B70613 (166 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(595464..596585) FT /EC_number="3.1.3.3" FT /function="REMOVES A PHOSPHATE FROM PHOSPHOSERINE FT [CATALYTIC ACTIVITY: Phosphoserine + H2O = serine + FT phosphate]." FT /gene="serB1" FT /locus_tag="Rv0505c" FT /note="Rv0505c, (MTCY20G9.32c), len: 373 aa. Possible FT serB1, phosphoserine phosphatase (EC 3.1.3.3), equivalent FT (but longer ~70 aa in N-terminus) to S72914|serB FT phosphoserine phosphatase from Mycobacterium leprae (300 FT aa), FASTA scores: opt: 1570, E(): 0, (83.0% identity in FT 306 aa overlap). C-terminus highly similar to FT CAB55344.1|AJ010584 phosphoserine phosphatase from FT Streptomyces coelicolor (266 aa). Low similarity to FT SERB_ECOLI|P06862 phosphoserine phosphatase from FT Escherichia coli strains K12 and O157:H7 (322 aa), FASTA FT scores: opt: 148, E(): 0.043, (24.0% identity in 150 aa FT overlap). C-terminus is also similar to FT O33611|AB004855_1|IMD_STRCN PROTEIN INVOLVED IN INHIBITION FT OF MORPHOLOGICAL DIFFERENTIATION from Streptomyces cyaneus FT (277 aa), FASTA score: (37.7% identity in 252 aa overlap). FT SEEMS TO BELONG TO THE SERB FAMILY. Note that previously FT known as serB." FT /product="POSSIBLE PHOSPHOSERINE PHOSPHATASE SERB1 (PSP) FT (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE)" FT /standard_name="serB" FT CDS 596759..597202 FT /function="UNKNOWN." FT /gene="mmpS2" FT /locus_tag="Rv0506" FT /note="Rv0506, (MTCY20G9.33), len: 147 aa. Probable mmpS2, FT conserved membrane protein (see citation below), highly FT similar to other Mycobacterial proteins e.g. C-terminus of FT AAD44232.1|AF143772_38|AF143772|TmtpA from Mycobacterium FT avium (221 aa); P54880|MMS4_MYCLE|MMPS4 PUTATIVE MEMBRANE FT PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: FT opt: 392, E(): 1.3e-20, (43.7% identity in 151 aa FT overlap); and the PUTATIVE MEMBRANE PROTEINS from FT Mycobacterium tuberculosis MTV040_5, MTCY4D9_16, FT MTV037_15. BELONGS TO THE MMPS FAMILY." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS2" FT CDS 597199..600105 FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /gene="mmpL2" FT /locus_tag="Rv0507" FT /note="Rv0507, (MTCY20G9.34), len: 968 aa. Probable mmpL2, FT conserved transmembrane transport protein (see citations FT below), member of RND superfamily, highly similar to other FT Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium FT leprae (959 aa), FASTA scores: opt: 3699, E(): 0, (58.3% FT identity in 940 aa overlap); and the Mycobacterium FT tuberculosis proteins MTV037_14, MTV040_4, MTCY98_8, FT MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also FT similar to STMACTII_3|SC10A5_9 from Streptomyces FT coelicolor; and BSUB0|004_12 from Bacillus subtilis. FT C-terminal half similar to Q50086|U1740AB from FT Mycobacterium leprae (386 aa), FASTA scores: opt: 1526, FT E(): 0, (61.5% identity in 371 aa overlap). BELONGS TO THE FT MMPL FAMILY." FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL2" FT CDS 600098..600391 FT /function="UNKNOWN" FT /locus_tag="Rv0508" FT /note="Rv0508, (MTCY20G9.35), len: 97 aa. Conserved FT hypothetical protein, showing similarity with FT T36269|5123666|CAB45355.1|AL079345 probable redoxin from FT Streptomyces coelicolor (101 aa), FASTA scores: opt: 160, FT E(): 3.4e-05, (33.3% identity in 75 aa overlap); and FT E81943|NMA0966 probable thioredoxin from Neisseria FT meningitidis group A strain Z2491 (77 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 600441..601847 FT /EC_number="1.2.1.-" FT /function="INVOLVED IN PORPHYRIN BIOSYNTHESIS BY THE C5 FT PATHWAY (AT THE FIRST STEP) [CATALYTIC ACTIVITY: FT GLUTAMYL-TRNA(GLU) + NADPH = GLUTAMATE-1-SEMIALDEHYDE + FT NADP+ + TRNA(GLU)]." FT /gene="hemA" FT /locus_tag="Rv0509" FT /note="Rv0509, (MTCY20G9.36), len: 468 aa. Probable hemA, FT glutamyl-tRNA reductase (EC 1.2.1.-), equivalent to FT HEM1_MYCLE|P46724 GLUTAMYL-TRNA REDUCTASE from FT Mycobacterium leprae (467 aa), FASTA scores: opt: 2377, FT E(): 0, (82.3% identity in 463 aa overlap). Also highly FT similar (sometimes in part) to others e.g. FT Q9WX15|HEM1_STRCO GLUTAMYL-TRNA REDUCTASE from FT Streptomyces coelicolor (581 aa); P16618|HEM1_BACSU|HEMA FT GLUTAMYL-TRNA REDUCTASE from Bacillus subtilis (455 aa); FT etc. Contains PS00747 Glutamyl-tRNA reductase signature. FT BELONGS TO THE GLUTAMYL-TRNA REDUCTASE FAMILY." FT /product="PROBABLE GLUTAMYL-TRNA REDUCTASE HEMA (GLUTR)" FT misc_feature 600735..600806 FT /note="PS00747 Glutamyl-tRNA reductase signature" FT CDS 601857..602786 FT /EC_number="4.3.1.8" FT /function="INVOLVED IN PORPHYRIN BIOSYNTHESIS BY THE C5 FT PATHWAY (AT THE FOURTH STEP). TETRAPOLYMERIZATION OF THE FT MONOPYRROLE PBG INTO THE HYDROXYMETHYLBILANE FT PREUROPORPHYRINOGEN IN SEVERAL DISCRETE STEPS [CATALYTIC FT ACTIVITY: 4 porphobilinogen + H2O = hydroxymethylbilane + FT 4 NH3]." FT /gene="hemC" FT /locus_tag="Rv0510" FT /note="Rv0510, (MTCY21C8.01-MTCY20G9.37), len: 309 aa. FT Probable hemC, hydroxymethylbilane synthase FT (porphobilinogen deaminase) (EC 4.3.1.8), equivalent to FT HEM3B|Q49808|HEM3_MYCLE PORPHOBILINOGEN DEAMINASE from FT Mycobacterium leprae (315 aa), FASTA scores: opt: 889, FT E(): 0, (88.1% identity in 159 aa overlap). Also highly FT similar to others e.g. Q9WX16|HE31_STRCO PROBABLE FT PORPHOBILINOGEN DEAMINASE from Streptomyces coelicolor FT (319 aa); Q9L6Q2|HEM3_SALTY PORPHOBILINOGEN DEAMINASE from FT Salmonella typhimurium (313 aa); etc. BELONGS TO THE HMBS FT FAMILY. COFACTOR: COVALENTLY BINDS A DIPYRROMETHANE FT COFACTOR TO WHICH THE PORPHOBILINOGEN SUBUNITS ARE ADDED." FT /product="PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) FT (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) FT (PRE-UROPORPHYRINOGEN SYNTHASE)" FT CDS 602819..604516 FT /EC_number="2.1.1.107" FT /function="Possibly involved in the biosynthesis of FT siroheme and cobalamin [CATALYTIC ACTIVITY: 2 FT S-adenosyl-L-methionine + uroporphyrin III = 2 FT S-adenosyl-L-homocysteine + sirohydrochlorin]." FT /gene="hemD" FT /locus_tag="Rv0511" FT /note="Rv0511, (MTCY21C8.02), len: 565 aa. Probable hemD FT (alternate gene name: cysG), uroporphyrin-III FT C-methyltransferase (EC 2.1.1.107), highly similar to FT others e.g. CAC31936.1|AL583925 possible uroporphyrin-III FT C-methyltransferase from Mycobacterium leprae (563 aa); FT and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA FT scores: opt: 1946, E(): 0, (83.3% identity in 472 aa FT overlap); T36265|5123662|CAB45351.1|AL079345 probable FT uroporphyrin-III C-methyltransferase from Streptomyces FT coelicolor (565 aa); and similar to others e.g. FT AAK00606.1|AF221100_3|AF221100 from Selenomonas FT ruminantium subsp. ruminantium (505 aa); etc. Also similar FT to Rv2071c and Rv2847c from Mycobacterium tuberculosis. FT Note that previously known as cysG." FT /product="PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE FT HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III FT METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM)" FT /standard_name="cysG" FT CDS 604602..605591 FT /EC_number="4.2.1.24" FT /function="INVOLVED IN PORPHYRIN AND HEME BIOSYNTHESIS (AT FT THE SECOND STEP) [CATALYTIC ACTIVITY: 2 5-aminolevulinate FT = porphobilinogen + 2 H2O]." FT /gene="hemB" FT /locus_tag="Rv0512" FT /note="Rv0512, (MTCY20G10.02),len: 329 aa. Probable hemB, FT delta-aminolevulinic acid dehydratase (EC 4.2.1.24), FT equivalent to 46723|HEM2_MYCLE DELTA-AMINOLEVULINIC ACID FT DEHYDRATASE from Mycobacterium leprae (329 aa). Also FT highly similar to many e.g. P54919|HEM2_STRCO from FT Streptomyces coelicolor (330 aa); HEM2_ECOLI|P15002 from FT Escherichia coli (323 aa), FASTA scores: opt: 942, E(): 0, FT (47.6% identity in 317 aa overlap); etc. Contains PS00169 FT Delta-aminolevulinic acid dehydratase active site. BELONGS FT TO THE ALADH FAMILY. COFACTOR: ZINC." FT /product="PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE FT HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)" FT misc_feature 605340..605378 FT /note="PS00169 Delta-aminolevulinic acid dehydratase FT active site" FT CDS 605604..606152 FT /function="UNKNOWN" FT /locus_tag="Rv0513" FT /note="Rv0513, (MTCY20G10.03), len: 182 aa. Possible FT conserved transmembrane protein, with its N-terminus FT highly similar to S72925|B2168_C1_182 hypothetical protein FT from Mycobacterium leprae (103 aa), FASTA scores: opt: FT 217, E(): 8.2e-14, (45.3 % identity in 106 aa overlap)." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 606149..606448 FT /function="UNKNOWN" FT /locus_tag="Rv0514" FT /note="Rv0514, (MTCY20G10.04), len: 99 aa. Possible FT transmembrane protein." FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT CDS 606551..608062 FT /evidence=experimental FT /function="UNKNOWN. THOUGHT TO BE REGULATED BY FT Rv2720|LEXA." FT /locus_tag="Rv0515" FT /note="Rv0515, (MTCY20G10.05), len: 503 aa. Part of M. FT tuberculosis 13E12 repeat family. Almost identical to FT Rv0336 (99.8% identity in 503 aa overlap), possibly due to FT a recent gene duplication. Also similar to other M. FT tuberculosis hypothetical 13E12 repeat proteins e.g. FT Rv1148c, Rv1945, etc." FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT CDS complement(608059..608535) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0516c" FT /note="Rv0516c, (MTCY20G10.06c), len: 158 aa. Conserved FT hypothetical protein, showing some similarity to FT Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 FT aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 608746..610056 FT /EC_number="2.3.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0517" FT /note="Rv0517, (MTCY20G10.07), len: 436 aa. Possible FT acyltransferase (EC 2.3.1.-), integral membrane protein, FT equivalent (but longer 26 aa in N-terminus) to FT AAK44761.1|AE006954 putative acyltransferase from FT Mycobacterium tuberculosis strain CDC1551 (410 aa). Also FT similar to many acyltransferases e.g. MDMB_STRMY|Q00718 FT from Streptomyces mycarofaciens (387 aa), FASTA scores: FT opt: 200, E(): 1.1e-08, (28.2% identity in 394 aa FT overlap). And similar to Rv0111, Rv0228, Rv1254, Rv1565c FT from Mycobacterium tuberculosis." FT /product="POSSIBLE MEMBRANE ACYLTRANSFERASE" FT CDS 610188..610883 FT /function="UNKNOWN" FT /locus_tag="Rv0518" FT /note="Rv0518, (MTCY20G10.08), len: 231 aa. Possible FT exported protein; has hydrophobic N-terminus." FT /product="POSSIBLE EXPORTED PROTEIN" FT CDS complement(611172..612074) FT /function="UNKNOWN; COULD HAVE POSSIBLY A LIPOLYTIC FT ACTIVITY." FT /locus_tag="Rv0519c" FT /note="Rv0519c, (MTCY20G10.09c), len: 300 aa. Possible FT conserved membrane protein, with hydrophobic region near FT N-terminus. Could be a lipase (EC 3.1.-.-). Similar to FT Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis FT (312 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity FT in 299 aa overlap). Contains PS00120 Lipases, serine FT active site." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT misc_feature complement(611508..611537) FT /note="PS00120 Lipases, serine active site" FT CDS 612255..612605 FT /EC_number="2.1.1.-" FT /function="COULD CAUSE METHYLATION." FT /locus_tag="Rv0520" FT /note="Rv0520, (MTCY20G10.10), len: 116 aa. Possible FT fragment of methyltransferase (possibly first part) (EC FT 2.1.1.-), highly similar to part of several FT methyltransferases e.g. Q43445|U43683 FT S-ADENOSYL-L-METHIONINE:DELTA24-STEROL-C-METHYLTRANSFERAS FT E from Glycine max (Soybean)(367 aa), FASTA scores: opt: FT 190, E(): 2.3e-12, (39.2% identity in 74 aa overlap). Also FT some similarity to MTCY19G5_5 from Mycobacterium FT tuberculosis. Possibly continues as Rv0521 but we can find FT no frameshift to account for this." FT /product="POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT)" FT CDS 612598..612903 FT /EC_number="2.1.1.-" FT /function="COULD CAUSE METHYLATION" FT /locus_tag="Rv0521" FT /note="Rv0521, (replaces MTCY20G10.11), len: 101 aa. FT Possible fragment of methyltransferase (possibly second FT part) (EC 2.1.1.-), highly similar to C-terminus of FT several methyltransferases e.g. AAF87203.1|AF216282 FT sarcosine-dimethylglycine methyltransferase from FT Halorhodospira halochloris (279 aa). Possibly continuation FT of Rv0520 but we can find no frameshift to account for FT this." FT /product="POSSIBLE METHYLTRANSFERASE/METHYLASE (FRAGMENT)" FT CDS 613038..614342 FT /function="INVOLVED IN 4-AMINOBUTYRATE (GABA) DEGRADATION FT PATHWAY. TRANSPORTER FOR GABA. RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /gene="gabP" FT /locus_tag="Rv0522" FT /note="Rv0522, (MTCY20G10.12), len: 434 aa. Probable gabP, FT GABA permease (gamma-aminobutyrate permease), integral FT membrane protein, highly similar to others e.g. FT GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 FT aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in FT 424 aa overlap); etc. Also similar to other M. FT tuberculosis permeases e.g. MTCY13E10.06c FASTA score: FT (34.4% identity in 407 aa overlap). Contains PS00218 Amino FT acid permeases signature. Overlaps and extends FT Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO FT THE AMINO ACID PERMEASE FAMILY (APC FAMILY)." FT /product="PROBABLE GABA PERMEASE GABP (4-AMINO BUTYRATE FT TRANSPORT CARRIER) (GAMA-AMINOBUTYRATE PERMEASE)" FT misc_feature 613104..613196 FT /note="PS00218 Amino acid permeases signature" FT CDS complement(614326..614721) FT /function="UNKNOWN" FT /locus_tag="Rv0523c" FT /note="Rv0523c, (MTCY25D10.02), len: 131 aa. Conserved FT hypothetical protein, showing some similarity to M. FT tuberculosis proteins Rv1598c|MTCY336.06; and FT Rv1871c|MTCY336_06|O06592 (136 aa), FASTA scores: opt: FT 197, E(): 5e-08, (38.4% identity in 99 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 614835..616223 FT /EC_number="5.4.3.8" FT /function="INVOLVED IN PORPHYRIN BIOSYNTHESIS BY THE C5 FT PATHWAY (AT THE SECOND STEP) [CATALYTIC ACTIVITY: FT (S)-4-amino-5-oxopentanoate = 5-aminolevulinate]." FT /gene="hemL" FT /locus_tag="Rv0524" FT /note="Rv0524, (MTCY25D10.03), len: 462 aa. Probable hemL, FT glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8), FT equivalent to P46716|GSA_MYCLE GLUTAMATE-1-SEMIALDEHYDE FT 2,1-AMINOMUTASE from Mycobacterium leprae (446 aa), FASTA FT scores: opt: 1532, E(): 0, (82.6% identity in 460 aa FT overlap). Also highly similar to others e.g. FT Q9F2S0|GSA_STRCO from Streptomyces coelicolor (438 aa); FT Q06774|GSA_PROFR from Propionibacterium freudenreichii FT (441 aa); etc. Contains PS00600 Aminotransferases FT class-III pyridoxal-phosphate attachment site. BELONGS TO FT CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE." FT /product="PROBABLE GLUTAMATE-1-SEMIALDEHYDE FT 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE FT AMINOTRANSFERASE) (GSA-AT)" FT misc_feature 615630..615740 FT /note="PS00600 Aminotransferases class-III FT pyridoxal-phosphate attachment site" FT CDS 616223..616831 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0525" FT /note="Rv0525, (MTCY25D10.04), len: 202 aa. Conserved FT hypothetical protein, equivalent to FT Q49821|B2168_C3_276|S72912 hypothetical protein from FT Mycobacterium leprae (202 aa), FASTA scores: opt: 1151, FT E(): 0, (82.5% identity in 200 aa overlap). Also highly FT similar to CAC08377.1|AL392176 putative phosphoglycerate FT mutase from Streptomyces coelicolor (233 aa); and similar FT to SLL0395|Q55734 hypothetical 23.8 kDa protein from FT SYNECHOCYSTIS SP. (212 aa), FASTA scores: opt: 207, E(): FT 5.1e-07, (28.2% identity in 195 aa overlap). Also some FT similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09 FT hypothetical 39.2 kDa protein from Mycobacterium FT tuberculosis (364 aa), FASTA scores: opt: 236, E(): FT 1.1e-08, (34.3% identity in 198 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_unit 616828..616878 FT /note="51 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 616846..617496 FT /EC_number="1.-.-.-" FT /function="POSSIBLY ACTS ON THIOREDOXIN" FT /locus_tag="Rv0526" FT /note="Rv0526, (MTCY25D10.05), len: 216 aa. Possible FT thioredoxin protein (thiol-disulfide interchange protein) FT (EC 1.-.-.-), equivalent to Q49816|U2168C|S72901 FT hypothetical protein from Mycobacterium leprae (216 aa), FT FASTA scores: opt: 1144, E(): 0, (78.5% identity in 214 aa FT overlap). C-terminus shows some similarity to C-terminus FT of thioredoxins e.g. RESA_BACSU|P35160 resa protein from FT Bacillus subtilis (181 aa), FASTA scores: opt: 200, E(): FT 7.4e-06, (24.2% identity in 132 aa overlap); etc. Also FT similar to Mycobacterium tuberculosis thioredoxin-like FT proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194 FT Thioredoxin family active site. SEEMS TO BELONG TO THE FT THIOREDOXIN FAMILY." FT /product="POSSIBLE THIOREDOXIN PROTEIN (THIOL-DISULFIDE FT INTERCHANGE PROTEIN)" FT misc_feature 617116..617172 FT /note="PS00194 Thioredoxin family active site" FT CDS 617493..618272 FT /function="POSSIBLY INVOLVED IN CYTOCHROME C SYNTHESIS. FT MIGHT TRANSFER REDUCING EQUIVALENTS ACROSS THE CYTOPLASMIC FT MEMBRANE, PROMOTING EFFICIENT DISULFIDE BOND ISOMERIZATION FT OF PROTEINS LOCALIZED ON THE OUTER SURFACE OF THE FT MEMBRANE." FT /gene="ccdA" FT /locus_tag="Rv0527" FT /note="Rv0527, (MTCY25D10.06), len: 259 aa. Possible ccdA, FT cytochrome C-type biogenesis protein, integral membrane FT protein, equivalent to Q49810|B2168_C1_192|S72890 FT hypothetical protein from Mycobacterium leprae (262 aa), FT FASTA scores: opt: 1341, E(): 0, (79.0% identity in 262 aa FT overlap). Also highly similar to others e.g. CAC08380.1 FT (253 aa); CCDA_BACSU|P45706 cytochrome C-type biogenesis FT protein from Bacillus subtilis (235 aa), FASTA scores: FT opt: 307, E(): 7.4e-13, (30.4% identity in 237 aa FT overlap); etc. SEEMS TO BELONG TO THE DSBD SUBFAMILY. Note FT that previously known as ccsA." FT /product="POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN FT CCDA" FT /standard_name="ccsA" FT CDS 618305..619894 FT /function="UNKNOWN" FT /locus_tag="Rv0528" FT /note="Rv0528, (MTCY25D10.07), len: 529 aa. Probable FT conserved transmembrane protein, equivalent (shorter 14 aa FT in N-terminus) to CAC31926.1|AL583925 conserved membrane FT protein from Mycobacterium leprae (542 aa). Also highly FT similar to Q49817|B2168_C2_237|S72902 hypothetical protein FT from Mycobacterium leprae (364 aa), FASTA scores: opt: FT 1846, E(): 0, (81.1% identity in 338 aa overlap); and FT Q49811|B2168_C1_194|S72891 hypothetical protein from FT Mycobacterium leprae (106 aa), FASTA scores: opt: 506, FT E(): 3.8e-26, (73.6% identity in 106 aa overlap). Also FT highly similar to CAC08381.1|AL392176 putative integral FT membrane protein from Streptomyces coelicolor (574 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 619891..620865 FT /function="REQUIRED DURING CYTOCHROME BIOGENESIS AT THE FT STEP OF HEME ATTACHMENT." FT /gene="ccsA" FT /locus_tag="Rv0529" FT /note="Rv0529, (MTCY25D10.08), len: 324 aa. Possible ccsA, FT cytochrome C-type biogenesis protein, integral membrane FT protein, equivalent to NP_302558.1|NC_002677|B2168_C3_281 FT possible cytochrome C biogenesis protein from FT Mycobacterium leprae (327 aa), FASTA scores: opt: 1779, FT E(): 0, (82.9% identity in 327 aa overlap). Also highly FT similar to others e.g. CAC08382.1|AL392176 putative FT cytochrome biogenesis related protein from Streptomyces FT coelicolor (380 aa); CCSA_CHLRE|P48269 probable cytochrome FT c biogenesis protein from Chlamydomonas reinhardtii (353 FT aa), FASTA scores: opt: 449, E(): 1.3e-23, (34.4% identity FT in 247 aa overlap); etc. BELONGS TO THE FT CCMF/CYCK/CCL1/NRFE/CCSA FAMILY. Note that previously FT known as ccsB." FT /product="POSSIBLE CYTOCHROME C-TYPE BIOGENESIS PROTEIN FT CCSA" FT /standard_name="ccsB" FT CDS 620907..622124 FT /function="UNKNOWN" FT /locus_tag="Rv0530" FT /note="Rv0530, (MTCY25D10.09), len: 405 aa. Conserved FT hypothetical protein, similar in part to other FT hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 FT from Streptomyces coelicolor (1083 aa), FASTA scores: opt: FT 870, E(): 0, (39.5% identity in 443 aa overlap); etc. Also FT similar to Mycobacterium tuberculosis proteins e.g. FT Rv3868, Rv0282, Rv1798, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 622329..622646 FT /function="UNKNOWN" FT /locus_tag="Rv0531" FT /note="Rv0531, (MTCY25D10.10), len: 105 aa. Possible FT conserved membrane protein, highly similar to FT Y13803|MLB1306_1|CAA74131.1 hypothetical protein from FT Mycobacterium leprae (86 aa), FASTA scores: E(): 2.1e-24, FT (74.4% identity in 86 aa overlap); and FT NP_302557.1|NC_002677 putative membrane protein from FT Mycobacterium leprae (111 aa)." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT CDS 622793..624577 FT /function="UNKNOWN" FT /gene="PE_PGRS6" FT /locus_tag="Rv0532" FT /note="Rv0532, (MTCY25D10.11), len: 594 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to others FT e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis FT (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity FT in 536 aa overlap)." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS complement(624473..625480) FT /EC_number="2.3.1.41" FT /function="INVOLVED IN FATTY ACID BIOSYNTHESIS. CATALYZES FT THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS BY THE FT ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM FT MALONYL-ACP. KAS III CATALYZES THE FIRST CONDENSATION FT REACTION WHICH INITIATES FATTY ACID SYNTHESIS AND MAY FT THEREFORE PLAY A ROLE IN GOVERNING THE TOTAL RATE OF FATTY FT ACID PRODUCTION. POSSESSES BOTH ACETOACETYL-ACP SYNTHASE FT AND ACETYL TRANSACYLASE ACTIVITIES [CATALYTIC ACTIVITY: FT Acyl-[acyl-carrier protein] + malonyl-[acyl-carrier FT protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + FT [acyl-carrier protein]]." FT /gene="fabH" FT /locus_tag="Rv0533c" FT /note="Rv0533c, (MTCY25D10.12c), len: 335 aa. fabH FT (alternate gene name: mtFabH), 3-oxoacyl-[acyl-carrier FT protein] synthase III (EC 2.3.1.41) (see citations below), FT highly similar to others e.g. Q54206|FABH from FT STREPTOMYCES GLAUCESCENS (333 aa), FASTA scores: opt: FT 1109, E(): 0, (51.4% identity in 333 aa overlap); FT FABH_ECOLI|P24249 3-oxoacyl-[acyl-carrier-protein] FT synthase III (317 aa), FASTA scores: opt: 666, E(): 0, FT (37.1% identity in 318 aa overlap); etc. BELONGS TO THE FT FABH FAMILY. Note that previously known as fabH." FT /product="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III FT FABH (BETA-KETOACYL-ACP SYNTHASE III) (KAS III)" FT /standard_name="mtFabH" FT CDS complement(625562..626440) FT /EC_number="2.5.1.-" FT /function="INVOLVED IN MENAQUINONE BIOSYNTHESIS. FT CONVERSION OF 1,4-DIHYDROXY-2-NAPHTHOATE (DHNA) TO FT DIMETHYLMENAQUINONE (DMK). ATTACHES FT OCTAPRENYLPYROPHOSPHATE, A MEMBRANE-BOUND 40-CARBON SIDE FT CHAIN TO DHNA. THE CONVERSION OF DHNA TO DMK PROCEEDS IN FT THREE STAGES: THE REMOVAL OF THE CARBOXYL GROUP OF DHNA AS FT CO2, THE ATTACHMENT OF THE ISOPRENOID SIDE CHAIN, AND A FT QUINOL-TO-QUINONE OXIDATION, WHICH IS THOUGHT TO BE FT SPONTANEOUS." FT /gene="menA" FT /locus_tag="Rv0534c" FT /note="Rv0534c, (MTCY25D10.13c), len: 292 aa. Probable FT menA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase (EC FT 2.5.1.-), integral membrane protein, equivalent to FT Y13803|MLB1306_2|NP_302556.1 probable FT 4-dihydroxy-2-naphthoate octaprenyltransferase from FT Mycobacterium leprae (294 aa), FASTA scores: opt: 1509, FT E(): 0, (80.2% identity in 288 aa overlap). Also highly FT similar to others e.g. MENA_ECOLI|P32166|B3930 from FT Escherichia coli (308 aa), FASTA scores: opt: 495, E(): FT 2.9e-25, (36.3 identity in 289 aa overlap); etc. BELONGS FT TO THE MENA FAMILY." FT /product="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE FT MENA (DHNA-OCTAPRENYLTRANSFERASE)" FT CDS 626457..627251 FT /EC_number="2.4.2.28" FT /function="PHOSPHORYLATES 5'-methylthioadenosin [CATALYTIC FT ACTIVITY: 5'-methylthioadenosine + phosphate = adenine + FT 5-methylthio-D-ribose 1-phosphate]." FT /gene="pnp" FT /locus_tag="Rv0535" FT /note="Rv0535, (MTCY25D10.14c), len: 264 aa. Probable pnp, FT 5'-methylthioadenosine phosphorylase (EC 2.4.2.28), highly FT similar to others e.g. CAB90972.1|AL355832 putative FT methylthioadenosine phosphorylase from Streptomyces FT coelicolor (280 aa); etc. Also similar to Rv3307|deoD FT PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE (EC 2.4.2.1) from FT Mycobacterium tuberculosis (268 aa). BELONGS TO THE FT PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. Gene name could be FT inappropriate." FT /product="PROBABLE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE FT PNP (MTA PHOSPHORYLASE)" FT CDS 627248..628288 FT /EC_number="5.1.3.2" FT /function="POSSIBLY INVOLVED IN GALACTOSE METABOLISM FT [CATALYTIC ACTIVITY: UDP-GLUCOSE = UDP-GALACTOSE]." FT /gene="galE3" FT /locus_tag="Rv0536" FT /note="Rv0536, (MTCY25D10.15), len: 346 aa. Possible FT galE3, UDP-glucose 4-epimerase (EC 5.1.3.2), highly FT similar to CAB76986.1|AL159178 putative epimerase from FT Streptomyces coelicolor (334 aa); and similar to other FT epimerases e.g. NP_436775.1|NC_003078 putative NDP-glucose FT dehydrataseepimerase protein from Sinorhizobium meliloti FT (368 aa); AF143772|AF143772_7 GepiA from Mycobacterium FT avium strain 2151 (353 aa), FASTA scores: opt: 577, E(): FT 3.9e-29, (36.6% identity in 352 aa overlap); FT GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305 FT aa), FASTA scores: opt: 300, E(): 1.6e-12, (30.9% identity FT in 343 aa overlap); etc. Also similar to Mycobacterium FT tuberculosis proteins e.g. Rv3634c, Rv3784, etc. SEEMS TO FT BELONG TO THE SUGAR EPIMERASE FAMILY. Note that previously FT known as galE2." FT /product="PROBABLE UDP-GLUCOSE 4-EPIMERASE GALE3 FT (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHO-GALACTOSE 4-EPIMERASE)" FT /standard_name="galE2" FT CDS complement(628298..629731) FT /function="UNKNOWN" FT /locus_tag="Rv0537c" FT /note="Rv0537c, (MTCY25D10.16c), len: 477 aa. Probable FT integral membrane protein, showing weak similarity to FT YDNK_STRCO|P40180 hypothetical 41.2 kDa protein from FT Streptomyces coelicolor (411 aa), FASTA scores: opt: 122, FT E(): 0.85, (28.2% identity in 373 aa overlap)." FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT CDS 630040..631686 FT /function="UNKNOWN" FT /locus_tag="Rv0538" FT /note="Rv0538, (MTCY25D10.17), len: 548 aa. Possible FT conserved membrane protein. Middle region highly similar FT to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein FT from Mycobacterium bovis (295 aa) possible transmembrane FT protein with a repetitive proline, threonine-rich region FT at C-terminus." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT CDS 631743..632375 FT /EC_number="2.4.1.-" FT /function="SUBSTRATE (SUGAR) UNKNOWN [CATALYTIC ACTIVITY: FT NDP-sugar + dolichyl phosphate = NDP + dolichyl sugar FT phosphate]." FT /locus_tag="Rv0539" FT /note="Rv0539, (MTCY25D10.18), len: 210 aa. Probable FT dolichol-P-sugar synthase (EC 2.4.1.-), highly similar to FT CAB76989.1|AL159178 putative glycosyltransferase from FT Streptomyces coelicolor (242 aa), and similar to various FT dolichol-P-sugar synthetases and sugar transferases e.g. FT NP_126257.1|NC_000868 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE FT RELATED PROTEIN from Pyrococcus abyssi (211 aa); FT N-terminus of NP_127133.1|NC_000868 DOLICHOL-P-GLUCOSE FT SYNTHETASE from Pyrococcus abyssi (378 aa); N-terminus of FT NP_068880.1|NC_000917 putative dolichol-P-glucose FT synthetase from Archaeoglobus fulgidus (369 aa), FASTA FT scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap); FT Q26732 DOLICHYL-PHOSPHATE-MANNOSE SYNTHASE PRECURSOR from FT TRYPANOSOMA BRUCEI (267 aa), FASTA scores: opt: 179, E(): FT 0.0011, (30.7% identity in 205 aa overlap); etc. Also FT similar to Rv2051c|MTY25D10_18 from Mycobacterium FT tuberculosis. Contains S00017 ATP/GTP-binding site motif A FT (P-loop)." FT /product="PROBABLE DOLICHYL-PHOSPHATE SUGAR SYNTHASE FT (DOLICHOL-PHOSPHATE SUGAR SYNTHETASE) (DOLICHOL-PHOSPHATE FT SUGAR TRANSFERASE) (SUGAR PHOSPHORYLDOLICHOL SYNTHASE)" FT misc_feature 632286..632309 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 632372..633034 FT /function="UNKNOWN" FT /locus_tag="Rv0540" FT /note="Rv0540, (MTCY25D10.19), len: 220 aa. Conserved FT hypothetical protein, similar to hypothetical proteins FT from Streptomyces coelicolor: CAB76990.1|AL159178 (213 FT aa); N-terminus of BAA84086.1|AB032065 (446 aa); and FT CAB61872.1|AL133252|SCE46_21 (210 aa), FASTA scores: opt: FT 267, E(): 5.3e-10, (32.7% identity in 202 aa overlap). FT Also some similarity with D90913_63|PCC6803 from Synecho FT cystis sp (211 aa), FASTA scores: opt: 189, E(): 4.7e-06, FT (25.3 identity in 194 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(633055..634404) FT /function="UNKNOWN" FT /locus_tag="Rv0541c" FT /note="Rv0541c, (MTCY25D10.20c), len: 449 aa. Probable FT conserved integral membrane protein, highly similar FT (except first 40 residues) to CAB76994.1|AL159178 putative FT integral membrane protein from Streptomyces coelicolor FT (456 aa). Also some similarity to Q13724|GCS1_HUMAN FT MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (834 aa), FASTA FT scores: opt: 150, E(): 0.013, (27.1% identity in 339 aa FT overlap). Contains PS00041 Bacterial regulatory proteins, FT araC family signature." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT misc_feature complement(633667..633801) FT /note="PS00041 Bacterial regulatory proteins, araC family FT signature" FT CDS complement(634416..635504) FT /EC_number="6.2.1.26" FT /function="INVOLVED IN MENAQUINONE BIOSYNTHESIS. FT O-SUCCINYLBENZOIC ACID (OSB) TO O-SUCCINYLBENZOYL-COA FT (OSB-COA) [CATALYTIC ACTIVITY: ATP + O-succinylbenzoate + FT CoA = AMP + diphosphate + O-succinylbenzoyl-CoA]." FT /gene="menE" FT /locus_tag="Rv0542c" FT /note="Rv0542c, (MTCY25D10.21c), len: 362 aa. Possible FT menE, O-succinylbenzoic acid-CoA ligase (EC 6.2.1.26), FT highly similar to Q50170|AAA63145.1|U15187|XCLB FT 4-Coumarate--CoA ligase from Mycobacterium leprae (352 FT aa), FASTA scores: opt: 1815, E(): 0, (78.9% identity in FT 351 aa overlap). Also similar to N-terminus of acid-CoA FT ligases e.g. NP_471116.1|NC_003212 O-succinylbenzoic FT acid-CoA ligase from Listeria innocua (469 aa); FT NP_390957.1|NC_000964 O-succinylbenzoic acid-CoA ligase FT from Bacillus subtilis (486 aa); MENE_HAEIN|P44565 FT O-succinylbenzoic acid-CoA ligase from Haemophilus FT influenzae (452 aa), FASTA scores: opt: 307, E(): 4.6e-12, FT (25.4% identity in 339 aa overlap); etc. Also some FT similarity with fadD proteins from Mycobacterium FT tuberculosis. Contains PS00455 Putative AMP-binding domain FT signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FT FAMILY." FT /product="POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE FT (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)" FT misc_feature complement(635364..635399) FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(635573..635875) FT /function="UNKNOWN" FT /locus_tag="Rv0543c" FT /note="Rv0543c, (MTCY25D10.22c), len: 100 aa. Conserved FT hypothetical protein, equivalent to FT Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved FT hypothetical protein from Mycobacterium leprae (100 aa), FT FASTA scores: opt: 493, E(): 6.1e-30, (73.5% identity in FT 98 aa overlap). Some similarity to Rv3046c|NP_217562.1 FT from Mycobacterium tuberculosis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(635935..636213) FT /function="UNKNOWN" FT /locus_tag="Rv0544c" FT /note="Rv0544c, (MTCY25D10.23c), len: 92 aa. Possible FT conserved transmembrane protein, equivalent to FT NP_302470.1|NC_002677 possible membrane protein from FT Mycobacterium leprae (96 aa); and shows some similarity to FT MLU15187_33|Q50172|U296V from Mycobacterium leprae (36 FT aa), FASTA scores: opt: 151, E(): 2.1e-05, (71.4% identity FT in 35 aa overlap). Also some similarity with FT VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kDa proteolipid FT from Nephrops norvegicus (159 aa), FASTA scores: opt: 80, FT E(): 11, (26.1% identity in 88 aa overlap)." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(636210..637463) FT /function="INVOLVED IN LOW-AFFINITY INORGANIC PHOSPHATE FT TRANSPORT ACROSS THE MEMBRANE. RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /gene="pitA" FT /locus_tag="Rv0545c" FT /note="Rv0545c, (MTCY25D10.24c), len: 417 aa. Probable FT pitA, low-affinity inorganic phosphate transporter, FT integral membrane protein, equivalent to FT Q50173|NP_302471.1 pitA from Mycobacterium leprae (414 FT aa), FASTA scores: opt: 2035, E(): 0, (76.3% identity in FT 418 aa overlap). Also highly similar to others e.g. FT CAB59461.1|AL132644 putative low-affinity phosphate FT transport protein from Streptomyces coelicolor (423 aa); FT PITA_ECOLI|P37308 low-affinity inorganic phosphate FT transporter from Escherichia coli (499 aa), FASTA scores: FT opt: 304, E(): 6.9e-10, (32.5 % identity in 234 aa FT overlap); etc. BELONGS TO THE PHO-4 FAMILY OF FT TRANSPORTERS, PIT SUBFAMILY." FT /product="PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE FT TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA" FT CDS complement(637583..637969) FT /function="UNKNOWN" FT /locus_tag="Rv0546c" FT /note="Rv0546c, (MTCY25D10.25c), len: 128 aa. Conserved FT hypothetical protein, equivalent to FT AAA63111.1|U15187|Q50174|U296X hypothetical protein from FT Mycobacterium leprae (144 aa), FASTA scores: opt: 748, FT E(): 0, (84.2% identity in 133 aa overlap). Also highly FT similar to CAB95979.1|AL360034 conserved hypothetical FT protein from Streptomyces coelicolor (130 aa); and similar FT to AE000854_8|O26852 S-D-LACTOYLGLUTATHIONE METHYLGLYOXAL FT LYASE from Methanobacterium thermoautotropto (116 aa), FT FASTA scores: opt: 155, E(): 0.00019, (30.6% identity in FT 108 aa overlap); YAER_ECOLI hypothetical 14.7 kDa protein FT from Escherichia coli (129 aa), FASTA scores: opt: 104, FT E(): 0.42, (28.7% identity in 115 aa overlap). Also FT similar to Rv2068c from Mycobacterium tuberculosis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(638032..638916) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0547c" FT /note="Rv0547c, (MTCY25D10.26c), len: 294 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases e.g. fatty acyl-CoA reductase from FT Acinetobacter calcoaceticus (295 aa); FT NP_280196.1|NC_002607 3-oxoacyl-[acyl-carrier-protein] FT reductase from Halobacterium sp. NRC-1 (255 aa); FT NP_349214.1|NC_003030 Short-chain alcohol dehydrogenase FT family protein from Clostridium acetobutylicum (255 aa); FT etc. Also similar to several proteins from Mycobacterium FT tuberculosis e.g. Y04M_MYCTU|Q10783 putative FT oxidoreductase (341 aa), FASTA scores: opt: 644, E(): 0, FT (46.1% identity in 258 aa overlap)." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS complement(639012..639956) FT /EC_number="4.1.3.36" FT /function="INVOLVED IN MENAQUINONE BIOSYNTHESIS. CONVERT FT O-SUCCINYLBENZOYL-CoA (OSB-COA) TO FT 1,4-DIHYDROXY-2-NAPHTHOIC ACID (DHNA) [CATALYTIC ACTIVITY: FT O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + FT CoA]." FT /gene="menB" FT /locus_tag="Rv0548c" FT /note="Rv0548c, (MTCY25D10.27c), len: 314 aa. Probable FT menB, naphthoate synthase (dihydroxynaphthonic acid FT synthase) (EC 4.1.3.36), equivalent to FT NP_302473.1|NC_002677 naphthoate synthase from FT Mycobacterium leprae (300 aa). Also similar to others e.g. FT MENB_ECOLI|P27290 naphthoate synthase from Escherichia FT coli (285 aa), FASTA scores: opt: 599, E(): 9.3e-33, (48.1 FT identity in 285 aa overlap); etc. BELONGS TO THE ENOYL-COA FT HYDRATASE/ISOMERASE FAMILY." FT /product="PROBABLE NAPHTHOATE SYNTHASE MENB FT (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE)" FT CDS complement(640228..640641) FT /function="UNKNOWN" FT /locus_tag="Rv0549c" FT /note="Rv0549c, (MTCY25D10.28c), len: 137 aa. Conserved FT hypothetical protein, similar to Rv0960, Rv0065, and FT Rv1720c from Mycobacterium tuberculosis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(640638..640904) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0550c" FT /note="Rv0550c, (MTCY25D10.29c), len: 88 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(641096..642811) FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD8" FT /locus_tag="Rv0551c" FT /note="Rv0551c, (MTCY25D10.30c), len: 571 aa. Probable FT fadD8, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to FT many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA FT ligase (561 aa), FASTA scores: opt: 585, E(): 9.5e-30, FT (28.7% identity in 536 aa overlap); etc. Contains PS00455 FT Putative AMP-binding domain signature. Note other possible FT start sites exist downstream of this start." FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD8 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature complement(642131..642166) FT /note="PS00455 Putative AMP-binding domain signature" FT repeat_unit complement(642754..642811) FT /note="58 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT CDS 642889..644493 FT /function="UNKNOWN" FT /locus_tag="Rv0552" FT /note="Rv0552, (MTCY25D10.31), len: 534 aa. Conserved FT hypothetical protein, similar to others from several FT organisms. Also shows some similarity with regulatory FT proteins e.g. AEPA_ERWCA|Q06555 exoenzymes regulatory FT protein aepA [Precursor] from Erwinia carotovora (465 aa), FT FASTA scores: opt: 278, E(): 7.6e-11, (23.0% identity in FT 408 aa overlap). Also similar to Z99119|BSUB0016_28 from FT Bacillus subtilis (529 aa), FASTA scores: opt: 436, E(): FT 8.3e-20, (23.8% identity in 547 aa overlap). C-terminus is FT similar to MLRRNOPR_1 HYPOTHETICAL 17.7 kDa PROTEIN from FT Mycobacterium leprae (154 aa), FASTA score: (43.1% FT identity in 160 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 644490..645470 FT /EC_number="5.5.1.1" FT /function="POSSIBLY INVOLVED IN MENAQUINONE BIOSYNTHESIS. FT CATALYZES A SYN CYCLOISOMERIZATION [CATALYTIC ACTIVITY: FT 2,5-dihydro-5-oxofuran-2-acetate = FT cis,cis-hexadienedioate]." FT /gene="menC" FT /locus_tag="Rv0553" FT /note="Rv0553, (MTCY25D10.32), len: 326 aa. Probable menC, FT muconate cycloisomerase (EC 5.5.1.1), equivalent to FT NP_302476.1|NC_002677 putative isomerase/racemase from FT Mycobacterium leprae (334 aa). Also similar to other FT muconate cycloisomerases e.g. TCBD_PSESP|P27099 FT chloromuconate cycloisomerase (370 aa), FASTA scores: opt: FT 249, E(): 7.8e-09, (32.7% identity in 199 aa overlap). FT Also similar to O-succinylbenzoate-CoA synthases. BELONGS FT TO THE MANDELATE RACEMASE / MUCONATE LACTONIZING ENZYME FT FAMILY." FT /product="PROBABLE MUCONATE CYCLOISOMERASE MENC FT (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE)" FT CDS 645467..646255 FT /EC_number="1.11.1.-" FT /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS." FT /gene="bpoC" FT /locus_tag="Rv0554" FT /note="Rv0554, (MTCY25D10.33), len: 262 aa. Possible bpoC, FT peroxidase (non-haem peroxidase) (EC 1.11.1.-), equivalent FT to NP_302477.1|NC_002677 putative hydrolase from FT Mycobacterium leprae (265 aa). Also highly similar or FT similar to various hydrolases and peroxidases e.g. FT CAB38877.1|AL035707|T36181 probable hydrolase from FT Streptomyces coelicolor (272 aa); CAC48368.1|Y16952 FT putative hydrolase from Amycolatopsis mediterranei (284 FT aa); P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2 FT (bromide peroxidase) (EC 1.11.1.-) from Streptomyces FT aureofaciens (277 aa), FASTA scores: opt: 325, E(): FT 2.3e-15, (29.5% identity in 268 aa overlap); FT O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase FT (chloride peroxidase) (EC 1.11.1.10) from Streptomyces FT aureofaciens (278 aa); etc. Also similar to M. FT tuberculosis non-heme haloperoxidases and epoxide FT hydrolases e.g. Rv1938, Rv3617, etc." FT /product="POSSIBLE PEROXIDASE BPOC (NON-HAEM PEROXIDASE)" FT CDS 646298..647962 FT /EC_number="4.1.3.-" FT /EC_number="4.1.1.71" FT /function="INVOLVED IN MENAQUINONE BIOSYNTHESIS (AT THE FT FIRST STEP) [CATALYTIC ACTIVITY 1: ISOCHORISMATE + FT 2-KETOGLUTARATE = FT 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE + FT PYRUVATE + CO(2)] [CATALYTIC ACTIVITY 2: 2-OXOGLUTARATE = FT SUCCINATE SEMIALDEHYDE + CO(2)]." FT /gene="menD" FT /locus_tag="Rv0555" FT /note="Rv0555, (MTCY25D10.34), len: 554 aa. Probable menD, FT menaquinone biosynthesis protein, including FT 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate FT synthase (EC 4.1.3.-) and 2-oxoglutarate decarboxylase (EC FT 4.1.1.71) activities. Equivalent to NP_302478.1|NC_002677 FT putative FT 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate FT synthase / 2-oxoglutarate decarboxylase from Mycobacterium FT leprae (556 aa). Also similar to others e.g. FT MEND_BACSU|P23970 FT 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate FT synthase from Bacillus subtilis (548 aa), FASTA scores: FT opt: 488, E(): 2.3e-21, (34.3% identity in 545 aa FT overlap); etc. COFACTOR: THIAMINE PYROPHOSPHATE." FT /product="PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS FT PROTEIN MEND : FT 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE FT SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE FT (ALPHA- KETOGLUTARATE DECARBOXYLASE) (KDC)" FT CDS 647959..648474 FT /function="UNKNOWN" FT /locus_tag="Rv0556" FT /note="Rv0556, (MTCY25D10.35), len: 171 aa. Probable FT conserved transmembrane protein, equivalent to FT NP_302479.1|NC_002677 putative membrane protein from FT Mycobacterium leprae (175 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 648536..649672 FT /EC_number="2.4.1.-" FT /evidence=experimental FT /function="INVOLVED IN LIPOARABINOMANNAN (LAM) FT BIOSYNTHESIS." FT /gene="pimB" FT /locus_tag="Rv0557" FT /note="Rv0557, (MTCY25D10.36), len: 378 aa. pimB FT (alternate gene name: mtfB), mannosyltransferase (EC FT 2.4.1.-) (see citation below), similar to other various FT transferases e.g. NP_243554.1|NC_002570 FT alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol FT monomannoside transferase from Bacillus halodurans (381 FT aa); NP_249533.1|NC_002516 probable glycosyl transferase FT from Pseudomonas aeruginosa (406 aa); FT NP_419573.1|NC_002696 glycosyl transferase, group 1 family FT protein, from Caulobacter crescentus (455 aa); etc. Also FT similar to Q55598 hypothetical 44.9 kDa protein from FT SYNECHOCYSTIS SP (409 aa), FASTA scores: opt: 703, E(): 0, FT (33.9% identity in 378 aa overlap); GPI3_YEAST|P32363 FT n-acetylglucosaminyl-phosphatidylinositol biosynthetic FT protein (452 aa), FASTA scores: opt: 230, E(): 1.1e-07, FT (23.5% identity in 328 aa overlap)." FT /product="MANNOSYLTRANSFERASE PIMB" FT /standard_name="mtfB" FT CDS 649689..650393 FT /EC_number="2.1.1.-" FT /function="INVOLVED IN MENAQUINONE BIOSYNTHESIS (AT THE FT LAST STEP) CONVERTS DMKH2 INTO MKH2 [CATALYTIC ACTIVITY: FT S-ADENOSYL-L-METHIONINE + DEMETHYLMENAQUINOL = FT S-ADENOSYL-L-HOMOCYSTEINE + MENAQUINOL]." FT /gene="menH" FT /locus_tag="Rv0558" FT /note="Rv0558, (MTCY25D10.37), len: 234 aa. Probable menH FT (alternate gene name: menG), ubiquinone/menaquinone FT biosynthesis methlytransferase FT (2-heptaprenyl-1,4-naphthoquinone methyltransferase) (EC FT 2.1.1.-), equivalent to NP_302480.1|NC_002677 putative FT ubiquinone/menaquinone biosynthesis methyltransferase from FT Mycobacterium leprae (238 aa). Also highly similar to FT others e.g. CAB44537.1|AL078618|T34630 from Streptomyces FT coelicolor (231 aa); UBIE_ECOLI|P27851 from Escherichia FT coli strain K12 (251 aa), FASTA scores: opt: 421, E(): FT 1.2e-21, (43.2% identity in 227 aa overlap); FT GRC2_BACSU|P31113 from Bacillus subtilis (233 aa), FASTA FT scores: opt: 345, E(): 1.4e-16, (34.6% identity in 231 aa FT overlap); etc. BELONGS TO THE UBIE FAMILY. Note that FT previously known as ubiE." FT /product="PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS FT METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone FT methyltransferase)" FT /standard_name="menG; ubiE" FT CDS complement(650407..650745) FT /function="UNKNOWN" FT /locus_tag="Rv0559c" FT /note="Rv0559c, (MTCY25D10.38c), len: 112 aa. Possible FT conserved secreted protein, similar to FT NP_302481.1|NC_002677 putative secreted protein from FT Mycobacterium leprae (112 aa). Also similar to FT Y08B_MYCTU|Q11048 hypothetical 11.6 kDa protein FASTA FT scores: opt: 111, E(): 011, (25.4% identity in 114 aa FT overlap). Contains possible N-terminal signal sequence." FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT CDS complement(650779..651504) FT /EC_number="2.1.1.-" FT /evidence=experimental FT /function="POSSIBLY CAUSES METHYLATION" FT /locus_tag="Rv0560c" FT /note="Rv0560c, (MTCY25D10.39c), len: 271 aa. Possible FT benzoquinone methyltransferase (EC 2.1.1.-) (see citation FT below), similar to other hypothetical proteins and FT methyltransferases e.g. Q54300 METHYLTRANSFERASE (211 aa), FT FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity in FT 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c, etc FT from Mycobacterium tuberculosis. Rv0560c can be induced by FT salicylate and para-amino-salicylate (PAS)." FT /product="POSSIBLE BENZOQUINONE METHYLTRANSFERASE FT (METHYLASE)" FT CDS complement(651529..652755) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0561c" FT /note="Rv0561c, (MTCY25D10.40c), len: 408 aa. Possible FT oxidoreductase (EC 1.-.-.-), highly similar (except in FT first 30 aa) to NP_302482.1|NC_002677 putative FAD-linked FT oxidoreductase from Mycobacterium leprae (408 aa). Also FT similar to T34627 probable electron transfer FT oxidoreductase from Streptomyces coelicolor (430 aa); and FT some bacteriochlorophyll synthases e.g. FT NP_069300.1|NC_000917 bacteriochlorophyll synthase from FT Archaeoglobus fulgidus (410 aa); Q55087 GERANYLGERANYL FT HYDROGENASE (407 aa), FASTA scores: opt: 208, E(): FT 1.7e-06, (26.9% identity in 327 aa overlap)." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS 652771..653778 FT /EC_number="2.5.1.-" FT /function="POSSIBLY SUPPLIES POLYPRENYL DIPHOSPHATE." FT /gene="grcC1" FT /locus_tag="Rv0562" FT /note="Rv0562, (MTCY25D10.41), len: 335 aa. Probable FT grcC1, polyprenyl diphosphate synthetase (EC 2.5.1.-), FT equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate FT synthase component from Mycobacterium leprae (330 aa). FT Also similar to others (generally hepta (EC 2.5.1.30) or FT hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl FT diphosphate syntetase (348 aa), FASTA scores: opt: 599, FT E(): 4e-31, (33.2% identity in 307 aa overlap); etc. Also FT highly similar to Mycobacterium tuberculosis proteins FT Rv0989c|grcC2|NP_215504.1|MTCI237.03c PROBABLE FT POLYPRENYL-DIPHOSPHATE SYNTHASE (325 aa); Rv3383c, FT Rv3398c, etc. Contains PS00444 Polyprenyl synthetases FT signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY." FT /product="PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 FT (POLYPRENYL PYROPHOSPHATE SYNTHETASE)" FT misc_feature 653413..653451 FT /note="PS00444 Polyprenyl synthetases signature 2" FT CDS 653879..654739 FT /EC_number="3.4.24.-" FT /evidence=experimental FT /function="POSSIBLY INVOLVED IN ADAPTATION. HYDROLIZES FT SPECIFIC PEPTIDES AND/OR PROTEINS." FT /gene="htpX" FT /locus_tag="Rv0563" FT /note="Rv0563, (MTV039.01, MTCY25D10.42), len: 242 aa FT (alternative start at position 654006). Probable htpX, FT protease heat shock protein X (EC 3.4.24.-) (transmembrane FT protein), equivalent to NP_302484.1|NC_002677 putative FT peptidase from Mycobacterium leprae (287 aa). Also highly FT similar to others e.g. CAC08262.1|AL392146 putative FT peptidase from Streptomyces coelicolor (287 aa); FT NP_387431.1|NC_003047 PUTATIVE PROTEASE TRANSMEMBRANE FT PROTEIN from Sinorhizobium meliloti (319 aa); FT NP_105051.1|NC_002678 heat shock protein (htpX) from FT Mesorhizobium loti (336 aa); FT NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein FT HtpX, possibly protease (htpX) from Methanococcus FT jannaschii (284 aa), FASTA scores: opt: 660, E(): 0, (46.5 FT identity in 245 aa overlap). Continuation of MTCY25D10.42. FT TBparse score is 0.887. BELONGS TO PEPTIDASE FAMILY M48 FT (ZINC METALLOPROTEASE). COFACTOR: Zinc." FT /product="PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT FT SHOCK PROTEIN HTPX" FT misc_feature 654272..654301 FT /note="PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature" FT CDS complement(654924..655949) FT /EC_number="1.1.1.94" FT /function="Involved in de novo phospholipid biosynthesis; FT glycerol-3 phosphate formation [CATALYTIC ACTIVITY: FT Sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + FT NAD(P)H]." FT /gene="gpdA1" FT /locus_tag="Rv0564c" FT /note="Rv0564c, (MTV039.02c), len: 341 aa. Possible FT gpdA1(alternate gene names: gpsA, glyC), FT glycerol-3-phosphate dehydrogenase [NAD(P)+] dependent (EC FT 1.1.1.94), similar to many other glycerol-3-phosphate FT dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus FT subtilis (345 aa), FASTA scores: opt: 731, E(): 0, (37.3% FT identity in 332 aa overlap); etc. Also similar to FT Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from FT Mycobacterium tuberculosis (334 aa), FASTA scores: opt: FT 740, E(): 0, (40.4% identity in 322 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO FT THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT FAMILY. TBparse score is 0.891." FT /product="PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT [NAD(P)+] GPDA1 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE FT DEHYDROGENASE) (NAD(P)H-DEPENDENT FT DIHYDROXYACETONE-PHOSPHATE REDUCTASE)" FT /standard_name="gpsA; glyC" FT misc_feature complement(655239..655262) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(656010..657470) FT /EC_number="1.14.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0565c" FT /note="Rv0565c, (MTV039.03c), len: 486 aa. Probable FT monoxygenase (EC 1.14.-.-), highly similar to FT NP_301173.1|NC_002677 putative monooxygenase from FT Mycobacterium leprae (494 aa). Also highly similar to FT others e.g. NP_421371.1|NC_002696 monooxygenase FT (flavin-binding family) from Caulobacter crescentus (498 FT aa); C-terminus of NP_051574.1|NC_000958 FT arylesterase/monoxygenase from Deinococcus radiodurans FT (833 aa); P12015|CYMO_ACISP CYCLOHEXANONE MONOOXYGENASE FT (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA FT scores: opt: 354, E(): 2.1e-16, (23.7% identity in 435 aa FT overlap); etc. Also similar to other putative FT monoxygenases from Mycobacterium tuberculosis e.g. Rv3854c FT (489 aa), MTCY01A6.14 (489 aa), MTV013_4 (495 aa), FT MTCY31.20 (495 aa). TBparse score is 0.902." FT /product="PROBABLE MONOOXYGENASE" FT CDS complement(657548..658039) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0566c" FT /note="Rv0566c, (MTV039.04c), len: 163 aa. Conserved FT hypothetical protein, similar to others e.g. FT P77482|YAJQ_ECOLI HYPOTHETICAL 19.0 KDa PROTEIN from FT Escherichia coli (169 aa), FASTA scores: opt: 422, E(): FT 5.4e-20, (44.1 identity in 161 aa overlap); etc. TBparse FT score is 0.844." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT tRNA 658109..658189 FT /gene="tRNA-Tyr(GTA)" FT /anticodon=(pos:658143..658145,aa:Tyr) FT /product="transfer RNA-Tyr(GTA)" FT CDS 658321..659340 FT /EC_number="2.1.1.-" FT /function="CAUSES METHYLATION" FT /locus_tag="Rv0567" FT /note="Rv0567, (MTV039.05), len: 339 aa. Probable FT methyltransferase (EC 2.1.1.-), similar to several e.g. FT P39896|TCMO_STRGA TETRACENOMYCIN POLYKETIDE SYNTHESIS FT 8-O-METHYLTRANSFERASE from Streptomyces glaucescens (339 FT aa), FASTA scores: opt: 685, E(): 0, (35.8% identity in FT 335 aa overlap); P10950|HIOM_BOVIN HYDROXYINDOLE FT O-METHYLTRANSFERASE (EC 2.1.1.4) from Bos taurus (345 aa), FT FASTA scores: opt: 509, E(): 3.4e-27, (30.7% identity in FT 332 aa overlap) etc. TBparse score is 0.910." FT /product="PROBABLE METHYLTRANSFERASE/METHYLASE" FT CDS 659450..660868 FT /EC_number="1.14.-.-" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /gene="cyp135B1" FT /locus_tag="Rv0568" FT /note="Rv0568, (MT0594, MTV039.06), len: 472 aa. Possible FT cyp135B1, cytochrome P450 (EC 1.14.-.-), similar to FT putative cytochrome P-450 monoxygenases and other FT cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP FT PROBABLE CYTOCHROME P450 from Anabaena sp. strain PCC 7120 FT (459 aa), FASTA scores: opt: 525, E(): 7.2e-27, (31.9% FT identity in 417 aa overlap); etc. Also similar to others FT from Mycobacterium tuberculosis e.g. FT Rv0327c|NP_214841.1|NC_000962|CYP135A1|MT0342|MTCY63.32c FT PUTATIVE CYTOCHROME P450 (449 aa), FASTA scores: opt: FT 1080, E(): 0, (40.5% identity in 444 aa overlap); FT Rv3685c|NP_218202.1|NC_000962 PUTATIVE CYTOCHROME P450 FT (476 aa); Rv0136|NP_214650.1|NC_000962 PUTATIVE CYTOCHROME FT P450 (441 aa); etc. Contains cytochrome P450 cysteine FT heme-iron ligand signature (PS00086). TBparse score is FT 0.896." FT /product="POSSIBLE CYTOCHROME P450 135B1 CYP135B1" FT misc_feature 660590..660619 FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS 661003..661269 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0569" FT /note="Rv0569, (MTV039.07), len: 88 aa. Conserved FT hypothetical protein. C-terminus highly similar to FT AAA63065.1|U15184|MLU15184_10 hypothetical protein from FT Mycobacterium leprae (53 aa), FASTA scores: opt: 140, E(): FT 0.0046, (64.7% identity in 34 aa overlap). Also similar to FT T36824|SCI35.11 hypothetical protein from Streptomyces FT coelicolor (64 aa); and N-terminus of T36956 probable FT DNA-binding protein from Streptomyces coelicolor (323 aa). FT Also highly similar to FT Rv2302|MTCY339.07c|NP_216818.1|NC_000962 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (80 FT aa), FASTA scores: opt: 300, E(): 1.4e-13, (61.8% identity FT in 76 aa overlap). TBparse score is 0.932." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 661295..663373 FT /EC_number="1.17.4.-" FT /function="INVOLVED IN THE DNA REPLICATION PATHWAY (AT THE FT FIRST REACTION). PROVIDES THE PRECURSORS NECESSARY FOR DNA FT SYNTHESIS [CATALYTIC ACTIVITY: 2'-deoxyribonucleoside FT diphosphate + oxidized thioredoxin + H2O = ribonucleoside FT diphosphate + reduced thioredoxin]." FT /gene="nrdZ" FT /locus_tag="Rv0570" FT /note="Rv0570, (MTV039.08), len: 692 aa. Probable nrdZ, FT ribonucleoside-diphosphate reductase, large subunit (EC FT 1.17.4.-), highly similar to others e.g. FT NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide FT reductase from Archaeoglobus fulgidus (752 aa), FASTA FT scores: opt: 2001, E(): 0, (52.5% identity in 562 aa FT overlap) (N-terminus shorter); U73619|TAU73619_1|T37459 FT ribonucleotide reductase from Thermoplasma acidophilum FT (857 aa), FASTA scores: opt: 1678, E(): 0, (43.7% identity FT in 723 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE FT DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY. TBparse score is FT 0.907." FT /product="PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE FT (LARGE SUBUNIT) NRDZ (RIBONUCLEOTIDE REDUCTASE)" FT CDS complement(663487..664818) FT /function="UNKNOWN" FT /locus_tag="Rv0571c" FT /note="Rv0571c, (MTV039.09c), len: 443 aa. Conserved FT hypothetical protein, highly similar to the products of FT two adjacent orfs in Mycobacterium leprae: FT AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258 FT aa), FASTA scores: opt: 1071, E(): 0, (72.5% identity in FT 233 aa overlap); and AAA63058.1|U15184|U650T hypothetical FT protein (86 aa), FASTA scores: opt: 192, E(): 6.4e-06, FT (70.8% identity in 48 aa overlap). Also similar to others FT e.g. NP_107072.1|NC_002678 hypothetical protein from FT Mesorhizobium loti (235 aa); NP_213031.1|NC_000918 FT hypothetical protein from Aquifex aeolicus (175 aa); etc. FT And similar to part of hypothetical proteins from FT Mycobacterium tuberculosis e.g. C-terminus of FT Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352 aa), FT FASTA scores: opt: 592, E(): 7e-32, (49.3% identity in FT 205 aa overlap); N-terminus of FT Rv2030c|NP_216546.1|NC_000962 (681 aa). TBparse score is FT 0.908." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(665042..665383) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0572c" FT /note="Rv0572c, (MTV039.10c), len: 113 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(665851..667242) FT /function="UNKNOWN" FT /locus_tag="Rv0573c" FT /note="Rv0573c, (MTV039.11c), len: 463 aa. Conserved FT hypothetical protein, similar to other conserved FT hypothetical proteins and some nicotinate FT phosphoribosyltransferases e.g. NP_213718.1|NC_000918 FT hypothetical protein from Aquifex aeolicus (426 aa); FT AL109962|T36953|SCJ1.20 conserved hypothetical protein FT from Streptomyces coelicolor (438 aa), FASTA scores: opt: FT 1089, E(): 0, (49.4% identity in 385 aa overlap); FT P_391053.1|Z99120|BSUB0017_57|NC_000964 protein similar to FT nicotinate phosphoribosyltransferase from Bacillus FT subtilis (490 aa), FASTA scores: opt: 955, E():0, (43.5% FT identity in 356 aa overlap); etc. Also similar to FT Q10641|Y03F_MYCTU|MTCY130.15c|Rv1330c CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (509 FT aa), FASTA scores: opt: 761, E(): 0, (38.4% identity in FT 437 aa overlap). TBparse score is 0.897." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(667252..668394) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0574c" FT /note="Rv0574c, (MTV039.12c), len: 380 aa. Conserved FT hypothetical protein, showing similarity with other FT hypothetical proteins and polyglutamate synthases FT (encapsulation proteins) e.g. FT AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA FT from Myxococcus xanthus (405 aa); M24150|BACCAPABC_3|CapA FT polyglutamate synthase (encapsulation protein) from FT B.anthracis (411 aa), FASTA scores: opt: 261, E(): FT 4.3e-10, (25.8% identity in 287 aa overlap); etc. TBparse FT score is 0.920." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(668579..669745) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0575c" FT /note="Rv0575c, (MTV039.13c), len: 388 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to many diverse FT oxidoreductases and monooxygenases e.g. FT AL109974|SCF34_5|T36404 probable monooxygenase from FT Streptomyces coelicolor (407 aa), FASTA scores: opt: 786, FT E(): 0, (38.7% identity in 398 aa overlap); FT P96555|AB000564 SALICYLATE HYDROXYLASE from SPHINGOMONAS FT (395 aa), FASTA scores: opt: 267, E():5e-11, (26.4% FT identity in 390 aa overlap). Also similar to FT Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis FT (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity FT in 345 aa overlap). TBparse score is 0.868. The FT transcription of this CDS seems to be activated in FT macrophages (see citation below)." FT /product="POSSIBLE OXIDOREDUCTASE" FT CDS 669848..671152 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0576" FT /note="Rv0576, (MTV039.14), len: 434 aa. Probable FT transcriptional regulator, ArsR family. N-terminus highly FT similar to others e.g. NP_102487.1|NC_002678 FT transcriptional regulator from Mesorhizobium loti (104 FT aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR FT family) from Bacillus halodurans (109 aa); etc. C-terminal FT region (~240-434) shows similarity with D67028_1 from FT Rhodococcus rhodochrous (112 aa); and Rv0738 from FT Mycobacterium tuberculosis (182 aa). N-terminus also FT highly similar to Rv2034 from Mycobacterium tuberculosis FT (107 aa). Contains helix-turn-helix motif at aa 23-43 FT (Score 1628, +4.73 SD). TBparse score is 0.901." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY ARSR-FAMILY)" FT CDS 671166..671951 FT /evidence=experimental FT /function="UNKNOWN" FT /gene="TB27.3" FT /locus_tag="Rv0577" FT /note="Rv0577, (MTV039.15), len: 261 aa. TB27.3, conserved FT hypothetical protein. Corresponds to O53774|CF30_MYCTU 27 FT kDa ANTIGEN CFP30B from Mycobacterium tuberculosis culture FT filtrate (260 aa), FASTA scores: opt: 1781, E(): 0, FT (100.0% identity in 260 aa overlap). Also similar to FT several hypothetical proteins and hydroxylases from FT Steptomyces sp. e.g. T35032 probable hydroxylase from FT Streptomyces coelicolor (263 aa); Q55078 orfA gene product FT from Streptomyces sp. (275 aa), FASTA scores: E(): 1.5e-1 FT 9, (38.6% identity in 264 aa overlap); D89734_1|P95754 DNA FT for SgaA SGAA PROTEIN from Streptomyces griseus; and FT SC9B10_20 from Streptomyces coelicolor (267 aa), FASTA FT score: (38.9 identity in 252 aa overlap). Also similar to FT Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257 FT aa), FASTA scores: E(): 1.1e-20, (32.0% identity in 259 aa FT overlap). TBparse score is 0.899." FT /product="CONSERVED HYPOTHETICAL PROTEIN TB27.3" FT CDS complement(671996..675916) FT /function="UNKNOWN" FT /gene="PE_PGRS7" FT /locus_tag="Rv0578c" FT /note="Rv0578c, (MTV039.16c), len: 1306 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT many other PGRS proteins e.g. MTCY493.04|Z95844 from FT Mycobacterium tuberculosis (1329 aa), FASTA scores: opt: FT 3994, E(): 0, (54.6% identity in 1375 aa overlap). FT Contains two PS00583 pfkB family of carbohydrate kinases FT signatures possibly fortuitously. TBparse score is 0.867." FT /product="PE-PGRS FAMILY PROTEIN" FT misc_feature complement(673034..673108) FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1" FT misc_feature complement(673880..673954) FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1" FT CDS 676238..676996 FT /function="UNKNOWN" FT /locus_tag="Rv0579" FT /note="Rv0579, (MTV039.17), len: 252 aa. Conserved FT hypothetical protein, showing some similarity to others FT e.g. AE001747_4 hypothetical protein from Thermotoga FT maritima (247 aa), FASTA scores: opt: 612, E(): 0, (39.6% FT identity in 235 aa overlap); AE001004_2 hypothetical FT protein from Archaeoglobus fulgidus (159 aa), FASTA FT scores: opt: 196, E(): 1e-06, (28.3% identity in 159 aa FT overlap); etc. TBparse score is 0.911." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(677125..677616) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0580c" FT /note="Rv0580c, (MTV039.18c), len: 163 aa. Conserved FT hypothetical protein, equivalent to AAA90989.1|U20446|MK35 FT lipoprotein precursor from Mycobacterium kansasii (225 FT aa). TBparse score is 0.910." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 677710..677925 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0581" FT /note="Rv0581, (MTV039.19), len: 71 aa. Conserved FT hypothetical protein, showing weak similarity to several FT Mycobacterium tuberculosis proteins including FT P95003|Z83863|Rv2550c|MTCY159_6 CONSERVED HYPOTHETICAL FT PROTEIN (81 aa), FASTA scores: opt: 93, E(): 3.2, (25.7% FT identity in 70 aa overlap); Rv2871; Rv1241; etc. Also FT shows weak similarity to X05648|SGSPH_1 from Streptomyces FT glaucescens (77 aa), FASTA scores: opt: 92, E(): 3.6, FT (35.4% identity in 65 aa overlap). TBparse score is FT 0.864." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 677922..678329 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0582" FT /note="Rv0582, (MTV039.20), len: 135 aa. Hypothetical FT unknown protein. TBparse score is 0.894." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(678389..679075) FT /function="UNKNOWN" FT /gene="lpqN" FT /locus_tag="Rv0583c" FT /note="Rv0583c, (MTV039.21c), len: 228 aa. Probable lpqN, FT conserved lipoprotein, equivalent to FT AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein FT precursor from Mycobacterium kansasii (225 aa), FASTA FT scores: opt: 945, E(): 0, (62.7% identity in 228 aa FT overlap); and similar to others from Mycobacteria e.g. FT Rv0040c and Rv1016c from Mycobacterium tuberculosis. FT Contains N-terminal signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site. TBparse score is 0.908." FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQN" FT misc_feature complement(679016..679048) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 679229..681862 FT /function="UNKNOWN" FT /locus_tag="Rv0584" FT /note="Rv0584, (MTV039.22), len: 877 aa. Possible FT conserved exported protein, similar to other hypothetical FT proteins which are not necessarily secreted e.g. FT CAB61925.1|AL133278 putative secreted protein from FT Streptomyces coelicolor (772 aa); FT AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen FT PG87 from Porphyromonas gingivalis (781 aa), FASTA scores: FT opt: 637, E(): 2.1e-30, (29.1% identity in 794 aa FT overlap); etc. Contains PS00699 Nitrogenases component 1 FT alpha and beta subunits signature 1. Has potential FT N-terminal signal peptide. TBparse score is 0.913." FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT misc_feature 679523..679546 FT /note="PS00699 Nitrogenases component 1 alpha and beta FT subunits signature 1" FT CDS complement(681885..684272) FT /function="UNKNOWN" FT /locus_tag="Rv0585c" FT /note="Rv0585c, (MTV039.23c, MTCY19H5.37), len: 795 aa. FT Probable conserved integral membrane protein. C-terminus FT similar to CAB88984.1|AL353864 putative integral membrane FT protein from Streptomyces coelicolor (299 aa); and FT C-terminal region of CAC01311.1|AL390968 putative integral FT membrane protein from Streptomyces coelicolor (925 aa). FT Also some similarity with Rv0204 from Mycobacterium FT tuberculosis. TBparse score is 0.928." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 684410..685132 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0586" FT /note="Rv0586, (MTCY19H5.36c), len: 240 aa. Probable FT transcriptional regulator, GntR family, similar to many FT e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase FT operon regulatory protein from Escherichia coli (258 aa), FT FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in FT 232 aa overlap); etc. Also similar to other M. FT tuberculosis transcriptional regulators GntR proteins e.g. FT Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial FT regulatory proteins, gntR family signature and probable FT helix-turn helix motif from aa 35-56 (Score 1531, +4.40 FT SD)." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (GNTR-FAMILY)" FT misc_feature 684518..684583 FT /note="PS00043 Bacterial regulatory proteins, gntR family FT signature" FT CDS 685129..685926 FT /evidence=experimental FT /function="UNKNOWN." FT /gene="yrbE2A" FT /locus_tag="Rv0587" FT /note="Rv0587, (MTCY19H5.35c), len: 265 aa. yrbE2A, FT hypothetical unknown integral membrane protein, part of FT mce2 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI FT hypothetical 27.9 kDa protein from Escherichia coli (260 FT aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity FT in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical FT protein from Haemophilus influenzae (261 aa), FASTA FT scores: opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa FT overlap); NP_302654.1|NC_002677 conserved membrane protein FT from Mycobacterium leprae (267 aa); etc." FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE2A" FT CDS 685928..686815 FT /function="UNKNOWN." FT /gene="yrbE2B" FT /locus_tag="Rv0588" FT /note="Rv0588, (MTCY19H5.34c), len: 295 aa. yrbE2B, FT hypothetical unknown integral membrane protein, part of FT mce2 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI FT hypothetical 27.9 kDa protein from Escherichia coli (260 FT aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % FT identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 FT hypothetical protei from Haemophilus influenzae (261 aa), FT FASTA scores: opt: 234, E(): 6.3e-08, (24.2% identity in FT 215 aa overlap); NP_302655.1|NC_002677 conserved membrane FT protein from Mycobacterium leprae (289 aa); etc." FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE2B" FT CDS 686821..688035 FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce2A" FT /locus_tag="Rv0589" FT /note="Rv0589, (MTCY19H5.33c), len: 404 aa. mce2A; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); FT O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also FT highly similar to others e.g. FT AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry FT protein from Mycobacterium bovis BCG (454 aa); FT NP_302656.1|NC_002677 putative cell invasion protein from FT Mycobacterium leprae (441 aa); CAC12798.1|AL445327 FT putative secreted protein from Streptomyces coelicolor FT (418 aa); etc. Also highly similar, but longer 21 aa, to FT P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from FT Mycobacterium tuberculosis (432 aa), FASTA scores: opt: FT 1324, E(): 0, (62.6% identity in 436 aa overlap). Contains FT a possible N-terminal signal or anchor sequence. Note that FT previously known as mce2." FT /product="MCE-FAMILY PROTEIN MCE2A" FT /standard_name="mce2" FT CDS 688032..688859 FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce2B" FT /locus_tag="Rv0590" FT /note="Rv0590, (MTCY19H5.32c), len: 275 aa. mce2B; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07414|Rv0170|MTCI28.10|mce1B (346 aa); FT O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly FT similar to others e.g. NP_302657.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (346 aa); FT P45391|YRBD_ECOLI hypothetical 19.6 kDa protein from FT Escherichia coli (183 aa), FASTA scores: opt: 160, E(): FT 0.00099, (28.3% identity in 166 aa overlap); FT P45029|YRBD_HAEIN|HI1085 hypothetical protein from FT Haemophilus influenzae (167 aa), FASTA scores: opt: 135, FT E():0.035, (25.9% identity in 143 aa overlap); etc. FT Contains possible N-terminal signal or anchor sequence." FT /product="MCE-FAMILY PROTEIN MCE2B" FT CDS 688808..689062 FT /function="UNKNOWN, BUT COULD BE INVOLVED IN HOST CELL FT INVASION." FT /locus_tag="Rv0590A" FT /note="Rv0590A, len: 84 aa. Probable continuation of FT mce2B|Rv0590. Can find no frameshift to account for this. FT Possible nucleotide G missing at 688793 as there are 5 in FT Mycobacterium bovis but only 4 in CDC1551. Strong FT similarity to C-terminus of other Mce proteins e.g. FT AL583926|AL583926_38 from Mycobacterium leprae strain TN FT (346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in FT 84 aa overlap)." FT /product="MCE-FAMILY RELATED PROTEIN" FT CDS 689059..690504 FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce2C" FT /locus_tag="Rv0591" FT /note="Rv0591, (MTCY19H5.31c), len: 481 aa. mce2C; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07415|R0171|MTCI28.11|mce1C (515 aa); FT O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly FT similar to others e.g. NP_302658.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (519 aa); FT CAC12796.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (351 aa); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), and may contain FT N-terminal signal or anchor sequence. Has highly Pro-rich FT C-terminus." FT /product="MCE-FAMILY PROTEIN MCE2C" FT misc_feature 689299..689322 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 690501..692027 FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="mce2D" FT /locus_tag="Rv0592" FT /note="Rv0592, (MTCY19H5.30c), len: 508 aa. mce2D; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07416|Rv0172|MTCI28.12|mce1D (530 aa); FT O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly FT similar to others e.g. NP_302659.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (531 aa); FT CAC12795.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich FT C-terminus and may contain N-terminal signal or anchor FT sequence." FT /product="MCE-FAMILY PROTEIN MCE2D" FT CDS 692024..693232 FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST FT CELL INVASION." FT /gene="lprL" FT /locus_tag="Rv0593" FT /note="Rv0593, (MTCY19H5.29c), len: 402 aa. Possible lprL FT (alternate gene name: mce2E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E FT (390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); FT etc. Also highly similar to others e.g. FT NP_302660.1|NC_002677 putative lipoprotein from FT Mycobacterium leprae (392 aa); CAC12794.1|AL445327 FT putative secreted protein from Streptomyces coelicolor FT (413 aa); etc. Contains possible signal sequence and FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRL (MCE-FAMILY FT LIPOPROTEIN MCE2E)" FT /standard_name="mce2E" FT misc_feature 692129..692161 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 693237..694787 FT /function="UNKNOWN, BUT THOUGHT INVOLVED IN HOST CELL FT INVASION." FT /gene="mce2F" FT /locus_tag="Rv0594" FT /note="Rv0594, (MTCY19H5.28c), len: 516 aa. mce2F; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), similar to Mycobacterium FT tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 FT aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also FT highly similar to others e.g. NP_302661.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (516 FT aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from FT Mycobacterium avium (80 aa) (similarity on C-terminus); FT CAC12793.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (433 aa); etc. Contains possible FT N-terminal signal or anchor sequence." FT /product="MCE-FAMILY PROTEIN MCE2F" FT CDS complement(694839..695231) FT /function="UNKNOWN" FT /locus_tag="Rv0595c" FT /note="Rv0595c, (MTCY19H5.27), len: 130 aa. Conserved FT hypothetical protein, similar to other conserved FT hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 FT aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562 FT plasmid stability protein from Pseudomonas syringae (139 FT aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity FT in 88 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(695228..695485) FT /function="UNKNOWN" FT /locus_tag="Rv0596c" FT /note="Rv0596c, (MTCY19H5.26), len: 85 aa. Conserved FT hypothetical protein, highly similar in part to other M. FT tuberculosis hypothetical proteins e.g. Rv0626, Rv3181c, FT Rv3385c, Rv3407, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(695668..696903) FT /function="UNKNOWN" FT /locus_tag="Rv0597c" FT /note="Rv0597c, (MTCY19H5.25), len: 411 aa. Conserved FT hypothetical protein, highly similar to Rv3179 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (429 FT aa). Also similar to AAF76191.1|AF271296_1|AF271296 FT putative ATP/GTP binding protein from Mycobacterium FT smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (441 FT aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity FT in 416 aa overlap) (N-terminus longer). Also similar to FT other hypothetical proteins e.g. NP_085874.1|NC_002679 FT hypothetical protein from Mesorhizobium loti (435 aa) FT (N-terminus longer). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature complement(696805..696828) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(697154..697567) FT /function="UNKNOWN" FT /locus_tag="Rv0598c" FT /note="Rv0598c, (MTCY19H5.24), len: 137 aa. Conserved FT hypothetical protein; similar to Rv2596|Y0B5_MYCTU|Q50625 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (134 aa), FASTA scores: opt: 254, E(): FT 8.2e-12, (41.5% identity in 130 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(697564..697800) FT /function="UNKNOWN" FT /locus_tag="Rv0599c" FT /note="Rv0599c, (MTCY19H5.23), len: 78 aa. Conserved FT hypothetical protein, similar to Rv2595|Y0B6_MYCTU|Q50626 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (81 aa), FASTA scores: opt: 160, E(): FT 6.2e-07, (35.8% identity in 81 aa overlap). N-terminus FT shows stong similarity with N-terminus of FT NP_104908.1|NC_002678 hypothetical protein from FT Mesorhizobium loti (89 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(697904..698410) FT /EC_number="2.7.3.-" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM." FT /locus_tag="Rv0600c" FT /note="Rv0600c, (MTCY19H5.22), len: 168 aa (probable FT partial CDS). Probable two-component sensor kinase (second FT part) (EC 2.7.3.-), similar to part (C-termini) of many FT others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from FT Streptomyces coelicolor (535 aa), FASTA scores: opt: 347, FT E(): 1.9e-12, (33.0% identity in 206 aa overlap); etc. FT Note that sequence was checked and no errors were FT detected, which would allow this and the upstream ORF to FT be joined. Start changed since first submission (- 39 FT aa)." FT /product="PROBABLE TWO COMPONENT SENSOR KINASE [SECOND FT PART]" FT CDS complement(698524..698994) FT /EC_number="2.7.3.-" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM." FT /locus_tag="Rv0601c" FT /note="Rv0601c, (MTCY19H5.21), len: 156 aa (probable FT partial CDS). Probable two-component sensor kinase (first FT part) (EC 2.7.3.-), similar to part (N-termini) of others FT e.g. Q0375|CUTS_STRLI cuts protein from streptomyces FT lividans (414 aa), FASTA scores: opt: 230, E(): 3.1e-08, FT (39.1% identity in 115 aa overlap). Note that the sequence FT was checked and no errors were detected that would allow FT this and the downstream ORF to be joined." FT /product="PROBABLE TWO COMPONENT SENSOR KINASE [FIRST FT PART]" FT CDS complement(699038..699799) FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM." FT /gene="tcrA" FT /locus_tag="Rv0602c" FT /note="Rv0602c, (MTCY19H5.20), len: 253 aa. Probable tcrA, FT two-component DNA-binding response regulator, highly FT similar to others e.g. NP_107959.1|NC_002678 two-component FT response regulator from Mesorhizobium loti (239 aa); etc. FT Also similar to many other Mycobacterium tuberculosis FT two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c FT RESPONSE REGULATOR HOMOLOG TRCR (TCRV) (257 aa), FASTA FT score: (47.4 identity in 232 aa overlap); etc." FT /product="PROBABLE TWO COMPONENT DNA BINDING FT TRANSCRIPTIONAL REGULATORY PROTEIN TCRA" FT CDS 699856..700167 FT /function="UNKNOWN" FT /locus_tag="Rv0603" FT /note="Rv0603, (MTCY19H5.19c), len: 103 aa. Possible FT exported protein with hydrophobic stretch at aa 7-29." FT /product="POSSIBLE EXPORTED PROTEIN" FT CDS 700239..701189 FT /function="UNKNOWN" FT /gene="lpqO" FT /locus_tag="Rv0604" FT /note="Rv0604, (MTCY19H5.18c), len: 316 aa. Probable lpqO, FT conserved lipoprotein, highly similar to Rv2999|lppY FT PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (321 FT aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in FT 312 aa overlap). Contains probable N-terminal signal FT sequence and PS00013 Prokaryotic membrane lipoprotein FT lipid attachment site." FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQO" FT misc_feature 700275..700307 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT repeat_unit complement(701247..701369) FT /note="123 bp imperfect direct repeat 2, 92/103 bp FT identical to first copy at 709425..709548, FT AGCCCCGGCTCGACGCGGCATAGGGTGGCCACCGTGGCCGAAGCGTTCCATGCGACC FT GTGCCGTGGCGAGGATCCCGGCCGAACATGGCCCATTGAACGAGGACGTCATCGCAC FT GACGCCTGC" FT repeat_region 701384..702767 FT /insertion_seq="IS1536" FT /note="IS1536, len: 1384 bp. Partial copy of insertion FT sequence IS_1536." FT CDS 701406..702014 FT /evidence=experimental FT /function="PREVENTS THE COINTEGRATION OF FOREIGN DNA FT BEFORE INTEGRATION INTO THE CHROMOSOME." FT /locus_tag="Rv0605" FT /note="Rv0605, (MTCY19H5.17c), len: 202 aa. Possible FT resolvase for IS_Y349 element, similar to several FT Mycobacterial hypothetical proteins and weakly similar to FT Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA FT scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa FT overlap). Contains PS00397 Site-specific recombinases FT active site and probable helix-turn helix motif from aa FT 9-30 (Score 1815, +5.37 SD)." FT /product="POSSIBLE RESOLVASE" FT misc_feature 701592..701618 FT /note="PS00397 Site-specific recombinases active site" FT CDS 702016..702759 FT /function="THOUGHT TO BE REQUIRED FOR THE TRANSPOSITION OF FT THE INSERTION ELEMENT IS_1536." FT /locus_tag="Rv0606" FT /note="Rv0606, (MTCY19H5.16c), len: 247 aa. Possible FT truncated transposase for IS_1536 element, highly similar FT to N-terminus of other transposases from Mycobacterium FT tuberculosis e.g. FT YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c PUTATIVE FT TRANSPOSASE from Mycobacterium tuberculosis (460 aa), FT FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa FT overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to FT N-terminus of MTV002_57|Rv2792 RESOLVASE from M. FT tuberculosis (193 aa), FASTA score: (87.4% identity in 238 FT aa overlap)." FT /product="POSSIBLE TRANSPOSASE (FRAGMENT)" FT CDS 702813..703199 FT /function="UNKNOWN" FT /locus_tag="Rv0607" FT /note="Rv0607, (MTCY19H5.15c), len: 128 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 703244..703489 FT /function="UNKNOWN" FT /locus_tag="Rv0608" FT /note="Rv0608, (MTCY19H5.14c), len: 81 aa. Conserved FT hypothetical protein, similar to several other M. FT tuberculosis hypothetical short proteins e.g. FT Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: FT 159, E(): 1.2e-09, (43.0% identity in 86 aa overlap); FT Rv2760c (89 aa); Rv1740 (70 aa), etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 703486..703887 FT /function="UNKNOWN" FT /locus_tag="Rv0609" FT /note="Rv0609, (MTCY19H5.13c), len: 133 aa. Conserved FT hypothetical protein, similar to several Mycobacterium FT tuberculosis hypothetical proteins e.g. FT YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 CONSERVED FT HYPOTHETICAL PROTEIN (139 aa), FASTA scores: opt: 262, FT E(): 8.1e-12, (39.1% identity in 128 aa overlap); FT MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 CONSERVED FT HYPOTHETICAL PROTEIN (131 aa), FASTA score: (42.9% FT identity in 126 aa overlap), Rv0565c, Rv3854c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 703830..704057 FT /function="UNKNOWN" FT /locus_tag="Rv0609A" FT /note="Rv0609A, len: 75 aa. Conserved hypothetical FT protein, highly similar to part of upstream ORF FT Rv0612|MTCY19H5.09c CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (201 aa), FASTA scores: opt: FT 154, E(): 1.8e-05, (74.3% identity in 35 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_unit complement(703912..703985) FT /note="74 bp imperfect direct repeat 2, 64/73 bp identical FT to first copy at 706790..706863, FT CACAGCGGACACCACAAAGCCCGCCGCTGCCACCGGATCGTCGGAACGAAAATAGTC FT GTACCCGTGAGCCTCGC" FT CDS complement(704752..705909) FT /function="UNKNOWN" FT /locus_tag="Rv0610c" FT /note="Rv0610c, (MTCY19H5.11), len: 385 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(705961..706344) FT /function="UNKNOWN" FT /locus_tag="Rv0611c" FT /note="Rv0611c, (MTCY19H5.10), len: 127 aa. Hypothetical FT unknown protein. Note that first start has been taken FT although this overlaps slightly with the upstream ORF." FT /product="HYPOTHETICAL PROTEIN" FT CDS 706324..706929 FT /function="UNKNOWN" FT /locus_tag="Rv0612" FT /note="Rv0612, (MTCY19H5.09c), len: 201 aa. Conserved FT hypothetical protein, highly similar, but in part, to FT downstream ORF Rv0609A CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (75 aa); and showing weak FT similarity with other hypothetical proteins from FT Mycobacterium tuberculosis. Note that first start has been FT taken although this overlaps slightly with the upstream FT ORF." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_unit complement(706790..706863) FT /note="74 bp imperfect direct repeat 1, 64/73 bp identical FT to second copy at 703912..703985, FT CACATCGGACACGACGAAACCCGCCGCTGCCACCGGATCGTCGGAGCGGAAGTAGTC FT GTACCCGTCGGCCTCGC" FT CDS complement(706948..709515) FT /function="UNKNOWN" FT /locus_tag="Rv0613c" FT /note="Rv0613c, (MTCY19H5.08), len: 855 aa. Hypothetical FT unknown protein. Contains a very short region with strong FT similarity to several preprotein translocases e.g. FT P47847|SECA_LISMO preprotein translocase seca subunit (836 FT aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in FT 70 aa overlap, and 72.7% identity in 22 aa overlap)." FT /product="HYPOTHETICAL PROTEIN" FT CDS 709356..710348 FT /function="UNKNOWN" FT /locus_tag="Rv0614" FT /note="Rv0614, (MTCY19H5.07c), len: 330 aa. Conserved FT hypothetical protein, similar in part to Mycobacterium FT tuberculosis hypothetical proteins e.g. FT YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c CONSERVED FT HYPOTHETICAL PROTEIN (323 aa), FASTA scores: opt: 200, FT E(): 0.00016, (28.3% identity in 269 aa overlap); FT MTCY9F9_15 FASTA score: (40.3% identity in 144 aa FT overlap), Rv1949c, Rv2542, etc. Several start sites are FT possible; first start has been chosen. Note that this ORF FT overlaps with the upstream ORF." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_unit complement(709425..709548) FT /note="123 bp imperfect direct repeat 1, 92/103 bp FT identical to second copy at 701247..701369, FT AGCCTCGGCTGGCCGCGGCATAAGGTGGCCACCGTGGCCGAAGCGTTCGATGCGACC FT CAAGCCGTGGCGAGAATCCTGGCCGAACATGGCCCATTGAGCGAGGACGACATCGCA FT CGACGCCTGC" FT repeat_unit 709585..709663 FT /note="79 bp imperfect direct repeat 1, 73/78 bp identical FT to second copy at 711624..711702, FT TAGGGTTCGGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGACGGACGTGAGC FT TGCTGTTCTTTTCGCTGCCCGG" FT CDS 710345..710587 FT /function="UNKNOWN" FT /locus_tag="Rv0615" FT /note="Rv0615, (MTCY19H5.06c), len: 80 aa. Probable FT integral membrane protein." FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT CDS complement(710584..710850) FT /function="UNKNOWN" FT /locus_tag="Rv0616c" FT /note="Rv0616c, (MTCY19H5.05), len: 88 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 711006..711407 FT /function="UNKNOWN" FT /locus_tag="Rv0617" FT /note="Rv0617, (MTCY19H5.04c), len: 133 aa. Conserved FT hypothetical protein, similar to Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv2494, Rv3320c, FT Rv0749, Rv0277c, Rv2530c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 711536..712231 FT /EC_number="2.7.7.10" FT /function="INVOLVED IN GALACTOSE METABOLISM (LELOIR FT PATHWAY) [CATALYTIC ACTIVITY: UTP + alpha-D-galactose FT 1-phosphate = diphosphate + UDP-galactose]." FT /gene="galTa" FT /locus_tag="Rv0618" FT /note="Rv0618, (MTCY19H5.03c), len: 231 aa (probable FT partial CDS). Probable galTa, first part of FT galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), FT highly similar to N-terminal half of other galT proteins FT e.g. P13212|GAL7_STRLI galactose-1-phosphate FT uridylyltransferase from Streptomyces lividans (354 aa), FT FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in FT 177 aa overlap); etc. Also highly similar to N-terminal FT half of some UDP glucose--hexose-1-phosphate FT uridylyltransferases (EC 2.7.7.12). N-terminal 28 aa FT similar to MTCY20H11.08|Rv0627|MTCY20H11.08 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 FT aa), FASTA score: (71.4% identity in 28 overlap). Cosmid FT sequence is correct but there may be a frameshift mutation FT in this region which would allow the two ORFs to be FT joined. BELONGS TO THE GALACTOSE-1-PHOSPHATE FT URIDYLYLTRANSFERASE FAMILY 1. Note that previously known FT as galT'." FT /product="PROBABLE GALACTOSE-1-PHOSPHATE FT URIDYLYLTRANSFERASE GALTA [FIRST PART]" FT /standard_name="galT'" FT repeat_unit 711624..711702 FT /note="79 bp imperfect direct repeat 2, 73/78 bp identical FT to first copy at 709585..709663, FT TAGGGTTCTGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGATGGCCGTGACC FT TGCTGTTCTTTTCGCTGCCCGG" FT CDS <712174..712719 FT /EC_number="2.7.7.10" FT /function="INVOLVED IN GALACTOSE METABOLISM (LELOIR FT PATHWAY) [CATALYTIC ACTIVITY: UTP + alpha-D-galactose FT 1-phosphate = diphosphate + UDP-galactose]." FT /gene="galTb" FT /locus_tag="Rv0619" FT /note="Rv0619, (MTCY19H5.02c), len: 181 aa (probable FT partial CDS). Probable galTb, second part of FT galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), FT highly similar to C-terminal half of other galT proteins FT e.g. P13212|GAL7_STRLI galactose-1-phosphate FT uridylyltransferase from Streptomyces lividans (354 aa), FT FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in FT 186 aa overlap), etc. Cosmid sequence is correct but there FT may be a frameshift mutation in this region which would FT allow the two ORFS to be joined. BELONGS TO THE FT GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Note FT that previously known as 'galT." FT /product="PROBABLE GALACTOSE-1-PHOSPHATE FT URIDYLYLTRANSFERASE GALTB [SECOND PART]" FT /standard_name="'galT" FT CDS 712716..713807 FT /EC_number="2.7.1.6" FT /function="INVOLVED IN GALACTOSE METABOLISM (LELOIR FT PATHWAY) (AT THE FIRST REACTION) [CATALYTIC ACTIVITY: ATP FT + D-galactose = ADP + D-galactose 1-phosphate]." FT /gene="galK" FT /locus_tag="Rv0620" FT /note="Rv0620, (MTCY19H5.01c, MTCY20H10.01), len: 363 aa. FT Probable galK, galactokinase (EC 2.7.1.6), similar to FT others e.g. P13227|GAL1_STRLI GALACTOKINASE from FT Streptomyces lividans (397 aa); P06976|GAL1_ECOLI FT galactokinase from Escherichia coli (381 aa), FASTA FT scores: opt: 669, E(): 0, (35.9% identity in 365 aa FT overlap); etc. Contains PS00106 Galactokinase signature FT and PS00560 Serine carboxypeptidases, histidine active FT site. BELONGS TO THE GHMP KINASE FAMILY. GALK SUBFAMILY." FT /product="PROBABLE GALACTOKINASE GALK (GALACTOSE KINASE)" FT misc_feature 712740..712775 FT /note="PS00106 Galactokinase signature" FT misc_feature 712959..712985 FT /note="PS00560 Serine carboxypeptidases, histidine active FT site" FT CDS 714202..715266 FT /function="UNKNOWN" FT /locus_tag="Rv0621" FT /note="Rv0621, (MTCY20H10.02), len: 354 aa. Possible FT membrane protein; contains potential membrane spanning FT regions. Also contains PS00017 ATP/GTP-binding site motif FT A (P-loop)." FT /product="POSSIBLE MEMBRANE PROTEIN" FT misc_feature 715081..715104 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 715370..716317 FT /function="UNKNOWN" FT /locus_tag="Rv0622" FT /note="Rv0622, (MTCY20H10.03), len: 315 aa. Possible FT membrane protein; contains potential membrane spanning FT region. Shows weak similarity with Mycobacterium FT tuberculosis hypothetical proteins Rv1804c, Rv1810, etc. FT Start changed since first submission (-26 aa)." FT /product="POSSIBLE MEMBRANE PROTEIN" FT CDS 716410..716664 FT /function="UNKNOWN" FT /locus_tag="Rv0623" FT /note="Rv0623, (MTCY20H10.04), len: 84 aa. Conserved FT hypothetical protein, highly similar to FT NP_384911.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (84 aa). Also similar to several FT Mycobacterium tuberculosis hypothetical proteins e.g FT MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 CONSERVED FT HYPOTHETICAL PROTEIN (70 aa), FASTA score: (73.5% identity FT in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c FT CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA score: (73.5 FT identity in 68 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 716664..717059 FT /function="UNKNOWN" FT /locus_tag="Rv0624" FT /note="Rv0624, (MTCY20H10.05), len: 131 aa. Conserved FT hypothetical protein, highly similar to Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv1741, Rv0609, FT Rv2759c,Rv0565c, Rv3854c, Rv3083, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(717153..717893) FT /function="UNKNOWN" FT /locus_tag="Rv0625c" FT /note="Rv0625c, (MTCY20H10.06c), len: 246 aa. Probable FT conserved transmembrane protein, showing similarity with FT others e.g. CAB61866.1|AL133252 putative integral membrane FT protein from Streptomyces coelicolor (249 aa). Also FT similar to Rv1491c|MTCY277_13 from Mycobacterium FT tuberculosis. Contains potential membrane spanning FT regions." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 718025..718285 FT /function="UNKNOWN" FT /locus_tag="Rv0626" FT /note="Rv0626, (MTCY20H10.07), len: 86 aa. Conserved FT hypothetical protein, similar to Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv0596c, Rv3385c, FT Rv3407,Rv3181c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 718282..718689 FT /function="UNKNOWN" FT /locus_tag="Rv0627" FT /note="Rv0627, (MTCY20H11.08), len: 135 aa. Conserved FT hypothetical protein, similar to Mycobacterium FT tuberculosis hypothetical proteins Rv0595c and Rv0665." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(718761..719912) FT /function="UNKNOWN" FT /locus_tag="Rv0628c" FT /note="Rv0628c, (MTCY20H10.09c), len: 383 aa. Conserved FT hypothetical protein, highly similar to FT Rv0874c|YZ02_MYCTU|Q10536 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (386 aa), FASTA scores: FT opt: 2082, E(): 0, (81.5% identity in 383 aa overlap). FT Also some similarity to P72543|SPU62616_1 HYPOTHETICAL FT PROTEIN from Synechococcus, FASTA scores: E(): 2.8e-28, FT (36.6 identity in 265 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(720005..721732) FT /EC_number="3.1.11.5" FT /function="INVOLVED IN HOMOLOGOUS RECOMBINATION." FT /gene="recD" FT /locus_tag="Rv0629c" FT /note="Rv0629c, (MTCY20H10.10c), len: 575 aa. Probable FT recD, exonuclease V, alpha chain (exodeoxyribonuclease V, FT alpha chain) (EC 3.1.11.5) (see citation below), highly FT similar to other exonucleases e.g. FT AF157643_3|AAD46809.1|recD Escherichia coli RecD protein FT homolog from Mycobacterium smegmatis (554 aa); FT P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease v 67kd FT polypeptide (EC 3.1.11.5) (EXONUCLEASE V ALPHA CHAIN) from FT Escherichia coli strain K12 (608 aa), FASTA scores: opt: FT 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). CONSIST OF THREE SUBUNITS; RECB|Rv0630c, FT RECC|Rv0631c AND RECD." FT /product="PROBABLE EXONUCLEASE V (ALPHA CHAIN) RECD FT (EXODEOXYRIBONUCLEASE V ALPHA CHAIN) (EXODEOXYRIBONUCLEASE FT V POLYPEPTIDE)" FT misc_feature complement(721202..721225) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(721729..725013) FT /EC_number="3.1.11.5" FT /function="INVOLVED IN HOMOLOGOUS RECOMBINATION." FT /gene="recB" FT /locus_tag="Rv0630c" FT /note="Rv0630c, (MTCY20H10.11c), len: 1094 aa. Probable FT recB, exonuclease V, beta chain (exodeoxyribonuclease V, FT beta chain) (EC 3.1.11.5) (see citation below), highly FT similar to other exonucleases e.g. FT AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein FT homolog from Mycobacterium smegmatis (1083 aa); FT P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 FT kDa polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) FT from Escherichia coli strain K12 (1180 aa), FASTA scores: FT opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD FT SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c FT AND RECD|Rv0629c." FT /product="PROBABLE EXONUCLEASE V (BETA CHAIN) RECB FT (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V FT POLYPEPTIDE) (CHI-SPECIFIC ENDONUCLEASE)" FT misc_feature complement(724930..724953) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(725013..728306) FT /EC_number="3.1.11.5" FT /function="INVOLVED IN HOMOLOGOUS RECOMBINATION." FT /gene="recC" FT /locus_tag="Rv0631c" FT /note="Rv0631c, (MTCY20H10.12c), len: 1097 aa. Probable FT recC, exonuclease V, gamma chain (exodeoxyribonuclease V, FT gamma chain) (EC 3.1.11.5) (see Mizrahi & Andersen 1998), FT highly similar to other exonucleases e.g. FT AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein FT homolog from Mycobacterium smegmatis (1085 aa); FT P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease v 125 kDa FT polypeptide (EC 3.1.11.5) (EXONUCLEASE V GAMMA CHAIN) from FT Escherichia coli strain K12 (1122 aa), FASTA scores: opt: FT 954, E(): 0, (29.2% identity in 1109 aa overlap); etc. FT CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC AND FT RECD|Rv0629c. The transcription of this CDS seems to be FT activated specifically in host granulomas (see FT Ramakrishnan et al., 2000)." FT /product="PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC FT (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE FT V POLYPEPTIDE)" FT CDS complement(728583..729278) FT /EC_number="4.2.1.17" FT /evidence=experimental FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + FT H(2)O]." FT /gene="echA3" FT /locus_tag="Rv0632c" FT /note="Rv0632c, (MTCY20H10.13c), len: 231 aa. Probable FT echA3, enoyl-CoA hydratase (EC 4.2.1.17), almost identical FT to the MTU88877_1 enoyl-CoA hydratase of Mycobacterium FT tuberculosis field isolate NTI64719, FASTA score: (92.4% FT identity in 184 aa overlap). Also similar to others e.g. FT P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter FT capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA FT scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa FT overlap); etc." FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA3 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT CDS complement(729327..730166) FT /function="UNKNOWN" FT /locus_tag="Rv0633c" FT /note="Rv0633c, (MTCY20H11.14c), len: 279 aa. Possible FT exported protein; has hydrophobic stretch at aa 23-41." FT /product="POSSIBLE EXPORTED PROTEIN" FT CDS complement(730320..731033) FT /EC_number="3.1.2.6" FT /function="THOUGHT TO BE INVOLVED IN GLYOXAL PATHWAY. FT THIOLESTERASE THAT CATALYSES THE HYDROLYSIS OF FT S-D-LACTOYL-GLUTATHIONE TO FORM GLUTATHIONE AND D-LACTIC FT ACID [CATALYTIC ACTIVITY: (S)-(2-hydroxyacyl)glutathione + FT H2O = glutathione + a 2-hydroxy acid anion]." FT /locus_tag="Rv0634c" FT /note="Rv0634c, (MTCY20H10.15c), len: 237 aa. Possible FT glyoxalase II (EC 3.1.2.6), equivalent to FT NP_302290.1|NC_002677 putative glyoxylase II from FT Mycobacterium leprae (238 aa); and similar to FT U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kDa protein FT from Mycobacterium leprae (218 aa), FASTA scores: opt: FT 281, E(): 3.9e-12, (31.8% identity in 201 aa overlap). FT Also similar to other glyoxalases and FT metallo-beta-lactamase family proteins e.g. FT NP_386770.1|NC_003047 PUTATIVE HYDROXYACYLGLUTATHIONE FT HYDROLASE from Sinorhizobium meliloti (256 aa); etc. Also FT similar to other putative glyoxylases from Mycobacterium FT tuberculosis e.g. Rv1637c. BELONGS TO THE GLYOXALASE II FT FAMILY. COFACTOR: BINDS TWO ZINC IONS." FT /product="POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE FT HYDROLASE) (GLX II)" FT CDS 731113..731364 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0634A" FT /note="Rv0634A, len: 83 aa. Hypothetical unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT tRNA 731494..731566 FT /gene="tRNA-Thr(GGT)" FT /anticodon=(pos:731527..731529,aa:Thr) FT /product="transfer RNA-Thr(GGT)" FT tRNA 731603..731676 FT /gene="tRNA-Met(CAT)" FT /anticodon=(pos:731637..731639,aa:Met) FT /product="transfer RNA-Met(CAT)" FT CDS 731712..731879 FT /function="INVOLVED IN TRANSLATION MECHANISM." FT /gene="rpmG2" FT /locus_tag="Rv0634B" FT /note="Rv0634B, len: 55 aa. Probable rpmG2, 50S ribosomal FT protein L33. Note that Mycobacterium tuberculosis has a FT second rpmG gene: FT P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 PUTATIVE 50S FT RIBOSOMAL PROTEIN L33 (55 aa), FASTA scores: opt: 391, FT E(): 2.9e-25, (100.0% identity in 55 aa overlap). BELONGS FT TO THE L33P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L33 RPMG2" FT CDS 731930..732406 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0635" FT /note="Rv0635, (MTCY20H10.16), len: 158 aa. Conserved FT hypothetical protein, equivalent to NP_302287.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (159 aa); and highly similar to YV31_MYCLE|P54879 FT conserved hypothetical protein from Mycobacterium leprae FT (166 aa), FASTA scores: opt: 387, E(): 5.9e-21, (43.4% FT identity in 145 aa overlap). Also similar FT CAB77410.1|AL160431|SCD82.07 hypothetical protein from FT Streptomyces coelicolor (150 aa). And highly similar to FT two hypothetical proteins from Mycobacterium tuberculosis: FT Rv0504c|YV31_MYCTU|Q11168 (166 aa), FASTA scores: opt: FT 405, E(): 3.2e-22, (45.0% identity in 140 aa overlap); and FT Rv0637|MTY20H10_19 (2 ORFs downstream) (166 aa), FASTA FT score: (48.7% identity in 150 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 732393..732821 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0636" FT /note="Rv0636, (MTCY20H10.17), len: 142 aa. Conserved FT hypothetical protein, equivalent to NP_302286.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (142 aa). Also highly similar to FT CAB77411.1|AL160431|SCD82.08 hypothetical protein from FT Streptomyces coelicolor (142 aa); and similar to others FT e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid FT E04) (298 aa), FASTA scores: opt: 167, E(): 0.00064, (31.6 FT identity in 117 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 732825..733325 FT /function="UNKNOWN" FT /locus_tag="Rv0637" FT /note="Rv0637, (MTCY20H10.18), len: 166 aa. Conserved FT hypothetical protein, equivalent to FT NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved FT hypothetical protein from Mycobacterium leprae (166 aa), FT FASTA scores: opt: 352, E(): 4e-19, (39.2% identity in 148 FT aa overlap); and highly similar to others from FT Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved FT hypothetical protein (159 aa). Also highly similar to FT CAB77410.1|AL160431|SCD82.07 hypothetical protein from FT Streptomyces coelicolor (150 aa); FT Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved FT hypothetical protein (two ORFs upstream) from FT Mycobacterium tuberculosis (158 aa), FASTA score: (49.3% FT identity in 150 aa overlap); and FT Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168 FT hypothetical protein from Mycobacterium tuberculosis (166 FT aa), FASTA scores: opt: 380, E(): 3.8e-21, (43.1% identity FT in 137 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT tRNA 733524..733596 FT /gene="tRNA-Trp(CCA)" FT /anticodon=(pos:733557..733559,aa:Trp) FT /product="transfer RNA-Trp(CCA)" FT CDS 733737..734222 FT /function="ESSENTIAL FOR PROTEIN EXPORT." FT /gene="secE1" FT /locus_tag="Rv0638" FT /note="Rv0638, (MTCY20H10.19), len: 161 aa. Probable FT secE1, preprotein translocase (tail-anchored membrane FT protein) (see citation below), highly similar at FT C-terminal half to others e.g. P36690|SECE_STRGR FT PREPROTEIN TRANSLOCASE SECE SUBUNIT from Streptomyces FT griseus (86 aa), FASTA scores: opt: 220, E(): 4.6e-06, FT (35.4% identity in 96 aa overlap); P16920|SECE_ECOLI FT preprotein translocase sece subunit from Escherichia coli FT strains K12 and O157:H7 (127 aa), FASTA scores: opt: 122, FT E(): 0.34, (37.0% identity in 54 aa overlap); etc. FT Contains PS01067 Protein secE/sec61-gamma signature. FT BELONGS TO THE SECE/SEC61-GAMMA FAMILY. PART OF THE FT PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE FT SECA|Rv3240c, SECD|Rv2587c, SECE, SECF|Rv2586c, FT SECG|Rv1440 AND SECY|Rv0732. Note that previously known as FT secE." FT /product="PROBABLE PREPROTEIN TRANSLOCASE SECE1" FT /standard_name="secE" FT misc_feature 734058..734144 FT /note="PS01067 Protein secE/sec61-gamma signature" FT CDS 734254..734970 FT /evidence=experimental FT /function="INFLUENCES TRANSCRIPTION TERMINATION AND FT ANTITERMINATION. ACTS AS A COMPONENT OF THE TRANSCRIPTION FT COMPLEX, AND INTERACTS WITH THE TERMINATION FACTOR RHO AND FT RNA POLYMERASE." FT /gene="nusG" FT /locus_tag="Rv0639" FT /note="Rv0639, (MTCY20H10.20), len: 238 aa. Probable nusG, FT transcription antitermination protein, equivalent to FT NP_302283.1|NC_002677 transcription antitermination FT protein nusG from Mycobacterium leprae (228 aa). Also FT highly similar to others e.g. P36260|NUSG_STRGR from FT Streptomyces griseus (294 aa), FASTA scores: opt: 845, FT E(): 0, (55.4% identity in 233 aa overlap); etc. Note that FT shorter at the N-terminus than other nusG. Contains FT PS01014 Transcription termination factor nusG signature. FT BELONGS TO THE NUSG FAMILY." FT /product="PROBABLE TRANSCRIPTION ANTITERMINATION PROTEIN FT NUSG" FT misc_feature 734914..734943 FT /note="PS01014 Transcription termination factor nusG FT signature" FT CDS 735022..735450 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA." FT /gene="rplK" FT /locus_tag="Rv0640" FT /note="Rv0640, (MTCY20H11.21), len: 142 aa. Probable rplK, FT 50S ribosomal protein L11, equivalent to FT NP_302282.1|NC_002677 50S ribosomal protein L11 from FT Mycobacterium leprae (142 aa). Also highly similar to FT others e.g. P48954|RL11_STRCO|SCD82.19 50s ribosomal FT protein L11 from Streptomyces coelicolor (144 aa), FASTA FT scores: opt: 763, E(): 0, (84.6% identity in 143 aa FT overlap); etc. Contains PS00359 Ribosomal protein L11 FT signature. BELONGS TO THE L11P FAMILY OF RIBOSOMAL FT PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L11 RPLK" FT misc_feature 735403..735447 FT /note="PS00359 Ribosomal protein L11 signature" FT CDS 735517..736224 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA AND IS LOCATED IN THE NEIGHBORHOOD OF THE SITE WHERE FT ELONGATION FACTOR TU IS BOUND TO THE RIBOSOME." FT /gene="rplA" FT /locus_tag="Rv0641" FT /note="Rv0641, (MTCY20H10.22), len: 235 aa. Probable rplA, FT 50S ribosomal protein L1, equivalent to FT NP_302281.1|NC_002677 50S ribosomal protein L1 from FT Mycobacterium leprae (235 aa). Also highly similar to FT others e.g. P3625|RL1_STRGR 50s ribosomal protein L1 from FT Streptomyces griseus (240 aa), FASTA scores: opt: 1081, FT E(): 0, (72.2% identity in 230 aa overlap); etc. BELONGS FT TO THE L1P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L1 RPLA" FT CDS complement(736298..737203) FT /EC_number="2.1.1.-" FT /evidence=experimental FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary FT hydroxy group with an adjacent methyl branch; Olefinic FT mycolic acid methyl transferase." FT /gene="mmaA4" FT /locus_tag="Rv0642c" FT /note="Rv0642c, (MTCY20H10.23c), len: 301 aa. mmaA4, FT methoxy mycolic acid synthase 4 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid FT modification protein) from Mycobacterium bovis BCG strain FT Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic FT acid synthase 4 from Mycobacterium leprae (298 aa); and FT highly similar to others from Mycobacteria e.g. downstream FT ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c PUTATIVE METHOXY FT MYCOLIC ACID SYNTHASE 3 from Mycobacterium tuberculosis FT (293 aa)." FT /product="METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL FT MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT CDS complement(737268..738149) FT /EC_number="2.1.1.-" FT /evidence=experimental FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary FT hydroxy group with an adjacent methyl branch; Olefinic FT mycolic acid methyl transferase." FT /gene="mmaA3" FT /locus_tag="Rv0643c" FT /note="Rv0643c, (MTCY20H10.24c), len: 293 aa. mmaA3, FT methoxy mycolic acid synthase 3 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid FT modification protein) from Mycobacterium bovis BCG strain FT Pasteur (289 aa); and highly similar to others from FT Mycobacteria e.g. upstream ORF FT P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY FT MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis FT (301 aa)." FT /product="METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL FT MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT CDS complement(738297..739160) FT /EC_number="2.1.1.-" FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary FT hydroxy group with an adjacent methyl branch; Olefinic FT mycolic acid methyl transferase. HAS ALSO CYCLOPROPANE FT FUNCTION." FT /gene="mmaA2" FT /locus_tag="Rv0644c" FT /note="Rv0644c, (MTCY20H10.25c), len: 287 aa. mmaA2, FT methoxy mycolic acid synthase 2 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid FT modification protein) from Mycobacterium bovis BCG strain FT Pasteur (287 aa); and highly similar to others from FT Mycobacteria e.g. upstream ORF FT P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY FT MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis FT (301 aa). Note that alternative start is at position FT 739247." FT /product="METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 (METHYL FT MYCOLIC ACID SYNTHASE 2) (MMA2) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT CDS complement(739327..740187) FT /EC_number="2.1.1.-" FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary FT hydroxy group with an adjacent methyl branch; Olefinic FT mycolic acid methyl transferase." FT /gene="mmaA1" FT /locus_tag="Rv0645c" FT /note="Rv0645c, (MTCY20H10.26c), len: 286 aa. mmaA1, FT methoxy mycolic acid synthase 1 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from FT Mycobacterium leprae (286 aa); and highly similar to FT others from Mycobacteria e.g. upstream ORF FT P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY FT MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis FT (301 aa)." FT /product="METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL FT MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT CDS complement(740234..741139) FT /EC_number="3.1.-.-" FT /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR FT METABOLISM." FT /gene="lipG" FT /locus_tag="Rv0646c" FT /note="Rv0646c, (MTCY20H10.27c), len: 301 aa. Probable FT lipG, lipase/esterase (EC 3.1.-.-), equivalent to FT NP_302278.1|NC_002677 probable hydrolase from FT Mycobacterium leprae (304 aa). Also highly similar to FT various hydrolases, especially lipases e.g. FT AA61351.1|X88895 carboxyl esterase from Acinetobacter FT calcoaceticus (312 aa), FASTA scores: opt: 867, E(): 0, FT (50.2% identity in 279 aa overlap); etc. Also similar to FT transferases e.g. P77026 MACROLIDE 2'-PHOSPHOTRANSFERASE FT II from Escherichia coli (279 aa), FASTA scores: E(): FT 1.3e-14, (32.5% identity in 286 aa overlap). Similar to M. FT tuberculosis non-heme bromoperoxidases and epoxide FT hydrolases." FT /product="PROBABLE LIPASE/ESTERASE LIPG" FT CDS complement(741151..742617) FT /function="UNKNOWN" FT /locus_tag="Rv0647c" FT /note="Rv0647c, (MTCY20H10.28c), len: 488 aa. Conserved FT hypothetical protein, equivalent to NP_302277.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (448 aa). Also showing similarity to a variety of FT hypothetical ABC1-LIKE proteins or conserved hypothetical FT proteins e.g. D90908_28|P73627 ABC1-LIKE PROTEIN from FT Synechocystis (585 aa), FASTA scores: E(): 1.8e-31, (29.1% FT identity in 474 aa overlap); Q55884 HYPOTHETICAL6 5.0 KD FT PROTEIN (567 aa), FASTA scores: opt: 583, E(): 5.7e-30, FT (28.1% identity in 416 aa overlap); etc. Also similar to FT Rv3197 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 742719..746366 FT /EC_number="3.2.1.-" FT /evidence=experimental FT /function="Alpha-mannosidase activity: hydrolysis of FT terminal, non-reducing alpha-D-mannose residues in FT alpha-D-mannosides." FT /locus_tag="Rv0648" FT /note="Rv0648, (MTCY20H10.29), len: 1215 aa. FT Alpha-mannosidase (EC 3.2.1.-) (see citation below), FT showing some similarity to hypothetical proteins and FT various sugar hydrolases e.g. SYCSLRA_6|Q55528 FT HYPOTHETICAL 1 20.4 kDa PROTEIN from Synechocystis (1042 FT aa), FASTA scores: opt: 260, E(): 3.6e-08, (23.4% identity FT in 602 aa overlap); etc. Contains PS00659 Glycosyl FT hydrolases family 5 signature." FT /product="ALPHA-MANNOSIDASE" FT misc_feature 742719..742748 FT /note="PS00659 Glycosyl hydrolases family 5 signature" FT CDS 746363..747037 FT /EC_number="2.3.1.39" FT /function="INVOLVED IN LIPID METABOLISM; FATTY ACID FT BIOSYNTHESIS [CATALYTIC ACTIVITY: MALONYL-CoA + FT [ACYL-CARRIER PROTEIN] = CoA + MALONYL-[ACYL-CARRIER FT PROTEIN]]." FT /gene="fabD2" FT /locus_tag="Rv0649" FT /note="Rv0649, (MTCY20H10.30), len: 224 aa. Possible FT fabD2, malonyl CoA-acyl carrier protein transacylase (EC FT 2.3.1.39), similar to MTFABD|FABD_MYCTU|Q10501|Rv2243 FT malonyl CoA-acyl carrier protein transacylase from FT Mycobacterium tuberculosis (302 aa), FASTA scores: opt: FT 133, E(): 0.074, (31.3% identity in 147 aa overlap)." FT /product="POSSIBLE MALONYL COA-ACYL CARRIER PROTEIN FT TRANSACYLASE FABD2 (MCT)" FT CDS 747037..747945 FT /EC_number="2.7.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN SPECIFIC SUGAR FT METABOLISM OR REGULATION." FT /locus_tag="Rv0650" FT /note="Rv0650, (MTCY20H10.31), len: 302 aa. Possible sugar FT kinase, highly similar to others e.g. CAB95296.1|AL359779 FT putative sugar kinase from Streptomyces coelicolor (317 FT aa); NP_406512.1|NC_003143 putative sugar kinase from FT Yersinia pestis (290 aa); NP_229269.1|NC_000853 FT glucokinase from Thermotoga maritima (317 aa); etc. FT Contains PS01125 ROK family signature. BELONGS TO THE ROK FT (NAGC/XYLR) FAMILY." FT /product="POSSIBLE SUGAR KINASE" FT misc_feature 747436..747519 FT /note="PS01125 ROK family signature" FT CDS 748276..748812 FT /evidence=experimental FT /function="INVOLVED IN TRANSLATION MECHANISMS." FT /gene="rplJ" FT /locus_tag="Rv0651" FT /note="Rv0651, (MTCY20H10.32), len: 178 aa. Probable rplJ, FT 50S ribosomal protein L10, equivalent to FT NP_302276.1|NC_002677 50S ribosomal protein L10 from FT Mycobacterium leprae (177 aa). Also highly similar to FT others e.g. P36257|RL10_STRGR 50s ribosomal protein L10 FT from Streptomyces griseus (185 aa), FASTA scores: opt: FT 633, E(): 0, (59.0 % identity in 173 aa overlap); etc. FT BELONGS TO THE L10P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L10 RPLJ" FT CDS 748849..749241 FT /evidence=experimental FT /function="INVOLVED IN TRANSLATION MECHANISMS: SEEMS TO BE FT THE BINDING SITE FOR SEVERAL OF THE FACTORS INVOLVED IN FT PROTEIN SYNTHESIS AND APPEARS TO BE ESSENTIAL FOR ACCURATE FT TRANSLATION." FT /gene="rplL" FT /locus_tag="Rv0652" FT /note="Rv0652, (MTCY20H10.33), len: 130 aa. Probable rplL FT (alternate gene name: L7|L12), 50S ribosomal protein FT L7/L12, equivalent to NP_302275.1|NC_002677 50S ribosomal FT protein L7/L12 from Mycobacterium leprae (130 aa); and FT P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from FT Mycobacterium bovis (130 aa). Also highly similar to FT others e.g. P02396|RL7_STRGR 50S RIBOSOMAL PROTEIN L7/L12 FT from Streptomyces griseus (127 aa); etc. BELONGS TO THE FT L12P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L7/L12 RPLL FT (SA1)" FT /standard_name="L7|L12" FT CDS complement(749234..749929) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0653c" FT /note="Rv0653c, (MTCI376.23, MTCY20H10.34c), len: 231 aa. FT Possible transcriptional regulator, TetR family, similar FT in N-terminus to others e.g. CAC03642.1|AL391338 putative FT TetR-family transcriptional regulator from Streptomyces FT coelicolor (190 aa); Q51597 CAM REPRESSOR from Pseudomonas FT putida (186 aa), FASTA scores: opt: 150, E(): 0.00085, FT (27.8% identity in 97 aa overlap); etc. Also some FT similarity to Mycobacterium tuberculosis hypothetical FT transcriptional regulators Rv0681 and Rv1816. Contains FT probable helix-turn helix motif from aa 27-48 (Score 1156, FT +3.12 SD)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT CDS 750000..751505 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0654" FT /note="Rv0654, (MTCI376.22), len: 501 aa. Probable FT dioxygenase (EC 1.-.-.-), highly similar to others eg FT AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase FT (involved in tetraene formation) from Streptomyces FT antibioticus (456 aa); CAB56138.1| AL117669 putative FT dioxygenase from Streptomyces coelicolor (503 aa); T51734 FT neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid FT dioxygenase) from Arabidopsis thaliana (538 aa); Q53353 FT LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas FT paucimobilis (Sphingomonas paucimobilis), FASTA scores: FT opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa FT overlap); etc. Also some similarity with FT Rv0913c|MTCY21C12.07c POSSIBLE DIOXYGENASE from FT Mycobacterium tuberculosis (501 aa), FASTA score: (29.5% FT identity in 522 aa overlap)." FT /product="PROBABLE DIOXYGENASE" FT CDS 751517..752596 FT /evidence=experimental FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT RIBONUCLEOTIDE ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY FT COUPLING TO THE TRANSPORT SYSTEM." FT /gene="mkl" FT /locus_tag="Rv0655" FT /note="Rv0655, (MTCI376.21), len: 359 aa. Possible mkl, FT ribonucleotide-transport ATP-binding protein ABC FT transporter (see Braibant et al., 2000), equivalent to FT P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT FT ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa), FT FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa FT overlap). Also highly similar to many e.g. FT AB92896.1|AL356992 putative ABC-transporter ATP-binding FT protein from Streptomyces coelicolor (343 aa); FT NP_253146.1|NC_002516 probable ATP-binding component of FT ABC transporter from Pseudomonas aeruginosa (269 aa); FT P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding FT protein from Escherichia coli (269 aa), FASTA scores: opt: FT 644, E(): 3.4e-33, (38.5% identity in 244 aa overlap); FT etc. Also similar to many other Mycobacterium tuberculosis FT ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 FT aa), FASTA score: (33.6% identity in 241 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00211 ABC transporters family signature. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /product="POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING FT PROTEIN ABC TRANSPORTER MKL" FT misc_feature 751694..751717 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 752006..752050 FT /note="PS00211 ABC transporters family signature" FT CDS complement(752984..753367) FT /function="UNKNOWN" FT /locus_tag="Rv0656c" FT /note="Rv0656c, (MTCI376.20), len: 127 aa. Conserved FT hypothetical protein, showing similarity with proteins FT from Mycobacterium tuberculosis e.g. Rv2757c, Rv2546, FT etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(753462..753617) FT /function="UNKNOWN" FT /locus_tag="Rv0657c" FT /note="Rv0657c, (MTCI376.19), len: 51 aa. Conserved FT hypothetical protein, showing similarity with hypothetical FT proteins from Mycobacterium tuberculosis e.g. FT Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa), FT FASTA scores: opt: 107, E(): 0.0038, (45.8% identity in 48 FT aa overlap), Rv2871, Rv1560, etc. Also some similarity FT with AL020958|SC4H8_7 from Streptomyces coelicolor (66 FT aa), FASTA score: (41.0% identity in 39 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(753693..754409) FT /evidence=experimental FT /function="UNKNOWN. SUPPOSED INVOLVED IN STATIONARY-PHASE FT SURVIVAL." FT /locus_tag="Rv0658c" FT /note="Rv0658c, (MTCI376.18), len: 238 aa. Probable FT conserved integral membrane protein, equivalent to a FT predicted homologous protein from Mycobacterium smegmatis FT (see citation below), and showing some similarity with FT P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from FT Escherichia coli (217 aa), FASTA scores: opt: 174, E(): FT 5.3e-05, (25.6% identity in 223 aa overlap). Also similar FT to Rv1863c and Rv0804 from Mycobacterium tuberculosis." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS complement(754685..754993) FT /function="UNKNOWN" FT /locus_tag="Rv0659c" FT /note="Rv0659c, (MTCI376.17), len: 102 aa. Conserved FT hypothetical protein, weakly similar to other FT Mycobacterium tuberculosis hypothetical proteins e.g. FT Rv1942c, Rv1495, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(754980..755225) FT /function="UNKNOWN" FT /locus_tag="Rv0660c" FT /note="Rv0660c, (MTCI376.16), len: 81 aa. Conserved FT hypothetical protein, showing some similarity to FT AF016485_130 from Halobacterium sp (100 aa), FASTA scores: FT (32.4% identity in 74 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(755335..755772) FT /function="UNKNOWN" FT /locus_tag="Rv0661c" FT /note="Rv0661c, (MTCI376.15), len: 145 aa. Conserved FT hypothetical protein, similar to Mycobacterium FT tuberculosis hypothetical proteins e.g. FT Rv2863|MTV003.09|MTV003_7 (126 aa), FASTA scores: E(): FT 0.00087, (30.4% identity in 125 aa overlap), FT Rv0749|MTV041.23 (163 aa); Rv0277c, Rv2530c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(755769..756137) FT /function="UNKNOWN" FT /locus_tag="Rv0662c" FT /note="Rv0662c, (MTCI376.14), len: 133 aa. Conserved FT hypothetical protein, showing weak similarity with other FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Rv2871, Rv1241, Rv2550c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 756137..758500 FT /EC_number="3.1.6.1" FT /function="THOUGHT TO PLAY AN IMPORTANT ROLE IN THE FT MINERALIZATION OF SULFATES [CATALYTIC ACTIVITY: A phenol FT sulfate + H2O = a phenol + sulfate]." FT /gene="atsD" FT /locus_tag="Rv0663" FT /note="Rv0663, (MTCI376.13c), len: 787 aa. Possible atsD, FT arylsulfatase (EC 3.1.6.1), similar to others e.g. FT P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa FT (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity FT in 544 aa overlap); etc. Also similar to FT P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from FT Mycobacterium tuberculosis (787 aa), FASTA score: (38.9% FT identity in 769 aa overlap); and other arylsulfatases from FT Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa), FT Rv0711, etc. Contains PS00523 Sulfatases signature 1. FT BELONGS TO THE SULFATASE FAMILY." FT /product="POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE FT SULPHOHYDROLASE) (ARYLSULPHATASE)" FT misc_feature 756395..756433 FT /note="PS00523 Sulfatases signature 1" FT CDS 758532..758804 FT /function="UNKNOWN" FT /locus_tag="Rv0664" FT /note="Rv0664, (MTCI376.12c), len: 90 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 758801..759139 FT /function="UNKNOWN" FT /locus_tag="Rv0665" FT /note="Rv0665, (MTCI376.11c), len: 112 aa. Conserved FT hypothetical protein, similar to Rv0627 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 FT aa), and showing similarity with Rv0595c." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 759136..759309 FT /function="UNKNOWN" FT /locus_tag="Rv0666" FT /note="Rv0666, (MTCI376.10c), len: 57 aa. Possible FT membrane protein; has hydrophobic stretch at aa 29-47." FT /product="POSSIBLE MEMBRANE PROTEIN" FT CDS 759807..763325 FT /EC_number="2.7.7.6" FT /evidence=experimental FT /function="CATALYZES THE TRANSCRIPTION OF DNA INTO RNA FT USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS SUBSTRATES FT [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N FT DIPHOSPHATE + {RNA}(N)]." FT /gene="rpoB" FT /locus_tag="Rv0667" FT /note="Rv0667, (MTCI376.08c), len: 1172 aa. rpoB, FT DNA-directed RNA polymerase, beta chain (EC 2.7.7.6) (see FT Miller et al., 1994; Ahmad et al., 2000), equivalent to FT P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta FT chain from Mycobacterium leprae (1178 aa). Also highly FT similar to others e.g. AAF60349.1|AF242549_1|AF242549 FT DNA-dependent RNA polymerase beta subunit from FT Amycolatopsis mediterranei (1167 aa); CAB77428.1|AL160431 FT DNA-directed RNA polymerase beta chain from Streptomyces FT coelicolor (1161 aa); etc. Start site chosen on basis of FT RBS but alternative start exists at position 14359. FT BELONGS TO THE RNA POLYMERASE BETA CHAIN FAMILY." FT /product="DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB FT (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT)" FT CDS 763370..767320 FT /EC_number="2.7.7.6" FT /evidence=experimental FT /function="CATALYZES THE TRANSCRIPTION OF DNA INTO RNA FT USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS SUBSTRATES FT [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N FT DIPHOSPHATE + {RNA}(N)]." FT /gene="rpoC" FT /locus_tag="Rv0668" FT /note="Rv0668, (MTCI376.07c), len: 1316 aa. rpoC, FT DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6) (see FT Miller et al., 1994), equivalent to FT P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA FT polymerase (EC 2.7.7.6) beta' chain from Mycobacterium FT leprae (1316 aa), FASTA scores: opt: 8295, E(): 0, (95.6% FT identity in 1316 aa overlap). Also highly similar to FT others e.g. CAB77429.1|AL160431 DNA-directed RNA FT polymerase beta' chain (fragment) from Streptomyces FT coelicolor (1059 aa); P37871|RPOC_BACSU from Bacillus FT subtilis (1199 aa), FASTA scores: opt: 2367, E(): 0, (52.9 FT identity in 1317 aa overlap); etc. BELONGS TO THE RNA FT POLYMERASE BETA' CHAIN FAMILY." FT /product="DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC FT (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' FT SUBUNIT)." FT CDS complement(767684..769597) FT /EC_number="3.-.-.-" FT /function="UNKNOWN; HYDROLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM." FT /locus_tag="Rv0669c" FT /note="Rv0669c, (MTCI376.05), len: 637 aa. Possible FT hydrolase (EC 3.-.-.-), highly similar to various FT hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 FT alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FT FASTA scores: opt: 1490, E(): 0, (41.2% identity in 651 aa FT overlap); NP_063946.1|NM_019893 mitochondrial ceramidase FT from Homo sapiens (761 aa); P_446098.1|NM_053646 FT N-acylsphingosine amidohydrolase 2 from Rattus norvegicus FT (761 aa); BAB09641.1|AB016885 neutral ceramidase from FT Arabidopsis thaliana (705 aa); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /product="POSSIBLE HYDROLASE" FT misc_feature complement(769520..769543) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 769792..770550 FT /EC_number="3.1.21.2" FT /function="INVOLVED IN BASE EXCISION REPAIR. ENDONUCLEASE FT IV PLAYS A ROLE IN DNA REPAIR. IT CLEAVES PHOSPHODIESTER FT BONDS AT APURINIC OR APYRIMIDINIC SITES (AP SITES) TO FT PRODUCE NEW 5' ENDS THAT ARE BASE-FREE DEOXYRIBOSE FT 5-PHOSPHATE RESIDUES [CATALYTIC ACTIVITY: Endonucleolytic FT cleavage to 5'-phosphooligonucleotide end-products]." FT /gene="end" FT /locus_tag="Rv0670" FT /note="Rv0670, (MTCI376.04c), len: 252 aa. Probable end FT (alternate gene name: nfo), endonuclease IV (apurinase) FT (EC 3.1.21.2) (see citation below), equivalent to FT END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV FT (apurinase) from Mycobacterium leprae (252 aa), FASTA FT scores: opt: 1463, E(): 0, (85.6% identity in 250 aa FT overlap). Also similar to others e.g. FT Q9S2N2|END4_STRCO|NFO|SC6E10.05 PROBABLE ENDONUCLEASE IV FT from Streptomyces coelicolor (294 aa); etc. Contains FT PS00729 AP endonucleases family 2 signatures 1 and 2 FT (PS00729, and PS00730). BELONGS TO THE AP ENDONUCLEASES FT FAMILY 2. COFACTOR: BINDS 3 ZINC IONS." FT /product="PROBABLE ENDONUCLEASE IV END FT (ENDODEOXYRIBONUCLEASE IV) (APURINASE)" FT /standard_name="nfo" FT misc_feature 769957..769983 FT /note="PS00729 AP endonucleases family 2 signature 1" FT misc_feature 770263..770286 FT /note="PS00730 AP endonucleases family 2 signature 2" FT CDS 770582..771424 FT /function="UNKNOWN" FT /gene="lpqP" FT /locus_tag="Rv0671" FT /note="Rv0671, (MTCI376.03c), len: 280 aa. Possible lpqP, FT conserved lipoprotein, similar to FT U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 FT aa), FASTA scores: opt: 449, E(): 2.4e-22, (37.6% identity FT in 242 aa overlap). Also highly similar to FT lpqC|Rv3298c|MTCY71.38c PUTATIVE LIPOPROTEIN from FT Mycobacterium tuberculosis (304 aa). Also similar to a FT large variety of proteins including various esterases and FT poly(3-hydroxyalkanoate) depolymerases, e.g. FT NP_249234.1|NC_002516 hypothetical protein from FT Pseudomonas aeruginosa (322 aa); C-terminus of FT AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase FT EstA from Piromyces equi (536 aa); part of FT P52090|PHA1_PSELE POLY(3-HYDROXYALKANOATE) DEPOLYMERASE C FT PRECURSOR from Pseudomonas lemoignei (414 aa); FT CAC10310.1|AL442629 putative secreted protein from FT Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal FT sequence and contains appropriately positioned (PS00013) FT Prokaryotic membrane lipoprotein lipid attachment site." FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPQP" FT misc_feature 770603..770635 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 771484..773112 FT /EC_number="1.3.99.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE8" FT /locus_tag="Rv0672" FT /note="Rv0672, (MTCI376.02c), len: 545 aa. Probable fadE8, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT many e.g. CAC33951.1|AL589708 putative acyl-CoA FT dehydrogenase from Streptomyces coelicolor (557 aa); FT P33224|AIDB_ECOLI|B4187 aidb protein (ACYL-COA FT DEHYDROGENASES FAMILY) from Escherichia coli strain K12 FT (546 aa), FASTA scores: opt: 1369, E(): 0, (44.1% identity FT in 524 aa overlap); etc. Also similar to several other M. FT tuberculosis proteins e.g. Rv0154cRv0154c|MTCI5.28c FASTA FT score: (26.3% identity in 342 aa overlap); etc. Contains FT acyl-CoA dehydrogenases signature 2 (PS00073). BELONG TO FT THE ACYL-CoA DEHYDROGENASES FAMILY." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE8" FT misc_feature 772666..772725 FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT CDS 773123..774061 FT /EC_number="4.2.1.17" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + FT H(2)O]." FT /gene="echA4" FT /locus_tag="Rv0673" FT /note="Rv0673, (MTCI376.01c, MTV040.01), len: 312 aa. FT Possible echA4, enoyl-CoA hydratase (EC 4.2.1.17), showing FT similarity with others e.g. NP_419216.1|NC_002696 FT enoyl-CoA hydratase/isomerase family protein from FT Caulobacter crescentus (256 aa); Q52995|ECHH_RHIME FT PROBABLE ENOYL-CoA HYDRATASE from Sinorhizobium meliloti FT (257 aa), FASTA scores: opt: 210, E(): 1.2e-06, (27.9% FT identity in 280 aa overlap); etc. Also similar to other FT enoyl-CoA hydratases from Mycobacterium tuberculosis e.g. FT P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 ENOYL-COA FT HYDRATASE (318 aa), FASTA score: (27.1% identity in 280 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop)." FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA4 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT misc_feature 773405..773428 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 774064..774786 FT /function="UNKNOWN" FT /locus_tag="Rv0674" FT /note="Rv0674, (MTV040.02), len: 240 aa. Conserved FT hypothetical protein, highly similar to AC13063.1|AL445503 FT conserved hypothetical protein from Streptomyces FT coelicolor (268 aa); and similar to NP_438100.1|NC_003078 FT putative regulator of phenylacetic acid degradation ArsR FT family protein from Sinorhizobium meliloti (306 aa) and FT other proteins e.g. AB011837|AB011837_13 hypothetical FT protein from Bacillus halodurans (298 aa), FASTA scores: FT opt: 148, E(): 0.0081, (25.1% identity in 235 aa overlap); FT etc. TBparse score is 0.915." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 774783..775574 FT /EC_number="4.2.1.17" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + FT H(2)O]." FT /gene="echA5" FT /locus_tag="Rv0675" FT /note="Rv0675, (MTV040.03), len: 263. Probable echA5, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to several e.g. FT NP_252116.1|NC_002516 probable enoyl FT CoA-hydratase/isomerase from Pseudomonas aeruginosa (256 FT aa); Q20376 PROTEIN SIMILAR TO ENOYL-CoA HYDRATASE from FT Caenorhabditis elegans (258 aa), FASTA scores: opt: 697, FT E(): 0, (47.3% identity in 245 aa overlap); etc. Also FT similar to others from Mycobacterium tuberculosis e.g. FT Z92669|MTCY8D5_17 (262 aa), FASTA scores: opt: 493, E(): FT 3.6e-25, (39.1% identity in 243 aa overlap); etc. TBparse FT score is 0.904." FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA5 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT misc_feature 775071..775133 FT /note="PS00166 Enoyl-CoA hydratase/isomerase signature" FT CDS complement(775586..778480) FT /evidence=experimental FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /gene="mmpL5" FT /locus_tag="Rv0676c" FT /note="Rv0676c, (MTV040.04c), len: 964 aa. Probable mmpL5, FT conserved transmembrane transport protein (see Tekaia et FT al., 1999), member of RND superfamily, highly similar to FT other Mycobacterial proteins e.g. MTV037_14, MTCY98_8, FT MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, FT etc. Also similar to other Mycobacterial mmpl proteins FT e.g. P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4 FT from Mycobacterium leprae (959 aa), FASTA scores: opt: FT 3991, E(): 0, (62.8% identity in 933 aa overlap); etc. FT BELONGS TO THE MMPL FAMILY. TBparse score is 0.884." FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL5" FT CDS complement(778477..778905) FT /evidence=experimental FT /function="UNKNOWN." FT /gene="mmpS5" FT /locus_tag="Rv0677c" FT /note="Rv0677c, (MTV040.05c), len: 142 aa. Possible mmpS5, FT conserved membrane protein (see Tekaia et al., 1999), FT highly similar to other Mycobacterial proteins e.g. FT P54880|MMS4_MYCLE PUTATIVE MEMBRANE PROTEIN from FT Mycobacterium leprae (154 aa), FASTA scores: opt: 443, FT E(): 1.4e-23, (47.1% identity in 155 aa overlap); etc. FT Also similar to others from Mycobacterium tuberculosis. FT BELONGS TO THE MMPS FAMILY. TBparse score is 0.901." FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN MMPS5" FT CDS 778990..779487 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0678" FT /note="Rv0678, (MTV040.06), len: 165 aa. Conserved FT hypothetical protein, showing weak similarity with FT AL049754|SCH10_10 hypothetical protein from Streptomyces FT coelicolor (152 aa), FASTA scores: opt: 149, E(): 0.0018, FT (22.9% identity in 140 aa overlap). TBparse score is FT 0.910." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(779543..780040) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0679c" FT /note="Rv0679c, (MTV040.07c), len: 165 aa. Conserved FT hypothetical Thr-rich protein, similar in part to FT neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% FT identity in 131 aa overlap); and Rv0314c (220 aa). FT Contains probable N-terminal signal sequence. TBparse FT score is 0.894." FT /product="CONSERVED HYPOTHETICAL THREONINE RICH PROTEIN" FT CDS complement(780042..780416) FT /function="UNKNOWN" FT /locus_tag="Rv0680c" FT /note="Rv0680c, (MTV040.08c), len: 124 aa. Possible FT conserved transmembrane protein, showing similarity with FT C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved FT hypothetical protein from Mycobacterium tuberculosis (220 FT aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity FT in 102 aa overlap). Also some similarity to upstream ORF FT Rv0679c|MTV040.07c CONSERVED HYPOTHETICAL THREONINE RICH FT PROTEIN (124 aa), FASTA score: (35.1% identity in 131 aa FT overlap). Contains probable N-terminal signal sequence. FT TBparse score is 0.877." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 780721..781311 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0681" FT /note="Rv0681, (MTV040.09), len: 196 aa. Probable FT transcription regulator, TetR family, similar to others FT and especially many tetracycline repressors e.g. T34657 FT probable transcription regulator from Streptomyces FT coelicolor (189 aa); FT AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator FT from Bacillus subtilis (191 aa), FASTA scores: opt: 213, FT E(): 1.6e-07, (28.8% identity in 153 aa overlap); FT P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from FT Escherichia coli (217 aa), FASTA scores: opt: 145, E(): FT 0.0068, (39.0% identity in 59 aa overlap); etc. Contains FT helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD). FT TBparse score is 0.897." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT CDS 781560..781934 FT /function="PROTEIN S12 IS INVOLVED IN THE TRANSLATION FT INITIATION STEP." FT /gene="rpsL" FT /locus_tag="Rv0682" FT /note="Rv0682, (MTV040.10), len: 124 aa. Probable rpsL, FT 30S ribosomal protein S12 (see citations below), FT equivalent to others from Mycobacteria e.g. FT P41195|RS12_MYCSM 30S RIBOSOMAL PROTEIN S12 from FT Mycobacterium smegmatis (124 aa); P51999|RS12_MYCAV 30S FT RIBOSOMAL PROTEIN S12 from Mycobacterium avium (124 aa); FT etc. Also highly similar to others from other organisms FT e.g. P97222|RS12_STRCO 30S RIBOSOMAL PROTEIN S12 from FT Streptomyces roseosporus, lividans and coelicolor (123 FT aa); etc. Contains PS00055 Ribosomal protein S12 FT signature. BELONGS TO THE S12P FAMILY OF RIBOSOMAL FT PROTEINS. TBparse score is 0.893." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S12 RPSL" FT misc_feature 781686..781709 FT /note="PS00055 Ribosomal protein S12 signature" FT CDS 781934..782404 FT /function="PROTEIN S7 BINDS SPECIFICALLY TO PART OF THE 3' FT END OF 16S RIBOSOMAL RNA." FT /gene="rpsG" FT /locus_tag="Rv0683" FT /note="Rv0683, (MTV040.11), len: 156 aa. Probable rpsG, FT 30S ribosomal protein S7 (see citation below), equivalent FT to others from Mycobacteria e.g. P41193|RS7_MYCSM 30S FT RIBOSOMAL PROTEIN S7 from Mycobacterium smegmatis (156 FT aa), FASTA scores: opt: 986, E(): 0, (96.2% identity in FT 156 aa overlap); Q53539|RS7_MYCBO 30S RIBOSOMAL PROTEIN S7 FT from Mycobacterium bovis (156 aa); etc. Also highly FT similar to others e.g. Q9L0K4|RS7_STRCO 30S RIBOSOMAL FT PROTEIN S7 from Streptomyces coelicolor (156 aa); etc. FT Contains PS00052 Ribosomal protein S7 signature. BELONGS FT TO THE S7P FAMILY OF RIBOSOMAL PROTEINS. TBparse score is FT 0.907." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S7 RPSG" FT misc_feature 781991..782071 FT /note="PS00052 Ribosomal protein S7 signature" FT CDS 782485..784590 FT /evidence=experimental FT /function="THIS PROTEIN PROMOTES THE GTP-DEPENDENT FT TRANSLOCATION OF THE NASCENT PROTEIN CHAIN FROM THE A-SITE FT TO THE P-SITE OF THE RIBOSOME." FT /gene="fusA1" FT /locus_tag="Rv0684" FT /note="Rv0684, (MTV040.12, MTCY210.01), len: 701 aa. FT Probable fusA1, elongation factor G, equivalent to FT P30767|EFG_MYCLE|S31150 translation elongation factor EF-G FT from Mycobacterium leprae (701 aa), FASTA scores: opt: FT 2521, E(): 0, (88.2% identity in 432 aa overlap). Also FT highly similar to others e.g. CAB81852.1|AL161691 FT elongation factor G from Streptomyces coelicolor (708 aa); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop) and PS00301 GTP-binding elongation factors FT signature. BELONGS TO THE GTP-BINDING ELONGATION FACTOR FT FAMILY, EF-G/EF-2 SUBFAMILY. TBparse score is 0.872. Note FT that previously known as fusA." FT /product="PROBABLE ELONGATION FACTOR G FUSA1 (EF-G)" FT /standard_name="fusA" FT misc_feature 782542..782565 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 782644..782691 FT /note="PS00301 GTP-binding elongation factors signature" FT CDS 784821..786011 FT /evidence=experimental FT /function="THIS PROTEIN PROMOTES THE GTP-DEPENDENT BINDING FT OF AMINOACYL-TRNA TO THE A-SITE OF RIBOSOMES DURING FT PROTEIN BIOSYNTHESIS." FT /gene="tuf" FT /locus_tag="Rv0685" FT /note="Rv0685, (MTCY210.02), len: 396 aa. Probable tuf, FT iron-regulated elongation factor EF-Tu, equivalent to FT JC2262 translation elongation factor Tu from Mycobacterium FT leprae (396 aa). Also highly similar to others e.g. FT P42439|EFTU_CORGL ELONGATION FACTOR TU (EF-TU) from FT Corynebacterium glutamicum (396 aa); etc. Contains PS00017 FT ATP/GTP-binding site motif A, and PS00301 GTP-binding FT elongation factors signature. BELONGS TO THE GTP-BINDING FT ELONGATION FACTOR FAMILY, EF-TU/EF-1A SUBFAMILY." FT /product="PROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF FT (EF-TU)" FT misc_feature 784875..784898 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 784977..785024 FT /note="PS00301 GTP-binding elongation factors signature" FT CDS 786149..786946 FT /function="UNKNOWN" FT /locus_tag="Rv0686" FT /note="Rv0686, (MTCY210.03), len: 265 aa. Probable FT membrane protein, with hydrophobic N-terminus. TBparse FT score is 0.908." FT /product="PROBABLE MEMBRANE PROTEIN" FT CDS 787099..787926 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0687" FT /note="Rv0687, (MTCY210.04), len: 275 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), highly FT similar to various dehydrogenases (generally SDR family) FT e.g. U17129|RSU17129_7 short-chain dehydrogenase from FT Rhodococcus erythropolis (275 aa), FASTA scores: opt: FT 1112, E(): 0, (61.2% identity in 268 aa overlap); FT MMU34072_2 steroid dehydrogenase from Musmus culus (260 FT aa), FASTA scores: opt: 390, E(): 2.2e-17, (34.1% identity FT in 267 aa overlap); etc. Also similar to FT MTV002_16|O33292|Rv2750 DEHYDROGENASE from Mycobacterium FT tuberculosis (272 aa). Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. TBparse score is FT 0.920." FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT misc_feature 787576..787662 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 787940..789160 FT /EC_number="1.-.-.-" FT /function="FERREDOXINS ARE IRON-SULFUR PROTEINS THAT FT TRANSFER ELECTRONS IN A WIDE VARIETY OF METABOLIC FT REACTIONS." FT /locus_tag="Rv0688" FT /note="Rv0688, (MTCY210.05), len: 406 aa. Putative FT ferredoxin reductase (EC 1.-.-.-), highly similar to FT others e.g. BAB55881.1|AB054975 ferredoxin reductase from FT Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 FT putative ferredoxin reductase from Streptomyces coelicolor FT (420 aa); PPU24215_8|Q51973 P-CUMATE DIOXYGENASE FT FERREDOXIN REDUCTASE SUBUNIT from Pseudomonas putida (402 FT aa), FASTA scores: opt: 738, E(): 0, (38.8% identity in FT 330 aa overlap); etc. Also similar to Rv0253 and Rv1869c FT from Mycobacterium tuberculosis. COULD BELONG TO THE FT BACTERIAL TYPE FERREDOXIN FAMILY. TBparse score is 0.909." FT /product="PUTATIVE FERREDOXIN REDUCTASE" FT CDS complement(789157..789411) FT /function="UNKNOWN" FT /locus_tag="Rv0689c" FT /note="Rv0689c, (MTCY210.06c), len: 84 aa. Hypothetical FT unknown protein. TBparse score is 0.879." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(790024..791073) FT /function="UNKNOWN" FT /locus_tag="Rv0690c" FT /note="Rv0690c, (MTCY210.07c), len: 349 aa. Conserved FT hypothetical protein, showing similarity with FT NP_386956.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 FT AGR_L_1570p from Agrobacterium tumefaciens (346 aa); FT NP_421938.1|NC_002696 conserved hypothetical protein from FT Caulobacter crescentus (370 aa). TBparse score is 0.918." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(791070..791666) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /locus_tag="Rv0691c" FT /note="Rv0691c, (MTCY210.08c), len: 198 aa. Probable FT transcriptional regulator, highly similar to FT AAC77476.1|U17129 unknown protein from Rhodococcus FT erythropolis (185 aa); and showing similarity with FT putative regulatory proteins eg FT STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c FT transcriptional repressor from Streptomyces glaucescens FT (226 aa), FASTA scores: opt: 178, E(): 8.5e-06, (27.9% FT identity in 201 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop) and probable FT helix-turn helix motifs from aa 34-55 (Score 1100, +2.93 FT SD) and 151-172 (Score 1124, +3.02 SD). TBparse score is FT 0.934." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT misc_feature complement(791226..791249) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 791831..792160 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0692" FT /note="Rv0692, (MTCY210.09), len: 109 aa. Conserved FT hypothetical protein, highly similar to FT U17129|RSU17129_3|AAC77477.1 unknown protein from FT Rhodococcus erythropolis (95 aa), FASTA scores: opt: 393, FT E(): 8.8e-22, (68.2% identity in 88 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 792157..793332 FT /function="REQUIRED FOR COENZYME PYRROLO-QUINOLINE-QUINONE FT (PQQ) BIOSYNTHESIS." FT /gene="pqqE" FT /locus_tag="Rv0693" FT /note="Rv0693, (MTCY210.10), len: 391 aa. Probable pqqE FT (alternate gene name: pqqIII), coenzyme PQQ synthesis FT protein E, similar to others AE001109_9|O30258|PQQE FT COENZYME PQQ SYNTHESIS PROTEIN from Archaeoglobus fulgidus FT (375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in FT 377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis FT protein e from Acinetobacter calcoaceticus (384 aa), FASTA FT scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa FT overlap); etc. Also similar to C-terminus of heme FT biosynthesis proteins e.g. O28270|AF2009 HEME BIOSYNTHESIS FT PROTEIN (NIRJ-2) from Archaeoglobus fulgidus (468 aa). FT Note that also highly similar to FT U17129|RSU17129_4|AAC77478.1 unknown protein from FT Rhodococcus erythropolis (405 aa), FASTA scores: opt: FT 1997, E(): 0, (73.3% identity in 390 aa overlap). COULD FT BELONG TO THE MOAA / NIFB / PQQE FAMILY. TBparse score is FT 0.919." FT /product="PROBABLE COENZYME PQQ SYNTHESIS PROTEIN E PQQE FT (COENZYME PQQ SYNTHESIS PROTEIN III)" FT /standard_name="pqqIII" FT CDS 793335..794525 FT /EC_number="1.1.2.3" FT /function="INVOLVED IN RESPIRATION; CATALYZES CONVERSION FT OF LACTATE INTO PYRUVATE [CATALYTIC ACTIVITY: (S)-LACTATE FT + 2 FERRICYTOCHROME C = PYRUVATE + 2 FERROCYTOCHROME C]." FT /gene="lldD1" FT /locus_tag="Rv0694" FT /note="Rv0694, (MTCY210.11), len: 396 aa. Possible lldD1, FT L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar FT to NP_302368.1|NC_002677 L-lactate dehydrogenase from FT Mycobacterium leprae (414 aa). Also similar to others e.g. FT NP_384560.1|NC_003047 PUTATIVE L-LACTATE DEHYDROGENASE FT (CYTOCHROME) PROTEIN from Sinorhizobium meliloti (403 aa); FT NP_251072.1|NC_002516 L-lactate dehydrogenase from FT Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI FT L-lactate dehydrogenase (cytochrome) from Escherichia coli FT strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5 FT identity in 380 aa overlap); etc; and also similar to FT other oxidoreductases. Note that also highly similar to FT RSU17129_5|AAC77479.1|U17129 unknown protein from FT Rhodococcus erythropolis (392 aa), FASTA scores: opt: FT 2006, E(): 0, (74.1% identity in 386 aa overlap). Also FT similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 POSSIBLE FT L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium FT tuberculosis (414 aa). BELONGS TO THE FMN-DEPENDENT FT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. TBparse score is FT 0.918." FT /product="POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) FT LLDD1" FT CDS 794715..795470 FT /function="UNKNOWN" FT /locus_tag="Rv0695" FT /note="Rv0695, (MTCY210.12), len: 251 aa. Conserved FT hypothetical protein, similar to many creatinine FT amidohydrolases or hypothetical proteins e.g. FT NP_443048.1|NC_000911 creatinine amidohydrolase from FT Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210 FT protein similar to creatinine amidohydrolase from Listeria FT monocytogenes (249 aa); T35153|SC5A7.04c hypothetical FT protein from Streptomyces coelicolor (273 aa); etc. Note FT that highly similar to RSU17129_10|AAC77474.1|U17129 FT unknown protein from Rhodococcus erythropolis (230 aa), FT FASTA scores: opt: 693, E(): 0, (55.7% identity in 237 aa FT overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_unit 795467..795518 FT /note="52 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 795519..796931 FT /EC_number="2.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0696" FT /note="Rv0696, (MTCY210.13), len: 470 aa. Probable FT membrane sugar transferase (EC 2.-.-.-), similar (except FT in N-terminus) to NP_069157.1|NC_000917 glycosyl FT transferase from Archaeoglobus fulgidus (324 aa); FT NP_279985.1|NC_002607 rhamnosyl transferase from FT Halobacterium sp. NRC-1 (299 aa); NP_059113.1|NM_017417 FT polypeptide N-acetylgalactosaminyltransferase 8 from (637 FT aa). Note that also highly similar to P46370|YTH1_RHOER FT HYPOTHETICAL 55.3 KDA PROTEIN from Rhodococcus FT erythropolis (513 aa), FASTA scores: opt: 1514, E(): 0, FT (51.8% identity in 469 aa overlap). TBparse score is FT 0.924." FT /product="PROBABLE MEMBRANE SUGAR TRANSFERASE" FT CDS 796933..798372 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0697" FT /note="Rv0697, (MTCY210.14, unknown), len: 479 aa. FT Probable dehydrogenase (EC 1.-.-.-), highly similar to FT P30772|YTUR_MYCLE HYPOTHETICAL 24 kDa PROTEIN from FT Mycobacterium leprae (220 aa), FASTA scores: opt: 557, FT E(): 1.7e-28, (46.2% identity in 223 aa overlap). Also FT highly similar to P46371|YTH2_RHOER HYPOTHETICAL 53.0 KDA FT GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 FT aa); and similar to many dehydrogenases e.g. FT NP_250814.1|NC_002516 probable dehydrogenase from FT Pseudomonas aeruginosa (545 aa); BAA13145.1|D86622 FAD FT dependent L-sorbose dehydrogenase from Gluconobacter FT oxydans (531 aa); etc. Also similar to Rv1279 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis." FT /product="PROBABLE DEHYDROGENASE" FT CDS 798833..799444 FT /function="UNKNOWN" FT /locus_tag="Rv0698" FT /note="Rv0698, (MTCY210.15), len: 203 aa. Conserved FT hypothetical protein, highly similar to C-terminus of FT Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (188 aa), FASTA scores: E(): FT 2.1e-07, (54.8% identity in 73 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 799629..799850 FT /function="UNKNOWN" FT /locus_tag="Rv0699" FT /note="Rv0699, (MTCY210.17), len: 73 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 800487..800792 FT /evidence=experimental FT /function="THIS PROTEIN IS INVOLVED IN THE BINDING OF tRNA FT TO THE RIBOSOMES, AND IN THE REGULATION OF rRNA FT BIOSYNTHESIS (BY MODULATING THE EFFICIENCY OF FT TRANSCRIPTIONAL TERMINATION). INTERACTS WITH FT NUSB|Rv2533c." FT /gene="rpsJ" FT /locus_tag="Rv0700" FT /note="Rv0700, (MTCY210.19), len: 101 aa. rpsJ (alternate FT gene name: nusE), 30S ribosomal protein S10 (see Gopal et FT al., 2001), equivalent to RS10_MYCLE P307653 30S ribosomal FT protein S10 from Mycobacterium leprae (101 aa), FASTA FT scores: opt: 645, E(): 0, (97.0% identity in 101 aa FT overlap). Also highly similar to others e.g. FT CAB82069.1|AL161803 30S ribosomal protein S10 from FT Streptomyces coelicolor (102 aa); etc. Contains PS00361 FT Ribosomal protein S10 signature. BELONGS TO THE S10P FT FAMILY OF RIBOSOMAL PROTEINS." FT /product="30S RIBOSOMAL PROTEIN S10 RPSJ (TRANSCRIPTION FT ANTITERMINATION FACTOR NUSE)" FT /standard_name="nusE" FT misc_feature 800571..800618 FT /note="PS00361 Ribosomal protein S10 signature" FT CDS 800809..801462 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA AND MAY PARTICIPATE IN THE FORMATION OF THE FT PEPTIDYLTRANSFERASE CENTER OF THE RIBOSOME." FT /gene="rplC" FT /locus_tag="Rv0701" FT /note="Rv0701, (MTCY210.20), len: 217 aa. Probable rplC, FT 50S ribosomal protein L3, equivalent to O06044|RL3_MYCBO FT 50S RIBOSOMAL PROTEIN L3 from Mycobacterium bovis BCG (217 FT aa); and P30762|RL3_MYCLE 50S RIBOSOMAL PROTEIN L3 from FT Mycobacterium leprae (217 aa). Also highly similar to FT others e.g. CAB82070.1|AL161803 50S ribosomal protein L3 FT from Streptomyces coelicolor (214 aa); P52860|RL3_THETH FT ribosomal protein l3 from Thermus aquaticus (206 aa), FT FASTA scores: opt: 717, E(): 0, (55.2% identity in 210 aa FT overlap); etc. Contains PS00474 Ribosomal protein L3 FT signature. BELONGS TO THE L3P FAMILY OF RIBOSOMAL FT PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L3 RPLC" FT misc_feature 801124..801195 FT /note="PS00474 Ribosomal protein L3 signature" FT CDS 801462..802133 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY AND SPECIFICALLY TO FT 23S RRNA." FT /gene="rplD" FT /locus_tag="Rv0702" FT /note="Rv0702, (MTCY210.21), len: 223 aa. Probable rplD, FT 50S ribosomal protein L4, equivalent to O06045|RL4_MYCBO FT 50S RIBOSOMAL PROTEIN L4 from Mycobacterium bovis BCG (223 FT aa); O06114|RL4_MYCSM 50S RIBOSOMAL PROTEIN L4 from FT Mycobacterium smegmatis (215 aa); and MLCB2492_3 50S FT ribosomal protein L4 from Mycobacterium leprae (230 aa). FT Also highly similar to others e.g. CAB82071.1|AL161803 50S FT ribosomal protein L4 from Streptomyces coelicolor (219 FT aa); P28601|RL4_BACST 50s ribosomal protein L4 from FT Bacillus stearothermophilus (207 aa), FASTA scores: opt: FT 522, E(): 3.5e-26, (42.4% identity in 198 aa overlap); FT etc. BELONGS TO THE L4P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L4 RPLD" FT CDS 802133..802435 FT /evidence=experimental FT /function="BINDS TO A SPECIFIC REGION ON THE 23S RRNA." FT /gene="rplW" FT /locus_tag="Rv0703" FT /note="Rv0703, (MTCY21.22), len: 100 aa. Probable rplW, FT 50S ribosomal protein L23, equivalent to O06046|RL23_MYCBO FT 50S RIBOSOMAL PROTEIN L23 from Mycobacterium bovis BCG FT (100 aa); and MLCB2492_4 50S RIBOSOMAL PROTEIN L23 from FT Mycobacterium leprae (100 aa). Also highly similar to FT others e.g. CAB82072.1|AL161803 50S ribosomal protein L23 FT from Streptomyces coelicolor (139 aa) (N-terminus longer); FT P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus FT stearothermophilus (95 aa), FASTA scores: opt: 275, E(): FT 1.4e-13, (50.5% identity in 95 aa overlap); etc. Contains FT PS00050 Ribosomal protein L23 signature. BELONGS TO THE FT L23P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L23 RPLW" FT misc_feature 802370..802417 FT /note="PS00050 Ribosomal protein L23 signature" FT repeat_unit 802429..802477 FT /note="49 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 802528..803370 FT /evidence=experimental FT /function="THIS PROTEIN IS A PRIMARY 23S RRNA-BINDING FT PROTEIN. IT HAS PEPTIDYLTRANSFERASE ACTIVITY." FT /gene="rplB" FT /locus_tag="Rv0704" FT /note="Rv0704, (MTCY210.23), len: 280 aa. Probable rplB, FT 50S ribosomal protein L2, equivalent to O06047|RL2_MYCBO FT 50S RIBOSOMAL PROTEIN L2 from Mycobacterium bovis BCG (280 FT aa); and MLCB2492_5M 50S RIBOSOMAL PROTEIN L2 from FT Mycobacterium leprae (280 aa). Also highly similar to FT others e.g. CAB82073.1|AL161803 50S ribosomal protein L2 FT from Streptomyces coelicolor (278 aa); P42919|RL2_BACSU FT 50s ribosomal protein l2 (bl2) from Bacillus subtilis (276 FT aa), FASTA scores: opt: 1179, E(): 0, (61.1% identity in FT 275 aa overlap); etc. Contains PS00467 Ribosomal protein FT L2 signature. BELONGS TO THE L2P FAMILY OF RIBOSOMAL FT PROTEINS." FT /product="PROBABLE 50S ribosomal protein L2 RPLB" FT misc_feature 803182..803217 FT /note="PS00467 Ribosomal protein L2 signature" FT CDS 803411..803692 FT /evidence=experimental FT /function="PROTEIN S19 FORMS A COMPLEX WITH S13 THAT BINDS FT STRONGLY TO THE 16S RIBOSOMAL RNA." FT /gene="rpsS" FT /locus_tag="Rv0705" FT /note="Rv0705, (MTCY210.24), len: 93 aa. Probable rpsS, FT 30S ribosomal protein S19, equivalent to S36895 ribosomal FT protein S19 from Mycobacterium bovis (93 aa), FASTA FT scores: opt: 623, E(): 0, (98.9% identity in 93 aa FT overlap); and NP_302261.1|NC_002677 30S ribosomal protein FT S19 from Mycobacterium leprae (93 aa). Also highly similar FT to others e.g. CAB82074.1|AL161803 30S ribosomal protein FT S19 from Streptomyces coelicolor (93 aa); etc. Contains FT PS00323 Ribosomal protein S19 signature. BELONGS TO THE FT S19P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S19 RPSS" FT misc_feature 803567..803641 FT /note="PS00323 Ribosomal protein S19 signature" FT CDS 803689..804282 FT /evidence=experimental FT /function="THIS PROTEIN BINDS SPECIFICALLY TO 23S RRNA; FT ITS BINDING IS STIMULATED BY OTHER RIBOSOMAL PROTEINS, FT E.G., L4, L17, AND L20. IT IS IMPORTANT DURING THE EARLY FT STAGES OF 50S RECONSTITUTION." FT /gene="rplV" FT /locus_tag="Rv0706" FT /note="Rv0706, (MTCY210.25), len: 197 aa. Probable rplV, FT 50S ribosomal protein L22, equivalent to O06115|RL22_MYCSM FT 50S RIBOSOMAL PROTEIN L22 from Mycobacterium smegmatis FT (153 aa); MBS10OPER_7 50S RIBOSOMAL PROTEIN L22 from FT Mycobacterium bovis BCG; and MLCB2492_7 50S ribosomal FT protein L22 from Mycobacterium leprae (175 aa). Also FT highly similar to others e.g. CAB82075.1|AL161803 50S FT ribosomal protein L22 from Streptomyces coelicolor (125 FT aa); P42060|RL22_BACSU 50s ribosomal protein L22 from FT Bacillus subtilis (113 aa), FASTA scores: opt: 368, E(): FT 2.4e-13, (52.8% identity in 108 aa overlap); etc. Contains FT PS00464 Ribosomal protein L22 signature, and contains FT repetitive sequence at C-terminus. BELONGS TO THE L22P FT FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L22 RPLV" FT misc_feature 803965..804039 FT /note="PS00464 Ribosomal protein L22 signature" FT CDS 804282..805106 FT /evidence=experimental FT /function="THIS PROTEIN IS INVOLVED IN THE BINDING OF FT INITIATOR MET-TRNA." FT /gene="rpsC" FT /locus_tag="Rv0707" FT /note="Rv0707, (MTCY210.26), len: 274 aa. Probable rpsC, FT 30S ribosomal protein S3, equivalent to FT O06048|RS3_MYCBO|MBS10OPER_8 30S RIBOSOMAL PROTEIN S3 from FT Mycobacterium bovis BCG (274 aa); and MLCB2492_8 30S FT RIBOSOMAL PROTEIN S3 from Mycobacterium leprae (281 aa). FT Also highly similar to others e.g. CAB82076.1|AL161803 30S FT ribosomal protein S3 from Streptomyces coelicolor (277 FT aa); P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2) FT from Bacillus subtilis (217 aa), FASTA scores: opt: 794, FT E(): 0, (52.8% identity in 212 aa overlap); etc. BELONGS FT TO THE S3P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S3 RPSC" FT CDS 805110..805526 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA AND IS LOCATED AT THE A SITE OF THE FT PEPTIDYLTRANSFERASE CENTER." FT /gene="rplP" FT /locus_tag="Rv0708" FT /note="Rv0708, (MTCY210.27), len: 138 aa. Probable rplP, FT 50S ribosomal protein L16, equivalent to FT O06049|RL16_MYCBO|MBS10OPER_9 50S RIBOSOMAL PROTEIN L16 FT from Mycobacterium bovis BCG (138 aa); and MLCB2492_9 50S FT RIBOSOMAL PROTEIN L16 from Mycobacterium leprae (138 aa). FT Also highly similar to others e.g. CAB82077.1|AL161803 50S FT ribosomal protein L16 from Streptomyces coelicolor (139 FT aa); P14577|RL16_BACSU 50s ribosomal protein l16 from FT Bacillus subtilis (144 aa), FASTA scores: opt: 600, E(): FT 0, (63.2% identity in 136 aa overlap); etc. Contains FT PS00701 Ribosomal protein L16 signature 2. BELONGS TO THE FT L16P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L16 RPLP" FT misc_feature 805353..805388 FT /note="PS00701 Ribosomal protein L16 signature 2" FT CDS 805526..805759 FT /evidence=experimental FT /function="INVOLVED IN TRANSLATION MECHANISMS." FT /gene="rpmC" FT /locus_tag="Rv0709" FT /note="Rv0709, (MTCY210.28), len: 77 aa. Probable rpmC, FT 50S ribosomal protein L29, equivalent to FT O06050|RL29_MYCBO|MBS10OPER_10 50S RIBOSOMAL PROTEIN L29 FT from Mycobacterium bovis BCG (75 aa); and FT O32989|RL29_MYCLE|MLCB2492_10 50S RIBOSOMAL PROTEIN L29 FT from Mycobacterium leprae (80 aa). Also highly similar to FT others e.g. Q9L0D2|RL29_STRCO 50S RIBOSOMAL PROTEIN L29 FT from Streptomyces coelicolor (74 aa); P12873|RL29_BACSU FT 50s ribosomal protein l29 from Bacillus subtilis (66 aa), FT FASTA scores: opt: 225, E(): 8.3e-11, (58.6% identity in FT 58 aa overlap); etc. BELONGS TO THE L29P FAMILY OF FT RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L29 RPMC" FT CDS 805756..806166 FT /evidence=experimental FT /function="PROTEIN S17 BINDS SPECIFICALLY TO THE 5' END OF FT 16S RIBOSOMAL RNA." FT /gene="rpsQ" FT /locus_tag="Rv0710" FT /note="Rv0710, (MTCY210.29), len: 136 aa. Probable rpsQ, FT 30S ribosomal protein S17, equivalent to O06051|RS17_MYCBO FT 30S|MBS10OPER_11 30S RIBOSOMAL PROTEIN S17 from FT Mycobacterium bovis BCG (136 aa); and MLCB2492_11 30S FT RIBOSOMAL PROTEIN S17 from Mycobacterium leprae (126 aa). FT Also highly similar to others e.g. CAB82079.1|AL161803 30S FT ribosomal protein S17 from Streptomyces coelicolor (95 FT aa); P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16) FT from Bacillus subtilis (86 aa), FASTA scores: opt: 305, FT E(): 1.6e-11, (60.5% identity in 81 aa overlap); etc. FT Contains PS00056 Ribosomal protein S17 signature." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S17 RPSQ" FT misc_feature 806080..806118 FT /note="PS00056 Ribosomal protein S17 signature" FT CDS 806335..808698 FT /EC_number="3.1.6.1" FT /function="THOUGHT TO PLAY AN IMPORTANT ROLE IN THE FT MINERALIZATION OF SULFATES [CATALYTIC ACTIVITY: A phenol FT sulfate + H2O = a phenol + sulfate]." FT /gene="atsA" FT /locus_tag="Rv0711" FT /note="Rv0711, (MTCY210.30), len: 787 aa. Possible atsA, FT arylsulfatase (EC 3.1.6.1), similar to others e.g. FT P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa FT (532 aa), FASTA scores: opt: 439, E(): 2.9e-21, (30.8% FT identity in 552 aa overlap); etc. Also similar to other FT hypothetical arylsulfatases from Mycobacterium FT tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 FT Sulfatases signature 1, and PS00149 Sulfatases signature FT 2. BELONGS TO THE SULFATASE FAMILY." FT /product="POSSIBLE ARYLSULFATASE ATSA (ARYL-SULFATE FT SULPHOHYDROLASE) (ARYLSULPHATASE)" FT misc_feature 806452..806496 FT /note="PS00678 Beta-transducin family Trp-Asp repeats FT signature" FT misc_feature 806575..806613 FT /note="PS00523 Sulfatases signature 1" FT misc_feature 806731..806760 FT /note="PS00149 Sulfatases signature 2" FT CDS 808746..809645 FT /function="UNKNOWN" FT /locus_tag="Rv0712" FT /note="Rv0712, (MTCY210.31), len: 299 aa. Conserved FT hypothetical protein, similar to others e.g. FT NP_106128.1|NC_002678 hypothetical protein from FT Mesorhizobium loti (372 aa); D90901_33|P72841 HYPOTHETICAL FT 48.1 kDa PROTEIN from Synechocystis sp (410 aa), FASTA FT scores: E(): 1.1e-07, (28.8% identity in 299 aa overlap); FT etc. Slight similarity to carboxykinases. Similar to FT C-terminal part of Rv3703c CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (425 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 809946..810887 FT /function="UNKNOWN" FT /locus_tag="Rv0713" FT /note="Rv0713, (MTCY210.32), len: 313 aa. Probable FT conserved transmembrane protein, similar to FT Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis FT (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8% FT identity in 282 aa overlap); MLCB2492_12|O32991 FT HYPOTHETICAL 10.7 kDa PROTEIN from Mycobacterium leprae FT (95 aa)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 811373..811741 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA." FT /gene="rplN" FT /locus_tag="Rv0714" FT /note="Rv0714, (MTCY210.33), len: 122 aa. Probable rplN, FT 50S ribosomal protein L14, equivalent to FT O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S RIBOSOMAL PROTEIN FT L14 from Mycobacterium leprae (122 aa). Also highly FT similar to others e.g. CAB82080.1|AL161803 50S ribosomal FT protein L14 from Streptomyces coelicolor (122 aa); FT P33100|RL14_MICLU 50s ribosomal protein L14 from FT Micrococcus luteus (122 aa), FASTA scores: opt: 674, E(): FT 0, (85.2% identity in 122 aa overlap); etc. Contains FT PS00049 Ribosomal protein L14 signature. BELONGS TO THE FT L14P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L14 RPLN" FT misc_feature 811550..811630 FT /note="PS00049 Ribosomal protein L14 signature" FT CDS 811742..812059 FT /evidence=experimental FT /function="THIS PROTEIN IS FOUND IN THE RIBONUCLEOPROTEIN FT CORE AND IS INVOLVED IN THE EARLY ASSEMBLY OF THE 50S FT SUBUNIT. IT IS NOT INVOLVED IN THE FUNCTIONS OF THE MATURE FT 50S SUBUNIT." FT /gene="rplX" FT /locus_tag="Rv0715" FT /note="Rv0715, (MTCY210.34), len: 105 aa. Probable rplX, FT 50S ribosomal protein L24, equivalent to FT O32994|MLCB2492_15 50S RIBOSOMAL PROTEIN L24 from FT Mycobacterium leprae (105 aa). Also highly similar to FT others e.g. CAB82081.1|AL161803 50S ribosomal protein L24 FT from Streptomyces coelicolor (107 aa); P12876|RL24_BACSU FT 50s ribosomal protein L24 (bl23) from Bacillus subtilis FT (103 aa), FASTA scores: opt: 363, E(): 1.8e-18, (56.7% FT identity in 104 aa overlap); etc. Contains PS01108 FT Ribosomal protein L24 signature. BELONGS TO THE L24P FT FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L24 RPLX" FT misc_feature 811766..811810 FT /note="PS01108 Ribosomal protein L24 signature" FT CDS 812059..812622 FT /evidence=experimental FT /function="THIS IS ONE OF 3 PROTEINS THAT MEDIATE THE FT ATTACHMENT OF THE 5S RNA INTO THE LARGE RIBOSOMAL FT SUBUNIT." FT /gene="rplE" FT /locus_tag="Rv0716" FT /note="Rv0716, (MTCY210.35), len: 187 aa. Probable rplE, FT 50S ribosomal protein L5, equivalent to MLCB2492_16 50S FT RIBOSOMAL PROTEIN L5 from Mycobacterium leprae (187 aa). FT Also highly similar to others e.g. CAB82082.1|AL161803 50S FT ribosomal protein L5 from Streptomyces coelicolor (185 FT aa); P33098|RL5_MICLU 50S RIBOSOMAL PROTEIN L5 from FT Micrococcus luteus (191 aa), FASTA scores: opt: 930, E(): FT 0, (73.8% identity in 183 aa overlap); etc. BELONGS TO THE FT L5P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE" FT CDS 812627..812812 FT /function="KNOWN TO BE REQUIRED FOR THE ASSEMBLY OF 30S FT PARTICLES AND MAY ALSO BE RESPONSIBLE FOR DETERMINING THE FT CONFORMATION OF THE 16S RRNA AT THE A SITE." FT /gene="rpsN1" FT /locus_tag="Rv0717" FT /note="Rv0717, (MTCY210.36), len: 61 aa. Probable rpsN1, FT 30S ribosomal protein S14, equivalent to FT MLCB2492_17|O32996 RIBOSOMAL PROTEIN S14 from FT Mycobacterium leprae (61 aa). Also highly similar to FT others e.g. CAB82083.1|AL161803 30S ribosomal protein S14 FT from Streptomyces coelicolor (61 aa); P24320|RS14_THETH FT 30s ribosomal protein S14 from Thermus aquaticus (subsp. FT thermophilus) (60 aa), FASTA scores: opt: 316, E(): FT 2e-19,(70.0% identity in 60 aa overlap); etc. Contains FT PS00527 Ribosomal protein S14 signature. BELONGS TO THE FT S14P FAMILY OF RIBOSOMAL PROTEINS. Note that previously FT known as rpsN." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S14 RPSN1" FT /standard_name="rpsN" FT misc_feature 812693..812761 FT /note="PS00527 Ribosomal protein S14 signature" FT repeat_unit 812835..812921 FT /note="87 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT repeat_unit 812922..812975 FT /note="54 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 812976..813374 FT /evidence=experimental FT /function="BINDS DIRECTLY TO THE CENTRAL DOMAIN OF 16S FT RIBOSOMAL RNA." FT /gene="rpsH" FT /locus_tag="Rv0718" FT /note="Rv0718, (MTCY210.37), len: 132 aa. Probable rpsH, FT 30S ribosomal protein S8, equivalent to O32997|MLCB2492_18 FT 30S RIBOSOMAL PROTEIN S8 from Mycobacterium leprae (132 FT aa). Also highly similar to others e.g. FT CAB82084.1|AL161803 30S ribosomal protein S8 from FT Streptomyces coelicolor (132 aa); P33106|RS8_MICLU 30s FT ribosomal protein S8 from Micrococcus luteus (132 aa), FT FASTA scores: opt: 669, E(): 0, (77.3% identity in 132 aa FT overlap); etc. Contains PS00053 Ribosomal protein S8 FT signature. BELONGS TO THE S8P FAMILY OF RIBOSOMAL FT PROTEINS." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S8 RPSH" FT misc_feature 813279..813332 FT /note="PS00053 Ribosomal protein S8 signature" FT CDS 813398..813937 FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA AND IS LOCATED AT THE AMINOACYL-TRNA BINDING SITE OF FT THE PEPTIDYLTRANSFERASE CENTER." FT /gene="rplF" FT /locus_tag="Rv0719" FT /note="Rv0719, (MTCY210.38), len: 179 aa. Probable rplF, FT 50S ribosomal protein L6, equivalent to O32998|MLCB2492_19 FT 50S RIBOSOMAL PROTEIN L6 from Mycobacterium leprae (179 FT aa). Also highly similar to others e.g. FT P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S FT ribosomal protein L6 from Streptomyces coelicolor (179 FT aa), FASTA scores: opt: 872, E(): 0, (70.4% identity in FT 179 aa overlap); etc. Contains PS00525 Ribosomal protein FT L6 signature 1. BELONGS TO THE L6P FAMILY OF RIBOSOMAL FT PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L6 RPLF" FT misc_feature 813860..813886 FT /note="PS00525 Ribosomal protein L6 signature 1" FT CDS 813940..814308 FT /function="THIS IS ONE OF 3 PROTEINS THAT MEDIATE THE FT ATTACHMENT OF THE 5S RNA INTO THE LARGE RIBOSOMAL FT SUBUNIT." FT /gene="rplR" FT /locus_tag="Rv0720" FT /note="Rv0720, (MTCY210.39), len: 122 aa. Probable rplR, FT 50S ribosomal protein L18, equivalent to FT O32999|MLCB2492_20|RL18_MYCLE 50S RIBOSOMAL PROTEIN L18 FT from Mycobacterium leprae (122 aa). Also highly similar to FT others e.g. CAB82086.1|AL161803 50S ribosomal protein L18 FT from Streptomyces coelicolor (127 aa); P33102|RL18_MICLU FT 50s ribosomal protein L18 from Micrococcus luteus (119 FT aa), FASTA scores: opt: 447, E(): 8.7e-24, (60.4% identity FT in 111 aa overlap); etc. BELONGS TO THE L18P FAMILY OF FT RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L18 RPLR" FT CDS 814328..814990 FT /evidence=experimental FT /function="PROTEIN S5 IS IMPORTANT IN THE ASSEMBLY AND FT FUNCTION OF THE 30S RIBOSOMAL SUBUNIT." FT /gene="rpsE" FT /locus_tag="Rv0721" FT /note="Rv0721, (MTCY210.40), len: 220 aa. Probable rpsE, FT 30S ribosomal protein S5, equivalent to MLCB2492_21 FT RIBOSOMAL PROTEIN S5 from Mycobacterium leprae (217 aa). FT Also highly similar to others e.g. P46790|RS5_STRCO 30s FT ribosomal protein S5 from Streptomyces coelicolor (167 FT aa), FASTA scores: opt: 889, E(): 0, (82.1% identity in FT 162 aa overlap); etc. Note N-terminus is extented compared FT to other rpsE genes. Contains PS00585 Ribosomal protein S5 FT signature, PTS HPr component phosphorylation sites FT signature. BELONGS TO THE S5P FAMILY OF RIBOSOMAL FT PROTEINS." FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S5 RPSE" FT misc_feature 814502..814600 FT /note="PS00585 Ribosomal protein S5 signature" FT misc_feature 814607..814654 FT /note="PS00589 PTS HPR component serine phosphorylation FT site signature" FT CDS 814993..815190 FT /function="INVOLVED ION TRANSLATION MECHANISMS." FT /gene="rpmD" FT /locus_tag="Rv0722" FT /note="Rv0722, (MTCY210.41), len: 65 aa. Probable rpmD, FT 50S ribosomal protein L30, equivalent to O33001 RIBOSOMAL FT PROTEIN L30 from Mycobacterium leprae (71 aa). Also highly FT similar to others e.g. P46789|RL30_STRCO 50S RIBOSOMAL FT PROTEIN L30 from Streptomyces coelicolor (60 aa); FT P02430|RL30_ECOLI 50S ribosomal protein L30 from FT Escherichia coli (58 aa), FASTA scores: opt: 168, E(): FT 1.5e-13, (53.7% identity in 54 aa overlap); etc. BELONGS FT TO THE L30P FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L30 RPMD" FT CDS 815190..815630 FT /evidence=experimental FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA." FT /gene="rplO" FT /locus_tag="Rv0723" FT /note="Rv0723, (MTCY210.42), len: 146 aa. Probable rplO, FT 50S ribosomal protein L15, equivalent to FT MLCB2492_23|O33002 50S RIBOSOMAL PROTEIN L15 from FT Mycobacterium leprae (146 aa). Also highly similar to FT others e.g. P46787|RL15_STRCO|SCD31.46 50S RIBOSOMAL FT PROTEIN L15 from Streptomyces coelicolor (151 aa); FT P19946|RL15_BACSU 50s ribosomal protein L15 from Bacillus FT subtilis (146 aa), FASTA scores: opt: 419, E(): 6.5e-20, FT (51.0% identity in 145 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), and PS00475 FT Ribosomal protein L15 signature. BELONGS TO THE L15P FT FAMILY OF RIBOSOMAL PROTEINS." FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L15 RPLO" FT misc_feature 815259..815282 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 815517..815609 FT /note="PS00475 Ribosomal protein L15 signature" FT CDS 815663..817534 FT /EC_number="3.4.21.-" FT /evidence=experimental FT /function="INVOLVED IN DIGESTION OF THE CLEAVED SIGNAL FT PEPTIDES. THIS ACTIVITY IS NECESSARY TO MAINTAIN PROPER FT SECRETION OF MATURE PROTEINS ACROSS THE MEMBRANE." FT /gene="sppA" FT /locus_tag="Rv0724" FT /note="Rv0724, (MTCY210.43), len: 623 aa. Possible sppA, FT protease IV (endopeptidase IV) (EC 3.4.21.-), equivalent FT (but longer 23 aa) to MLCB2492_24|O33003 ENDOPEPTIDASE IV FT from Mycobacterium leprae (602 aa). Also similar to others FT e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA FT from Caulobacter crescentus (594 aa); FT P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from FT Escherichia coli strain K-12 (618 aa), FASTA scores: opt: FT 582, E(): 8.9e-27, (34.1% identity in 525 aa overlap); FT etc. BELONGS TO PEPTIDASE FAMILY S49." FT /product="POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) FT (SIGNAL PEPTIDE PEPTIDASE)" FT CDS complement(817531..>817866) FT /function="UNKNOWN" FT /locus_tag="Rv0724A" FT /note="Rv0724A, len: 111 aa. Similarity suggests that this FT CDS should be continuation of Rv0725c but we can find no FT frame-shift to account for this. Possible extended protein FT is very similar to other hypothetical Mycobacterium FT tuberculosis proteins e.g. Rv1729c|Z81360_12 (312 aa), FT FASTA scores: opt: 399, E(): 2e-19, (58.7% identity in 109 FT aa overlap); Rv0731c, Rv0726c, etc. Frame-shift could FT occur at nt 817866. Same sequence for strain CDC1551 and FT Mycobacterium bovis." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(817539..818444) FT /function="UNKNOWN" FT /locus_tag="Rv0725c" FT /note="Rv0725c, (MTCY210.44c), len: 301 aa. Conserved FT hypothetical protein, similar to hypothetical proteins FT from Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c, FT Rv3399, etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical FT 36.1 kDa protein cy31.21c (325 aa), FASTA scores: opt: FT 600, E(): 3.9e-32, (43.8% identity in 219 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(818537..819640) FT /function="UNKNOWN" FT /locus_tag="Rv0726c" FT /note="Rv0726c, (MTCY210.45c), len: 367 aa. Conserved FT hypothetical protein, highly similar to other conserved FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa), FT FASTA scores: opt: 646, E(): 0, (38.3% identity in 329 aa FT overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also FT similar to proteins from Mycobacterium leprae and other FT organisms e.g. T35930 hypothetical protein SC9B5.10 from FT Streptomyces coelicolor (303 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(819843..820499) FT /EC_number="4.1.2.17" FT /function="INVOLVED IN FUCOSE METABOLISM (AT THE THIRD FT STEP) [CATALYTIC ACTIVITY: L-FUCULOSE 1-PHOSPHATE = FT GLYCERONE PHOSPHATE + (S)-LACTALDEHYDE]." FT /gene="fucA" FT /locus_tag="Rv0727c" FT /note="Rv0727c, (MTV41.01c, MTCY210.46c), len: 218 aa. FT Possible fucA, L-fuculose-1-phosphate aldolase (EC FT 4.1.2.17), similar to many e.g. NP_386339.1|NC_003047 FT PUTATIVE L-FUCULOSE PHOSPHATE ALDOLASE PROTEIN from FT Sinorhizobium meliloti (222 aa); P11550|FUCA_ECOLI FT L-FUCULOSE PHOSPHATE ALDOLASE from Escherichia strain K12 FT (215 aa), FASTA scores: opt: 372, E(): 4.1e-19, (34.6% FT identity in 185 aa overlap); etc. BELONGS TO THE ALDOLASE FT CLASS II FAMILY, ARAD/FUCA SUBFAMILY. COFACTOR: BINDS ONE FT ZINC ION PER MOLECULE. TBparse score is 0.878." FT /product="POSSIBLE L-FUCULOSE PHOSPHATE ALDOLASE FUCA FT (L-FUCULOSE-1-PHOSPHATE ALDOLASE)" FT CDS complement(820496..821476) FT /EC_number="1.1.1.95" FT /function="INVOLVED AT THE FIRST COMMITTED STEP IN THE FT 'PHOSPHORYLATED' PATHWAY OF L-SERINE BIOSYNTHESIS. FT CATALYZES THE OXIDATION OF D-3-PHOSPHOGLYCERATE TO FT 3-PHOSPHOHYDROXYPYRUVATE [CATALYTIC ACTIVITY: FT 3-PHOSPHOGLYCERATE + NAD(+) = 3-PHOSPHOHYDROXYPYRUVATE + FT NADH]." FT /gene="serA2" FT /locus_tag="Rv0728c" FT /note="Rv0728c, (MTV041.02c), len: 326 aa. Possible serA2, FT D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar FT to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate FT dehydrogenase from Bacillus subtilis (344 aa), FASTA FT scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa FT overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 FT D-3-phosphoglycerate dehydrogenase from Mycobacterium FT tuberculosis (528 aa). TBparse score is 0.882." FT /product="POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE FT SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH)" FT CDS 821507..822853 FT /EC_number="2.7.1.17" FT /function="PHOSPHORYLATES D-XYLULOSE [CATALYTIC ACTIVITY: FT ATP + D-XYLULOSE = ADP + D-XYLULOSE 5-PHOSPHATE]." FT /gene="xylB" FT /locus_tag="Rv0729" FT /note="Rv0729, (MTV041.03), len: 448 aa. Possible xylB, FT D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus FT highly similar to AAD09880.1|U77912 unknown protein from FT Mycobacterium bovis (102 aa); and N-terminus highly FT similar to T45387|Z98756|MLCB2492_25 hypothetical protein FT from Mycobacterium leprae (110 aa), FASTA scores: opt: FT 427, E(): 1.1e-19, (60.9% identity in 110 aa overlap). FT Also similar to xylA/xylB genes from various bacterial FT species e.g. AAC26499.1|AF045245 D-xylulose-kinase from FT Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913 FT xylulokinase from Escherichia coli strain K12 (484 aa), FT FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in FT 478 aa overlap); etc. Also similar to Rv3696c|glpK FT PROBABLE GLYCEROL KINASE (EC 2.7.1.30) from Mycobacterium FT tuberculosis (517 aa). BELONGS TO THE FUCOKINASE / FT GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. FT TBparse score is 0.895." FT /product="POSSIBLE D-XYLULOSE KINASE XYLB (XYLULOKINASE) FT (XYLULOSE KINASE)" FT CDS 822866..823594 FT /function="UNKNOWN" FT /locus_tag="Rv0730" FT /note="Rv0730, (MTV041.04), len: 242 aa. Conserved FT hypothetical protein, only equivalent to FT Z98756|MLCB2492_26 HYPOTHETICAL PROTEIN from Mycobacterium FT leprae (227 aa), FASTA scores: opt: 1180, E(): 0, (83.5% FT identity in 218 aa overlap). TBparse score is 0.899." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(823683..824639) FT /function="UNKNOWN" FT /locus_tag="Rv0731c" FT /note="Rv0731c, (MTV041.05c), len: 318 aa. Conserved FT hypothetical protein, highly similar to other conserved FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Rv0726c|MTCY210.45c (367 aa), FASTA score: (60.9% identity FT in 317 aa overlap); Rv3399, Rv1729c, etc. TBparse score is FT 0.880." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 824800..826125 FT /function="ESSENTIAL FOR PROTEIN EXPORT. INTERACTS WITH FT SECA|Rv3240c AND SECE|Rv0638 TO ALLOW THE TRANSLOCATION OF FT PROTEINS ACROSS THE PLASMA MEMBRANE, BY FORMING PART OF A FT CHANNEL." FT /gene="secY" FT /locus_tag="Rv0732" FT /note="Rv0732, (MTV041.06), len: 441 aa. Probable SecY, FT preprotein translocase (integral membrane protein) (see FT citation below), equivalent to NP_302243.1|NC_002677 SecY FT subunit of preprotein translocase from Mycobacterium FT leprae (438 aa); AAC04389.1|AF047021 preprotein FT translocase subunit from Mycobacterium smegmatis (438 aa); FT and U77912|MBU77912_1 preprotein translocase subunit from FT Mycobacterium bovis (441 aa), FASTA scores: opt: 2802, FT E(): 0, (99.8% identity in 441 aa overlap). Also highly FT similar to others e.g. P46785|SECY_STRCO PREPROTEIN FT TRANSLOCASE SECY SUBUNIT from Streptomyces coelicolor (437 FT aa); etc. Contains PS00755 and PS00756 protein secY FT signatures 1 and 2. BELONGS TO THE SECE/SEC61-ALPHA FT FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION FT APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, FT SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY." FT /product="PROBABLE PREPROTEIN TRANSLOCASE SECY" FT misc_feature 825022..825081 FT /note="PS00755 Protein secY signature 1" FT misc_feature 825325..825381 FT /note="PS00756 Protein secY signature 2" FT CDS 826122..826667 FT /EC_number="2.7.4.3" FT /evidence=experimental FT /function="THIS SMALL UBIQUITOUS ENZYME IS ESSENTIAL FOR FT MAINTENANCE AND CELL GROWTH [CATALYTIC ACTIVITY: ATP + AMP FT = ADP + ADP]." FT /gene="adk" FT /locus_tag="Rv0733" FT /note="Rv0733, (MTV041.07), len: 181 aa. Probable adk, FT adenylate kinase (ATP-AMP transphosphorylase) (EC FT 2.7.4.3), equivalent to Z98756|MLCB24 92_28 probable FT adenylate kinase from Mycobacterium leprae (181 aa), FASTA FT scores: opt: 978, E(): 0, (83.6% identity in 177 aa FT overlap); and AAF86323.1|AF271342 putative adenylate FT kinase from Mycobacterium marinum (124 aa) (N-terminus FT shorter). Also highly similar to others e.g. FT P43414|KAD_STRCO ADENYLATE KINASE from Streptomyces FT coelicolor (217 aa), FASTA score: (43.0% identity in 186 FT aa overlap); etc. Contains PS00113 Adenylate kinase FT signature. BELONGS TO THE ADENYLATE KINASE FAMILY. TBparse FT score is 0.869." FT /product="PROBABLE ADENYLATE KINASE ADK (ATP-AMP FT TRANSPHOSPHORYLASE)" FT misc_feature 826362..826397 FT /note="PS00113 Adenylate kinase signature" FT CDS 826670..827470 FT /EC_number="3.4.11.18" FT /function="REMOVES THE AMINO-TERMINAL METHIONINE FROM FT NASCENT PROTEINS [CATALYTIC ACTIVITY: L-METHIONYLPEPTIDE + FT H2O = L-METHIONINE + PEPTIDE]." FT /gene="mapA" FT /locus_tag="Rv0734" FT /note="Rv0734, (MTV041.08), len: 266 aa. Probable mapA, FT methionine aminopeptidase (map) (EC 3.4.11.18), equivalent FT to Z98756|MLCB2492_29 probable methionine aminopeptidase FT from Mycobacterium leprae (266 aa), FASTA scores: opt: FT 1717, E(): 0, (83.4% identity in 265 aa overlap). Also FT highly similar to many e.g. T35553 methionine FT aminopeptidase from Streptomyces coelicolor (278 aa); etc. FT Also similar to Rv2861c|MAPB PROBABLE METHIONINE FT AMINOPEPTIDASE from Mycobacterium tuberculosis (285 aa). FT BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FT FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. FT TBparse score is 0.893." FT /product="PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) FT (PEPTIDASE M) (MetAP)" FT /standard_name="map" FT CDS 827543..828076 FT /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT FT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC FT INITIATION SITES AND THEN IS RELEASED." FT /gene="sigL" FT /locus_tag="Rv0735" FT /note="Rv0735, (MTV041.09), len: 177 aa. Probable sigL, FT alternative RNA polymerase sigma factor (rpoE) (see FT citations below), highly similar to many proteins of the FT extracytoplasmatic function (ECF) subfamily e.g. FT CAB72200.1|AL138851 putative RNA polymerase sigma factor FT from Streptomyces coelicolor (194 aa); Q06909|CARQ_MYXXA FT RNA POLYMERASE SIGMA FACTOR CARQ from Myxococcus xanthus FT (174 aa), FASTA scores: opt: 251, E(): 9.6e-11, (32.9% FT identity in 161 aa overlap); etc. Also similar to FT MTCI61_4, MTU87242_1, and MLU15180_30 from Mycobacterium FT tuberculosis. Contains PS01063 Sigma-70 factors ECF FT subfamily signature and probable helix-turn helix motif FT from aa 139-160 (Score 1134, +3.05 SD). BELONGS TO THE FT SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. TBparse score is FT 0.902." FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGL" FT misc_feature 827660..827698 FT /note="PS01063 Sigma-70 factors ECF subfamily signature" FT CDS 828140..828892 FT /function="UNKNOWN" FT /locus_tag="Rv0736" FT /note="Rv0736, (MTV041.10), len: 250 aa. Probable FT conserved membrane protein, showing weak similarity with FT AL133469|SCM10_32 putative membrane protein from FT Streptomyces coelicolor (216 aa), FASTA scores: opt: 180, FT E(): 0.00018, (34.3% identity in 216 aa overlap). TBparse FT score is 0.911." FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT CDS 829207..829704 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0737" FT /note="Rv0737, (MTV041.11), len: 165 aa. Possible FT transcriptional regulator, similar to others e.g. FT BAB69161.1|AB070937 regulator protein from Streptomyces FT avermitilis (169 aa); NP_419731.1|NC_002696 FT transcriptional regulator MarR family from Caulobacter FT crescentus (148 aa) (homology only at C-terminus); etc. FT Also shows weak similarity to AB0014|AB001488_14 FT hypothetical protein from Bacillus subtilis (164 aa), FT FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in FT 116 aa overlap), which is similar to slyY gene of S. FT typhimurium required for survival in macrophage. Contains FT possible helix-turn helix motif from aa 73-94 (Score 1138, FT +3.06 SD). TBparse score is 0.888." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 830062..830610 FT /function="UNKNOWN" FT /locus_tag="Rv0738" FT /note="Rv0738, (MTV041.12), len: 182 aa. Conserved FT hypothetical protein, showing weak similarity with FT hypothetical proteins from Mycobacterium tuberculosis: FT Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7|Z80343 FT hypothetical protein from Mycobacterium tuberculosis (194 FT aa), FASTA scores: opt: 172, E(): 0.0004, (24.2% identity FT in 178 aa overlap); and C-terminus of Rv0576. TBparse FT score is 0.886." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 830855..831661 FT /function="UNKNOWN" FT /locus_tag="Rv0739" FT /note="Rv0739, (MTV041.13), len: 268 aa. Conserved FT hypothetical protein, showing some similarity to FT Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA FT score: (37.6% identity in 101 aa overlap)and Rv0025 (120 FT aa), FASTA score: (32.4% identity in 142 aa overlap). FT TBparse score is 0.942." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 831776..832303 FT /function="UNKNOWN" FT /locus_tag="Rv0740" FT /note="Rv0740, (MTV041.14), len: 175 aa. Conserved FT hypothetical protein; C-terminus (possibly part of FT truncated IS1557) shows nearly perfect identity to FT Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in FT 81 aa overlap). Also shows weak similarity to MTV007_5 FT hypothetical protein from Mycobacterium tuberculosis (313 FT aa), FASTA score: (34.5% identity in 110 aa overlap); and FT MLCL536_27 hypothetical protein from Mycobacterium leprae FT (315 aa), FASTA score: (34.5% identity in 84 aa overlap). FT TBparse score is 0.909." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT repeat_region 832352..832868 FT /insertion_seq="IS1557'-1" FT /note="IS1557'-1, len: 517 bp. Region similar to Insertion FT sequence IS1557 on MTCY373- (IS1557- 1st copy)." FT CDS 832534..832848 FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1557." FT /locus_tag="Rv0741" FT /note="Rv0741, (MTV041.15), len: 104 aa. Probable FT truncated transposase for IS1557, showing similarity to FT transposases and IS elements e.g. U63997|EFU63997_1 FT insertion sequence from Enterococcus faecium (424 aa), FT FASTA score: (31.0% identity in 87 aa overlap). Very high FT similarity with the C-terminal part of Z73419|MTCY373_3 2 FT IS1557 from Mycobacterium tuberculosis (444 aa), FASTA FT score: (86.5% identity in 104 aa overlap)." FT /product="PROBABLE TRANSPOSASE (FRAGMENT)" FT CDS 832981..833508 FT /function="UNKNOWN" FT /gene="PE_PGRS8" FT /locus_tag="Rv0742" FT /note="Rv0742, (MTV041.16), len: 175 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to many FT Mycobacterium tuberculosis PGRS-type proteins e.g. FT Z78020|MTCY1A11_25 (498 aa), FASTA scores: opt: 766, E(): FT 6.1e-25, (73.6% identity in 178 aa overlap). Similarity FT suggests ORF starts with ATA start codon. TBparse score is FT 0.846." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS complement(833886..834443) FT /function="UNKNOWN" FT /locus_tag="Rv0743c" FT /note="Rv0743c, (MTV041.17c), len: 185 aa. Hypothetical FT unknown protein. TBparse score is 0.918." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(834440..834946) FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0744c" FT /note="Rv0744c, (MTV041.18c), len: 168 aa. Possible FT transcriptional regulator, showing weak similarity with FT O86661|SC4A2.05 PUTATIVE TWO-COMPONENT SENSOR from FT Streptomyces coelicolor (436 aa), FASTA scores: opt: 117, FT E(): 0.88, (37.25% identity in 94 aa overlap); and some FT putative excisionases or transposases. Also weakly similar FT to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (114 FT aa); and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (148 aa). Equivalent to AAK45006 from FT Mycobacterium tuberculosis strain CDC1551 (179 aa) but FT shorter 11 aa. Contains probable helix-turn helix motif FT from aa 5-26 (Score 1350, +3.78 SD). TBparse score is FT 0.925." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 835154..835681 FT /function="UNKNOWN" FT /locus_tag="Rv0745" FT /note="Rv0745, (MTV041.19), len: 175 aa. Conserved FT hypothetical protein; shows high similarity to a 50 aa FT region of Rv3649|Z95436|MTY15C10_3 CONSERVED HYPOTHETICAL FT PROTEIN, similar to ATP-dependent helicases, from FT Mycobacterium tuberculosis (771 aa), FASTA scores: opt: FT 225, E(): 7e-06, (70.0% identity in 50 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 835701..838052 FT /function="UNKNOWN" FT /gene="PE_PGRS9" FT /locus_tag="Rv0746" FT /note="Rv0746, (MTV041.20), len: 783 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. FT tuberculosis (914 aa), FASTA scores: opt: 2429, E(): 0, FT (56.9% identity in 873 aa overlap). Also similar to other FT PE-PGRS FAMILY PROTEINS e.g. AL0212|MTV008_46 FASTA score: FT (48.8% identity in 887 aa overlap); etc. TBparse score is FT 0.860." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 838451..840856 FT /function="UNKNOWN" FT /gene="PE_PGRS10" FT /locus_tag="Rv0747" FT /note="Rv0747, (MTV041.21), len: 801 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. FT tuberculosis (914 aa), FASTA scores: opt: 2772, E(): 0, FT (60.9% identity in 941 aa overlap). Also similar to other FT PE-PGRS FAMILY PROTEINS e.g. Z95844|MTCY493_2 FASTA score: FT (50.2% identity in 815 aa overlap). Contains PS00012 FT Phosphopantetheine attachment site." FT /product="PE-PGRS FAMILY PROTEIN" FT misc_feature 840371..840418 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 840947..841204 FT /function="UNKNOWN" FT /locus_tag="Rv0748" FT /note="Rv0748, (MTV041.22), len: 85 aa. Conserved FT hypothetical protein, N-terminus similar to N-terminal FT region of NP_436939.1|NC_003078 HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (75 aa). Also similar to FT Mycobacterium tuberculosis proteins Rv2871 CONSERVED FT HYPOTHETICAL PROTEIN (75 aa); Rv1241, Rv2132, Rv3321c, FT etc. TBparse score is 0.875." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 841228..841656 FT /function="UNKNOWN" FT /locus_tag="Rv0749" FT /note="Rv0749, (MTV041.23), len: 142 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins from Mycobacterium tuberculosis e.g. Rv0749, FT Rv0277c, Rv2530c, etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(841737..841874) FT /function="UNKNOWN" FT /locus_tag="Rv0749A" FT /note="Rv0749A, len: 45 aa. Conserved hypothetical protein FT (probably gene fragment), similar to part (aa 250-292) of FT Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa), FT FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity in FT 43 aa overlap)." FT /product="HYPOTHETICAL PROTEIN (FRAGMENT)" FT CDS 842033..842278 FT /function="UNKNOWN" FT /locus_tag="Rv0750" FT /note="Rv0750, (MTV041.24), len: 81 aa. Conserved FT hypothetical protein, showing almost perfect overlap with FT C-terminus of Rv0740|MTV041_14 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (175 aa), FASTA FT scores: (93.8% identity in 81 aa overlap). Possible FT duplication. TBparse score is 0.872." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(842347..843231) FT /EC_number="1.1.1.31" FT /function="Catalyzes the NAD-dependent, reversible FT oxidation of 3-hydroxbutyrate to methylmalonate [CATALYTIC FT ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD+ = FT 2-methyl-3-oxopropanoate + NADH]." FT /gene="mmsB" FT /locus_tag="Rv0751c" FT /note="Rv0751c, (MTV041.25c), len: 294 aa. Probable mmsB, FT 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly FT similar to others e.g. NP_102847.1|NC_002678 FT 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti FT (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate FT dehydrogenase from Caulobacter crescentus (298 aa); A32867 FT 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus FT (346 aa); etc. Also similar to methylmalonate semialdehyde FT dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate FT semialdehyde dehydrogenase from Pseudomonas aeruginosa FT (298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity FT in 297 aa overlap). Also similar to 6-phosphogluconate FT dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 FT and Rv1844c. Contains PS00895 3-hydroxyisobutyrate FT dehydrogenase signature. BELONGS TO THE FT 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY." FT /product="PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB FT (HIBADH)" FT misc_feature complement(843172..843216) FT /note="PS00895 3-hydroxyisobutyrate dehydrogenase FT signature" FT CDS complement(843242..844414) FT /EC_number="1.3.99.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE9" FT /locus_tag="Rv0752c" FT /note="Rv0752c, (MTV041.26c), len: 390 aa. Probable fadE9, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT many e.g. NP_437985.1|NC_003078 putative acyl-CoA FT dehydrogenase protein from Sinorhizobium meliloti (380 FT aa); Z99123|BSUB0020_14 from Bacillus subtilis (379 aa), FT FASTA scores: opt: 853, E(): 0, (39.8% identity in 384 aa FT overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases FT signature 1, and PS00073 Acyl-Co Adehydrogenases signature FT 2. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE9" FT misc_feature complement(843335..843394) FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT misc_feature complement(844013..844051) FT /note="PS00072 Acyl-CoA dehydrogenases signature 1" FT CDS complement(844421..845953) FT /EC_number="1.2.1.27" FT /evidence=experimental FT /function="PLAYS A ROLE IN VALINE AND PYRIMIDINE FT METABOLISM. BINDS FATTY ACYL-CoA [CATALYTIC ACTIVITY: FT 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + FT CO2 + NADH]." FT /gene="mmsA" FT /locus_tag="Rv0753c" FT /note="Rv0753c, (MTV041.27c), len: 510 aa. Probable mmsA, FT methylmalonic acid semialdehyde dehydrogenase (EC FT 1.2.1.27), highly similar to others e.g. FT NP_420115.1|NC_002696 putative methylmalonate-semialdehyde FT dehydrogenase from Caulobacter crescentus (499 aa); FT L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid FT semialdehyde dehydrogenase from Streptomyces coelicolor FT (500 aa), FASTA score: (51.6% identity in 498 aa overlap); FT M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 FT methylmalonate-semialdehyde dehydrogenase from Pseudomonas FT aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0, FT (47.9% identity in 507 aa overlap); etc. Note that also FT highly similar to malonic semialdehyde oxidative FT decarboxylases e.g. NP_104968.1|NC_002678 malonic FT semialdehyde oxidative decarboxylase from Mesorhizobium FT loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC FT SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from FT Sinorhizobium meliloti (498 aa); etc. Contains PS00070 FT Aldehyde dehydrogenases cysteine active site. BELONGS TO FT THE ALDEHYDE DEHYDROGENASES FAMILY." FT /product="PROBABLE METHYLMALONATE-SEMIALDEHYDE FT DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE FT DEHYDROGENASE) (MMSDH)" FT misc_feature complement(845096..845131) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT CDS 846159..847913 FT /function="UNKNOWN" FT /gene="PE_PGRS11" FT /locus_tag="Rv0754" FT /note="Rv0754, (MTV041.28), len: 584 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to others FT e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis FT (1660 aa), FASTA score: (48.7% identity in 345 aa FT overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis FT (778 aa), FASTA score: (41.6% identity in 442 aa overlap); FT etc." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS complement(848103..850040) FT /function="UNKNOWN" FT /gene="PPE12" FT /locus_tag="Rv0755c" FT /note="Rv0755c, (MTV041.29), len: 645 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT others e.g. Z82098|MTCY3C7_23 from Mycobacterium FT tuberculosis (582 aa), FASTA scores: (56.1% identity in FT 636 aa overlap); Z92774|MTCY6G11_5 from Mycobacterium FT tuberculosis (552 aa), FASTA scores: (55.8% identity in FT 590 aa overlap); etc." FT /product="PPE FAMILY PROTEIN" FT CDS complement(850342..850527) FT /function="COULD BE REQUIRED FOR THE TRANSPOSITION OF AN FT INSERTION ELEMENT." FT /locus_tag="Rv0755A" FT /note="Rv0755A, len: 61 aa. Putative transposase (possibly FT gene fragment), similar to C-terminal part of FT Q9EZM2|ISMav2|AF286339_1 putative transposase from FT Mycobacterium paratuberculosis (395 aa), FASTA scores: FT opt: 284, E(): 5e-13, (83.02% identity in 53 aa overlap); FT and to SCJ11.25c|Q9RI80 possible noncomposite transposon FT transposase from Streptomyces coelicolor (283 aa)." FT /product="PUTATIVE TRANSPOSASE (FRAGMENT)" FT tRNA complement(850642..850713) FT /gene="tRNA-Thr(TGT)" FT /anticodon=(pos:850679..850681,aa:Thr) FT /product="transfer RNA-Thr(TGT)" FT CDS complement(850741..851466) FT /function="UNKNOWN" FT /locus_tag="Rv0756c" FT /note="Rv0756c, (MTCY369.01c), len: 241 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS 851608..852351 FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM. PART OF FT THE TWO COMPONENT REGULATORY SYSTEM PHOP/PHOQ. THIS FT PROTEIN IS THOUGHT TO BE A POSITIVE REGULATOR FOR THE FT PHOSPHATE REGULON, REQUIRED FOR INTRACELLULAR GROWTH. FT TRANSCRIPTION OF THIS OPERON IS POSITIVELY REGULATED BY FT PHOB AND PHOR|Rv0758 WHEN PHOSPHATE IS LIMITED." FT /gene="phoP" FT /locus_tag="Rv0757" FT /note="Rv0757, (MTCY369.02), len: 247 aa. Possible phoP, FT two component system response phosphate regulon FT transcriptional regulator (see citations below), highly FT similar to various transcriptional regulators e.g. FT CAC32360.1|AL583945 putative two component system response FT regulator from Streptomyces coelicolor (271 aa); T45446 FT probable two-component response regulator from FT Mycobacterium leprae (253 aa); and similar to phoP FT proteins e.g. P13792|PHOP_BACSU alkaline phosphatase FT synthesis transcription regulatory protein from Bacillus FT subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, FT (41.0% identity in 234 aa overlap); etc. Also highly FT similar to Rv3765c from Mycobacterium tuberculosis (234 FT aa), Rv1033c (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FT FASTA score: (45.4% identity in 229 aa overlap); FT MTCY10G2_16 and MTU88959_1." FT /product="POSSIBLE TWO COMPONENT SYSTEM RESPONSE FT TRANSCRIPTIONAL POSITIVE REGULATOR PHOP" FT CDS 852396..853853 FT /EC_number="2.7.-.-" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM. THIS PROTEIN IS THOUGHT TO BE A SENSOR KINASE FOR FT THE PHOSPHATE REGULON. TRANSCRIPTION OF THIS OPERON IS FT POSITIVELY REGULATED BY PHOB|Rv0757 AND PHOR WHEN FT PHOSPHATE IS LIMITED." FT /gene="phoR" FT /locus_tag="Rv0758" FT /note="Rv0758, (MTCY369.03), len: 485 aa. Possible phoR, FT two component system response phosphate sensor kinase FT membrane-associated (EC 2.7.-.-), highly similar to FT various sensor kinases e.g. CAC32361.1|AL583945 putative FT two component system histidine kinase from Streptomyces FT coelicolor (524 aa); NP_349365.1|NC_003030 FT Membrane-associated sensory histidine kinase with HAMP FT domain from Clostridium acetobutylicum (482 aa); and FT similar to phoP proteins e.g. NP_372216.1|NC_002758 FT alkaline phosphatase synthesis sensor protein from FT Staphylococcus aureus (554 aa); P23545|PHOR_BACSU alkaline FT phosphatase synthesis sensor from Bacillus subtilis (579 FT aa), FASTA scores: opt: 515, E(): 1.9e-25, (40.0% identity FT in 230 aa overlap); etc. Also similar to proteins from FT Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: FT (34.5% identity in 264 aa overlap), MTU88959_2 (509 aa), FT MTCY10G2_17, etc." FT /product="POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR FT KINASE MEMBRANE ASSOCIATED PHOR" FT CDS complement(853825..854157) FT /function="UNKNOWN" FT /locus_tag="Rv0759c" FT /note="Rv0759c, (MTCY369.04c), len: 110 aa. Conserved FT hypothetical protein, highly similar (but shorter 45 aa in FT N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A FT HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae FT (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity FT in 150 aa overlap). Also highly similar (but N-terminus FT always shorter) to HIT-like proteins and protein kinase FT inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like FT protein from Rhodococcus sp. (141 aa); FT NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) FT from Borrelia burgdorferi (149 aa) ; FT P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN FT from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689 FT HIT (histidine triad) family protein from Thermoplasma FT volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C FT inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa), FT FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in FT 111 aa overlap); etc. Also shows similarity with FT Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 FT HYPOTHETICAL HIT-LIKE PROTEIN (144 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(854267..854686) FT /function="UNKNOWN" FT /locus_tag="Rv0760c" FT /note="Rv0760c, (MTCY369.05), len: 139 aa. Conserved FT hypothetical protein, similar to N-terminal part of FT Rv2042c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (265 aa), FASTA scores: opt: 150, E(): FT 4.1e-05, (28.7% identity in 136 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(854699..855826) FT /EC_number="1.1.1.1" FT /function="THOUGHT TO CATALYZE THE REVERSIBLE OXIDATION OF FT ETHANOL TO ACETALDEHYDE WITH THE CONCOMITANT REDUCTION OF FT NAD. PROBABLY ACTS ON PRIMARY OR SECONDARY ALCOHOLS OR FT HEMIACETALS [CATALYTIC ACTIVITY: An alcohol + NAD+ = an FT aldehyde or ketone + NADH]." FT /gene="adhB" FT /locus_tag="Rv0761c" FT /note="Rv0761c, (MTCY369.06c), len: 375 aa. Possible adhB, FT zinc-containing alcohol dehydrogenase NAD-dependent (EC FT 1.1.1.1), similar to others e.g. AAC15839.1|AF060871_4 FT hypothetical alcohol dehydrogenase from Rhodococcus FT rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0, FT (46.8% identity in 370 aa overlap); P80468|ADH2_STRCA FT ALCOHOL DEHYDROGENASE II from Struthio camelus (Ostrich) FT (379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha FT chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA FT scores: opt: 872, E(): 0, (39.1% identity in 379 aa FT overlap); etc. Also similar to adhD alcohol dehydrogenase FT from Mycobacterium tuberculosis (368 aa). Contains PS00059 FT Zinc-containing alcohol dehydrogenases signature. BELONGS FT TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY." FT /product="POSSIBLE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FT NAD DEPENDENT ADHB" FT misc_feature complement(855602..855646) FT /note="PS00059 Zinc-containing alcohol dehydrogenases FT signature" FT CDS complement(855925..856470) FT /function="UNKNOWN" FT /locus_tag="Rv0762c" FT /note="Rv0762c, (MTCY369.07c), len: 181 aa. Conserved FT hypothetical protein, showing weak similarity to FT D90907_77|P73575 HYPOTHETICAL 31.3KD PROTEIN from FT Synechocystis sp, FASTA scores: E(): 0.0012, (30.4% FT identity in 92 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature complement(855943..855966) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(856473..856679) FT /function="FERREDOXINS ARE IRON-SULFUR PROTEINS THAT FT TRANSFER ELECTRONS IN A WIDE VARIETY OF METABOLIC FT REACTIONS. PROBABLY INVOLVED IN ELECTRON TRANSPORT FOR FT CYTOCHROME P-450 SYSTEM." FT /locus_tag="Rv0763c" FT /note="Rv0763c, (MTCY369.08c), len: 68 aa. Possible FT ferredoxin, similar to others and related proteins e.g. FT P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from FT Streptomyces griseolus (68 aa); FT AAK31349.1|AF350429_2|AF350429 putative ferredoxin from FT Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 FT phthalate dioxygenase ferredoxin subunit from Arthrobacter FT keyseri (64 aa); etc. Probably involved in electron FT transport for cytochrome P-450 system e.g. downstream ORF FT Rv0764c|MTCY369.09c PROBABLE CYTOCHROME P450 51 from FT Mycobacterium tuberculosis (451 aa), FASTA scores: opt: FT 137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also FT similar to putative ferredoxins Rv3503c and Rv1786 from FT Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL FT TYPE FERREDOXIN FAMILY." FT /product="POSSIBLE FERREDOXIN" FT CDS complement(856682..858037) FT /EC_number="1.14.14.-" FT /evidence=experimental FT /function="INVOLVED IN STEROL BIOSYNTHESIS. ITS PRECISE FT BIOLOGICAL SUBSTRATE IS NOT KNOWN. CATALYZES FT C14-DEMETHYLATION OF LANOSTEROL, 24,25-DIHYDROLANOSTEROL FT AND OBTUSIFOLIOL WHICH IS CRITICAL FOR ERGOSTEROL FT BIOSYNTHESIS. IT TRANSFORMS LANOSTEROL INTO 4,4'-DIMETHYL FT CHOLESTA-8,14,24-TRIENE-3-BETA-OL." FT /gene="cyp51" FT /locus_tag="Rv0764c" FT /note="Rv0764c, (MT0788, MTCY369.09c), len: 451 aa. cyp51, FT cytochrome P450 51 (sterol 14-alpha demethylase) (EC FT 1.14.14.-), similar to others e.g. Q16850|CP51_HUMAN FT CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA FT DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo FT sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% FT identity in 439 aa overlap); NP_172633.1|NC_003070 FT putative obtusifoliol 14-alpha demethylase from FT Arabidopsis thaliana (488 aa); P93596|CP51_WHEAT FT CYTOCHROME P450 51 (CYPL1) (P450-L1A1) (OBTUSIFOLIOL FT 14-ALPHA DEMETHYLASE) from Triticum aestivum (453 aa); FT etc. Also similar to many other Mycobacterium tuberculosis FT cytochromes P450 e.g. Rv1394c, FASTA score: (22.5% FT identity in 444 aa overlap). Contains PS00086 Cytochrome FT P450 cysteine heme-iron ligand signature. BELONGS TO THE FT CYTOCHROME P450 FAMILY." FT /product="CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) FT (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA FT DEMETHYLASE) (P450-14DM)" FT misc_feature complement(856850..856879) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(858037..858864) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM, POSSIBLY ELECTRON TRANSFERT." FT /locus_tag="Rv0765c" FT /note="Rv0765c, (MTCY369.10c), len: 275 aa. Probable FT oxidoreductase (EC 1.-.-.-), similar others e.g. FT P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate FT dehydrogenase from Bacillus subtilis (261 aa), FASTA FT scores: opt: 385, E(): 1.8e-17, (30.6% identity in 252 aa FT overlap); AAF81239.1|AF263012 putative beta-ketoacyl FT reductase from Streptomyces griseus (274 aa); FT NP_436514.1|NC_003037 putative oxidoreductase from FT Sinorhizobium meliloti (240 aa); etc. Also similar to FT several other oxidoreductases from Mycobacterium FT tuberculosis e.g. Rv1544|MTCY48.21, FASTA score: (32.6% FT identity in 267 aa overlap); etc. Contains PS00061 FT Short-chain alcohol dehydrogenase family signature." FT /product="PROBABLE OXIDOREDUCTASE" FT misc_feature complement(858343..858429) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(858864..860072) FT /EC_number="1.14.-.-" FT /evidence=experimental FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /gene="cyp123" FT /locus_tag="Rv0766c" FT /note="Rv0766c, (MT0790, MTCY369.11c), len: 402 aa. FT Probable cyp123, cytochrome P-450 (EC 1.14.-.-), similar FT to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 FT from Saccharopolyspora erythraea (405 aa), FASTA scores: FT opt: 770, E(): 0, (36.9% identity in 406 aa overlap); FT T36526 probable cytochrome P450 hydroxylase from FT Streptomyces coelicolor (411 aa); P27632|CPXM_BACSU FT CYTOCHROME P450 109 from Bacillus subtilis (405 aa); etc. FT Also similar to several other cytochromes P-450 from FT Mycobacterium tuberculosis e.g. Rv1256c|MTCY50.26 (405 FT aa), FASTA score: (35.2% identity in 389 aa overlap); etc. FT Contains PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY." FT /product="PROBABLE CYTOCHROME P450 123 CYP123" FT misc_feature complement(859017..859046) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(860069..860710) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0767c" FT /note="Rv0767c, (MTCY369.12c), len: 213 aa. Conserved FT hypothetical protein, showing weak similarity with FT AL133220|SCC75A_26 HYPOTHETICAL PROTEIN from Streptomyces FT coelicolor (215 aa), FASTA scores: opt: 152, E(): 0.0048, FT (28.4% identity in 204 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 860912..862381 FT /EC_number="1.2.1.-" FT /evidence=experimental FT /function="OXIDIZES A VARIETY OF ALDEHYDES [CATALYTIC FT ACTIVITY: An aldehyde + NAD+ + H2O = an acid + NADH]." FT /gene="aldA" FT /locus_tag="Rv0768" FT /note="Rv0768, (MTCY369.13), len: 489 aa. Probable aldA, FT NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly FT similar to others e.g. AAL14238.1|AY052630 6-oxolauric FT acid dehydrogenase from Rhodococcus ruber (474 aa); FT NP_285450.1|NC_001264 aldehyde dehydrogenase from FT Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 FT NADP-dependent aldehyde dehydrogenase from Bacillus FT halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde FT dehydrogenase precursor from Atriplex hortensis (Mountain FT spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% FT identity in 486 aa overlap); etc. Also highly similar to FT Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium FT tuberculosis (487 aa). Contains PS00687 Aldehyde FT dehydrogenases glutamic acid active site. BELONGS TO THE FT ALDEHYDE DEHYDROGENASES FAMILY." FT /product="PROBABLE ALDEHYDE DEHYDROGENASE NAD DEPENDENT FT ALDA (ALDEHYDE DEHYDROGENASE [NAD+])" FT misc_feature 861683..861706 FT /note="PS00687 Aldehyde dehydrogenases glutamic acid FT active site" FT CDS 862412..863158 FT /EC_number="1.-.-.-" FT /evidence=experimental FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0769" FT /note="Rv0769, (MTCY369.14), len: 248 aa. Probable FT dehydrogenase/reductase (EC 1.-.-.-), similar to others, FT especially short-chain type dehydrogenases/reductases and FT 3-oxoacyl-(acyl-carrier protein) reductases e.g. FT NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa); FT NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) FT reductase from Bacillus halodurans (246 aa); FT P28643|FABG_CUPLA 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE from Cuphea lanceolata (320 aa); FT P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase FT from Escherichia coli (255 aa), FASTA scores: opt: 536, FT E(): 6.5e-27, (37.7% identity in 247 aa overlap); etc. FT Also similar to others from Mycobacterium tuberculosis FT e.g. MTCY02B10.14, FASTA score: (33.7% identity in 249 aa FT overlap); etc." FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT repeat_unit 863155..863255 FT /note="101 bp Mycobacterial Interspersed Repetitive Unit, FT Class I" FT CDS 863256..864143 FT /EC_number="1.1.1.-" FT /evidence=experimental FT /function="UNKNOWN; 3-HYDROXYISOBUTYRATE DEHYDROGENASE FT FAMILY PROTEIN PROBABLY INVOLVED IN CELLULAR METABOLISM." FT /locus_tag="Rv0770" FT /note="Rv0770, (MTCY369.15), len: 295 aa. Probable FT dehydrogenase/reductase, 3-hydroxyisobutyrate FT dehydrogenase family (EC 1.1.1.-), possibly FT 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) or FT 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), similar FT to others e.g. P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE FT REDUCTASE (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from FT Escherichia coli strain K12 (294 aa), FASTA scores: opt: FT 469, E(): 6.7e-22, (34.4% identity in 282 aa overlap); FT P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase FT (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA FT scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa FT overlap); etc. Also similar to others from Mycobacterium FT tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO FT THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY." FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT CDS 864140..864574 FT /EC_number="4.1.1.44" FT /function="INVOLVED IN AROMATIC HYDROCARBONS CATABOLISM. FT THOUGHT TO BE INVOLVED IN THE CATABOLISM OF FT PROTOCATECHUATE TO SUCCINATE-AND ACETYL-CoA IN THE FT BETA-KETOADIPATE PATHWAY (AT THE THIRD STEP) [CATALYTIC FT ACTIVITY: 2-CARBOXY-5-OXO-2,5-DIHYDROFURAN-2-ACETATE = FT 5-OXO-4,5-DIHYDROFURAN-2-ACETATE + CO(2)]." FT /locus_tag="Rv0771" FT /note="Rv0771, (MTCY369.16), len: 144 aa. Possible FT 4-carboxymuconolactone decarboxylase (EC 4.1.1.44), FT showing similarity with other carboxymuconolactone FT decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein FT from Pseudomonas putida (130 aa); P20370|DC4C_ACICA FT 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) from FT Acinetobacter sp. ADP1 (134 aa), FASTA scores: opt: 174, FT E(): 0.00075, (31.4% identity in 121 aa overlap); FT C-terminus of NP_421214.1|NC_002696 3-oxoadipate FT enol-lactone hydrolase/4-carboxymuconolactone FT decarboxylase from Caulobacter crescentus (393 aa); FT C-terminus of T47115 probable 4-carboxymuconolactone FT decarboxylase / 3-oxoadipate enol-lactone hydrolase from FT Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative FT gamma carboxymuconolactone decarboxylase from Yersinia FT pestis (131 aa); etc." FT /product="POSSIBLE 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FT (CMD)" FT CDS 864586..865854 FT /EC_number="6.3.4.13" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT SECOND STEP) [CATALYTIC ACTIVITY: ATP + FT 5-PHOSPHORIBOSYLAMINE + GLYCINE = ADP + PHOSPHATE + FT 5'-PHOSPHORIBOSYLGLYCINAMIDE]." FT /gene="purD" FT /locus_tag="Rv0772" FT /note="Rv0772, (MTCY369.17), len: 422 aa. Probable purD, FT phosphoribosylamine--glycine ligase (EC 6.3.4.13), FT equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 FT PHOSPHORIBOSYLAMINE--GLYCINE LIGASE from Mycobacterium FT leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8% FT identity in 422 aa overlap). Also highly similar to others FT e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine FT ligase from Streptomyces coelicolor (416 aa); FT P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from FT Escherichia coli (429 aa), FASTA scores: opt: 1039, E(): FT 0, (42.7% identity in 431 aa overlap); etc. BELONGS TO THE FT GARS FAMILY." FT /product="PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE FT PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) FT (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) FT (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)" FT CDS complement(865851..867389) FT /EC_number="3.5.1.-" FT /EC_number="2.3.2.2" FT /function="BESIDES THE CEPHALOSPORIN ACYLASE I ACTIVITY FT WHICH CONVERTS GL-7ACA INTO 7-ACA; THIS ENZYME DISPLAYS FT SOME GAMMA GLUTAMYLTRANSPEPTIDASE ACTIVITY: GGT PLAYS A FT KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE FT SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [CATALYTIC FT ACTIVITY 1: 7-BETA-(4-CARBOXYBUTANAMIDO)-CEPHALOSPORANIC FT ACID + H2O = 7-AMINOCEPHALOSPORANIC ACID + GLUTARIC ACID] FT [CATALYTIC ACTIVITY 2: (5-L-glutamyl)-peptide + an amino FT acid = peptide + 5-L-glutamyl-amino acid]." FT /gene="ggtA" FT /locus_tag="Rv0773c" FT /note="Rv0773c, (MTCY369.18), len: 512 aa. Probable ggtA, FT bifunctional acylase including cephalosporin acylase (EC FT 3.5.1.-), and gamma-glutamyl transpeptidase (EC 2.3.2.2); FT highly similar to others e.g. NP_295247.1|NC_001263 FT cephalosporin acylase from Deinococcus radiodurans (535 FT aa); NP_248854.1|NC_002516 probable FT gamma-glutamyltranspeptidase from Pseudomonas aeruginosa FT (538 aa); P15557|PAC1_PSES3 ACYLASE ACY 1 [INCLUDES: FT CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE); FT GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)] from Pseudomonas sp. FT strain SE83 (558 aa), FASTA scores: opt: 784, E(): 0, FT (34.2% identity in 526 aa overlap); FT NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein FT similar to gamma-glutamyltransferase from Bacillus FT subtilis (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1% FT identity in 516 aa overlap); etc. Also similar to FT Rv2394|ggtB from Mycobacterium tuberculosis. Member of FT GL-7ACA ACYLASES AND TO GGT group." FT /product="PROBABLE BIFUNCTIONAL ACYLASE GGTA: FT CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE) + FT GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)" FT CDS complement(867440..868351) FT /function="UNKNOWN; COULD HAVE POSSIBLY A LIPOLYTIC FT ACTIVITY." FT /locus_tag="Rv0774c" FT /note="Rv0774c, (MTCY369.19c), len: 303 aa. Possible FT conserved exported protein with hydrophobic region near FT N-terminus, highly similar, except in N-terminus, to FT Rv0519c|Z97831|MTY20G10.09c|O33364 HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (300 aa), FASTA scores: FT opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). FT Contains PS00061 Short-chain alcohol dehydrogenase family FT signature, and PS00120 Lipases, serine active site. So FT could be a lipase (EC 3.1.-.-). Start changed since first FT submission (-9 aa)." FT /product="PROBABLE CONSERVED EXPORTED PROTEIN" FT misc_feature complement(867533..867619) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT misc_feature complement(867788..867817) FT /note="PS00120 Lipases, serine active site" FT CDS 868407..869030 FT /function="UNKNOWN" FT /locus_tag="Rv0775" FT /note="Rv0775, (MTCY369.20), len: 207 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins e.g. ECAE000186_11|MG1655 HYPOTHETICAL PROTEIN FT from Escherichia coli strain K-12 (178 aa), FASTA scores: FT E(): 6.4e-05, (27.2% identity in 147 aa overlap); FT P41037|BIH_ECOLI hypothetical transcriptional regulator FT from Escherichia coli (103 aa), FASTA scores: opt: 138, FT E(): 0.003, (30.9% identity in 97 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(868984..869763) FT /function="UNKNOWN" FT /locus_tag="Rv0776c" FT /note="Rv0776c, (MTCY369.21a), len: 259 aa. Conserved FT hypothetical protein, similar (except first 50 aa) to FT P72737|D90900_57 hypothetical protein from Synechocystis FT sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E(): FT 1.7e-15, (30.5% identity in 266 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 870008..871426 FT /EC_number="4.3.2.2" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT EIGHT STEP) [CATALYTIC ACTIVITY: FT 1-(5-PHOSPHORIBOSYL)-4-(N-SUCCINO-CARBOXAMIDE) FT -5-AMINOIMIDAZOLE = FUMARATE + FT 5'-PHOSPHORIBOSYL-5-AMINO-4-IMIDAZOLECARBOXAMIDE (ALSO FT CATALYZES: N6-(1,2-DICARBOXYETHYL)AMP = FUMARATE + AMP)]." FT /gene="purB" FT /locus_tag="Rv0777" FT /note="Rv0777, (MTCY369.21b), len: 472 aa. Probable purB, FT adenylosuccinate lyase (EC 4.3.2.2), equivalent (but FT shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB FT ADENYLOSUCCINATE LYASE from Mycobacterium leprae (487 aa), FT FASTA scores: opt: 2640, E(): 0, (86.7% identity in 472 aa FT overlap). More similar to eukaryotic adenylosuccinate FT lyases than to prokaryotic adenylosuccinate lyases e.g. FT P54822|PUR8_MOUSE ADENYLOSUCCINATE LYASE from Mus musculus FT (484 aa), FASTA scores: opt: 762, E(): 0, (32.4% identity FT in 445 aa overlap); CAB99134.1|AL390188 putative FT adenylosuccino lyase (fragment) from Streptomyces FT coelicolor (362 aa); etc. Contains PS00163 Fumarate lyases FT signature. BELONGS TO THE LYASE 1 FAMILY, ADENYLOSSUCINATE FT LYASE SUBFAMILY." FT /product="PROBABLE ADENYLOSUCCINATE LYASE PURB FT (ADENYLOSUCCINASE) (ASL) (ASASE)" FT misc_feature 870833..870862 FT /note="PS00163 Fumarate lyases signature" FT CDS 871431..872675 FT /EC_number="1.14.-.-" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /gene="cyp126" FT /locus_tag="Rv0778" FT /note="Rv0778, (MT0802, MTCY369.22), len: 414 aa. Possible FT cyp126, cytochrome P-450 (EC 1.14.-.-), similar to other FT cytochromes and related proteins e.g. FT AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from FT Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 FT cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) FT (lin C) from Pseudomonas incognita (406 aa), FASTA scores: FT opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. FT Also similar to others from Mycobacterium tuberculosis FT e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 FT Cytochrome P450 cysteine heme-iron ligand signature." FT /product="POSSIBLE CYTOCHROME P450 126 CYP126" FT misc_feature 872496..872525 FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(872672..873292) FT /function="UNKNOWN" FT /locus_tag="Rv0779c" FT /note="Rv0779c, (MTCY369.23c), len: 206 aa. Possible FT conserved transmembrane protein, equivalent to FT Z95151|MLCB5_14 O05747 conserved hypothetical protein from FT Mycobacterium leprae (206 aa), FASTA scores: opt: 902, FT E(): 0, (67.2% identity in 204 aa overlap)." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 873343..874236 FT /EC_number="6.3.2.6" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT SEVENTH STEP) [CATALYTIC ACTIVITY: ATP + FT 1-(5-phosphoribosyl)-4-carboxy-5-aminoimidazole + FT L-aspartate = ADP + phosphate + FT 1-(5-phosphoribosyl)-4-(N-succino-carboxamide)-5-aminoimi FT da zole]." FT /gene="purC" FT /locus_tag="Rv0780" FT /note="Rv0780, (MTCY369.24), len: 297 aa. purC, FT phosphoribosylaminoimidazole- succinocarboxamide synthase FT (EC 6.3.2.6) (see citations below), equivalent to FT MTU34957_1|PURC FT phosphoribosylaminoimidazole-succinocarboxamide synthase FT from Mycobacterium leprae (297 aa), FASTA scores: opt: FT 1986, E(): 0, (99.3% identity in 297 aa overlap). Also FT similar to others e.g. CAB56351.1|AL118514 FT phosphoribosylaminoimidazole-succinocarboxamide synthase FT from Streptomyces coelicolor (299 aa); etc. Contains FT PS01058 SAICAR synthetase signature 2. BELONGS TO THE FT SAICAR SYNTHETASE FAMILY." FT /product="PHOSPHORIBOSYLAMINOIMIDAZOLE- SUCCINOCARBOXAMIDE FT SYNTHASE PURC (SAICAR SYNTHETASE)" FT misc_feature 873922..873948 FT /note="PS01058 SAICAR synthetase signature 2" FT CDS 874233..874943 FT /EC_number="3.4.21.83" FT /function="CLEAVES PEPTIDE BONDS ON THE C-TERMINAL SIDE OF FT LYSYL AND ARGININYL RESIDUES [CATALYTIC ACTIVITY: FT HYDROLYSIS OF ARG-|-XAA AND LYS-|-XAA BONDS IN FT OLIGOPEPTIDES, EVEN WHEN P1' RESIDUE IS PROLINE]." FT /gene="ptrBa" FT /locus_tag="Rv0781" FT /note="Rv0781, (MTCY369.25), len: 236 aa. Probable ptrBa, FT first part of protease II (EC 3.4.21.83), equivalent to FT N-terminus of NP_302455.1|NC_002677 protease II from FT Mycobacterium leprae (724 aa). Also highly similar to FT N-termini of many proteases II e.g. FT P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia FT coli strains K12 and HB101 (707 aa), FASTA scores: opt: FT 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); FT etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted FT homologues of protease II, but we can find no error in the FT cosmid sequence to account for this. BELONGS TO PEPTIDASE FT FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FT FAMILY. Note that previously known as ptrBb." FT /product="PROBABLE PROTEASE II PTRBA [FIRST PART] FT (OLIGOPEPTIDASE B)" FT /standard_name="ptrBb" FT CDS 874732..876390 FT /EC_number="3.4.21.83" FT /function="CLEAVES PEPTIDE BONDS ON THE C-TERMINAL SIDE OF FT LYSYL AND ARGININYL RESIDUES [CATALYTIC ACTIVITY: FT HYDROLYSIS OF ARG-|-XAA AND LYS-|-XAA BONDS IN FT OLIGOPEPTIDES, EVEN WHEN P1' RESIDUE IS PROLINE]." FT /gene="ptrBb" FT /locus_tag="Rv0782" FT /note="Rv0782, (MTCY369.26), len: 552 aa. Probable ptrBb, FT second part of protease II (EC 3.4.21.83), equivalent to FT C-terminus of NP_302455.1|NC_002677 protease II from FT Mycobacterium leprae (724 aa). Also highly similar to FT N-termini of many proteases II e.g. FT P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia FT coli strains K12 and HB101 (707 aa), FASTA scores: opt: FT 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. FT ORFs Rv0782 and Rv0781 appear to be a frameshifted FT homologues of protease II, but we can find no error in the FT cosmid sequence to account for this. BELONGS TO PEPTIDASE FT FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FT FAMILY. Note that previously known as ptrBa." FT /product="PROBABLE PROTEASE II PTRBB [SECOND PART] FT (OLIGOPEPTIDASE B)" FT /standard_name="ptrBa" FT CDS complement(876818..878440) FT /function="TRANSLOCASE THAT CONFERS RESISTANCE TO FT SUBSTANCES OF HIGH HYDROPHOBICITY. INVOLVED IN TRANSPORT FT OF MULTIDRUG ACROSS THE MEMBRANE (EXPORT): MULTIDRUG FT RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /gene="emrB" FT /locus_tag="Rv0783c" FT /note="Rv0783c, (MTCY369.27c), len: 540 aa. Possible emrB, FT integral membrane drug efflux protein, member of major FT facilitator superfamily (MFS), equivalent to FT AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from FT Mycobacterium avium (538 aa). Also similar to other FT membrane proteins e.g. CAB61606.1|AL133210 putative export FT protein from Streptomyces coelicolor (496 aa); FT NP_108371.1|NC_002678 efflux pump protein FarB from FT Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897| FT multidrug resistance protein b homologue from Haemophilus FT influenzae (510 aa), FASTA scores: opt: 706, E(): 1.3e-36, FT (30.4% identity in 408 aa overlap); etc. Also similar to FT Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 FT aa), FASTA score: (28.2% identity in 408 aa overlap); and FT Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 FT aa), FASTA score: (26.8% identity in 496 aa overlap). FT BELONGS TO THE MAJOR FACILITATOR FAMILY; ALSO KNOWN AS THE FT DRUG RESISTANCE TRANSLOCASE FAMILY." FT /product="POSSIBLE MULTIDRUG RESISTANCE INTEGRAL MEMBRANE FT EFFLUX PROTEIN EMRB" FT CDS 878638..879324 FT /function="UNKNOWN" FT /locus_tag="Rv0784" FT /note="Rv0784, (MTC369.28), len: 228 aa. Conserved FT hypothetical protein, with some similarity to FT MLCB5_20|O05752 hypothetical protein from Mycobacterium FT leprae (193 aa), FASTA scores: opt: 141, E(): 0.0022, FT (36.0% identity in 114 aa overlap). Also similar to FT N-terminus of NP_253002.1|NC_002516 conserved hypothetical FT protein from Pseudomonas aeruginosa (253 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 879340..881040 FT /function="UNKNOWN" FT /locus_tag="Rv0785" FT /note="Rv0785, (MTCY369.29), len: 566 aa. Conserved FT hypothetical protein, highly similar to other conserved FT hypothetical proteins e.g. NP_105777.1| NC_002678 FT hypothetical protein from Mesorhizobium loti (552 aa); FT SC5F8.14|CAB93742.1|AL357613 conserved hypothetical FT protein from Streptomyces coelicolor (557 aa); FT AE001863|AE001863_31 from Deinococcus radiodurans (554 FT aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in FT 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd FT protein (470 aa), FASTA scores: opt: 169, E(): 0.0014, FT (23.8% identity in 542 aa overlap); etc. Also similar to FT Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 FT aa), FASTA score: (26.7% identity in 587 aa overlap). And FT shows similarity with other dehydrogenases." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(881075..881464) FT /function="UNKNOWN" FT /locus_tag="Rv0786c" FT /note="Rv0786c, (MTCY369.30c), len: 129 aa. Conserved FT hypothetical protein, similar to three other hypothetical FT proteins from Streptomyces coelicolor e.g. FT SC7H1.08c|T35703 hypothetical protein (202 aa), FASTA FT scores: opt: 241, E(): 5.1e-10, (41.0% identity in 105 aa FT overlap); SC3A7.08|T29426 (211 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 881459..882418 FT /function="UNKNOWN" FT /locus_tag="Rv0787" FT /note="Rv0787, (MTCY369.31), len: 319 aa. Hypothetical FT unknown protein, equivalent to AAK45053.1 from FT Mycobacterium tuberculosis strain CDC1551 (242 aa) but FT longer 77 aa." FT /product="HYPOTHETICAL PROTEIN" FT CDS 882524..882763 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0787A" FT /note="Rv0787A, len: 79 aa. Conserved hypothetical FT protein, equivalent to MLCB5.24 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (79 aa), FASTA scores: opt: 434, FT (84.8% identity in 79 aa overlap). Also similar to FT P12049|YEXA_BACSU HYPOTHETICAL 9.7 kDa PROTEIN from FT Bacillus subtilis (84 aa), FASTA scores: opt: 172, E(): FT 4e-06, (44.4% identity in 72 aa overlap). BELONGS TO THE FT UPF0062 FAMILY." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 882760..883434 FT /EC_number="6.3.5.3" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT FOURTH STEP) [CATALYTIC ACTIVITY: ATP + FT 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = FT ADP + phosphate + 5'-phosphoribosylformylglycinamidine + FT L-glutamate]." FT /gene="purQ" FT /locus_tag="Rv0788" FT /note="Rv0788, (MTCY369.32), len: 224 aa. Probable purQ, FT phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3), FT equivalent to MLCB5_24|Z95151|O05756|PURQ FT PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from FT Mycobacterium leprae (224 aa), FASTA scores: opt: 1341, FT E(): 0, (88.7% identity in 222 aa overlap). Also highly FT similar to others e.g. P12041|PURQ_BACSU FT PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I from Bacillus FT subtilis (227 aa), FASTA scores: opt: 691, E(): 8.6e-39, FT (47.7% identity in 214 aa overlap); etc. Contains PS00442 FT Glutamine amidotransferases class-I active site. BELONGS FT TO TYPE-1 GLUTAMINE AMIDOTRANSFERASES." FT /product="PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE FT SYNTHASE I PURG (FGAM SYNTHASE I)" FT misc_feature 883003..883038 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS complement(883451..884050) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0789c" FT /note="Rv0789c, (MTCY369.33c), len: 199 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(884072..884800) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0790c" FT /note="Rv0790c, (MTCY369.34c), len: 242 aa. Hypothetical FT unknown protein." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(884797..885840) FT /function="UNKNOWN" FT /locus_tag="Rv0791c" FT /note="Rv0791c, (MTV042.01c, MTCY369.35c), len: 347 aa. FT Conserved hypothetical protein, similar (except in FT N-terminus) to others e.g. CAC44585.1|AL596162 conserved FT hypothetical protein from Streptomyces coelicolor (307 FT aa); NP_252643.1|NC_002516 hypothetical protein from FT Pseudomonas aeruginosa (364 aa); etc. Also some similarity FT with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 FT putative F420-dependent dehydrogenase from Rhodococcus FT erythropolis (295 aa); etc. And also similar in part to FT other proteins from Mycobacterium tuberculosis e.g. FT Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA scores: opt: FT 366, E(): 4e-16, (35.0% identity in 226 aa overlap); FT Rv3079c|MTCY22D7.02|Z83866 CONSERVED HYPOTHETICAL PROTEIN FT (275 aa), FASTA scores: opt: 342, E(): 1.2e-14, (31.6% FT identity in 234 aa overlap); Rv0044c POSSIBLE FT OXIDOREDUCTASE (264 aa). TBparse score is 0.916." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(885837..886646) FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0792c" FT /note="Rv0792c, (MTV042.02c), len: 269 aa. Probable FT transcriptional regulator, GntR-family, similar to many FT others of GntR family e.g. BSUB0018_189|Z99121 from FT Bacillus subtilis (243 aa), FASTA scores: opt: 367, E(): FT 1.5e-17, (32.1% identity in 246 aa overlap); FT P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA FT scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa FT overlap); etc. TBparse score is 0.932." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT CDS 886719..887024 FT /function="UNKNOWN" FT /locus_tag="Rv0793" FT /note="Rv0793, (MTV042.03), len: 101 aa. Conserved FT hypothetical protein, similar to others e.g. FT NP_250888.1|NC_002516 hypothetical protein from FT Pseudomonas aeruginosa (114 aa); AE 001908|AE001908_7 FT hypothetical protein from Deinococcus radiodurans (101 FT aa), FASTA scores: opt: 215, E(): 3.1e-09, (40.4% identity FT in 99 aa overlap); FT NP_440966.1|NC_000911|D90908|PCC6803|D90908_2 unknown FT protein from Synechocystis sp. strain PCC 6803 (147 aa), FT FASTA scores: opt: 194, E(): 4.5e-08, (31.1% identity in FT 90 aa overlap); etc. Also similar to FT Rv2749|MTV002.14|AL0089|MTV002_15 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (104 aa), FASTA FT scores: opt: 143, E(): 0.00026, (26.9% identity in 93 aa FT overlap). TBparse score is 0.912." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(887137..888636) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0794c" FT /note="Rv0794c, (MTV042.04c), len: 499 aa. Probable FT oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide FT dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC FT 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable FT oxidoreductase from Streptomyces coelicolor (477 aa); and FT similar to various oxidoreductases e.g. P08663|MERA_STAAU FT MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from FT Staphylococcus aureus (547 aa); FT AAK70920.1|AC087551_19|AC087551 putative lipoamide FT dehydrogenase from Oryza sativa (563 aa); FT NP_437349.1|NC_003078 putative FAD-dependent pyridine FT nucleotide-disulphide oxidoreductase, similar to mercuric FT reductases protein from Sinorhizobium meliloti (473 aa); FT Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC FT 1.8.1.4) from Haloferax volcanii (475 aa); FT P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 FT aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity FT in 467 aa overlap); FT P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 FT DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from FT Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: FT opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa FT overlap); etc. TBparse score is 0.909. Note that FT previously known as lpdB." FT /product="PROBABLE OXIDOREDUCTASE" FT /standard_name="lpdB" FT repeat_unit 889017..889020 FT /note="4 bp direct repeat: GAGG, at the right end of FT IS6110" FT repeat_unit 889021..889048 FT /note="28 bp inverted repeat at the left end of IS6110, FT TGAACCGCCCCGGCATGTCCGGAGACTC" FT repeat_region 889021..890375 FT /insertion_seq="IS6110-1" FT /note="IS6110-1, len: 1355 bp. Insertion sequence IS6110." FT CDS 889072..889398 FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /locus_tag="Rv0795" FT /note="Rv0795, (MTV042.05), len: 108 aa. Putative FT transposase for IS6110 (fragment), identical to Q50686 FT INSERTION ELEMENT IS6110 (108 aa), FASTA score: (100.0 % FT identity in 108 aa overlap). TBparse score is 0.928." FT /product="PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS6110 (FRAGMENT)" FT CDS <889395..890333 FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /locus_tag="Rv0796" FT /note="Rv0796, (MTV042.06), len: 312 aa. Putative FT transposase for IS6110. TBparse score is 0.926." FT /product="PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS6110" FT repeat_unit complement(890348..890375) FT /note="28 bp inverted repeat at the right end of IS6110, FT TGAACCGCCCCGGTGAGTCCGGAGACTC" FT repeat_unit 890376..890379 FT /note="4 bp direct repeat: GAGG, at the left end of FT IS6110" FT CDS 890388..891482 FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1547." FT /locus_tag="Rv0797" FT /note="Rv0797, (MTCI249B.03c, MTV042.07), len 364 aa. FT Putative transposase for IS1547; almost identical to (but FT 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium FT tuberculosis (383 aa). Also similar to other transposases FT e.g. MAIS1110A _1|Q48909 transposase from Mycobacterium FT avium (464 aa), FASTA scores: opt: 226, E(): 2.4e-08, FT (30.7% identity in 199 aa overlap). Also slight similarity FT to Rv2014|MTCY39.03c from Mycobacterium tuberculosis (222 FT aa), FASTA score: (24.8% identity in 141 aa overlap)." FT /product="PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS1547" FT repeat_region 890388..891479 FT /insertion_seq="IS1547-1" FT /note="IS1547-1, len: 1092 bp. Insertion sequence IS1547." FT CDS complement(891472..892269) FT /db_xref="O07181" FT /evidence=experimental FT /function="UNKNOWN. SUPPOSED RELEASED FROM THE ENVELOPE TO FT THE OUTSIDE DURING GROWTH." FT /gene="cfp29" FT /locus_tag="Rv0798c" FT /note="Rv0798c, (MTCI429B.02), len: 265 aa. cfp29, 29 kDa FT antigen (see citations below). Highly similar to FT Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from FT Brevibacterium linens (266 aa), FASTA scores: (58.5% FT identity in 265 aa overlap). Also shows similarity with FT NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima FT (262 aa)." FT /product="29 KDa ANTIGEN CFP29" FT CDS complement(892266..893273) FT /function="UNKNOWN" FT /locus_tag="Rv0799c" FT /note="Rv0799c, (MTCY07H7A.10, MTCI429B.01), len: 335 aa. FT Conserved hypothetical protein, similar to Q50021|U2266C FT from Mycobacterium leprae (146 aa), FASTA scores: opt: FT 147, E(): 0.0016, (33.3% identity in 117 aa overlap); FT Q50020|U2266B from Mycobacterium leprae (27 aa), FASTA FT scores: opt: 94, E(): 1.3, (56.5% identity in 23 aa FT overlap). Also highly similar to others e.g. FT CAC01593.1|AL391041 conserved hypothetical protein from FT Streptomyces coelicolor (316 aa); AF088897|AF088897_9 FT hypothetical protein from Zymomonas mobilis (322 aa), FT FASTA scores: opt: 1132, E(): 0, (56.1% identity in 303 aa FT overlap); P76536|ECAE000330_8 hypothetical protein from FT Escherichia coli strain K-12 (308 aa), FASTA scores: E(): FT 2.2e-30, (37.4% identity in 297 aa overlap); etc. Also FT similar to some tyrA proteins." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 893318..894619 FT /EC_number="3.4.11.-" FT /evidence=experimental FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS." FT /gene="pepC" FT /locus_tag="Rv0800" FT /note="Rv0800, (MTCY07H7A.09c), len: 433 aa. Probable FT pepC, aminopeptidase I (EC 3.4.11.-), highly similar (but FT shorter 17 aa) to Q50022|PEPX AMINOPEPTIDASE from FT Mycobacterium leprae (443 aa), FASTA scores: opt: 2237, FT E(): 0, (78.3% identity in 433 aa overlap). Also highly FT similar to others from Eukaryotes and bacteria, e.g. FT T36482 probable aminopeptidase from Streptomyces FT coelicolor (432 aa), P14904|AMPL_YEAST vacuolar FT aminopeptidase I precursor from Saccharomyces cerevisiae FT (514 aa), FASTA scores: opt: 425, E(): 4.8e-21, (31.0% FT identity in 445 aa overlap); etc. Also similar to FT hypothetical proteins e.g. P38821|YHR3_YEAST hypothetical FT 54.2 kDa protein from Saccharomyces cerevisiae (490 aa), FT FASTA scores: opt: 429, E(): 2.5e-21, (34.8% identity in FT 443 aa overlap); etc." FT /product="PROBABLE AMINOPEPTIDASE PEPC" FT CDS 894631..894978 FT /function="UNKNOWN" FT /locus_tag="Rv0801" FT /note="Rv0801, (MTCY07H7A.08c), len: 115 aa. Conserved FT hypothetical protein, similar to many hypothetical FT proteins from Streptomyces sp. e.g. FT SCD840A.20|AB81865.1|AL161691 hypothetical protein from FT Streptomyces coelicolor (145 aa); AF072709|AF072709_8 from FT Streptomyces lividans (131 aa), FASTA scores: opt: 120, FT E(): 0.2, (26.3% identity in 118 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(894972..895628) FT /function="UNKNOWN" FT /locus_tag="Rv0802c" FT /note="Rv0802c, (MTCY07H7A.07c), len: 218 aa. Conserved FT hypothetical protein, showing partial similarity with many FT acetyltransferases and hypothetical proteins e.g. FT P96579|BSUB0003_68 PROBABLE ACETYLTRANSFERASE from FT Bacillus subtilis (183 aa), FASTA scores: E(): 0.0044, FT (26.4% identity in 110 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 895820..898084 FT /EC_number="6.3.5.3" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT FOURTH STEP) [CATALYTIC ACTIVITY: ATP + FT 5'-PHOSPHORIBOSYLFORMYLGLYCINAMIDE + L-GLUTAMINE + H(2)O = FT ADP + PHOSPHATE + 5'-PHOSPHORIBOSYLFORMYLGLYCINAMIDINE + FT L-GLUTAMATE]." FT /gene="purL" FT /locus_tag="Rv0803" FT /note="Rv0803, (MTCY07H7A.06c), len: 754 aa. purL, FT phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3) FT (see citations below), equivalent to NP_302451.1|NC_002677 FT phosphoribosylformylglycinamidine synthase II from FT Mycobacterium leprae (754 aa). Also highly similar to FT others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor FT (752 aa); P12042|PURL_BACSU from Bacillus subtilis (742 FT aa), FASTA score: (44.7% identity in 716 aa); etc. Start FT was chosen by similarity. BELONGS TO THE FGAMS FAMILY." FT /product="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II FT PURL (FGAM SYNTHASE II)" FT CDS 898081..898710 FT /function="UNKNOWN" FT /locus_tag="Rv0804" FT /note="Rv0804, (MTCY07H7A.05c), len: 209 aa. Conserved FT hypothetical protein, showing similarity with C-terminus FT of Rv1863c|MTCY359.10 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (256 aa), FASTA scores: opt: FT 199, E(): 1.2e-05, (33.2% identity in 220 aa overlap); and FT Rv0658c. Contains PS01151 Fimbrial biogenesis outer FT membrane usher protein signature." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature 898480..898512 FT /note="PS01151 Fimbrial biogenesis outer membrane usher FT protein signature" FT CDS 898831..899787 FT /function="UNKNOWN" FT /locus_tag="Rv0805" FT /note="Rv0805, (MTCY07H7A.04c), len: 318 aa. Conserved FT hypothetical protein, equivalent to Q50024 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa), FT FASTA scores: opt: 1713, E(): 0, (82.5% identity in 315 aa FT overlap). Also shows similarity with hypothetical proteins FT and icc proteins e.g. SC9B1.22c|T35867 hypothetical FT protein from Streptomyces coelicolor (305 aa); FT P36650|ICC_ECOLI icc protein from Escherichia coli (275 FT aa), FASTA scores: opt: 310, E(): 8.9e-14, (31.3% identity FT in 214 aa overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(899732..901330) FT /EC_number="5.1.3.2" FT /function="THOUGHT TO BE INVOLVED IN EXOPOLYSACCHARIDE FT AND/OR LIPOPOLYSACCHARIDE BIOSYNTHETIC PATHWAY [CATALYTIC FT ACTIVITY: UDP-GLUCOSE = UDP-GALACTOSE]." FT /gene="cpsY" FT /locus_tag="Rv0806c" FT /note="Rv0806c, (MTCY07H7A.03), len: 532 aa. Possible FT cpsY, UDP-glucose-4-epimerase (EC 5.1.3.2), equivalent to FT Q50025|CPSY probable UDP-glucose-4-epimerase from FT Mycobacterium leprae (542 aa), FASTA scores: opt: 2964, FT E(): 0, (82.3% identity in 530 aa overlap). Also similar FT to AAC38286.1|AF019760|SACB CpsY homolog (involved in FT meningococcal capsule biosynthesis) from Neisseria FT meningitidis serogroup A (545 aa); Q51151 CAPSULE GENE FT COMPLEX UPD-GLUCOSE-4-EPIMERASE (GALE) from Neisseria FT meningitidis (373 aa), FASTA scores: opt: 496, E(): FT 9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of FT CAB75373.1|AL139298 putative transferase from Streptomyces FT coelicolor (942 aa); and many hypothetical proteins from FT Streptomyces coelicolor. SEEMS TO BELONG TO THE SUGAR FT EPIMERASE FAMILY." FT /product="POSSIBLE UDP-GLUCOSE-4-EPIMERASE CPSY FT (GALACTOWALDENASE) (UDP-GALACTOSE-4-EPIMERASE) (URIDINE FT DIPHOSPHATE GALACTOSE-4-EPIMERASE) (URIDINE FT DIPHOSPHO-GALACTOSE-4-EPIMERASE)" FT CDS 901635..902024 FT /function="UNKNOWN" FT /locus_tag="Rv0807" FT /note="Rv0807, (MTCY07H7A.02c), len: 129 aa. Conserved FT hypothetical protein, equivalent to O05761|MLCB5_31 FT HYPOTHETICAL 14.0 kDa PROTEIN from Mycobacterium leprae FT (131 aa), FASTA scores: E(): 0, (73.4% identity in 128 aa FT overlap). Also highly similar to BAA89438.1|AB003158|ORF3 FT HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes FT (132 aa); and C-terminus of SCD25.20|CAB56364.1|AL118514 FT hypothetical protein from Streptomyces coelicolor (202 FT aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 902111..903694 FT /EC_number="2.4.2.14" FT /evidence=experimental FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT FIRST STEP) [CATALYTIC ACTIVITY: FT 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate FT = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + FT H2O]." FT /gene="purF" FT /locus_tag="Rv0808" FT /note="Rv0808, (MTCY07H7A.01c), len: 527 aa. purF, FT amidophosphoribosyltransferase (EC 2.4.2.14), equivalent FT to MLCB5_32|Q50028|PURF from Mycobacterium leprae (556 FT aa), FASTA scores: (91.3% identity in 518 aa overlap); and FT CAB96578.1|AJ278609 phosphoribosyl pyrophosphate FT amidotransferase from Mycobacterium smegmatis (511 aa)(see FT citation below). Also highly similar to others e.g. FT BAA89439.1|AB003158 amidophosphoribosyl transferase from FT Corynebacterium ammoniagenes (490 aa); P00497|PUR1_BACSU FT amidophosphoribosyltransferase precursor from Bacillus FT subtilis (476 aa), FASTA scores: opt: 1412, E(): 0, (46.2% FT identity in 470 aa overlap); etc. Contains PS00103 FT Purine/pyrimidine phosphoribosyl transferases signature. FT BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FT FAMILY." FT /product="AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE FT PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) FT (GPATASE)" FT misc_feature 903251..903289 FT /note="PS00103 Purine/pyrimidine phosphoribosyl FT transferases signature" FT CDS 903725..904819 FT /EC_number="6.3.3.1" FT /evidence=experimental FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT FIFTH STEP) [CATALYTIC ACTIVITY: ATP + FT 5'-PHOSPHORIBOSYLFORMYLGLYCINAMIDINE = ADP + PHOSPHATE + FT 5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE]." FT /gene="purM" FT /locus_tag="Rv0809" FT /note="Rv0809, (MTV043.01), len: 364 aa. Probable purM, FT 5'-phosphoribosyl-5-aminoimidazole synthetase (EC FT 6.3.3.1), equivalent to NP_302446.1|NC_002677 FT 5'-phosphoribosyl-5-aminoimidazole synthase from FT Mycobacterium leprae (364 aa). Also highly similar to many FT e.g. P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE FT CYCLO-LIGASE from Bacillus subtilis (346 aa), FASTA FT scores: opt: 1023, E(): 0, (46.5% identity in 331 aa FT overlap); U68765|STU68765_2 from Salmonella typhimurium FT (345 aa), FASTA scores: opt: 1014, E():0, (47.6% identity FT in 330 aa overlap); etc. TBparse score is 0.901." FT /product="PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE FT CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE FT SYNTHETASE) (AIR SYNTHASE)" FT CDS complement(904905..905087) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0810c" FT /note="Rv0810c, (MTV043.02c), len: 60 aa. Conserved FT hypothetical protein, with its N-terminus highly similar FT to NP_302445.1|NC_002677 conserved hypothetical protein FT from Mycobacterium leprae (62 aa); and AL118514|SCD25_24 FT hypothetical protein from Streptomyces coelicolor (84 aa), FT FASTA scores: opt: 180, E(): 5.7e-07, (51.8% identity in FT 56 aa overlap). TBparse score is 0.876." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(905234..906340) FT /function="UNKNOWN" FT /locus_tag="Rv0811c" FT /note="Rv0811c, (MTV043.03c), len: 368 aa. Conserved FT hypothetical protein, equivalent to FT U2266F|U15182|MLU15182_13 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (366 aa), FASTA scores: opt: 1870, FT E(): 0, (77.4% identity in 367 aa overlap). Also highly FT similar to BAA89441.1|AB003158|ORF4 HYPOTHETICAL PROTEIN FT from Corynebacterium ammoniagenes (359 aa); and FT CAB94085.1|AL358692 CONSERVED HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor (321 aa). TBparse score is 0.912." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 906423..907292 FT /EC_number="2.6.1.-" FT /function="ACTS ON AMINO ACIDS." FT /locus_tag="Rv0812" FT /note="Rv0812, (MTV043.04), len: 289 aa. Probable amino FT acid aminotransferase (EC 2.6.1.-), similar to other amino FT acid aminotransferases, generelly CLASS-IV OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, and FT especially ILVE proteins and PABC proteins e.g. FT B76065.1|AL157953 putative aminotransferase from FT Streptomyces coelicolor (273 aa); NP_069766.1|NC_000917 FT branched-chain amino acid aminotransferase (ilvE) from FT Archaeoglobus fulgidus (290 aa); P54692|DAAA_BACLI FT D-ALANINE AMINOTRANSFERASE from Bacillus licheniformis FT (283 aa); P28305|PABC_ECOLI|B1096 FT 4-AMINO-4-DEOXYCHORISMATE LYASE (EC 4.-.-.-) (ADC lyase) FT From Escherichia coli strain K12 (269 aa), FASTA scores: FT opt: 165, E(): 0.00064, (26.8% identity in 198 aa FT overlap); etc. Note that previously known as pabC. TBparse FT score is 0.915." FT /product="PROBABLE AMINO ACID AMINOTRANSFERASE" FT /standard_name="pabC" FT CDS complement(907338..908018) FT /function="UNKNOWN" FT /locus_tag="Rv0813c" FT /note="Rv0813c, (MTV043.05c), len: 226 aa. Conserved FT hypothetical protein, highly similar to U15182|MLU15182_16 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (242 aa), FT FASTA scores: opt: 1191, E(): 0, (78.3% identity in 226 aa FT overlap); and NP_302442.1|NC_002677 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium leprae (228 aa). Also similar FT to AB94083.1|AL358692|SCD66.16 HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor (191 aa); and Rv2717c|MTCY05A6_37 FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (164 FT aa), FASTA score: (30.4% identity in 171 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(908181..908483) FT /function="THOUGHT TO BE INVOLVED IN SULPHUR METABOLISM." FT /gene="sseC2" FT /locus_tag="Rv0814c" FT /note="Rv0814c, (MTV043.06c, O05794), len: 100 aa. sseC2, FT conserved hypothetical protein, highly similar to FT AAA62972.1|U15182|MLU15182_17 hypothetical protein from FT Mycobacterium leprae (143 aa), FASTA scores: opt: 545, FT E(): 0, (84.0% identity in 100 aa overlap); and FT NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved FT hypothetical protein from Mycobacterium leprae (100 aa), FT FASTA scores: opt: 647, E(): 0, (100.0% identity in 100 aa FT overlap). Also highly similar to M29612|SERCYSA_5 FT rhodanese-like protein from Saccharopolyspora erythraea FT (101 aa), FASTA scores: opt: 345, E(): 1.2e-18, (57.1% FT identity in 98 aa overlap); and similar at the C-terminus FT to the C-terminus of CAB94069.1|AL358692 conserved FT hypothetical protein from Streptomyces coelicolor (95 aa). FT Identical second copy present as Rv3118|MTCY164.28|SSEC1 FT from Mycobacterium tuberculosis (100 aa) (100.0% identity FT in 100 aa overlap). TBparse score is 0.853." FT /product="CONSERVED HYPOTHETICAL PROTEIN SSEC2" FT CDS complement(908485..909318) FT /EC_number="2.8.1.1" FT /evidence=experimental FT /function="MAY BE A SULFOTRANSFERASE INVOLVED IN THE FT FORMATION OF THIOSULFATE [CATALYTIC ACTIVITY: THIOSULFATE FT + CYANIDE = SULFITE + THIOCYANATE]." FT /gene="cysA2" FT /locus_tag="Rv0815c" FT /note="Rv0815c, (MTV043.07c, MT0837, O05793), len: 277 aa. FT Probable cysA2 (alternate gene name: sseC4), thiosulfate FT sulfurtransferase (EC 2.8.1.1) (see Wooff et al., 2002), FT equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE FT SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae FT (277 aa). Also highly similar to other putative FT thiosulfate sulfurtransferases e.g. P16385|THTR_SACER FT PUTATIVE THIOSULFATE SULFURTRANSFERASE from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (281 FT aa); NP_293941.1|NC_001263 thiosulfate sulfurtransferase FT from Deinococcus radiodurans (286 aa); etc. Identical FT second copy present as FT Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0% FT identity in 277 aa overlap). Contains PS00683 Rhodanese FT C-terminal signature at C-terminus. BELONGS TO THE FT RHODANESE FAMILY. TBparse score is 0.901." FT /product="PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 FT (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE FT TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)" FT /standard_name="sseC4" FT misc_feature complement(908524..908547) FT /note="PS00683 Rhodanese C-terminal signature" FT CDS complement(909611..910033) FT /EC_number="1.-.-.-" FT /function="THIOREDOXIN PARTICIPATES IN VARIOUS REDOX FT REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE FT CENTER DITHIOL, TO A DISULFIDE, & CATALYZES FT DITHIOL-DISULFIDE EXCHANGE REACTIONS." FT /gene="thiX" FT /locus_tag="Rv0816c" FT /note="Rv0816c, (MTV043.08c), len: 140 aa. Probable thiX, FT thioredoxin (EC 1.-.-.-), equivalent to FT ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium FT leprae (172 aa), FASTA scores: opt: 556, E(): 8.8e-31, FT (63.8% identity in 141 aa overlap); and similar to FT AAL08576.1|AF418548_2|AF418548 thioredoxin from FT Mycobacterium avium subsp. paratuberculosis (117 aa). Also FT similar to other bacterial thioredoxins e.g. FT CAB95303.1|AL359779 putative thioredoxin from Streptomyces FT coelicolor (126 aa); P33791|THIO_STRAU|TRX|TRXA FT THIOREDOXIN from Streptomyces aureofaciens (106 aa); etc. FT And similar to FT Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC FT THIOREDOXIN (TRX) (MPT46) from Mycobacterium tuberculosis FT (116 aa). Has hydrophobic stretch at N-terminus. SEEMS TO FT BELONG TO THE THIOREDOXIN FAMILY. TBparse score is 0.919." FT /product="PROBABLE THIOREDOXIN THIX" FT CDS complement(910030..910842) FT /function="UNKNOWN" FT /locus_tag="Rv0817c" FT /note="Rv0817c, (MTV043.09c), len: 270 aa. Probable FT conserved exported protein, with N-terminal signal FT sequence, equivalent (but shorter 13 aa) to FT U15182|MLU15182_22|U2266M probable exported protein from FT Mycobacterium leprae (283 aa), FASTA scores: opt: 1287, FT E(): 0, (73.0% identity in 270 aa overlap). TBparse score FT is 0.896." FT /product="PROBABLE CONSERVED EXPORTED PROTEIN" FT CDS 910972..911739 FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0818" FT /note="Rv0818, (MTV043.10), len: 255 aa. Probable FT transcriptional regulatory protein, highly similar to FT Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c FT TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces FT coelicolor (267 aa), FASTA scores: opt: 945, E(): 0, (61.5 FT identity in 239 aa overlap); and similar to others from FT other organisms. Also similar to Rv2884|MTCY274.15|Z74024 FT from Mycobacterium tuberculosis (252 aa), FASTA scores: FT opt: 662, E(): 0, (47.8% identity in 226 aa overlap). FT TBparse score is 0.889." FT /product="TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 911736..912683 FT /function="UNKNOWN" FT /locus_tag="Rv0819" FT /note="Rv0819, (MTV043.11), len: 315 aa. Conserved FT hypothetical protein, equivalent to FT U2266N|U15182|MLU15182_24 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (312 aa), FASTA scores: opt: 1540, FT E(): 0, (75.2% identity in 314 aa overlap). Also highly FT similar to CAB88484.1|AL353816 putative acetyltransferase FT from Streptomyces coelicolor (309 aa). TBparse score is FT 0.893" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 912726..913502 FT /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC FT PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR FT ENERGY COUPLING TO THE TRANSPORT SYSTEM. THIS IS ONE OF FT THE PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED FT PHOSPHATE TRANSPORT." FT /gene="phoT" FT /locus_tag="Rv0820" FT /note="Rv0820, (MTV043.12), len: 258 aa. Probable phoT, FT phosphate-transport ATP-binding protein ABC transporter FT (see citation below), equivalent to FT PhoT|MLU15182_28|U15182 phosphate transport system ABC FT transporter from Mycobacterium leprae (258 aa), FASTA FT scores: opt: 1556, E(): 0, (91.5% identity in 258 aa FT overlap). Also highly similar to others e.g. FT CAB88472.1|AL353816 phosphate ABC transport system FT ATP-binding protein from Streptomyces coelicolor (258 aa); FT etc. Note that also highly similar to many PstB proteins FT e.g. AAC15686.1|AF045938|PstB putative ABC transporter FT nucleotide binding subunit from Mycobacterium smegmatis FT (258 aa). Contains PS00211 ABC transporters family FT signature and PS00017 ATP/GTP-binding site motif A FT (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS). TBparse score is 0.910." FT /product="PROBABLE PHOSPHATE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER PHOT" FT misc_feature 912834..912857 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 913170..913214 FT /note="PS00211 ABC transporters family signature" FT CDS complement(913558..914199) FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL REGULATION OF FT ACTIVE TRANSPORT OF INORGANIC PHOSPHATE ACROSS THE FT MEMBRANE." FT /gene="phoY2" FT /locus_tag="Rv0821c" FT /note="Rv0821c, (MTV043.13c), len: 213 aa. Probable phoY2, FT phosphate-transport system regulatory protein, highly FT similar to PhoY|MLU15182_29|U15182 phosphate transport FT system regulator from Mycobacterium leprae (222 aa), FASTA FT scores: opt: 1268, E(): 0, (93.0% identity in 213 aa FT overlap). Also similar to others e.g. FT NP_384620.1|NC_003047 PROBABLE PHOSPHATE TRANSPORT SYSTEM FT TRANSCRIPTIONAL REGULATOR PROTEIN from Sinorhizobium FT meliloti (237 aa); etc. Also highly similar to FT MTCI418A.03c|Z96070|PhoY1 PROBABLE PHOSPHATE TRANSPORT FT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from FT Mycobacterium tuberculosis (221 aa), FASTA scores: opt: FT 937, E(): 0, (63.4% identity in 213 aa overlap). BELONGS FT TO THE PHOU FAMILY. TBparse score is 0.910." FT /product="PROBABLE PHOSPHATE-TRANSPORT SYSTEM FT TRANSCRIPTIONAL REGULATORY PROTEIN PHOY2" FT CDS complement(914257..916311) FT /function="UNKNOWN" FT /locus_tag="Rv0822c" FT /note="Rv0822c, (MTV043.14c), len: 684 aa. Conserved FT hypothetical protein, highly similar in the region between FT aa 370 - 580 to U2266O|U15182|MLU15182_30 HYPOTHETICAL FT PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: FT opt: 819, E(): 0, (60.6% identity in 221 aa overlap). More FT extended similarity to Rv3267|Z92771|MTCY71_7 from FT Mycobacterium tuberculosis (498 aa), FASTA scores: opt: FT 434, E(): 2.2e-17, (26.6% identity in 541 aa overlap), and FT Rv3484. Also similar to various proteins, preferiously FT putative membrane proteins and membrane-bound regulatory FT proteins e.g. CAC44512.1|AL596138 putative membrane FT protein from Streptomyces coelicolor (524 aa); FT U56901|BSU56901_1 regulatory protein from Bacillus FT subtilis (391 aa), FASTA scores: opt: 225, E(): 1.3e-05, FT (24.7% identity in 340 aa overlap). Contains hydrophobic FT stretch (aa ~ 160-195) and PS00041 Bacterial regulatory FT proteins, araC family signature. TBparse score is 0.904." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT misc_feature complement(914365..914487) FT /note="PS00041 Bacterial regulatory proteins, araC family FT signature" FT CDS complement(916477..917646) FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0823c" FT /note="Rv0823c, (MTV043.15c), len: 389 aa. Possible FT transcriptional regulator (resembles nitrogen regulation FT protein), equivalent (but longer 24 aa in N-terminus) to FT MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium FT leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3% FT identity in 384 aa overlap) (see citation below). Also FT highly similar to CAB63312.1|AL133471|SCC82.03c FT hypothetical protein from Streptomyces coelicolor (406 FT aa); and to many transcriptional regulators members of FT UPF0034 FAMILY (NIFR3/SMM1) e.g. D26185|BAC180K_143 FT protein similar to transcriptional regulator (nitrogen FT regulation protein) from Bacillus subtilis (333 aa), FASTA FT scores: opt: 609, E(): 1.4e-32, (38.3% identity in 326 aa FT overlap); NP_349795.1|NC_003030 NifR3 family enzyme from FT Clostridium acetobutylicum (321 aa); etc. Contains PS01136 FT Uncharacterized protein family UPF0034 signature. TBparse FT score is 0.908." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT misc_feature complement(917251..917307) FT /note="PS01136 Uncharacterized protein family UPF0034 FT signature" FT CDS complement(917734..918750) FT /EC_number="1.14.99.6" FT /evidence=experimental FT /function="CATALYZES THE PRINCIPAL CONVERSION OF SATURATED FT FATTY ACIDS TO UNSATURATED FATTY ACIDS. THOUGHT TO CONVERT FT STEAROYL-ACP TO OLEOYL-ACP BY INTRODUCTION OF A CIS DOUBLE FT BOND BETWEEN CARBONS DELTA-9 AND DELTA-10 OF THE ACYL FT CHAIN [CATALYTIC ACTIVITY: Stearoyl-[acyl-carrier protein] FT + AH2 + O2 = oleoyl-[acyl-carrier protein] + A + 2 H2O]." FT /gene="desA1" FT /locus_tag="Rv0824c" FT /note="Rv0824c, (MTV043.16c), len: 338 aa. Probable desA1 FT (alternate gene name: des), acyl-[acyl-carrier protein] FT desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6) (see FT Jackson et al., 1997), equivalent to U15182|MLU15182_32 FT acyl-[ACP] desaturase from Mycobacterium leprae (338 aa), FT FASTA scores: opt: 1880, E(): 0, (79.9% identity in 338 aa FT overlap); and highly similar in part to fragment FT CAB96061.1|AJ250019 Steroyl-ACP-desaturase from FT Mycobacterium avium subsp. paratuberculosis (93 aa). Also FT similar to other fatty acid desaturases e.g. T35035 FT probable acyl-[acyl-carrier protein] desaturase from FT Streptomyces coelicolor (328 aa); Q40731|STAD_ORYSA FT ACYL-[ACYL-CARRIER PROTEIN] DESATURASE PRECURSOR from FT Oryza sativa (Rice) (390 aa); etc. Also highly similar to FT desA2|Rv1094 from Mycobacterium tuberculosis (275 aa). FT Contains PS00225 Crystallins beta and gamma 'Greek key' FT motif signature. BELONGS TO THE FATTY ACID DESATURASE FT FAMILY. COFACTOR: FERREDOXIN, FERREDOXIN NADPH REDUCTASE, FT AND NADPH. TBparse score is 0.898." FT /product="PROBABLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE FT DESA1 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) FT (PROTEIN DES)" FT /standard_name="des" FT misc_feature complement(917896..917943) FT /note="PS00225 Crystallins beta and gamma 'Greek key' FT motif signature" FT CDS complement(918912..919553) FT /function="UNKNOWN" FT /locus_tag="Rv0825c" FT /note="Rv0825c, (MTV043.17c), len: 213 aa. Conserved FT hypothetical protein, highly similar, but in part (between FT aa ~43-96) to fadD27|Rv0275c|MTV035.03 PUTATIVE FT FATTY-ACID-CoA LIGASE from Mycobacterium tuberculosis (241 FT aa), FASTA scores: E(): 7.3e-09, (32.6% identity in 190 aa FT overlap). Also shows similarity with other proteins from FT Mycobacterium tuberculosis e.g. Rv0078|AL0214|MTV030_22 FT (201 aa), FASTA scores: opt:118, E(): 0.32, (34.5% FT identity in 113 aa overlap); etc. TBparse score is 0.914." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 919634..920689 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0826" FT /note="Rv0826, (MTV043.18), len: 351 aa. Conserved FT hypothetical protein, similar to FT CAB94053.1|AL358672|SC7A12.06 hypothetical protein from FT Streptomyces coelicolor (300 aa); and FT NP_421372.1|NC_002696 hypothetical protein from FT Caulobacter crescentus (299 aa). Also similar to other FT proteins from Mycobacterium tuberculosis e.g. FT Rv1645c|Z85982|MTCY06H11.09 (351 aa), FASTA scores: opt: FT 1199, E(): 0, (57.5% identity in 299 aa overlap); Rv2237; FT Rv0276; etc. TBparse score is 0.918." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(920741..921133) FT /evidence=experimental FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0827c" FT /note="Rv0827c, (MTV043.19c), len: 130 aa. Probable FT transcriptional regulator, similar to many e.g. FT CAC42856.1|AL592292 putative regulatory protein from FT Streptomyces coelicolor (115 aa); NP_301626.1|NC_002677 FT putative ArsR-family transcriptional regulator from FT Mycobacterium leprae (140 aa); BSUB0011_75|O31844|Z99114 FT YOZA PROTEIN from Bacillus subtilis (107 aa), FASTA FT scores: opt: 208, E(): 3.2e-08, (35.5% identity in 93 aa FT overlap); etc. Also similar to MTCY27.22c|Z95208 from FT Mycobacterium tuberculosis (135 aa), FASTA scores: opt: FT 201, E(): 1.2e-07, (35.7% identity in 98 aa overlap). FT Contains probable helix-turn helix motif from aa 42-63 FT (Score 1300, +3.61 SD). BELONGS TO THE ARSR FAMILY OF FT TRANSCRIPTIONAL REGULATORS. TBparse score is 0.907." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS complement(921191..921613) FT /EC_number="3.5.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN DEAMINATION OF FT SPECIFIC SUBSTRATE." FT /locus_tag="Rv0828c" FT /note="Rv0828c, (MTV043.20c), len: 140 aa. Possible FT deaminase (EC 3.5.-.-), with its N-terminus highly similar FT to middle part of NP_302602.1|NC_002677 possible FT cytidine/deoxycytidylate deaminase from Mycobacterium FT leprae (171 aa). Also similar to other deaminases e.g. FT CAC18715.2|AL451182 putative deaminase from Streptomyces FT coelicolor (167 aa); NP_251189.1|NC_002516 probable FT deaminase from Pseudomonas aeruginosa (151 aa); FT NP_108387.1|NC_002678 nitrogen fixation protein gene from FT Mesorhizobium loti (149 aa); etc. Also similar to many FT conserved hypothetical proteins e.g. NP_389200.1|NC_000964 FT hypothetical protein from Bacillus subtilis (156 aa), FT FASTA scores: E(): 1.3e-07, (38.9% identity in 95 aa FT overlap); etc. And similar to Rv3752c possible deaminase FT from Mycobacterium tuberculosis. Contains PS00903 Cytidine FT and deoxycytidylate deaminases zinc-binding region FT signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE FT DEAMINASES FAMILY." FT /product="POSSIBLE DEAMINASE" FT misc_feature complement(921443..921556) FT /note="PS00903 Cytidine and deoxycytidylate deaminases FT zinc-binding region signature" FT CDS 921575..921865 FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1605'." FT /locus_tag="Rv0829" FT /note="Rv0829, (MTV043.21), len: 96 aa. Possible FT transposase for IS1605' (fragment), similar to C-terminal FT end of many mycobacterial transposases and hypothetical FT proteins e.g. Z74024|MTCY274_16 from Mycobacterium FT tuberculosis (460 aa), FASTA scores: opt: 668, E(): FT 6.2e-32, (98.9% identity in 93 aa overlap); FT MTV002_57|O33333 TRANSPOSASE from Mycobacterium FT tuberculosis ; L07627|SERRY1_1 insertion element IS1136 FT from Saccharopolyspora erythraea (90 aa), FASTA score: FT (34.9% identity in 83 aa overlap)." FT /product="POSSIBLE TRANSPOSASE (FRAGMENT)" FT repeat_region 921575..921862 FT /insertion_seq="IS1605'" FT /note="IS1605', len: 288 bp. Insertion sequence IS1605'." FT CDS 921970..922875 FT /function="UNKNOWN" FT /locus_tag="Rv0830" FT /note="Rv0830, (MTV043.22), len: 301 aa. Conserved FT hypothetical protein, member of Mycobacterium tuberculosis FT protein family consisting of the proteins Rv0726c, FT Rv0731c, Rv3399, Rv1729c|Z81360|MTCY4C12_14c (312 aa), FT FASTA scores: opt: 1014, E(): 0, (54.1% identity in 292 aa FT overlap); etc. TBparse score is 0.917." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(922894..923709) FT /function="UNKNOWN" FT /locus_tag="Rv0831c" FT /note="Rv0831c, (MTV043.23c), len: 271 aa. Conserved FT hypothetical protein, similar to Rv0347|MTY13E10_7|Z95324 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (328 aa), FASTA scores: opt: 426, E(): FT 2.6e-21, (33.6% identity in 262 aa overlap). TBparse score FT is 0.939." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT tRNA complement(923803..923875) FT /gene="tRNA-Lys(TTT)" FT /anticodon=(pos:923840..923842,aa:Lys) FT /product="transfer RNA-Lys(TTT)" FT tRNA 923999..924072 FT /gene="tRNA-Glu(TTC)" FT /anticodon=(pos:924034..924036,aa:Glu) FT /product="transfer RNA-Glu(TTC)" FT tRNA 924110..924183 FT /gene="tRNA-Asp(GTC)" FT /anticodon=(pos:924144..924146,aa:Asp) FT /product="transfer RNA-Asp(GTC)" FT tRNA 924213..924286 FT /gene="tRNA-Phe(GAA)" FT /anticodon=(pos:924247..924249,aa:Phe) FT /product="transfer RNA-Phe(GAA)" FT CDS 924951..925364 FT /function="UNKNOWN" FT /gene="PE_PGRS12" FT /locus_tag="Rv0832" FT /note="Rv0832, (MTV043.24), len: 137 aa. Member of the FT Mycobacterium tuberculosis PE family, possibly PGRS FT subfamily of gly-rich proteins (see citation below), FT highly similar to many others e.g. MTCY1A11.25c|Z78020 FT (498 aa), FASTA scores: opt: 529, E(): 5.2e-22, (61.8% FT identity in 136 aa overlap); etc. Appears to have incurred FT frameshift as next ORF should be continuation; sequence FT has been checked but no error found. TBparse score is FT 0.875." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 925361..927610 FT /function="UNKNOWN" FT /gene="PE_PGRS13" FT /locus_tag="Rv0833" FT /note="Rv0833, (MTV043.25), len: 749 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), but lacking FT N-terminal domain (present in preceding ORF), possibly due FT to frameshift. Similar in part to many others e.g. FT MTCY28_25|Z95890 (914 aa), FASTA scores: opt: 2726, E(): FT 0, (60.1% identity in 776 aa overlap); etc. TBparse score FT is 0.859." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS complement(927837..930485) FT /function="UNKNOWN" FT /gene="PE_PGRS14" FT /locus_tag="Rv0834c" FT /note="Rv0834c, (MTV043.26c), len: 882 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002), highly FT similar to many others e.g. MTCY493_4|Z95844 (1329 aa), FT FASTA scores: opt: 2577, E(): 0, (52.0% identity in 950 aa FT overlap); etc. TBparse score is 0.860. Thought to be FT differentially expressed within host cells (see Triccas et FT al., 1999)." FT /product="PE-PGRS FAMILY PROTEIN" FT CDS 930953..931597 FT /function="UNKNOWN" FT /gene="lpqQ" FT /locus_tag="Rv0835" FT /note="Rv0835, (MTV043.27), len: 214 aa. Possible lpqQ, FT lipoprotein. Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. TBparse score is FT 0.944." FT /product="POSSIBLE LIPOPROTEIN LPQQ" FT misc_feature 930989..931021 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(932279..932932) FT /function="UNKNOWN" FT /locus_tag="Rv0836c" FT /note="Rv0836c, (MTV043.29c), len: 217 aa (start FT uncertain). Hypothetical unknown protein. TBparse score is FT 0.903." FT /product="HYPOTHETICAL PROTEIN" FT CDS complement(933003..934031) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0837c" FT /note="Rv0837c, (MTV043.30c), len: 342 aa. Hypothetical FT unknown protein. TBparse score is 0.941." FT /product="HYPOTHETICAL PROTEIN" FT CDS 934720..935490 FT /function="UNKNOWN" FT /gene="lpqR" FT /locus_tag="Rv0838" FT /note="Rv0838, (MTV043.31), len: 256 aa. Probable lpqR, FT conserved lipoprotein. Similar (except in N-terminus) to FT hypothetical proteins and D-alanyl-D-alanine dipeptidases FT e.g. NP_416005.1|NC_000913 hypothetical protein from FT Escherichia coli strain K12 (193 aa); FT NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from FT Caulobacter crescentus (212 aa); Q06241|VANX_ENTFC FT D-ALANYL-D-ALANINE DIPEPTIDASE from Enterococcus faecium FT (202 aa), FASTA scores: opt: 198, E(): 1.9e-05, (28.1% FT identity in 199 aa overlap); etc. Contains signal sequence FT and appropriately positioned PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. TBparse score is FT 0.931." FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQR" FT misc_feature 934756..934788 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 935577..936389 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0839" FT /note="Rv0839, (MTV043.32), len: 270 aa. Conserved FT hypothetical protein, similar to various hypothetical FT proteins or methyltransferases from yeast and bacteria FT e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical FT protein from Streptomyces coelicolor (273 aa), FASTA FT scores: opt: 1102, E(): 0, (58.6% identity in 263 aa FT overlap); T38024|Z98598|SPAC1B3.06c hypothetical protein FT from Schizosaccharomyces pombe (278 aa), FASTA scores: FT opt: 562, E(): 1.9e-3, (36.4% identity in 269 aa overlap); FT JC6531 avermectin B 5-O-methyltransferase (EC 2.1.1.-) FT from Streptomyces avermitilis (283 aa); etc. Also similar FT to other Mycobacterium tuberculosis hypothetical proteins FT that may be methyltransferases e.g. Rv1523, Rv2952, FT Rv1405c, etc. TBparse score is 0.926." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(936457..937317) FT /EC_number="3.4.11.5" FT /function="SPECIFICALLY CATALYZES THE REMOVAL OF FT N-TERMINAL PROLINE RESIDUES FROM PEPTIDES. THOUGHT TO FT RELEASE THE N-TERMINAL PROLINE FROM THE DIPEPTIDES, FT PRO-PRO, PRO-GLN, PRO-TRP AND PRO-TYR; ALSO FROM AMIDES FT (PRO-BETA NA) AND OLIGOPEPTIDES, PRO-LEU-GLYNH2, FT PRO-LEU-GLY AND PRO-PHE-GLY-LYS. HIGHER ACTIVITY TOWARD FT SMALL PEPTIDES (UP TO THREE RESIDUES), BUT VERY LOW FT ACTIVITY FOR LONGER PEPTIDES [CATALYTIC ACTIVITY: Release FT of a N-terminal proline from a peptide]." FT /gene="pip" FT /locus_tag="Rv0840c" FT /note="Rv0840c, (MTV043.33c), len: 286 aa. Possible pip, FT proline iminopeptidase (EC 3.4.11.5), similar to many e.g. FT P46541|PIP_BACCO PROLINE IMINOPEPTIDASE from BACILLUS FT COAGULANS (288 aa), FASTA scores: opt: 657, E(): 0, (37.6% FT identity in 282 aa overlap); NP_386922.1|NC_003047 FT PUTATIVE PROLINE IMINOPEPTIDASE PROTEIN from Sinorhizobium FT meliloti (296 aa); etc. BELONGS TO PEPTIDASE FAMILY S33. FT TBparse score is 0.948." FT /product="PROBABLE PROLINE IMINOPEPTIDASE PIP (PROLYL FT AMINOPEPTIDASE) (PAP)" FT CDS 937593..937835 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0841" FT /note="Rv0841, 80 aa. Conserved transmembrane protein, FT highly similar to C-terminus of next ORF Rv0842|O53854 FT PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis FT (442 aa), FASTA scores: opt: 246, E(): 3.3e-10, (59.7% FT identity in 72 aa overlap). Replace previous Rv0841c." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 938112..939404 FT /function="UNKNOWN" FT /locus_tag="Rv0842" FT /note="Rv0842, (MT0864, MTV043.35), len: 430 aa. Probable FT conserved integral membrane protein, showing similarity FT with other integral membrane proteins e.g. FT P28246|BCR_ECOLI BICYCLOMYCIN RESISTANCE PROTEIN from FT EScherichia coli (396 aa), FASTA scores: opt: 216, E(): FT 5.4e-07, (23.7% identity in 376 aa overlap); etc. TBparse FT score is 0.922." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 939388..940392 FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0843" FT /note="Rv0843, (MTV043.36), len: 334 aa. Probable FT dehydrogenase (EC 1.-.-.-), similar to various FT dehydrogenases e.g. Q46142|Q46142 TPP-DEPENDENT ACETOIN FT DEHYDROGENASE (326 aa), FASTA scores: opt: 500, E(): FT 2.4e-26, (32.3% identity in 300 aa overlap); FT P51267|ODPA_PORPU PYRUVATE DEHYDROGENASE E1 COMPONENT from FT Porphyra purpurea (344 aa), FASTA scores: opt: 451, E(): FT 4.7e-23, (29.6% identity in 311 aa overlap); etc. Also FT similar to Rv2497c|pdhA pyruvate dehydrogenase E1 FT component from Mycobacterium tuberculosis (367 aa). FT TBparse score is 0.928." FT /product="PROBABLE DEHYDROGENASE" FT CDS complement(940456..941106) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM AND FT REGULATES NITRATE/NITRITE." FT /gene="narL" FT /locus_tag="Rv0844c" FT /note="Rv0844c, (MTV043.37c), len: 216 aa. Possible narL, FT nitrate/nitrite response regulator protein, similar to FT many e.g. CAB44989.1|AJ131854 NarL protein from FT Pseudomonas stutzeri (218 aa); CAA75536.1|Y15252 FT nitrate/nitrite regulatory protein from Pseudomonas FT aeruginosa (216 aa); PCC6803|D64005|SYCSLRG_24 NarL FT protein from Synechocystis sp. (209 aa), FASTA scores: FT opt: 438, E(): 1.5e-23, (34.6% identity in 208 aa FT overlap); etc. Also similar to unidentified regulator e.g. FT CAB76009.1|AL157916 putative two-component system response FT regulator from Streptomyces coelicolor (224 aa); etc. FT Contains probable helix-turn helix motif from aa 170-191 FT (Score 1124, +3.02 SD). TBparse score is 0.890." FT /product="POSSIBLE NITRATE/NITRITE RESPONSE FT TRANSCRIPTIONAL REGULATORY PROTEIN NARL" FT CDS 941190..942467 FT /EC_number="2.7.-.-" FT /function="POSSIBLE SENSOR PART OF A TWO COMPONENT FT REGULATORY SYSTEM." FT /locus_tag="Rv0845" FT /note="Rv0845, (MTV043.38), len: 425 aa. Possible FT two-component sensor kinase (EC 2.7.-.-), with its FT C-terminus similar to C-terminal part of others e.g. FT NP_294951.1|NC_001263 two-component sensor histidine FT kinase from Deinococcus radiodurans (469 aa); FT CAC32293.1|AL583943 putative two component system FT histidine kinase from Streptomyces coelicolor (404 aa); FT NP_464546.1|NC_003210 protein similar to two-component FT sensor histidine kinase from Listeria monocytogenes (352 FT aa); BSUB0017_193|Z9912 two-component sensor kinase from FT Bacillus subtilis (360 aa), FASTA scores: opt: 275, E(): FT 1.6e-11, (30.3% identity in 234 aa overlap); etc. TBparse FT score is 0.938." FT /product="POSSIBLE TWO COMPONENT SENSOR KINASE" FT CDS complement(942680..944194) FT /EC_number="1.-.-.-" FT /function="MAY HAVE MULTICOPPER OXIDASE ACTIVITY." FT /locus_tag="Rv0846c" FT /note="Rv0846c, (MTV043.39c), len: 504 aa. Probable FT oxidase (EC 1.-.-.-), showing similarity with several FT oxidases, mainly L-ascorbate oxidases and copper FT resistance proteins A (precursors) e.g. P24792|ASO_CUCMA FT L-ASCORBATE OXIDASE PRECURSOR (ASCORBASE) (EC 1.10.3.3) FT from Cucurbita maxima (Pumpkin) (Winter squash) (579 aa), FT FASTA scores: opt: 423, E(): 5.8e-18, (28.4% identity in FT 493 aa overlap); AF010496|AF010496_32 potential FT multicopper oxidase from Rhodobacter capsulatus (491 aa), FT FASTA scores: opt: 490, E(): 2.7e-22, (28.8% identity in FT 510 aa overlap); 47452|PCOA_ECOLI COPPER RESISTANCE FT PROTEIN A PRECURSOR (BELONGS TO THE FAMILY OF MULTICOPPER FT OXIDASES) from Escherichia coli strain K12 (605 aa); etc. FT Contains PS00080 Multicopper oxidases signature 2 at FT C-terminus. SEEMS TO BELONG TO THE FAMILY OF MULTICOPPER FT OXIDASES. TBparse score is 0.904." FT /product="PROBABLE OXIDASE" FT misc_feature complement(942707..942742) FT /note="PS00080 Multicopper oxidases signature 2" FT CDS 944343..944735 FT /function="UNKNOWN" FT /gene="lpqS" FT /locus_tag="Rv0847" FT /note="Rv0847, (MTV043.40), len: 130 aa. Probable lpqS, FT lipoprotein. Contains possible signal sequence and PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site. FT TBparse score is 0.920." FT /product="PROBABLE LIPOPROTEIN LPQS" FT misc_feature 944382..944414 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 944938..946056 FT /EC_number="4.2.99.8" FT /function="THOUGHT TO BE INVOLVED IN CYSTEINE BIOSYNTHESIS FT [CATALYTIC ACTIVITY: O3-ACETYL-L-SERINE + H(2)S = FT L-CYSTEINE + ACETATE]." FT /gene="cysK2" FT /locus_tag="Rv0848" FT /note="Rv0848, (MTV043.41), len: 372 aa. Possible cysK2, FT cysteine synthase A (EC 4.2.99.8), but could be also a FT cysteine synthase B (EC 4.2.99.8) cysM2-product, similar FT to many e.g. NP_109408.1|NC_002682 cysteine synthase from FT Mesorhizobium loti (357 aa); Q44004|CYSM_ALCEU CYSTEINE FT SYNTHASE from Alcaligenes eutrophus strain CH34 (Ralstonia FT eutropha) (339 aa), FASTA scores: opt: 511, E(): 1.7e-25, FT (35.0% identity in 314 aa overlap); etc. BELONGS TO THE FT CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. FT COFACTOR: PYRIDOXAL PHOSPHATE. Note that previously known FT as cysM3." FT /product="POSSIBLE CYSTEINE SYNTHASE A CYSK2 FT (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE FT (THIOL)-LYASE) (CSASE)" FT /standard_name="cysM3" FT CDS 946056..947315 FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF FT UNDETERMINATED SUBSTRATE (POSSIBLY DRUG) ACROSS THE FT MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /locus_tag="Rv0849" FT /note="Rv0849, (MTV043.42), len: 419 aa. Probable FT conserved integral membrane transport protein, possibly FT member of major facilitator superfamily (MFS) involved in FT transport of drug, showing similarity with others e.g. FT T35055 probable transport system permease protein from FT Streptomyces coelicolor (436 aa); NP_295031.1|NC_001263 FT major facilitator family protein from Deinococcus FT radiodurans (458 aa); NP_455659.1|NC_003198 putative FT membrane transporter from Salmonella enterica subsp. FT enterica serovar Typhi (402 aa); etc. TBparse score is FT 0.908." FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT repeat_region 947311..947641 FT /insertion_seq="IS1606'" FT /note="IS1606', len: 331 bp. Insertion sequence IS1606'" FT CDS 947312..947644 FT /function="REQUIRED FOR THE TRANSPOSITION OF AN INSERTION FT ELEMENT." FT /locus_tag="Rv0850" FT /note="Rv0850, (MTV043.43), len: 110 aa. Putative FT transposase (fragment), similar in part to others e.g. FT Q45144|Q4514 TRANSPOSABLE ELEMENT IS31831 (436 aa), FASTA FT scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa FT overlap); etc." FT /product="PUTATIVE TRANSPOSASE (FRAGMENT)" FT CDS complement(947641..948468) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0851c" FT /note="Rv0851c, (MTV043.44c), len: 275 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), similar FT to many e.g. Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC FT 1.1.1.-)(SDR FAMILY) from Pseudomonas paucimobilis FT (Sphingomonas paucimobilis) (305 aa); D11473|PSELIG_1 C FT alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA FT scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa FT overlap); NP_421969.1|NC_002696 short chain dehydrogenase FT family protein from Caulobacter crescentus (278 aa); etc. FT Contains PS00061 Short-chain dehydrogenases/reductases FT family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is FT 0.913." FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT misc_feature complement(947956..948042) FT /note="PS00061 Short-chain dehydrogenases/reductases FT family signature" FT CDS 948559..949395 FT /EC_number="6.2.1.-" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadD16" FT /locus_tag="Rv0852" FT /note="Rv0852, (MTV043.45), len: 278 aa. Possible fadD16, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to FT various CoA ligases e.g. P18163|LCFB_RAT FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Rattus norvegicus FT (Rat) (699 aa); D49366|LEP4CCOALA_1 4-coumarate:CoA ligase FT from Lithospermum erythrorhizon (636 aa), FASTA scores: FT opt: 134, E(): 0.15, (26.8% identity in 213 aa overlap); FT orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from FT homo sapiens (human) (699 aa), FASTA score: (50.0% FT identity in 40 aa overlap); etc. Contains PS00626 FT Regulator of chromosome condensation (RCC1) signature 2." FT /product="POSSIBLE FATTY-ACID-CoA LIGASE FADD16 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT misc_feature 948757..948789 FT /note="PS00626 Regulator of chromosome condensation (RCC1) FT signature 2" FT CDS complement(949436..951118) FT /EC_number="4.1.1.-" FT /function="POSSIBLE INDOLE-3-PYRUVATE DECARBOXYLASE; EC FT 4.1.1.74 [CATALYTIC ACTIVITY: 3-(indol-3-yl)pyruvate = FT 2-(indol-3-yl)acetaldehyde + CO2], OR POSSIBLE PYRUVATE FT DECARBOXYLASE; EC 4.1.1.1 [CATALYTIC ACTIVITY: A 2-oxo FT acid = an aldehyde + CO2]." FT /gene="pdc" FT /locus_tag="Rv0853c" FT /note="Rv0853c, (MTV043.46c), len: 560 aa. Probable pdc, FT pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-), FT equivalent to NP_302424.1|NC_002677 pyruvate (or FT indolepyruvate) decarboxylase from Mycobacterium leprae FT (569 aa). Also highly similar to others e.g. FT AAB06571.1|L80006 indolepyruvate decarboxylase from FT Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE FT DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus FT var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE FT (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA FT scores: opt: 1642, E(): 0, (48.1% identity in 547 aa FT overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE FT DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from FT Enterobacter cloacae (552 aa), FASTA scores: opt: 1596, FT E(): 0, (46.8% identity in 551 aa overlap); etc. Contains FT PS00187 Thiamine pyrophosphate enzymes signature and FT PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR: FT THIAMINE PYROPHOSPHATE. TBparse score is 0.910." FT /product="PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE FT DECARBOXYLASE PDC" FT misc_feature complement(949775..949834) FT /note="PS00187 Thiamine pyrophosphate enzymes signature" FT misc_feature complement(950351..950374) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 951183..951626 FT /function="UNKNOWN" FT /locus_tag="Rv0854" FT /note="Rv0854, (MTV043.47), len: 147 aa. Conserved FT hypothetical protein, similar to several hypothetical FT protein from Mycobacterium leprae e.g. FT NP_301674.1|NC_002677 (144 aa); FT NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa), FASTA FT scores: opt: 193, E(): 1.6e-06, (24.6% identity in 134 aa FT overlap); NP_301218.1|NC_002677 (146 aa); MTCI28.04|Z97050 FT (184 aa), FASTA scores: opt: 171, E(): 5.8e-05, (21.5% FT identity in 135 aa overlap). Also similar to FT SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein FT from Streptomyces coelicolor (144 aa), FASTA scores: opt: FT 344, E(): 6.1e- 17, (37.6% identity in 141 aa overlap). FT And similar to many proteins from Mycobacterium FT tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857, etc. FT TBparse score is 0.903." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 951632..952711 FT /EC_number="5.1.-.-" FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION FT (RACEMIZATION)." FT /gene="far" FT /locus_tag="Rv0855" FT /note="Rv0855, (MTV043.48), len: 359 aa. Probable far, FT fatty acid-CoA racemase (EC 5.1.-.-), highly similar to FT CAB08122.1|Z94723 unknown protein from Mycobacterium FT leprae (253 aa) (C-terminus shorter). Also similar to many FT eukaryotic and bacteria racemases e.g. T35425 probable FT fatty acid CoA racemase from Streptomyces coelicolor (387 FT aa); P70473|AMAC_RAT ALPHA-METHYLACYL-CoA RACEMASE FT (2-METHYLACYL-CoA RACEMASE) (2-ARYLPROPIONYL-COA FT EPIMERASE) (EC 5.1.99.4) from Rattus norvegicus (Rat) (382 FT aa); NP_103687.1|NC_002678 probable fatty acid Co-A FT racemase from Mesorhizobium loti (389 aa); etc. Also FT similar to proteins from Mycobacterium tuberculosis e.g. FT Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360 FT aa), FASTA scores: opt: 1373, E(): 0, (56.8% identity in FT 359 aa overlap), Rv1866|MTCY359.07 (C-terminal half) (778 FT aa), Rv3272 (360 aa). TBparse score is 0.899." FT /product="PROBABLE FATTY-ACID-CoA RACEMASE FAR" FT CDS 952825..953229 FT /function="UNKNOWN" FT /locus_tag="Rv0856" FT /note="Rv0856, (MTV043.49), len: 134 aa. Conserved FT hypothetical protein, showing weak similarity with FT NP_301674.1| (NC_002677) conserved hypothetical protein FT from Mycobacterium leprae (144 aa); and SC6G10.02c|T35511 FT hypothetical protein from Streptomyces coelicolor (144 FT aa). Also highly similar to other proteins from FT Mycobacterium tuberculosis e.g. neighbouring ORF FT downstream Rv0857 CONSERVED HYPOTHETICAL PROTEIN (126 aa), FT FASTA scores: E(): 7.4e-27, (62.0% identity in 100 aa FT overlap); neighbouring ORF Rv0854|MTV043_47 CONSERVED FT HYPOTHETICAL PROTEIN (147 aa), FASTA scores: E(): 1.6e-15, FT (36.6% identity in 123 aa overlap), FT MTCI28.04|Z97050|MTCI28_4 (184 aa), FASTA scores: opt: FT 127, E(): 0.036, (26.0% identity in 127 aa overlap); and FT MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 123, E(): FT 0.06, (26.4% identity in 125 aa overlap). TBparse score is FT 0.913." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 953257..953730 FT /function="UNKNOWN" FT /locus_tag="Rv0857" FT /note="Rv0857, (MTV043.50), len: 157 aa. Conserved FT hypothetical protein, showing weak similarity with FT Q9X7Y8|SC6G10.02c|T35511 hypothetical protein from FT Streptomyces coelicolor (144 aa), FASTA scores: opt: 215, FT E(): 7.6e-08, (30.282% identity in 142 aa overlap). Also FT highly similar to other proteins from Mycobacterium FT tuberculosis e.g. upstream ORF Rv0856 (134 aa), FASTA FT scores: opt: 566, E(): 2e-32, (58.15% identity in 129 aa FT overlap); upstream ORF Rv0854 (147 aa), FASTA scores: opt: FT 401, E(): 7.2e-21, (41.8% identity in 146 aa overlap); FT MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 122, E(): FT 0.031, (29.4% identity in 85 aa overlap); and FT MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 114, E(): FT 0.1, (30.9% identity in 55 aa overlap). Length extended FT since first submission (+33 aa). TBparse score is 0.910." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(953727..954920) FT /EC_number="2.6.1.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0858c" FT /note="Rv0858c, (MTV043.51c), len: 397 aa. Probable FT aminotransferase (EC 2.6.1.-), highly similar to others FT from Eukaryota and bacteria, especially aspartate FT aminotransferases (transaminases) (EC 2.6.1.1), e.g. FT NP_177890.1|NC_003070 putative aminotransferase from FT Arabidopsis thaliana (440 aa); NP_419555.1|NC_002696 FT aminotransferase class I from Caulobacter crescentus (385 FT aa); NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative FT aminotransferase from Escherichia coli strain K12 (386 FT aa), FASTA scores: opt: 830, E(): 0, (38.0% identity in FT 389 aa overlap); X99521|TAX99521_1 aspartate FT aminotransferase from Thermus aquaticus (383 aa), FASTA FT scores: opt: 702, E(): 0, (34.9% identity in 393 aa FT overlap); etc. Also similar to other putative FT aminotransferases from Mycobacterium tuberculosis e.g. FT Rv2294, Rv3565, etc. TBparse score is 0.907." FT /product="PROBABLE AMINOTRANSFERASE" FT CDS 955077..956288 FT /EC_number="2.3.1.-" FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION." FT /gene="fadA" FT /locus_tag="Rv0859" FT /note="Rv0859, (MTV043.52), len: 403 aa. Possible fadA, FT acyl-CoA thiolase (EC 2.3.1.-), equivalent to FT NP_302423.1|NC_002677 putative beta-ketoadipyl CoA FT thiolase from Mycobacterium leprae (403 aa). Also highly FT similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl FT CoA thiolases, e.g. T35428 probable acetyl CoA FT acetyltransferase (thiolase) from Streptomyces coelicolor FT (404 aa); NP_250427.1|NC_002516 probable acyl-CoA thiolase FT from Pseudomonas aeruginosa (401 aa); FT NP_106253.1|NC_002678 probable acyl-CoA thiolase from FT Mesorhizobium loti (402 aa); NP_248919.1|NC_002516|PcaF FT beta-ketoadipyl CoA thiolase PcaF from Pseudomonas FT aeruginosa (401 aa); etc. Contains PS00098 Thiolases FT acyl-enzyme intermediate signature, PS00737 Thiolases FT signature 2 and PS00099 Thiolases active site. TBparse FT score is 0.849." FT /product="POSSIBLE ACYL-CoA THIOLASE FADA" FT misc_feature 955338..955394 FT /note="PS00098 Thiolases acyl-enzyme intermediate FT signature" FT misc_feature 956121..956171 FT /note="PS00737 Thiolases signature 2" FT misc_feature 956226..956267 FT /note="PS00099 Thiolases active site" FT CDS 956293..958455 FT /evidence=experimental FT /function="INVOLVED IN FATTY ACID DEGRADATION (PROBABLY IN FT FATTY ACID BETA-OXIDATION CYCLE)." FT /gene="fadB" FT /locus_tag="Rv0860" FT /note="Rv0860, (MTV043.53), len: 720 aa. Probable fadB, FT fatty oxidation protein, equivalent to FT NP_302422.1|NC_002677 putative fatty oxidation complex FT alpha subunit from Mycobacterium leprae (714 aa). Also FT highly similar to others and various proteins involved in FT fatty acid metabolism, e.g. T35429 probable fatty FT oxidation protein from Streptomyces coelicolor (733 aa); FT NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA FT dehydrogenase from Pseudomonas aeruginosa (714 aa); FT NP_418895.1|NC_002696 fatty oxidation complex alpha FT subunit from Caulobacter crescentus (709 aa); FT P40939|ECHA_HUMAN TRIFUNCTIONAL ENZYME ALPHA SUBUNIT FT [INCLUDES: LONG-CHAIN ENOYL-CoA HYDRATASE (EC 4.2.1.17); FT LONG CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE (EC 1.1.1.35)] FT from Homo sapiens (763 aa), FASTA scores: opt: 1176, E(): FT 0, (32.4% identity in 722 aa overlap); P21177|FADB_ECOLI FT FATTY OXIDATION COMPLEX ALPHA SUBUNIT [INCLUDES: ENOYL-COA FT HYDRATASE (EC 4.2.1.17); FT DELTA(3)-CIS-DELTA(2)-TRANS-ENOYL-CoA ISOMERASE (EC FT 5.3.3.8); 3-HYDROXYACYL-CoA DEHYDROGENASE (EC 1.1.1.35); FT 3- HYDROXYBUTYRYL-CoA EPIMERASE (EC 5.1.2.3)] from FT Escherichia coli strain K12 (729 aa), FASTA scores: opt: FT 873, E(): 0, (33.6% identity in 693 aa overlap); etc. FT TBparse score is 0.864." FT /product="PROBABLE FATTY OXIDATION PROTEIN FADB" FT CDS complement(958523..960151) FT /EC_number="3.6.1.-" FT /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. HAS FT HELICASE ACTIVITY: ACTS BY OPENING DNA EITHER AROUND THE FT RNA TRANSCRIPTION START SITE OR THE DNA DAMAGE." FT /gene="ercc3" FT /locus_tag="Rv0861c" FT /note="Rv0861c, (MTV043.54c), len: 542 aa. Probable ercc3, FT DNA helicase (EC 3.6.1.-) (see citation below), equivalent FT to NP_302420.1|NC_002677 probable DNA helicase from FT Mycobacterium leprae (549 aa). Also highly similar to FT others (shorter than several eukaryotic enzymes) e.g. FT NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA FT repair helicase from Treponema pallidum (606 aa), FASTA FT scores: opt: 1275, E(): 0, (47.5% identity in 592 aa FT overlap); Q00578|RA25_YEAST DNA REPAIR HELICASE from FT Saccharomyces cerevisiae (843 aa), FASTA scores: opt: 777, FT E(): 0, (30.4% identity in 605 aa overlap); FT P49135|XPB_MOUSE DNA-REPAIR PROTEIN COMPLEMENTING XP-B FT CELLS from Mus musculus (Mouse) (783 aa), FASTA scores: FT opt: 761, E(): 0, (36.3% identity in 375 aa overlap); etc. FT SEEMS TO BELONG TO THE HELICASE FAMILY. TBparse score is FT 0.899." FT /product="PROBABLE DNA HELICASE ERCC3" FT repeat_unit complement(960173..960225) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_unit complement(960226..960278) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_unit complement(960279..960333) FT /note="55 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS complement(960342..962612) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0862c" FT /note="Rv0862c, (MTV043.55c), len: 756 aa. Conserved FT hypothetical protein, equivalent to NP_302419.1|NC_002677 FT possible DNA-binding protein from Mycobacterium leprae FT (753 aa); and highly similar (except in C-terminus) to FT MLCB57.01|Z99494|T45333 hypothetical protein from FT Mycobacterium leprae (>577 aa, truncated), FASTA scores: FT opt: 3047, E(): 0, (78.9% identity in 578 aa overlap). FT Also similar in part to SCD12A.03c|AB93395.1|AL357524 FT hypothetical protein from Streptomyces coelicolor (867 FT aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 962599..962880 FT /function="UNKNOWN" FT /locus_tag="Rv0863" FT /note="Rv0863, (MTV043.56), len: 93 aa. Conserved FT hypothetical protein, highly similar to FT NP_302418.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (74 aa). Also weakly similar in part FT to U82598|ECU82598_135 HYPOTHETICAL PROTEIN from FT Escherichia coli, FASTA scores: (32.4% identity in 71 aa FT overlap); and M74011|YEPYSCOP_8 HYPOTHETICAL PROTEIN from FT Yersinia enterocolitica (165 aa), FASTA scores: (38.6 FT identity in 57 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 962890..963393 FT /function="INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN." FT /gene="moaC2" FT /locus_tag="Rv0864" FT /note="Rv0864, (MTV043.57), len: 167 aa. Probable moaC2, FT molybdopterin cofactor biosynthesis protein, highly FT similar to others e.g. CAB59676.1|AL132674 molybdenum FT cofactor biosynthesis protein from Streptomyces coelicolor FT (170 aa); NP_418834.1|NC_002696 molybdenum cofactor FT biosynthesis protein C from Caulobacter crescentus (186 FT aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor FT synthesis protein moaC from Arthrobacter nicotinovorans FT plasmid pAO1 (169 aa), FASTA scores: opt: 491, E(): FT 2.4e-29, (51.0% identity in 151 aa overlap); etc. Also FT highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE FT MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from FT Mycobacterium tuberculosis (170 aa), FASTA scores: opt: FT 491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and FT O53376|Rv3324c|MOAC3|MTV016.24c PUTATIVE MOLYBDENUM FT COFACTOR BIOSYNTHESIS PROTEIN C3 (177 aa). TBparse score FT is 0.907." FT /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS FT PROTEIN C 2 MOAC2" FT CDS 963390..963872 FT /function="INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS; FT INVOLVED IN THE BIOSYNTHESIS OF A DEMOLYBDO-COFACTOR FT (MOLYBDOPTERIN), NECESSARY FOR MOLYBDO-ENZYMES." FT /gene="mog" FT /locus_tag="Rv0865" FT /note="Rv0865, (MTV043.58), len: 160 aa. Probable mog, FT molybdopterin biosynthesis MOG protein, highly similar or FT similar to other molybdenum cofactor biosynthesis proteins FT e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis FT protein from Streptomyces coelicolor (179 aa); FT NP_301253.1|NC_002677 putative molybdenum cofactor FT biosynthesis protein from Mycobacterium leprae (181 aa); FT CAC39235.1|AJ312124 Mog protein from Eubacterium FT acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336 FT MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Haemophilus FT influenzae (197 aa), FASTA scores: opt: 306, E(): 9e-13, FT (39.6% identity in 139 aa overlap); P28694|MOG_ECOLI FT MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Escherichia FT coli (195 aa), FASTA scores: opt: 265, E(): 3.6e-10, (34.2 FT identity in 146 aa overlap); etc. Also highly similar to FT Rv0984|MTV044.12|MOAB2 POSSIBLE FT PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from FT Mycobacterium tuberculosis (181 aa). TBparse score is FT 0.914." FT /product="PROBABLE MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN" FT CDS 963869..964294 FT /function="POSSIBLY A MOLYBDENUM BIOSYNTHESIS COFACTOR. FT CONVERSION OF MOLYBDOPTERIN PRECURSOR Z INTO MOLYBDOPTERIN FT REQUIRES TRANSFER OF TWO SULFUR ATOMS TO PRECURSOR Z (TO FT GENERATE THE DITHIOLENE GROUP). THIS IS CATALYZED BY THE FT CONVERTING FACTOR COMPOSED OF A SMALL AND LARGE SUBUNIT." FT /gene="moaE2" FT /locus_tag="Rv0866" FT /note="Rv0866, (MTV043.59), len: 141 aa. Probable moaE2, FT molybdopterin converting factor E (molybdopterin FT converting factor (subunit 2)), similar to others e.g. FT Y10817|ANY10817_4|T44853 molybdopterin biosynthesis FT protein E chain from Arthrobacter nicotinovorans plasmid FT pAO1 (155 aa), FASTA scores: opt: 460, E(): 3.5e-27, (49.3 FT identity in 146 aa overlap); CAC01331.1|AL390968 moaE-like FT protein from Streptomyces coelicolor (152 aa); FT NP_389313.1|NC_000964 molybdopterin converting factor FT (subunit 2) from Bacillus subtilis (157 aa); etc. Also FT highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 PUTATIVE FT MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from FT Mycobacterium tuberculosis (147 aa), FASTA scores: opt: FT 321, E(): 5.9e-17, (40.9% identity in 132 aa overlap); and FT O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN FT from Mycobacterium tuberculosis (221 aa). TBparse score is FT 0.889." FT /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS FT PROTEIN E2 MOAE2 (MOLYBDOPTERIN CONVERTING FACTOR LARGE FT SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT FT 2)" FT CDS complement(964312..965535) FT /function="UNKNOWN. MAY BE PROMOTE THE RESUSCITATION AND FT GROWTH OF DORMANT, NONGROWING CELL." FT /gene="rpfA" FT /locus_tag="Rv0867c" FT /note="Rv0867c, (MTV043.60c), len: 407 aa. Possible rpfA, FT resuscitation-promoting factor (see citation below). FT N-terminus highly similar to N-terminal part (1-125 aa) of FT Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved FT hypothetical protein from Mycobacterium leprae (174 aa), FT FASTA scores: opt: 785, E(): 1.8e-18, (63.0% identity in FT 200 aa overlap); and highly similar to C-terminus of FT NP_301299.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (375 aa); and middle part of FT NP_302360.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (157 aa). N-terminus also highly FT similar in part of three secreted proteins from FT Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative FT secreted protein (244 aa). Regions highly similar to FT CAB76321.1|AL158060 putative membrane protein from FT Streptomyces coelicolor (121 aa); and middle part of FT CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa). FT Also highly similar in part to four FT resuscitation-promoting factors from Mycobacterium FT tuberculosis: Rv2450 (172 aa), Rv1009 (362 aa), Rv1884c FT (176 aa), and Rv2389c (154 aa). Contains a probable FT secretory signal sequence in N-terminus. TBparse score is FT 0.902." FT /product="POSSIBLE RESUSCITATION-PROMOTING FACTOR RPFA" FT CDS complement(965983..966261) FT /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS." FT /gene="moaD2" FT /locus_tag="Rv0868c" FT /note="Rv0868c, (MTV043.61c), len: 92 aa. Probable moaD2, FT molybdenum cofactor biosynthesis protein (molybdopterin FT converting factor (subunit 1)), similar to FT CAB88494.1|AL353816 putative molybdopterin converting FT factor from Streptomyces coelicolor (84 aa); and weakly FT similar to others MoaD proteins e.g. Z99111|BSUB0008_103 FT from Bacillus subtilis (77 aa), FASTA scores: opt: 86, FT E(): 2.8, (22.9% identity in 83 aa overlap); etc. Also FT some similarity with Rv3112|MOAD1|MTCY164.22 PUTATIVE FT MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from FT Mycobacterium tuberculosis (83 aa), FASTA scores: opt: FT 113, E(): 0.024, (31.3% identity in 83 aa overlap). FT TBparse score is 0.917." FT /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS FT PROTEIN D 2 MOAD2 (MOLYBDOPTERIN CONVERTING FACTOR SMALL FT SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT FT 1)" FT CDS complement(966265..967347) FT /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS; FT INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN PRECURSOR Z FT FROM GUANOSINE." FT /gene="moaA2" FT /locus_tag="Rv0869c" FT /note="Rv0869c, (MTV043.62c), len: 360 aa. Probable moaA2, FT molybdenum cofactor biosynthesis protein, highly similar FT to others e.g. CAB59437.1|AL132644|SCI8_6 molybdenum FT cofactor biosynthesis protein A from Streptomyces FT coelicolor (341 aa), FASTA scores: opt: 1336, E(): 0, FT (61.7% identity in 332 aa overlap); S57490|X78980|ANMOAA_1 FT molybdopterin cofactor synthesis protein from Arthrobacter FT nicotinovorans (fragment) (374 aa), FASTA scores: opt: FT 1059, E(): 0, (49.9% identity in 369 aa overlap); FT Q44118|MOAA_ARTNI PROBABLE MOLYBDOPTERIN COFACTOR FT SYNTHESIS PROTEIN A from Arthrobacter nicotinovorans FT plasmid pAO1 (355 aa); etc. Also similar to FT Rv3109|MTCY164.19|Z95150|MOAA1 PUTATIVE MOLYBDENUM FT COFACTOR BIOSYNTHESIS PROTEIN A from Mycobacterium FT tuberculosis (359 aa), FASTA scores: opt: 657, E(): 0, FT (36.6% identity in 309 aa overlap). BELONGS TO THE MOAA / FT NIFB / PQQE FAMILY. TBparse score is 0.895." FT /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS FT PROTEIN A2 MOAA2" FT CDS complement(967344..967733) FT /function="UNKNOWN" FT /locus_tag="Rv0870c" FT /note="Rv0870c, (MTV043.63c), len: 129 aa. Possible FT conserved integral membrane protein, highly similar to FT other membrane proteins: putative secreted proteins or FT hypothetical proteins e.g. CAC08263.1| AL392146 putative FT integral membrane protein from Streptomyces coelicolor FT (138 aa); NP_233433.1|NC_002506 conserved hypothetical FT protein from Vibrio cholerae (143 aa); FT NP_455572.1|NC_003198 putative membrane protein from FT Salmonella enterica subsp. enterica serovar Typhi (148 FT aa); P37065|YCCF_ECOLI HYPOTHETICAL 16.3 kDa PROTEIN from FT Escherichia coli (148 aa), FASTA scores: opt: 183, E(): FT 1.9e-06, (36.6% identity in 134 aa overlap); etc. TBparse FT score is 0.886." FT /product="POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT CDS 967898..968305 FT /evidence=experimental FT /function="UNKNOWN; THOUGHT TO ACT IN RESPONSE TO LOW FT TEMPERATURE." FT /gene="cspB" FT /locus_tag="Rv0871" FT /note="Rv0871, (MTV043.64), len: 135 aa. Probable cspB, FT cold shock-like protein B, equivalent to FT Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from FT Mycobacterium leprae (136 aa), FASTA scores: opt: 787, FT E(): 0, (86.0% identity in 136 aa overlap). Also highly FT similar (but often longer than) to others e.g. FT CAB93399.1|AL357524 cold shock protein B from Streptomyces FT coelicolor (127 aa); Q45099|CSPD_BACCE COLD SHOCK-LIKE FT PROTEIN CSPD from Bacillus cereus (66 aa); Y101 FT 81|LLCSPB_1 cold shock protein from Lactococcus lactis (66 FT aa), FASTA scores: opt: 220, E(): 2.5e-07, (48.3% identity FT in 60 aa overlap); etc. SEEMS TO BELONG TO THE COLD-SHOCK FT DOMAIN (CSD) FAMILY. TBparse score is 0.897." FT /product="PROBABLE COLD SHOCK-LIKE PROTEIN B CSPB" FT CDS complement(968424..970244) FT /evidence=experimental FT /function="UNKNOWN" FT /gene="PE_PGRS15" FT /locus_tag="Rv0872c" FT /note="Rv0872c, (MTV043.65c), len: 606 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002), similar to FT many e.g. MTCY24A1.04c|Z95207 (615 aa), FASTA scores: opt: FT 2636, E(): 0, (64.6% identity in 619 aa overlap); etc." FT /product="PE-PGRS FAMILY PROTEIN" FT misc_feature complement(968481..968504) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 970505..972457 FT /EC_number="1.3.99.-" FT /evidence=experimental FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /gene="fadE10" FT /locus_tag="Rv0873" FT /note="Rv0873, (MTV043.66-MTCY31.01), len: 650 aa. FT Probable fadE10, acyl-CoA dehydrogenase (EC 1.3.99.-), FT highly similar to many e.g. CAB91129.1|AL355913 putative FT acyl CoA dehydrogenase from Streptomyces coelicolor (658 FT aa); P50544|ACDV_MOUSE ACYL-CoA DEHYDROGENASE from Mus FT musculus (656 aa); D30647|RATVLCAD_1 very-long-chain FT Acyl-CoA dehydrogenase from Rattus norvegicus (655 aa), FT FASTA scores: opt: 675, E(): 0, (33.9% identity in 380 aa FT overlap); etc." FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE10" FT CDS complement(972546..973706) FT /function="UNKNOWN" FT /locus_tag="Rv0874c" FT /note="Rv0874c, (MTCY31.02c), len: 386 aa. Conserved FT hypothetical protein, highly similar in part to SPU62616_1 FT hypothetical protein from Synechococcus sp. (280 aa), FT FASTA scores: E(): 6.3e-26, (35.2% identity in 264 aa FT overlap); SYCSLLLH_102 from Synechocystis sp. (447 aa), FT FASTA scores: E(): 1.1e-18, (29.5% identity in 400 aa FT overlap). Also highly similar to Rv0628c|MTCY20H10_9 from FT Mycobacterium tuberculosis (383 aa), FASTA scores: E():0, FT (81.5% identity in 383 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(973806..974294) FT /function="UNKNOWN" FT /locus_tag="Rv0875c" FT /note="Rv0875c, (MTCY31.03c), len: 162 aa. Possible FT conserved exported protein, equivalent to MLCB57_11|O33056 FT possible exported protein from Mycobacterium leprae (162 FT aa), FASTA scores: opt: 789, E(): 0, (71.4% identity in FT 161 aa overlap)." FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT CDS complement(974291..975937) FT /function="UNKNOWN" FT /locus_tag="Rv0876c" FT /note="Rv0876c, (MTCY31.04c), len: 548 aa. Possible FT conserved transmembrane protein, equivalent to FT MLCB57_12|O33057 possible membrane protein from FT Mycobacterium leprae (579 aa), FASTA scores: opt: 2850, FT E(): 0, (81.0% identity in 568 aa overlap). Also highly FT similar (except in N-terminus) to CAB93403.1|AL357524 FT putative integral membrane protein from Streptomyces FT coelicolor (463 aa)." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 976075..976863 FT /function="UNKNOWN" FT /locus_tag="Rv0877" FT /note="Rv0877, (MTCY31.05), len: 262 aa. Conserved FT hypothetical protein, equivalent to MLCB57_13|O33058 FT conserved hypothetical protein from Mycobacterium leprae FT (269 aa), FASTA scores: E(): 0, (80.5% identity in 257 aa FT overlap). Also highly similar (except in C-terminus) to FT SCD12A.13|CAB93404.1|AL357524 hypothetical protein from FT Streptomyces coelicolor (308 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(976872..978203) FT /function="UNKNOWN" FT /gene="PPE13" FT /locus_tag="Rv0878c" FT /note="Rv0878c, (MTCY31.06c), len: 443 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: FT 1044, E(): 0, (47.4% identity in 397 aa overlap); FT MTV014_3, MTCI65_2, MTCY98_24, MTCY3C7_23, MTCY48_17, FT MTV004_5, MTV004_3, etc." FT /product="PPE FAMILY PROTEIN" FT CDS complement(978481..978756) FT /function="UNKNOWN" FT /locus_tag="Rv0879c" FT /note="Rv0879c, (MTCY31.07c), len: 91 aa. Possible FT conserved transmembrane protein, C-terminus highly similar FT to C-terminal part of MLCB57_14|O33059 conserved FT hypothetical protein from Mycobacterium leprae (91 aa), FT FASTA scores: E(): 1.2e-25, (76.9% identity in 91 aa FT overlap)." FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS 978934..979365 FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0880" FT /note="Rv0880, (MTCY31.08), len: 143 aa. Possible FT transcriptional regulator, MarR family, equivalent to FT MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family FT protein from Mycobacterium leprae (143 aa), FASTA scores: FT opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also FT similar to many others e.g. CAB93410.1|AL357524 putative FT marR-family protein from Streptomyces coelicolor (145 aa); FT NP_251757.1|NC_002516 probable transcriptional regulator FT from Pseudomonas aeruginosa (147 aa); etc. Also similar to FT Rv2327 from Mycobacterium tuberculosis (163 aa)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY MARR-FAMILY)" FT CDS 979362..980228 FT /EC_number="2.1.1.-" FT /function="CAUSES METHYLATION." FT /locus_tag="Rv0881" FT /note="Rv0881, (MTCY31.09), len: 288 aa. Possible rRNA FT methyltransferase (EC 2.1.1.-), highly similar to others FT and hypothetical proteins e.g. CAB76071.1|AL157953 FT putative rRNA methylase from Streptomyces coelicolor (272 FT aa); NP_421117.1|NC_002696 spoU rRNA methylase family FT protein from Caulobacter crescentus (268 aa); FT D90913_93|P74261 rRNA METHYLASE from Synechocystis sp. FT (274 aa), FASTA scores: E(): 1.1e-13, (26.3% identity in FT 278 aa overlap); P18644|TSNR_STRCN rRNA METHYLTRANSFERASE FT (EC 2.1.1.66) from Streptomyces cyaneus (Streptomyces FT curacoi) (269 aa), FASTA scores: E(): 3.7e-08, (23.9% FT identity in 268 aa overlap); etc. Equivalent to AAK45146.1 FT from Mycobacterium tuberculosis strain CDC1551 (242 aa) FT but longer 46 aa." FT /product="POSSIBLE RRNA METHYLTRANSFERASE (RRNA FT METHYLASE)" FT CDS 980225..980509 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0882" FT /note="Rv0882, (MTCY31.10), len: 94 aa. Probable FT transmembrane protein." FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT CDS complement(980506..981267) FT /function="UNKNOWN" FT /locus_tag="Rv0883c" FT /note="Rv0883c, (MTCY31.11c), len: 253 aa. Conserved FT hypothetical protein, equivalent to O3306|MLCB57_16 FT CONSERVED HYPOTHETICAL PROTEI from Mycobacterium leprae FT (251 aa), FASTA scores: E(): 0, (79.4% identity in 253 aa FT overlap). Also highly similar to N_terminus of FT AL009204|SC9B10_22 HYPOTHETICAL PROTEIN from Streptomyces FT coelicolor (352 aa), FASTA scores: E(): 6.1e-20, (35.0% FT identity in 246 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(981424..982554) FT /EC_number="2.6.1.52" FT /evidence=experimental FT /function="CATALYZES THE REVERSIBLE INTERCONVERSION OF FT PHOSPHOSERINE AND 2-OXOGLUTARATE TO 3-PHOSPHONOOXYPYRUVATE FT AND GLUTAMATE. REQUIRE BOTH IN THE MAJOR PHOSPHORYLATED FT PATHWAY OF SERINE BIOSYNTHESIS AND IN PYRIDOXINE FT BIOSYNTHESIS [CATALYTIC ACTIVITY: O-phospho-L-serine + FT 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate]." FT /gene="serC" FT /locus_tag="Rv0884c" FT /note="Rv0884c, (MTCY31.12c), len: 376 aa. Possible serC, FT phosphoserine aminotransferase (EC 2.6.1.52), equivalent FT to MLCB57_17 putative phosphoserine aminotransferase from FT Mycobacterium leprae (376 aa), FASTA scores: E(): 0, (87.5 FT identity in 376 aa overlap). Also highly similar to FT CAC08322.1|AL392149 putative aminotransferase from FT Streptomyces coelicolor (363 aa); and similar to other FT phosphoserine aminotransferases e.g. NP_386837.1|NC_003047 FT PUTATIVE PHOSPHOSERINE AMINOTRANSFERASE PROTEIN from FT Sinorhizobium meliloti (392 aa); P52878|SERC_METBA FT PHOSPHOSERINE AMINOTRANSFERASE from Methanosarcina barkeri FT (370 aa); P10658|SERC_RABIT|RABEPIP_1 PHOSPHOSERINE FT AMINOTRANSFERASE from Rabbit (370 aa), FASTA scores: opt: FT 271, E(): 3.5e-11, (24.5% identity in 368 aa overlap); FT etc. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE." FT /product="POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC FT (PSAT)" FT CDS 982762..983784 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0885" FT /note="Rv0885, (MTCY31.13), len: 340 aa. Conserved FT hypothetical protein, equivalent to O33063|MLCB57_18 FT possible transmembrane protein from Mycobacterium leprae FT (341 aa), FASTA score: (83.9% identity in 341 aa overlap). FT Also similar except in C-terminus to T35630 probable FT membrane protein from Streptomyces coelicolor (312 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 983803..985530 FT /EC_number="1.18.1.2" FT /function="SERVES AS THE FIRST ELECTRON TRANSFER PROTEIN FT IN ALL THE P450 SYSTEMS [CATALYTIC ACTIVITY: REDUCED FT ADRENODOXIN + NADP+ = OXIDIZED ADRENODOXIN + NADPH]." FT /gene="fprB" FT /locus_tag="Rv0886" FT /note="Rv0886, (MTCY31.14), len: 525 aa. Probable fprB, FT ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin FT oxidoreductase) (EC 1.18.1.2), equivalent to FT O3306|MLCB57_19 FERREDOXIN/FERREDOXIN--NADP REDUCTASE from FT Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6 FT identity in 560 aa overlap). Also highly similar or FT similar to others e.g. NP_294219.1|NC_001263 putative FT ferredoxin/ferredoxin--NADP reductase from Deinococcus FT radiodurans (479 aa) (N-terminus shorter); FT P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from FT homo sapiens (497 aa), FASTA scores: opt: 624, E(): 3e-30, FT (39.7% identity in 484 aa overlap); P08165|ADRO_BOVIN FT NADPH:ADRENODOXIN OXIDOREDUCTASE from Bos taurus (492 aa); FT etc. Also similar to others from Mycobacterium FT tuberculosis e.g. Rv3106, Rv3858c, etc. Contains PS00198 FT 4Fe-4S ferredoxins, iron-sulfur binding region signature." FT /product="PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB FT (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) FT REDUCTASE)" FT misc_feature 983938..983973 FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding FT region signature" FT CDS complement(985513..985971) FT /function="UNKNOWN" FT /locus_tag="Rv0887c" FT /note="Rv0887c, (MTCY31.15c), len: 152 aa. Conserved FT hypothetical protein, highly similar to others e.g. FT NP_436346.1|NC_003037 Hypothetical protein from FT Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (194 FT aa), FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity FT in 131 aa overlap); etc. Also shows weak similarity with FT transposases and related proteins." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 987233..988705 FT /function="UNKNOWN" FT /locus_tag="Rv0888" FT /note="Rv0888, (MTCY31.16), len: 490 aa. Probable exported FT protein. Equivalent to AAK45157.1 from Mycobacterium FT tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. FT Contains possible N-terminal signal sequence." FT /product="PROBABLE EXPORTED PROTEIN" FT CDS complement(988740..989861) FT /EC_number="4.1.3.7" FT /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE (KREBS FT CYCLE) [CATALYTIC ACTIVITY: Citrate + CoA = acetyl-CoA + FT H2O + oxaloacetate]." FT /gene="citA" FT /locus_tag="Rv0889c" FT /note="Rv0889c, (MTCY31.17c), len: 373 aa. Probable citA FT (alternate gene name: gltA), citrate synthase 2 (EC FT 4.1.3.7), highly similar to others e.g. FT CAB95899.1|AL359988 putative citrate synthase from FT Streptomyces coelicolor (387 aa); P39119|CISY_BACSU FT citrate synthase II from Bacillus subtilis (366 aa), FASTA FT scores: opt: 586, E(): 5.8e-30, (33.8% identity in 367 aa FT overlap); etc. Also similar to Rv0896|MTCY31.24 from FT Mycobacterium tuberculosis (29.2% identity in 274 aa FT overlap) and Rv1131. Contains PS00480 Citrate synthase FT signature. BELONGS TO THE CITRATE SYNTHASE FAMILY." FT /product="PROBABLE CITRATE SYNTHASE II CITA" FT /standard_name="gltA" FT misc_feature complement(989085..989123) FT /note="PS00480 Citrate synthase signature" FT CDS complement(989948..992596) FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /locus_tag="Rv0890c" FT /note="Rv0890c, (MTCY31.18c), len: 882 aa. Probable FT transcriptional regulatory protein, LuxR family, highly FT similar (but shorter 238 aa in N-terminus) to FT NP_302202.1|NC_002677 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also highly similar FT (generally in part) to others e.g. T50568 probable FT multi-domain regulatory protein from Streptomyces FT coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite FT response regulator protein from Escherichia coli (216 aa), FT FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in 99 FT aa overlap); etc. Also highly similar to others from FT Mycobacterium tuberculosis e.g. MTCY02B10_22, MTV008_44, FT MTV036_21, and MTCY31_24. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop), PS00622 Bacterial regulatory FT proteins, luxR family signature, and probable helix-turn FT helix motif from aa 836 to 857 (Score 1559, +4.50 SD). FT BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL FT REGULATORS." FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LUXR-FAMILY)" FT misc_feature complement(990011..990094) FT /note="PS00622 Bacterial regulatory proteins, luxR family FT signature" FT misc_feature complement(992531..992554) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(992598..993455) FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0891c" FT /note="Rv0891c, (MTCY31.19c), len: 285 aa. Possible FT transcriptional regulator, highly similar in N-terminus to FT NP_302202.1|NC_002677 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also highly similar FT to several Mycobacterium tuberculosis putative FT transcriptional regulators e.g. Q1102|MTCY02B10_22 FT PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (1159 aa), FT FASTA scores: opt: 702, E(): 8.3e-40, (50.6% identity in FT 247 aa overlap); MTV036_21; MTV008_44; MTCY02B10_23. Also FT shows similarity with several adenylate cyclases and FT hydrolases from other organisms." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT CDS 993853..995340 FT /EC_number="1.14.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0892" FT /note="Rv0892, (MTCY31.20), len: 495 aa. Probable FT monooxygenase (EC 1.14.-.-), highly similar to others e.g. FT NP_250787.1|NC_002516 probable flavin-binding FT monooxygenase from Pseudomonas aeruginosa (491 aa); FT CAB59668.1|AL132674 monooxygenase from Streptomyces FT coelicolor (519 aa); P12015|CYMO_ACIS cyclohexanone FT monooxygenase from Acinetobacter sp. (542 aa), FASTA FT scores: opt: 489, E(): 6.8e-26, (30.3% identity in 492 aa FT overlap); etc. Also highly similar to Rv0565c, Rv3854c, FT Rv3083, etc from Mycobacterium tuberculosis. Has FT hydrophobic stretch at N-terminus." FT /product="PROBABLE MONOOXYGENASE" FT CDS complement(995318..996295) FT /function="UNKNOWN" FT /locus_tag="Rv0893c" FT /note="Rv0893c, (MTCY31.21c), len: 325 aa. Conserved FT hypothetical protein, belongs in family with FT P96823|Rv0146|MTCI5.20 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (310 aa), FASTA scores: opt: FT 784, E(): 0, (43.2% identity in 308 aa overlap); Rv0726c, FT Rv0731c, Rv3399, etc. Also shows some similarity with FT others e.g. SC9B5.10|T35930 hypothetical protein from FT Streptomyces coelicolor (303 aa); BSUB0008_141|Q45500 FT HYPOTHETICAL 34.8 kDa PROTEIN from Bacillus subtilis (304 FT aa), FASTA scores: E(): 0.00033, (26.8% identity in 168 aa FT overlap); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 996524..997705 FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /locus_tag="Rv0894" FT /note="Rv0894, (MTCY31.22), len: 393 aa. Possible FT regulatory protein, LuxR family, highly similar in part to FT NP_302202.1|NC_002677 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also similar to FT others e.g. CAB95788.1|AL359949 putative multi-domain FT regulatory protein from Streptomyces coelicolor (780 aa); FT NP_107293.1|NC_002678 transcriptional regulator from FT Mesorhizobium loti (903 aa); etc. Also similar to other FT regulatory proteins from Mycobacterium tuberculosis e.g. FT Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity FT in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA FT score: (52.3% identity in 365 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY LUXR-FAMILY)" FT misc_feature 996722..996745 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 997782..999299 FT /function="UNKNOWN" FT /locus_tag="Rv0895" FT /note="Rv0895, (MTCY31.23), len: 505 aa. Conserved FT hypothetical protein; member of family with: Rv3740c, FT Rv3734c, Rv1425, Rv1760, etc. Shows some similarity with FT NP_301898.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (491 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 999472..1000767 FT /EC_number="4.1.3.7" FT /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE (KREBS FT CYCLE) [CATALYTIC ACTIVITY: Citrate + CoA = acetyl-CoA + FT H2O + oxaloacetate]." FT /gene="gltA2" FT /locus_tag="Rv0896" FT /note="Rv0896, (MTCY31.24), len: 431 aa. Probable gltA2, FT citrate synthase 1 (EC 4.1.3.7), highly similar to FT O33066|NP_302405.1|NC_002677 citrate synthase 1 from FT Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (91.0 FT identity in 431 aa overlap); and FT AAF04133.1|AF191033_1|AF191033 citrate synthase from FT Mycobacterium smegmatis (441 aa). Also highly similar to FT others e.g. AAF14286.1|AF181118_1|AF181118 citrate FT synthase from Streptomyces coelicolor (429 aa); FT P42457|CISY_CORGL CITRATE SYNTHASE from Corynebacterium FT glutamicum (437 aa), FASTA scores: opt: 1847, E(): 0, FT (63.0% identity in 433 aa overlap); etc. Also similar to FT two other Mycobacterium tuberculosis citrate synthases, FT Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (29.2% FT identity in 274 aa overlap) and Rv1131|MTCY22G8.20|gltA1 FT (393 aa). Contains PS00480 Citrate synthase signature. FT BELONGS TO THE CITRATE SYNTHASE FAMILY." FT /product="PROBABLE CITRATE SYNTHASE I GLTA2" FT misc_feature 1000387..1000425 FT /note="PS00480 Citrate synthase signature" FT CDS complement(1000808..1002415) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0897c" FT /note="Rv0897c, (MTCY31.25c), len: 535 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases from diverse organisms e.g. FT CAB94055.1|AL358672 putative oxidoreductase from FT Streptomyces coelicolor (540 aa); NP_147877.1|NC_000854 FT phytoene dehydrogenase from Aeropyrum pernix (549 aa); FT Q01671|CRTD_RHOSH methoxyneurosporene dehydrogenase from FT Rhodobacter sphaeroides (495 aa), FASTA scores: opt: 139, FT E(): 2.6e-06, (23.8% identity in 538 aa overlap); etc. FT Also similar to Rv1432, Rv2997, and Rv3829c from FT Mycobacterium tuberculosis." FT /product="PROBABLE OXIDOREDUCTASE" FT CDS complement(1002441..1002704) FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0898c" FT /note="Rv0898c, (MTCY31.26c), len: 87 aa. Conserved FT hypothetical protein, highly similar to FT CAC01589.1|AL391041 hypothetical protein from Streptomyces FT coelicolor (87 aa). Also shows some similarity to FT Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 FT aa), FASTA score: (28.8% identity in 73 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1002812..1003792 FT /db_xref="Q10557" FT /evidence=experimental FT /function="THE PROTEIN BEHAVED AS A PORIN OF LOW SPECIFIC FT ACTIVITY. STRUCTURAL PROTEIN THAT MAY PROTECT THE FT INTEGRITY OF THE BACTERIUM." FT /gene="ompA" FT /locus_tag="Rv0899" FT /note="Rv0899, (MTCY31.27), len: 326 aa. ompA, outer FT membrane protein A (see citation below). C-terminal region FT similar to C-terminus of many members of the OMPA family FT of outer membrane proteins, e.g. NP_458280.1|NC_003198 FT putative outer membrane protein from Salmonella enterica FT subsp. enterica serovar Typhi (220); NP_418008.1|NC_000913 FT putative outer membrane protein from Escherichia coli FT strain K12 (219 aa), FASTA scores: opt: 296, E(): 2.2e-11, FT (45.3% identity in 117 aa overlap); NP_231844.1|NC_002505 FT outer membrane protein OmpA from Vibrio cholerae (321 aa); FT Q05146|OMPA_BORAV OUTER MEMBRANE PROTEIN A PRECURSOR from FT Bordetella avium (194 aa); etc. A signal peptide sequence FT probably exists at the N-terminus. Contains PS00044 FT Bacterial regulatory proteins, lysR family signature. FT BELONGS TO THE OMPA FAMILY." FT /product="OUTER MEMBRANE PROTEIN A OMPA" FT misc_feature 1003304..1003381 FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS 1003805..1003957 FT /function="UNKNOWN" FT /locus_tag="Rv0900" FT /note="Rv0900, (MTCY31.28), len: 50 aa. Possible membrane FT protein, with hydrophobic domain from aa 4-26." FT /product="POSSIBLE MEMBRANE PROTEIN" FT CDS 1003957..1004484 FT /function="UNKNOWN" FT /locus_tag="Rv0901" FT /note="Rv0901, (MTCY31.29), len: 175 aa. Possible FT conserved exported or membrane protein, with hydrophobic FT N-terminus at aa 7-25. Shows some similarity in C-terminus FT to O33070|Z99494|MLCB57.59 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (113 aa), FASTA scores: opt: 204, FT E(): 3.2e-12, (44.9% identity in 78 aa overlap)." FT /product="POSSIBLE CONSERVED EXPORTED OR MEMBRANE PROTEIN" FT CDS complement(1004501..1005841) FT /EC_number="2.7.3.-" FT /evidence=experimental FT /function="SENSOR PART OF THE TWO COMPONENT REGULATORY FT SYSTEM PRRA/PRRB. THOUGHT TO BE INVOLVED IN THE FT ENVIRONMENTAL ADAPTATION , SPECIFICALLY IN AN EARLY PHASE FT OF THE INTRACELLULAR GROWTH." FT /gene="prrB" FT /locus_tag="Rv0902c" FT /note="Rv0902c, (MTCY31.30c), len: 446 aa. prrB, FT two-component sensor histidine kinase (EC 2.7.3.-) (see FT citations below), transmembrane protein, equivalent to FT MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase FT from Mycobacterium leprae (446 aa); and similar at FT C-termini to NP_301251.1|NC_002677 putative two-component FT system sensor kinase from Mycobacterium leprae (519 aa). FT C-terminus also similar to the C-termini of many FT sensor-like histidine kinase proteins e.g. FT P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor FT protein from Escherichia coli strain K12 (457 aa), FASTA FT scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa FT overlap); CAB89748.1|AL354616 putative two-component FT histidine kinase from Streptomyces coelicolor (483 aa); FT CAB82845.1|AJ277081 putative histidine kinase from FT Amycolatopsis mediterranei (472 aa); etc. Also similar in FT part to Mycobacterium tuberculosis proteins Rv3764c (475 FT aa); and Rv0982 (504 aa). Thought to be induced at FT phagocytosis (see Graham & Clark-Curtiss 1999)." FT /product="TWO COMPONENT SENSOR HISTIDINE KINASE PRRB" FT CDS complement(1005852..1006562) FT /evidence=experimental FT /function="TRANSCRIPTIONAL REGULATOR PART OF THE TWO FT COMPONENT REGULATORY SYSTEM PRRA/PRRB. THOUGHT TO BE FT INVOLVED IN THE ENVIRONMENTAL ADAPTATION , SPECIFICALLY IN FT AN EARLY PHASE OF THE INTRACELLULAR GROWTH." FT /gene="prrA" FT /locus_tag="Rv0903c" FT /note="Rv0903c, (MTCY31.31c), len: 236 aa. prrA, FT two-component response regulator (see citations below), FT equivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 FT two-component response regulator from Mycobacterium leprae FT (233 aa), FASTA scores: opt: 1414, E(): 0, (95.7% identity FT in 233 aa overlap); and similar to T45446 probable FT two-component response regulator from Mycobacterium leprae FT (253 aa). Also similar to many sensor-like histidine FT kinase proteins e.g. CAB88489.1|AL353816 putative FT two-component systen response regulator from Streptomyces FT coelicolor (248 aa); AAG36759.1|AF119221_1 |AF119221 FT response regulator from Corynebacterium glutamicum (232 FT aa); Q02540|COPR_PSESM transcriptional activator protein FT COPR from Pseudomonas syringae (pv. tomato) (227 aa), FT FASTA scores: opt: 600, E(): 0, (44.4% identity in 225 aa FT overlap); etc. Also similar to Rv0981 from Mycobacterium FT tuberculosis (230 aa), Rv3765c (234 aa), phoP (247 aa), FT etc. Thought to be induced at phagocytosis (see Graham & FT Clark-Curtiss 1999)." FT /product="TWO COMPONENT RESPONSE TRANSCRIPTIONAL FT REGULATORY PROTEIN PRRA" FT CDS complement(1006693..1008180) FT /EC_number="6.4.1.2" FT /function="THIS PROTEIN IS A COMPONENT OF THE ACETYL FT COENZYME A CARBOXYLASE COMPLEX; FIRST, BIOTIN CARBOXYLASE FT CATALYZES THE CARBOXYLATION OF THE CARRIER PROTEIN AND FT THEN THE TRANSCARBOXYLASE TRANSFERS THE CARBOXYL GROUP TO FT FORM MALONYL-CoA [CATALYTIC ACTIVITY ATP + ACETYL-CoA + FT HCO(3)(-) = ADP + PHOSPHATE + MALONYL-COA]." FT /gene="accD3" FT /locus_tag="Rv0904c" FT /note="Rv0904c, (MTCY31.32c, MT0927), len: 495 aa. FT Putative accD3, acetyl-CoA carboxylase carboxyl FT transferase, beta subunit (carboxyltransferase subunit of FT acetyl-CoA carboxylase) (EC 6.4.1.2), highly similar in FT part to AAA63045.1|U15184 zinc finger protein from FT Mycobacterium leprae (201 aa). Also highly similar to FT others e.g. CAC42827.1|Y17592 putative carboxyltransferase FT subunit of acetyl-CoA carboxylase from Corynebacterium FT glutamicum (491 aa); CAB86110.1|AL163003 putative acetyl FT CoA carboxylase (alpha and beta subunits) from FT Streptomyces coelicolor (458 aa); Q54776|ACCD_SYNP7 FT ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT FT BETA from Synechococcus sp. (305 aa); P12217|ACCD_MARPO FT ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT FT BETA from Marchantia polymorpha (316 aa), FASTA scores: FT opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap); FT etc. Also similar to Rv3280, Rv2502c, etc from FT Mycobacterium tuberculosis. BELONGS TO THE ACCD/PCCB FT FAMILY." FT /product="PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL FT TRANSFERASE (SUBUNIT BETA) ACCD3 (ACCASE BETA CHAIN)" FT CDS 1008207..1008938 FT /EC_number="4.2.1.17" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + FT H(2)O]." FT /gene="echA6" FT /locus_tag="Rv0905" FT /note="Rv0905, (MTCY31.33), len: 243 aa. Possible echA6, FT enoyl-CoA hydratase (EC 4.2.1.17), highly similar to FT ML15184|U15184 enoyl-CoA hydratase from Mycobacterium FT leprae (247 aa), FASTA score: (85.8% identity in 247 aa FT overlap). Also similar to many e.g. NP_250320.1|NC_002516 FT probable enoyl-CoA hydratase/isomerase from Pseudomonas FT aeruginosa (261 aa); NP_415911.1|NC_000913 putative enzyme FT from Escherichia coli strain K12 (255 aa); FT P24162|ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from FT Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 FT aa), FASTA scores: opt: 404, E():7.8e-21, (37.3% identity FT in 249 aa overlap); etc." FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA6 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT CDS 1008944..1010062 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0906" FT /note="Rv0906, (MTCY31.34), len: 372 aa. Conserved FT hypothetical protein, highly similar to others e.g. FT SC6A5.25|AL049485|T35416 hypothetical protein from FT Streptomyces coelicolor (370 aa), FASTA scores: opt: 1125, FT E(): 0, (51.3% identity in 335 aa overlap); FT NP_242955.1|NC_002570|BH2089 conserved protein from FT Bacillus halodurans (370 aa); etc. Also shows some FT similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer FT membrane protein roma (fragment) from Klebsiella FT pneumoniae (132 aa), FASTA scores: opt: 319, E(): 8.5e-14, FT (46.2% identity in 104 aa overlap); NP_105215.1|NC_002678 FT hypothetical protein which contains similarity to outer FT membrane protein romA from Enterobacter cloacae (350 aa); FT etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1010136..1011734 FT /function="UNKNOWN, POSSIBLY INVOLVED IN CELL WALL FT BIOSYNTHESIS." FT /locus_tag="Rv0907" FT /note="Rv0907, (MTCY21C12.01), len: 532 aa. Conserved FT hypothetical protein, possibly involved in cell wall FT biosynthesis: similar to many beta-lactamases, FT penicillin-binding proteins and hypothetical proteins e.g. FT NP_298910.1|NC_002488 beta-lactamase from Xylella FT fastidiosa (455 aa); Q06317|PBP4_NOCLA PENICILLIN-BINDING FT PROTEIN 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): FT 8.8e-05, (28.7% identity in 401 aa overlap); etc. FT N-terminus highly similar to AAA63047.1|U15184 FT hypothetical protein from Mycobacterium leprae (58 aa). FT Related to other putative esterases and penicillin binding FT proteins in Mycobacterium tuberculosis e.g. FT Rv1730c|MTCY04C12.15c (517 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1011731..1014124 FT /EC_number="3.6.1.-" FT /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY FT CATALYZES THE TRANSPORT OF UNDETERMINATED METAL CATION FT WITH HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE + FT UNDETERMINATED METAL CATION(OUT)]." FT /gene="ctpE" FT /locus_tag="Rv0908" FT /note="Rv0908, (MTCY21C12.02), len: 797 aa. Probable ctpE, FT metal cation-transporting ATPase P-type, transmembrane FT protein, E1-E2 family, highly similar to many e.g. FT AB93406.1|AL357524 putative integral membrane ATPase from FT Streptomyces coelicolor (802 aa); NP_346063.1|NC_003028 FT cation-transporting ATPase (E1-E2 family) from FT Streptococcus pneumoniae (778 aa); P37278|ATCL_SYNP7|PACL FT cation-transporting atpase from Synechococcus sp. strain FT PCC 7942 (Anacystis nidulans R2) (926 aa), FASTA scores: FT opt: 257, E(): 4.8e-33, (27.7% identity in 905 aa FT overlap); etc. Contains E1-E2 ATPases phosphorylation site FT (PS00154). BELONGS TO THE CATION TRANSPORT ATPASES FAMILY FT (E1-E2 ATPASES)." FT /product="PROBABLE METAL CATION TRANSPORTER ATPASE P-TYPE FT CTPE" FT misc_feature 1012631..1012651 FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT CDS 1014681..1014860 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0909" FT /note="Rv0909, (MTCY21C12.03), len: 59 aa. Conserved FT hypothetical protein, equivalent to NP_302399.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (56 aa). Also some similarity with AL022268|SC4H2_10c FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (97 aa), FT FASTA scores: opt: 106, E(): 0.13, (43.2% identity in 37 FT aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1014866..1015300 FT /function="UNKNOWN" FT /locus_tag="Rv0910" FT /note="Rv0910, (MTCY21C12.04), len: 144 aa. Conserved FT hypothetical protein, equivalent to NP_302398.1|NC_002677 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae FT (181 aa), FASTA scores: opt: 820, E(): 0, (83.9% identity FT in 143 aa overlap). Also similar to Rv1546|MTCY48.19c FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (143 FT aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1015398..1016171 FT /function="UNKNOWN" FT /locus_tag="Rv0911" FT /note="Rv0911, (MTCY21C12.05), len: 257 aa. Conserved FT hypothetical protein, showing similarity with hydroxylases FT and hypothetical proteins e.g. T35325 probable hydroxylase FT from Streptomyces coelicolor (265 aa); Q54242 hypothetical FT protein from Streptomyces, FASTA scores: opt: 372, E(): FT 8.8e-18, (32.0% identity in 256 aa overlap); FT AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV FT from Streptomyces peucetius (275 aa); AAA63051.1|U15184 FT hypothetical protein from Mycobacterium leprae (94 aa); FT etc. Also similar to Rv0577 HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (261 aa)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1016236..1016685 FT /function="UNKNOWN" FT /locus_tag="Rv0912" FT /note="Rv0912, (MTCY21C12.06), len: 149 aa. Probable FT conserved transmembrane protein, equivalent to FT Q50121|NP_302397.1|NC_002677 conserved hypothetical FT protein from Mycobacterium leprae (144 aa), FASTA scores: FT opt: 677, E(): 6.9e-38, (69.5% identity in 141 aa FT overlap)." FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT CDS complement(1017217..1018725) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0913c" FT /note="Rv0913c, (MTCY21C12.07c), len: 501 aa. Possible FT dioxygenase (EC 1.-.-.-), showing similarity with others FT e.g. AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage FT dioxygenase from Phaseolus vulgaris (543 aa); FT CAB56138.1|AL117669 putative dioxygenase from Streptomyces FT coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838 FT putative dioxygenase SimC5 from Streptomyces antibioticus FT (456 aa); Q53353|S65040 FT LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE (EC 1.13.11.43) from FT Pseudomonas paucimobilis (485 aa), FASTA scores: opt: 310, FT E(): 3.4e-20, (28.9% identity in 495 aa overlap); etc. FT Also some similarity with Rv0654|MTCI376.22 PROBABLE FT DIOXYGENASE from Mycobacterium tuberculosis (501 aa)." FT /product="POSSIBLE DIOXYGENASE" FT CDS complement(1018727..1019965) FT /EC_number="2.3.1.16" FT /function="THOUGHT TO BE INVOLVED IN DEGRADATIVE PATHWAYS FT SUCH AS FATTY ACID BETA_OXIDATION." FT /locus_tag="Rv0914c" FT /note="Rv0914c, (MTCY21C12.08c), len: 412 aa. Possible FT lipid carrier protein or keto acyl-CoA thiolase (EC FT 2.3.1.16), highly similar to NP_421905.1|NC_002696 FT thiolase family protein from Caulobacter crescentus (407 FT aa); and similar to others e.g. NP_107896.1|NC_002678 FT 3-ketoacyl-CoA thiolase from Mesorhizobium loti (392 aa); FT NP_385796.1|NC_003047 PUTATIVE 3-KETOACYL-CoA THIOLASE FT PROTEIN from Sinorhizobium meliloti (389 aa); FT NP_275932.1|NC_000916 lipid-transfer protein (sterol or FT nonspecific) from Methanothermobacter thermautotrophicus FT (383 aa); AB55378.1|AL117263 possible 3-ketoacyl-CoA FT thiolase from Leishmania major (441 aa), FASTA scores: FT opt: 547, E(): 3.1e-26, (31.0% identity in 435 aa FT overlap); etc. Also similar to Rv2790c, Rv1627c, Rv0244, FT etc from Mycobacterium tuberculosis. COULD BELONG TO THE FT THIOLASE FAMILY." FT /product="POSSIBLE LIPID CARRIER PROTEIN OR KETO ACYL-COA FT THIOLASE" FT CDS complement(1020058..1021329) FT /evidence=experimental FT /function="UNKNOWN. POSSIBLY A PROTECTIVE ANTIGEN INVOLVED FT WITH THE EARLY CONTROL OF INFECTION." FT /gene="PPE14" FT /locus_tag="Rv0915c" FT /note="Rv0915c, (MTCY21C12.09c), len: 423 aa. PPE14 FT (alternate gene name: MTB41). Member of the Mycobacterium FT tuberculosis PPE family (see citation below), highly FT similar to many e.g. Rv1807 from Mycobacterium FT tuberculosis (403 aa), FASTA scores: opt: 966, E(): FT 4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains FT PS00626 Regulator of chromosome condensation (RCC1) FT signature 2." FT /product="PPE FAMILY PROTEIN" FT /standard_name="MTB41" FT misc_feature complement(1020346..1020378) FT /note="PS00626 Regulator of chromosome condensation (RCC1) FT signature 2" FT CDS complement(1021344..1021643) FT /evidence=experimental FT /function="UNKNOWN." FT /gene="PE7" FT /locus_tag="Rv0916c" FT /note="Rv0916c, (MTCY21C12.10c), len: 99 aa. PE7 FT (alternate gene name: MTB10). Member of the Mycobacterium FT tuberculosis PE family (see citations below), similar to FT many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa), FT FASTA scores: opt: 321, E(): 1.3e-11, (53.5% identity in FT 99 aa overlap); etc." FT /product="PE FAMILY PROTEIN" FT /standard_name="MTB10" FT CDS 1022087..1023868 FT /evidence=experimental FT /function="HIGH-AFFINITY UPTAKE OF GLYCINE BETAINE. FT SUPPOSED RESPONSIBLE FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /gene="betP" FT /locus_tag="Rv0917" FT /note="Rv0917, (MTCY21C12.11), len: 593 aa. Possible betP, FT glycine betaine transporter, integral membrane protein, FT highly similar to many transporters, mainly glycine FT betaine transporters, e.g. P54582|BETP_CORGL glycine FT betaine transporter from Corynebacterium glutamicum FT (Brevibacterium flavum) (595 aa), FASTA scores: opt: 1367, FT E(): 0, (42.7% identity in 504 aa overlap); T35264 FT probable BCCT family transporter from Streptomyces FT coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine FT transporter from Bacillus halodurans (504 aa); FT NP_439848.1|NC_000907 high-affinity choline transport FT protein (betT) from Haemophilus influenzae (669 aa); etc. FT SEEMS TO BELONG TO THE BCCT (TC 2.33) FAMILY OF FT TRANSPORTERS." FT /product="POSSIBLE GLYCINE BETAINE TRANSPORT INTEGRAL FT MEMBRANE PROTEIN BETP" FT CDS 1024211..1024687 FT /evidence=experimental FT /function="UNKNOWN" FT /locus_tag="Rv0918" FT /note="Rv0918, (MTCY21C12.12), len: 158 aa. Conserved FT hypothetical protein, similar in part to Q50116 FT hypothetical protein from Mycobacterium leprae (44 aa), FT FASTA scores: opt: 132, E(): 0.0055, (65.6% identity in 32 FT aa overlap). Also some similarity in C-terminus with other FT hypothetical proteins e.g. NP_289961.1|NC_002655 FT hypothetical protein from Escherichia coli strain O157:H7 FT (94 aa); etc." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS 1024684..1025184 FT /function="UNKNOWN" FT /locus_tag="Rv0919" FT /note="Rv0919, (MTCY21C12.13), len: 166 aa. Conserved FT hypothetical protein, some similarity to Q50115 FT hypothetical protein from Mycobacterium leprae (90 aa), FT FASTA scores: opt: 243, E(): 5.3e-11, (56.5% identity in FT 85 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT tRNA complement(1025321..1025393) FT /gene="tRNA-Arg(CCT)" FT /anticodon=(pos:1025358..1025360,aa:Arg) FT /product="transfer RNA-Arg(CCT)" FT repeat_unit 1025458..1025472 FT /note="15 bp inverted repeat, ATTCGGTGTAAGTGG, at the left FT end of IS1554 element" FT repeat_region complement(1025458..1026893) FT /insertion_seq="IS1554" FT /note="IS1554, len: 1436 bp. Putative Insertion sequence FT element bounded by 15 bp inverted repeats." FT CDS complement(1025497..1026816) FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1554." FT /locus_tag="Rv0920c" FT /note="Rv0920c, (MTCY21C12.14c), len: 439 aa. Probable FT transposase for IS1554, highly similar to others e.g. FT MTCY441.35|Q45111 transposase from Mycobacterium FT tuberculosis (419 aa), FASTA scores: opt: 1113, E(): 0, FT (43.9% identity in 378 aa overlap); etc. Contains FT transposases mutator family signature (PS01007)." FT /product="PROBABLE TRANSPOSASE" FT misc_feature complement(1025953..1026027) FT /note="PS01007 Transposases, Mutator family, signature, D" FT repeat_unit complement(1026879..1026893) FT /note="15 bp inverted repeat, ATTCGGTGTAAGTGG, at the FT right end of IS1554 element" FT repeat_unit 1027061..1027076 FT /note="16 bp inverted repeat, TTGAGTGTGTTTTAGT, at the FT left end of IS element IS1535" FT repeat_region 1027061..1029360 FT /insertion_seq="IS1535" FT /note="IS1535, len: 2300 bp. Putative Insertion sequence FT element bounded by 16 bp inverted repeats." FT CDS 1027104..1027685 FT /evidence=experimental FT /function="PREVENTS THE COINTEGRATION OF FOREIGN DNA FT BEFORE INTEGRATION INTO THE CHROMOSOME." FT /locus_tag="Rv0921" FT /note="Rv0921, (MTCY21C12.15), len: 193 aa. Possible FT resolvase for IS1535, highly similar to many bacterial FT resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from FT Mycobacterium tuberculosis (295 aa), FASTA scores: opt: FT 537, E(): 5.7e-29, (51.8% identity in 166 aa overlap). FT Presents an helix turn helix motif." FT /product="POSSIBLE RESOLVASE" FT CDS 1027685..1029337 FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1535" FT /locus_tag="Rv0922" FT /note="Rv0922, (MTCY21C12.16), len: 550 aa. Possible FT transposase for IS1535, similar to many e.g. FT YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium FT tuberculosis (460 aa), FASTA scores: opt 939, E(): 0, FT (40.6% identity in 465 aa overlap); etc." FT /product="POSSIBLE TRANSPOSASE" FT repeat_unit complement(1029345..1029360) FT /note="16 bp inverted repeat, TTGAGTGTGTTTTAGT, at the FT right end of IS element IS1535" FT CDS complement(1029513..1030577) FT /function="UNKNOWN" FT /locus_tag="Rv0923c" FT /note="Rv0923c, (MTCY21C12.17c), len: 354 aa. Conserved FT hypothetical protein, showing similarity with C-terminal FT part of AF034138|AF034138_7|yjoB HYPOTHETICAL PROTEIN from FT Bacillus subtilis (200 aa), FASTA scores: opt: 193, E(): FT 4.2e-05, (32.3% identity in 167 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(1030578..1031864) FT /evidence=experimental FT /function="H(+)-STIMULATED, HIGHLY SELECTIVE, DIVALENT FT CATION UPTAKE SYSTEM. RESPONSIBLE FOR THE TRANSLOCATION OF FT THE DIVALENT METAL ACROSS THE MEMBRANE." FT /gene="mntH" FT /locus_tag="Rv0924c" FT /note="Rv0924c, (MTCY21C12.18c), len: 428 aa. mntH FT (alternative gene name: Nramp, Mramp), H+-dependent FT divalent cation-transport integral membrane protein (see FT citations below), equivalent to O69443|MNTH_MYCBO PROBABLE FT MANGANESE TRANSPORT PROTEIN MNTH (BRAMP) from FT Mycobacterium bovis (415 aa); and NP_302396.1|NC_002677 FT probable manganese transport protein from Mycobacterium FT leprae (426 aa). Also similar (but longer 51 aa in FT N-terminus) to AAA63075.1|U15184 SMF2 protein from FT Mycobacterium leprae (377 aa), FASTA scores: opt: 1780, FT E(): 0, (74.5% identity in 376 aa overlap). Also similar FT to many orthologues of the eukaryotic Nramp (natural FT resistance-associated macrophage protein), also known as FT mntH, e.g. NP_456951.1|NC_003198 manganese transport FT protein MntH from Salmonella enterica subsp. enterica FT serovar Typhi (413 aa); etc. BELONGS TO THE NRAMP FAMILY." FT /product="DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN MNTH (BRAMP) (MRAMP)" FT /standard_name="Nramp; Mramp" FT CDS complement(1031896..1032633) FT /function="UNKNOWN" FT /locus_tag="Rv0925c" FT /note="Rv0925c, (MTCY21C12.19c), len: 245 aa. Conserved FT hypothetical protein, similar to AL132991|SCF55_19 FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (197 FT aa), FASTA scores: opt: 459, E(): 1.2e-23, (39.3% identity FT in 201 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(1032710..1033786) FT /function="UNKNOWN" FT /locus_tag="Rv0926c" FT /note="Rv0926c, (MTCY21C12.20c), len: 358 aa. Conserved FT hypothetical protein, similar to Rv1059 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (354 FT aa). Also shows some similarity to AF170923|AF170923_3 FT dihydrodipicolinate reductase from Mastigocladus laminosus FT (278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7% FT identity in 276 aa overlap)." FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT CDS complement(1033840..1034631) FT /EC_number="1.-.-.-" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /locus_tag="Rv0927c" FT /note="Rv0927c, (MTCY21C12.21c), len: 263 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), similar FT to various dehydrogenases/reductases, notably FT 7-alpha-hydroxysteroid dehydrogenases and glucose FT 1-dehydrogenases e.g. P25529|HDHA_ECOLI FT 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli FT (255 aa), FASTA scores: opt: 551, E(): 1e-26, (39.5% FT identity in 248 aa overlap); NP_252778.1|NC_002516 FT probable short-chain dehydrogenase from Pseudomonas FT aeruginosa (253 aa); AAC44307.1|U59433 3-ketoacyl-acyl FT carrier protein reductase from Bacillus subtilis (246 aa); FT etc. Also similar to other dehydrogenases from FT Mycobacterium tuberculosis e.g. MTCY09F9.36, E():1.4e-18; FT MTCY369.14, E():8e-17; MTCY02B10.14, E():2.5e-14; FT MTCY09F9.23c, E():1.5e-13; MTCY03C7.07, E():1.9e-13. FT Contains PS00061 Short-chain dehydrogenases/reductases FT family signature, and PS00017 ATP/GTP-binding site motif A FT (P-loop). BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT misc_feature complement(1033900..1033923) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(1034107..1034193) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 1034903..1036015 FT /evidence=experimental FT /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC FT PHOSPHATE ACROSS THE MEMBRANE (IMPORT). THIS IS ONE OF THE FT PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED PHOSPHATE FT TRANSPORT." FT /gene="pstS3" FT /locus_tag="Rv0928" FT /note="Rv0928, (MTCY21C12.22), len: 370 aa. pstS3 FT (previously known as phoS2), phosphate-binding lipoprotein FT component of inorganic phosphate transport system (see FT citations below), highly similar to others from FT Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1 FT phosphate-binding protein 3 precursor (328 aa), FASTA FT scores: opt: 1772, E(): 0, (79.6% identity in 328 aa FT overlap); and highly similar to others e.g. FT AAF74819.1|AF137360_1|AF137360 periplasmic phosphate FT permease from Mycobacterium avium (369 aa). Also highly FT similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING FT PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1 FT PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from FT Mycobacterium tuberculosis (Mycobacterium tuberculosis FT seems to have three PstS-like proteins, others being FT Rv0932c and Rv0934c). Contains lipoprotein signature FT (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE FT RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN FT TRANSPORTERS." FT /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3 FT (PBP-3) (PSTS3) (PHOS1)" FT /standard_name="phoS2" FT misc_feature 1034939..1034971 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 1036028..1037002 FT /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC FT PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. FT THIS IS ONE OF THE PROTEINS REQUIRED FOR FT BINDING-PROTEIN-MEDIATED PHOSPHATE TRANSPORT." FT /gene="pstC2" FT /locus_tag="Rv0929" FT /note="Rv0929, (MTCY21C12.23), len: 324 aa. pstC2, FT phosphate-transport integral membrane ABC transporter (see FT citations below), highly similar to others e.g. FT NP_302394.1|NC_002677 membrane-bound component of FT phosphate transport from Mycobacterium leprae (319 aa); FT CAB88474.1|AL353816 phosphate ABC transport system FT permease protein from Streptomyces coelicolor (336 aa); FT NP_290359.1| NC_002655 high-affinity phosphate-specific FT transport system (cytoplasmic membrane component) from FT Escherichia coli strain O157:H7 (319 aa); etc. Also FT similar to Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE FT ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from FT Mycobacterium tuberculosis (338 aa). Contains FT binding-protein-dependent transport systems inner membrane FT component signature (PS00402)." FT /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC FT TRANSPORTER PSTC2" FT misc_feature 1036631..1036717 FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature" FT CDS 1036999..1037925 FT /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC FT PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. FT THIS IS ONE OF THE PROTEINS REQUIRED FOR FT BINDING-PROTEIN-MEDIATED PHOSPHATE TRANSPORT." FT /gene="pstA1" FT /locus_tag="Rv0930" FT /note="Rv0930, (MTCY21C12.24), len: 308 aa. Probable FT pstA1, phosphate-transport integral membrane ABC FT transporter (see citation below), highly similar to others FT e.g. NP_302393.1|NC_002677 membrane-bound component of FT phosphate transport from Mycobacterium leprae (304 aa); FT CAB88473.1|AL353816 phosphate ABC transport system FT permease protein from Streptomyces coelicolor (354 aa) FT (N-terminus longer); NP_312689.1|NC_002695 phosphate FT transport system permease protein PstA from Escherichia FT coli strain O157:H7 (296 aa); etc. Also similar to FT Rv0936|MTCY08D9.03c|PSTA2 PROBABLE TRANSMEMBRANE ABC FT TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from FT Mycobacterium tuberculosis (301 aa)." FT /product="PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE FT ABC TRANSPORTER PSTA1" FT CDS complement(1037920..1039914) FT /EC_number="2.7.1.-" FT /evidence=experimental FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE PHOSPHATE TRANSPORT. FT CAN PHOSPHORYLATE THE PEPTIDE SUBSTRATE MYELIN BASIC FT PROTEIN (MBP) AT SERINE AND THREONINE RESIDUES. CAN BE FT AUTOPHOSPHORYLATED ON THREONINE RESIDUES [CATALYTIC FT ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]." FT /gene="pknD" FT /locus_tag="Rv0931c" FT /note="Rv0931c, (MTCY08D9.08), len: 664 aa. pknD FT (alternate gene name: mbk), transmembrane serine/threonine FT protein kinase (EC 2.7.1.-) (see citations below), FT equivalent to CAB62227.1|AJ250200 putative FT serine/threonine protein kinase from Mycobacterium bovis FT BCG (291 aa); and highly similar in N-terminus to FT P54744|PKNB_MYCLE probable serine/threonine-specific FT protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 FT aa). Also highly similar to others, particularly in FT N-terminal half e.g. NP_243370.1|NC_002570 FT serine/threonine protein kinase from Bacillus halodurans FT (664 aa); NP_268044.1|NC_002662 serine/threonine protein FT kinase from Lactococcus lactis (627 aa); etc. Also highly FT similar to other serine/threonine protein kinases from FT Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA FT scores: opt: 1398, E: 0, (49.3% identity in 540 aa FT overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); FT etc. Contains Hank's kinase subdomain. Contains two FT transmembrane segments, which flank a highly repetitive FT region, suggesting a receptor-like anchoring. BELONGS TO FT THE SER/THR FAMILY OF PROTEIN KINASES. Experimental FT studies show evidence of auto-phosphorylation on a serine FT residue. Appears to be co-transcribed with Rv0932c|pstS2." FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D FT PKND (PROTEIN KINASE D) (STPK D)" FT /standard_name="mbk" FT misc_feature complement(1039477..1039515) FT /note="PS00108 Serine/Threonine protein kinases FT active-site signature" FT misc_feature complement(1039783..1039854) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS complement(1039936..1041048) FT /evidence=experimental FT /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC FT PHOSPHATE ACROSS THE MEMBRANE (IMPORT). THIS IS ONE OF THE FT PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED PHOSPHATE FT TRANSPORT." FT /gene="pstS2" FT /locus_tag="Rv0932c" FT /note="Rv0932c, (MTCY08D9.07), len: 370 aa. pstS2, FT phosphate-binding lipoprotein component of inorganic FT phosphate transport system (see citations below), highly FT similar to AAF74819.1|AF137360_1|AF137360 periplasmic FT phosphate permease from Mycobacterium avium (369 aa); FT Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC FT LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FT FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa FT overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING FT PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis FT (374 aa) (Mycobacterium tuberculosis seems to have three FT