LocusLink 21926
Expression Profile
MGI SwissProt Ensembl Affy UniGene RefSeq LocusLink GeneOntology
ID: MGI:104798
Symbol: Tnf
Name: tumor necrosis factor
ID: TNFA_MOUSE
Accession: P06804, O35853, Q62326, Q91VF3
Name: TNF
Species: Mus musculus
Protein: Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin).
Functions: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
ID: ENSMUSG00000024401
Gene Type: ensembl
Symbol: Tnf
Description: Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin). [Source:Uniprot/SWISSPROT;Acc:P06804]
Gene Class: Known
Chromosome: 17
Gene Start: 33694895
Gene End: 33697492
Strand: -1
ID: 102629_at
Chip: MG-U74Av2
ID: 1419607_at
Chip: MOE430A
ID: Msa.254.0_at
Chip: Mu11KsubB
ID: TNFa_at
ID: x02611_s_at
Chip: Mu11KsubB
ID: Mm.1293
Title: tumor necrosis factor
Gene: Tnf
Cytoband: 17 19.06 cM
ID: NM_013693
ID: NP_038721
Definition: tumor necrosis factor alpha; tumor necrosis factor-alpha; TNF alpha [Mus musculus].
ID: 21926
Symbol: Tnf
Name: tumor necrosis factor
ID: 0005125
Name: cytokine activity
ID: 0005164
Name: tumor necrosis factor receptor binding
ID: 0005886
Name: plasma membrane
ID: 0005887
Name: integral to plasma membrane
ID: 0006927
Name: programmed cell death\, transformed cells
ID: 0006952
Name: defense response
ID: 0006954
Name: inflammatory response
ID: 0006955
Name: immune response
ID: 0006959
Name: humoral immune response
ID: 0006968
Name: cellular defense response
ID: 0007275
Name: development
ID: 0007515
Name: lymph gland development
ID: 0008151
Name: cell growth and/or maintenance
ID: 0008283
Name: cell proliferation
ID: 0008284
Name: positive regulation of cell proliferation
ID: 0009887
Name: organogenesis
ID: 0016020
Name: membrane
ID: 0016021
Name: integral to membrane
ID: 0030141
Name: secretory granule
ID: 0042127
Name: regulation of cell proliferation
ID: 0045123
Name: cellular extravasation
ID: 0045670
Name: regulation of osteoclast differentiation
ID: 0045672
Name: positive regulation of osteoclast differentiation
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